The Plasticity of Pancreatic β-Cells

Liraglutide and sitagliptin counter beta- to alpha-cell transdifferentiation in diabetes

(2020) Neil Tanday et al.   JOURNAL OF ENDOCRINOLOGY

VMAT2 Safeguards β-Cells Against Dopamine Cytotoxicity Under High-Fat Diet–Induced Stress

(2020) Daisuke Sakano et al.   DIABETES

Mechanism of action of Imeglimin: A novel therapeutic agent for type 2 diabetes

(2020) Sophie Hallakou‐Bozec et al.   DIABETES OBESITY & METABOLISM

Noradrenergic fibers are associated with beta-cell dedifferentiation and impaired beta-cell function in humans

(2020) F. Cinti et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Acceleration of β Cell Aging Determines Diabetes and Senolysis Improves Disease Outcomes

(2019) Cristina Aguayo-Mazzucato et al.   Cell Metabolism

How, When, and Where Do Human β-Cells Regenerate?

(2019) Giorgio Basile et al.   Current Diabetes Reports

Endoplasmic reticulum stress, degeneration of pancreatic islet β-cells, and therapeutic modulation of the unfolded protein response in diabetes

(2019) Rajarshi Ghosh et al.   Molecular Metabolism

Death versus dedifferentiation: The molecular bases of beta cell mass reduction in type 2 diabetes

(2019) Tong Sun et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

IAPP in type II diabetes: Basic research on structure, molecular interactions, and disease mechanisms suggests potential intervention strategies

(2018) Shreyasi Asthana et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The Polycomb-Dependent Epigenome Controls β Cell Dysfunction, Dedifferentiation, and Diabetes

(2018) Tess Tsai-Hsiu Lu et al.   Cell Metabolism

Endogenous Reprogramming of Alpha Cells into Beta Cells, Induced by Viral Gene Therapy, Reverses Autoimmune Diabetes

(2018) Xiangwei Xiao et al.   Cell Stem Cell

RNA-Seq Analysis of Islets to Characterise the Dedifferentiation in Type 2 Diabetes Model Mice db/db

(2018) Abraham Neelankal John et al.   ENDOCRINE PATHOLOGY

MicroRNA Expression Analysis of In Vitro Dedifferentiated Human Pancreatic Islet Cells Reveals the Activation of the Pluripotency-Related MicroRNA Cluster miR-302s

(2018) Guido Sebastiani et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Activation of ACE2/angiotensin (1–7) attenuates pancreatic β cell dedifferentiation in a high-fat-diet mouse model

(2018) Xiuping Xuan et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

The type 2 diabetes-associated HMG20A gene is mandatory for islet beta cell functional maturity

(2018) Jose M. Mellado-Gil et al.   Cell Death & Disease

Pancreatic deletion of the interleukin-1 receptor disrupts whole body glucose homeostasis and promotes islet β-cell de-differentiation

(2018) Susan J. Burke et al.   Molecular Metabolism

Fatty Acid-Induced Lipotoxicity in Pancreatic Beta-Cells During Development of Type 2 Diabetes

(2018) Yoon S. Oh et al.   Frontiers in Endocrinology

The Cells of the Islets of Langerhans

(2018) Gabriela Da Silva Xavier   Journal of Clinical Medicine

Glucagon-Like Peptide-1 Increases Beta Cell Regeneration by Promoting Alpha- to Beta-Cell Transdifferentiation

(2018) Young-Sun Lee et al.   DIABETES

Reversal of angiotensin ll-induced β-cell dedifferentiation via inhibition of NF-κb signaling

(2018) Hong Chen et al.   MOLECULAR MEDICINE

Role of protein carbonylation in diabetes

(2017) Markus Hecker et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Human beta cell mass and function in diabetes: Recent advances in knowledge and technologies to understand disease pathogenesis

(2017) Chunguang Chen et al.   Molecular Metabolism

Evidence for Loss in Identity, De-Differentiation, and Trans-Differentiation of Islet β-Cells in Type 2 Diabetes

(2017) Chad S. Hunter et al.   Frontiers in Genetics

The Role of Inflammation in β-cell Dedifferentiation

(2017) Thierry M. Nordmann et al.   Scientific Reports

Evidence of β-Cell Dedifferentiation in Human Type 2 Diabetes

(2016) Francesca Cinti et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Dopamine D2 Receptor-Mediated Regulation of Pancreatic β Cell Mass

(2016) Daisuke Sakano et al.   Stem Cell Reports

Preserving Mafa Expression in Diabetic Islet β-Cells Improves Glycemic Controlin Vivo

(2015) Taka-aki Matsuoka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Downregulation of Long Noncoding RNA Meg3 Affects Insulin Synthesis and Secretion in Mouse Pancreatic Beta Cells

(2015) LiangHui You et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Imeglimin Normalizes Glucose Tolerance and Insulin Sensitivity and Improves Mitochondrial Function in Liver of a High-Fat, High-Sucrose Diet Mice Model

(2015) Guillaume Vial et al.   DIABETES

Generation of Functional Human Pancreatic β Cells In Vitro

(2014) Felicia W. Pagliuca et al.   CELL

Pancreatic β Cell Dedifferentiation in Diabetes and Redifferentiation following Insulin Therapy

(2014) Zhiyu Wang et al.   Cell Metabolism

Adult Duct-Lining Cells Can Reprogram into β-like Cells Able to Counter Repeated Cycles of Toxin-Induced Diabetes

(2013) Keith Al-Hasani et al.   DEVELOPMENTAL CELL

Inactivation of specific β cell transcription factors in type 2 diabetes

(2013) Shuangli Guo et al.   JOURNAL OF CLINICAL INVESTIGATION

Beta-Cell Dedifferentiation and Type 2 Diabetes

(2013) Yuval Dor et al.   NEW ENGLAND JOURNAL OF MEDICINE

Restoration of the Unfolded Protein Response in Pancreatic   Cells Protects Mice Against Type 1 Diabetes

(2013) F. Engin et al.   Science Translational Medicine

The Inactivation of Arx in Pancreatic α-Cells Triggers Their Neogenesis and Conversion into Functional β-Like Cells

(2013) Monica Courtney et al.   PLoS Genetics

Linking Metabolic Abnormalities to Apoptotic Pathways in Beta Cells in Type 2 Diabetes

(2013) Jibran Wali et al.   Cells

Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

(2012) Chutima Talchai et al.   CELL

Elevated Hedgehog/Gli signaling causes  -cell dedifferentiation in mice

(2011) L. Landsman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endoplasmic reticulum stress and pancreatic β-cell death

(2011) Sonya G. Fonseca et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Regulation of MafA Expression in Pancreatic  -Cells in db/db Mice With Diabetes

(2010) T.-a. Matsuoka et al.   DIABETES

Extreme makeover of pancreatic α-cells

(2010) Kenneth S. Zaret et al.   NATURE

Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss

(2010) Fabrizio Thorel et al.   NATURE

The Ectopic Expression of Pax4 in the Mouse Pancreas Converts Progenitor Cells into α and Subsequently β Cells

(2009) Patrick Collombat et al.   CELL

Pdx1 and other factors that regulate pancreatic β-cell survival

(2009) K. Fujimoto et al.   DIABETES OBESITY & METABOLISM

The Unfolded Protein Response: A Pathway That Links Insulin Demand with β-Cell Failure and Diabetes

(2008) Donalyn Scheuner et al.   ENDOCRINE REVIEWS