SIV Infection and the HIV Proteins Tat and Nef Induce Senescence in Adipose Tissue and Human Adipose Stem Cells, Resulting in Adipocyte Dysfunction

HIV antiretroviral drugs, dolutegravir, maraviroc and ritonavir-boosted atazanavir use different pathways to affect inflammation, senescence and insulin sensitivity in human coronary endothelial cells

(2020) Martine Auclair et al.   PLoS One

The Integrase Inhibitors Dolutegravir and Raltegravir Exert Proadipogenic and Profibrotic Effects and Induce Insulin Resistance in Human/Simian Adipose Tissue and Human Adipocytes

(2020) Jennifer Gorwood et al.   CLINICAL INFECTIOUS DISEASES

Impact of HIV/SIV infection and viral proteins on adipose tissue fibrosis and adipogenesis

(2019) Jennifer Gorwood et al.   AIDS

Metabolic complications affecting adipose tissue, lipid and glucose metabolism associated with HIV antiretroviral treatment

(2019) Claire Lagathu et al.   Expert Opinion On Drug Safety

Dolutegravir plus Two Different Prodrugs of Tenofovir to Treat HIV

(2019) Willem D.F. Venter et al.   NEW ENGLAND JOURNAL OF MEDICINE

Age-Dependent and -Independent Effects of Perivascular Adipose Tissue and Its Paracrine Activities during Neointima Formation

(2019) Eva Schütz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Higher Risk of Abdominal Obesity, Elevated Low-Density Lipoprotein Cholesterol, and Hypertriglyceridemia, but not of Hypertension, in People Living With Human Immunodeficiency Virus (HIV): Results From the Copenhagen Comorbidity in HIV Infection Study

(2018) Marco Gelpi et al.   CLINICAL INFECTIOUS DISEASES

Oxidative Stress Inhibits Healthy Adipose Expansion Through Suppression of SREBF1-Mediated Lipogenic Pathway

(2018) Yosuke Okuno et al.   DIABETES

Telmisartan Therapy Does Not Improve Lymph Node or Adipose Tissue Fibrosis More Than Continued Antiretroviral Therapy Alone

(2018) Netanya S Utay et al.   JOURNAL OF INFECTIOUS DISEASES

Factors Associated With Insulin Resistance in Adults With HIV Receiving Contemporary Antiretroviral Therapy: a Brief Update

(2018) Todd Hulgan   Current HIV/AIDS Reports

Relationships between Adipose Mitochondrial Function, Serum Adiponectin, and Insulin Resistance in Persons with HIV after 96 weeks of Antiretroviral Therapy

(2018) Todd Hulgan et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Progressive increases in fat mass occur in adults living with HIV on antiretroviral therapy, but patterns differ by sex and anatomic depot

(2018) Paula Debroy et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Adipose tissue senescence and inflammation in aging is reversed by the young milieu

(2018) Amiya Kumar Ghosh et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Brief Report

(2017) Jamison Norwood et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Human Immunodeficiency Virus Promotes Mitochondrial Toxicity

(2017) Summer J. Rozzi et al.   NEUROTOXICITY RESEARCH

Physiological Aging: Links Among Adipose Tissue Dysfunction, Diabetes, and Frailty

(2017) Michael B. Stout et al.   PHYSIOLOGY

HIV-1 Nef-induced cardiotoxicity through dysregulation of autophagy

(2017) Manish K. Gupta et al.   Scientific Reports

LMNA mutations resulting in lipodystrophy and HIV protease inhibitors trigger vascular smooth muscle cell senescence and calcification: Role of ZMPSTE24 downregulation

(2016) Pauline Afonso et al.   ATHEROSCLEROSIS

Weight Gain and Incident Diabetes Among HIV-Infected Veterans Initiating Antiretroviral Therapy Compared With Uninfected Individuals

(2016) Melissa Herrin et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Infectious SIV resides in adipose tissue and induces metabolic defects in chronically infected rhesus macaques

(2016) Jacob Couturier et al.   Retrovirology

The Influence of Aging on the Regenerative Potential of Human Adipose Derived Mesenchymal Stem Cells

(2016) Monika Marędziak et al.   Stem Cells International

The HIV proteins Tat and Nef promote human bone marrow mesenchymal stem cell senescence and alter osteoblastic differentiation

(2015) Carine Beaupere et al.   AGING CELL

Human adipose tissue as a reservoir for memory CD4+ T cells and HIV

(2015) Jacob Couturier et al.   AIDS

HIV Infection Is Associated With Progression of Subclinical Carotid Atherosclerosis

(2015) David B. Hanna et al.   CLINICAL INFECTIOUS DISEASES

Adipose Tissue Is a Neglected Viral Reservoir and an Inflammatory Site during Chronic HIV and SIV Infection

(2015) Abderaouf Damouche et al.   PLoS Pathogens

Impact of darunavir, atazanavir and lopinavir boosted with ritonavir on cultured human endothelial cells: beneficial effect of pravastatin

(2014) Martine Auclair et al.   ANTIVIRAL THERAPY

Immune Cell Toll-like Receptor 4 Mediates the Development of Obesity- and Endotoxemia-Associated Adipose Tissue Fibrosis

(2014) Isabelle K. Vila et al.   Cell Reports

HIV protease inhibitors induce senescence and alter osteoblastic potential of human bone marrow mesenchymal stem cells: beneficial effect of pravastatin

(2013) Sandra J. Hernandez-Vallejo et al.   AGING CELL

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

HIV-associated disruption of mucosal epithelium facilitates paracellular penetration by human papillomavirus

(2013) Sharof M. Tugizov et al.   VIROLOGY

Peripheral fat loss and decline in adipogenesis in older humans

(2012) Giuseppe Caso et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

LMNA Mutations Induce a Non-Inflammatory Fibrosis and a Brown Fat-Like Dystrophy of Enlarged Cervical Adipose Tissue

(2011) Véronique Béréziat et al.   AMERICAN JOURNAL OF PATHOLOGY

HIV-1 Tat protein impairs adipogenesis and induces the expression and secretion of proinflammatory cytokines in human SGBS adipocytes

(2011) Julieta Díaz-Delfín et al.   ANTIVIRAL THERAPY

Parsing p53 Transactivation

(2011) Judith Campisi   DEVELOPMENTAL CELL

Four faces of cellular senescence

(2011) Francis Rodier et al.   JOURNAL OF CELL BIOLOGY

Human immunodeficiency virus-1 Tat activates NF-κB via physical interaction with IκB-α and p65

(2011) Giuseppe Fiume et al.   NUCLEIC ACIDS RESEARCH

Could Metabolic Syndrome, Lipodystrophy, and Aging Be Mesenchymal Stem Cell Exhaustion Syndromes?

(2011) Eduardo Mansilla et al.   Stem Cells International

Fat tissue, aging, and cellular senescence

(2010) Tamara Tchkonia et al.   AGING CELL

Mitochondrial damage in adipose tissue of untreated HIV-infected patients

(2010) Glòria Garrabou et al.   AIDS

HIV Type 1 Alters Mesenchymal Stem Cell Differentiation Potential and Cell Phenotype ex Vivo

(2010) Eoin J. Cotter et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

HIV Type 1 Nef Is Released from Infected Cells in CD45+ Microvesicles and Is Present in the Plasma of HIV-Infected Individuals

(2010) A.D. Raymond et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Premature Senescence of Vascular Cells Is Induced by HIV Protease Inhibitors

(2010) Chloé Lefèvre et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

HIV-associated lipodystrophy: from fat injury to premature aging

(2010) Martine Caron-Debarle et al.   TRENDS IN MOLECULAR MEDICINE

Role of viral replication, antiretroviral therapy, and immunodeficiency in HIV-associated atherosclerosis

(2009) Priscilla Y Hsue et al.   AIDS

Human and simian immunodeficiency viruses deregulate early hematopoiesis through a Nef/PPARγ/STAT5 signaling pathway in macaques

(2008) Stéphane Prost et al.   JOURNAL OF CLINICAL INVESTIGATION

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY

Inflammatory and Coagulation Biomarkers and Mortality in Patients with HIV Infection

(2008) Lewis H Kuller et al.   PLOS MEDICINE