Neuromodulation of BAG co-chaperones by HIV-1 viral proteins and H2O2: implications for HIV-associated neurological disorders

Combination Drug Therapy for the Management of Alzheimer’s Disease

(2020) Md. Tanvir Kabir et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

SIV Infection and the HIV Proteins Tat and Nef Induce Senescence in Adipose Tissue and Human Adipose Stem Cells, Resulting in Adipocyte Dysfunction

(2020) Jennifer Gorwood et al.   Cells

Glia: victims or villains of the aging brain?

(2020) Isabel H. Salas et al.   NEUROBIOLOGY OF DISEASE

The lncRNA LOC102549805 (U1) modulates neurotoxicity of HIV-1 Tat protein

(2020) Bahareh Torkzaban et al.   Cell Death & Disease

BAG3 promotes autophagy and glutaminolysis via stabilizing glutaminase

(2019) Song Zhao et al.   Cell Death & Disease

Perturbation of synapsins homeostasis through HIV-1 Tat-mediated suppression of BAG3 in primary neuronal cells

(2019) Taha Mohseni Ahooyi et al.   Cell Death & Disease

Enhanced autophagic-lysosomal activity and increased BAG3-mediated selective macroautophagy as adaptive response of neuronal cells to chronic oxidative stress

(2019) Debapriya Chakraborty et al.   Redox Biology

A single-cell atlas of entorhinal cortex from individuals with Alzheimer’s disease reveals cell-type-specific gene expression regulation

(2019) Alexandra Grubman et al.   NATURE NEUROSCIENCE

Infusion of HIV-1 Nef-expressing astrocytes into the rat hippocampus induces enteropathy and interstitial pneumonitis and increases blood–brain-barrier permeability

(2019) Jocelyn Rivera et al.   PLoS One

Nef-induced CCL2 Expression Contributes to HIV/SIV Brain Invasion and Neuronal Dysfunction

(2019) Michael H. Lehmann et al.   Frontiers in Immunology

In Vivo Imaging of Hydrogen Peroxide with HyPer Probes

(2018) Dmitry S. Bilan et al.   ANTIOXIDANTS & REDOX SIGNALING

Network analysis of hippocampal neurons by microelectrode array in the presence of HIV-1 Tat and cocaine

(2018) Taha Mohseni Ahooyi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Pathways of cellular proteostasis in aging and disease

(2017) Courtney L. Klaips et al.   JOURNAL OF CELL BIOLOGY

A role of BAG3 in regulating SNCA/α-synuclein clearance via selective macroautophagy

(2017) Yu-Lan Cao et al.   NEUROBIOLOGY OF AGING

Time-Dependent, HIV-Tat-Induced Perturbation of Human Neurons In Vitro: Towards a Model for the Molecular Pathology of HIV-Associated Neurocognitive Disorders

(2017) Kim T. Gurwitz et al.   Frontiers in Molecular Neuroscience

A Surveillance Function of the HSPB8-BAG3-HSP70 Chaperone Complex Ensures Stress Granule Integrity and Dynamism

(2016) Massimo Ganassi et al.   MOLECULAR CELL

Oxidative Stress during HIV Infection: Mechanisms and Consequences

(2016) Alexander V. Ivanov et al.   Oxidative Medicine and Cellular Longevity

HIV-Tat Induces the Nrf2/ARE Pathway through NMDA Receptor-Elicited Spermine Oxidase Activation in Human Neuroblastoma Cells

(2016) Roberta Mastrantonio et al.   PLoS One

Breaking BAG: The Co-Chaperone BAG3 in Health and Disease

(2016) Christian Behl   TRENDS IN PHARMACOLOGICAL SCIENCES

Oxidative stress, mitochondrial dysfunction and neurodegenerative diseases; a mechanistic insight

(2015) Aashiq Hussain Bhat et al.   BIOMEDICINE & PHARMACOTHERAPY

HIV-1 Tat Alters Neuronal Autophagy by Modulating Autophagosome Fusion to the Lysosome: Implications for HIV-Associated Neurocognitive Disorders

(2015) J. Fields et al.   JOURNAL OF NEUROSCIENCE

BAG3 facilitates the clearance of endogenous tau in primary neurons

(2015) Zhinian Lei et al.   NEUROBIOLOGY OF AGING

Human Immunodeficiency Virus Type 1 Nef Inhibits Autophagy through Transcription Factor EB Sequestration

(2015) Grant R. Campbell et al.   PLoS Pathogens

BAG3 induces the sequestration of proteasomal clients into cytoplasmic puncta

(2014) Melania Minoia et al.   Autophagy

BAG1 is Neuroprotective in In Vivo and In Vitro Models of Parkinson’s Disease

(2014) Pawel Kermer et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Asymptomatic HIV-associated neurocognitive impairment increases risk for symptomatic decline

(2014) I. Grant et al.   NEUROLOGY

Effects of antioxidants on the quality and genomic stability of induced pluripotent stem cells

(2014) Lan Luo et al.   Scientific Reports

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Synaptodendritic injury with HIV-Tat protein: What is the therapeutic target?

(2013) Avindra Nath et al.   EXPERIMENTAL NEUROLOGY

HIV-associated neurocognitive disorder

(2013) David B Clifford et al.   LANCET INFECTIOUS DISEASES

Astrocytic expression of HIV-1 Nef impairs spatial and recognition memory

(2012) Gladys Chompre et al.   NEUROBIOLOGY OF DISEASE

BAG3 mediates chaperone-based aggresome-targeting and selective autophagy of misfolded proteins

(2011) Martin Gamerdinger et al.   EMBO REPORTS

HIV-1 Tat neurotoxicity: A model of acute and chronic exposure, and neuroprotection by gene delivery of antioxidant enzymes

(2011) Lokesh Agrawal et al.   NEUROBIOLOGY OF DISEASE

Oxygen matters: tissue culture oxygen levels affect mitochondrial function and structure as well as responses to HIV viroproteins

(2011) L M Tiede et al.   Cell Death & Disease

HIV-1 infection and cognitive impairment in the cART era: a review

(2010) Judith Schouten et al.   AIDS

HIV-1 Nef associates with p22-phox, a component of the NADPH oxidase protein complex

(2010) Siham Salmen et al.   CELLULAR IMMUNOLOGY

HIV proteins (gp120 and Tat) and methamphetamine in oxidative stress-induced damage in the brain: Potential role of the thiol antioxidant N-acetylcysteine amide

(2010) Atrayee Banerjee et al.   FREE RADICAL BIOLOGY AND MEDICINE

HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors

(2010) Robert K. Heaton et al.   JOURNAL OF NEUROVIROLOGY

Treatment of Alzheimer’s Disease with a Cholinesterase Inhibitor Combined with Antioxidants

(2010) Umberto Cornelli   Neurodegenerative Diseases

Cardiospheres Recapitulate a Niche-Like Microenvironment Rich in Stemness and Cell-Matrix Interactions, Rationalizing Their Enhanced Functional Potency for Myocardial Repair

(2010) Tao-Sheng Li et al.   STEM CELLS

Persistent Hijacking of Brain Proteasomes in HIV-Associated Dementia

(2009) Trung P. Nguyen et al.   AMERICAN JOURNAL OF PATHOLOGY

Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3

(2009) Martin Gamerdinger et al.   EMBO JOURNAL

HIV Regulation of Amyloid Beta Production

(2009) Lynn Pulliam   Journal of Neuroimmune Pharmacology

Human Immunodeficiency Virus Protein Tat Induces Synapse Loss via a Reversible Process That Is Distinct from Cell Death

(2008) H. J. Kim et al.   JOURNAL OF NEUROSCIENCE