How, When, and Where Do Human β-Cells Regenerate?

A Peninsular Structure Coordinates Asynchronous Differentiation with Morphogenesis to Generate Pancreatic Islets

(2019) Nadav Sharon et al.   CELL

Diabetes relief in mice by glucose-sensing insulin-secreting human α-cells

(2019) Kenichiro Furuyama et al.   NATURE

Pancreatic β Cell Regeneration as a Possible Therapy for Diabetes

(2018) Cristina Aguayo-Mazzucato et al.   Cell Metabolism

Endogenous Reprogramming of Alpha Cells into Beta Cells, Induced by Viral Gene Therapy, Reverses Autoimmune Diabetes

(2018) Xiangwei Xiao et al.   Cell Stem Cell

C-Peptide Decline in Type 1 Diabetes Has Two Phases: An Initial Exponential Fall and a Subsequent Stable Phase

(2018) Beverley M. Shields et al.   DIABETES CARE

Control of insulin secretion by GLP-1

(2018) Ben Jones et al.   PEPTIDES

GABA and Artesunate Do Not Induce Pancreatic α-to-β Cell Transdifferentiation In Vivo

(2018) Amanda M. Ackermann et al.   Cell Metabolism

Fifty years of pancreatic islet pathology in human type 1 diabetes: insights gained and progress made

(2018) Noel G. Morgan et al.   DIABETOLOGIA

Can GABA turn pancreatic α-cells into β-cells?

(2018) Decio L. Eizirik et al.   Nature Reviews Endocrinology

Combined Inhibition of DYRK1A, SMAD, and Trithorax Pathways Synergizes to Induce Robust Replication in Adult Human Beta Cells

(2018) Peng Wang et al.   Cell Metabolism

Forkhead box protein O1 (FoxO1) regulates hepatic serine protease inhibitor B1 (serpinB1) expression in a non-cell-autonomous fashion

(2018) Abdelfattah El Ouaamari et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

β Cells Persist in T1D Pancreata Without Evidence of Ongoing β-Cell Turnover or Neogenesis

(2017) Carol J Lam et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Co-localization of acinar markers and insulin in pancreatic cells of subjects with type 2 diabetes

(2017) Matilde Masini et al.   PLoS One

SerpinB1 Promotes Pancreatic β Cell Proliferation

(2016) Abdelfattah El Ouaamari et al.   Cell Metabolism

Single-Cell Mass Cytometry Analysis of the Human Endocrine Pancreas

(2016) Yue J. Wang et al.   Cell Metabolism

Inhibition of DYRK1A Stimulates Human β-Cell Proliferation

(2016) Ercument Dirice et al.   DIABETES

Differential Insulitic Profiles Determine the Extent of β-Cell Destruction and the Age at Onset of Type 1 Diabetes

(2016) Pia Leete et al.   DIABETES

Inhibition of TGF-β Signaling Promotes Human Pancreatic β-Cell Replication

(2016) Sangeeta Dhawan et al.   DIABETES

Novel factors modulating human β-cell proliferation

(2016) J. Shirakawa et al.   DIABETES OBESITY & METABOLISM

A combination of cytokines EGF and CNTF protects the functional beta cell mass in mice with short-term hyperglycaemia

(2016) Marie Lemper et al.   DIABETOLOGIA

Evidence of β-Cell Dedifferentiation in Human Type 2 Diabetes

(2016) Francesca Cinti et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Dynamic development of the pancreas from birth to adulthood

(2016) Susan Bonner-Weir et al.   UPSALA JOURNAL OF MEDICAL SCIENCES

PAR2 regulates regeneration, transdifferentiation and death

(2016) Ron Piran et al.   Cell Death & Disease

Proinflammatory Cytokines Induce Endocrine Differentiation in Pancreatic Ductal Cells via STAT3-Dependent NGN3 Activation

(2016) Ivan Achel Valdez et al.   Cell Reports

Persistent infection of human pancreatic cells with Coxsackievirus B4 is cured by fluoxetine

(2015) Enagnon Kazali Alidjinou et al.   ANTIVIRAL RESEARCH

Osteoprotegerin and Denosumab Stimulate Human Beta Cell Proliferation through Inhibition of the Receptor Activator of NF-κB Ligand Pathway

(2015) Nagesha Guthalu Kondegowda et al.   Cell Metabolism

Human pancreas development

(2015) R. E. Jennings et al.   DEVELOPMENT

Regulation of Cellular Identity in Cancer

(2015) Nilotpal Roy et al.   DEVELOPMENTAL CELL

BMP-7 Induces Adult Human Pancreatic Exocrine-to-Endocrine Conversion

(2015) Dagmar Klein et al.   DIABETES

Function of Isolated Pancreatic Islets From Patients at Onset of Type 1 Diabetes: Insulin Secretion Can Be Restored After Some Days in a Nondiabetogenic Environment In Vitro

(2015) Lars Krogvold et al.   DIABETES

Human β-Cell Proliferation and Intracellular Signaling: Part 3

(2015) Andrew F. Stewart et al.   DIABETES

The subcellular distribution of cyclin-D1 and cyclin-D3 within human islet cells varies according to the status of the pancreas donor

(2015) Kazuto Taniguchi et al.   DIABETOLOGIA

WS6 induces both alpha and beta cell proliferation without affecting differentiation or viability

(2015) Brian P. Boerner et al.   ENDOCRINE JOURNAL

A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication

(2015) Peng Wang et al.   NATURE MEDICINE

Inhibition of DYRK1A and GSK3B induces human β-cell proliferation

(2015) Weijun Shen et al.   Nature Communications

Reduced Ki67 Staining in the Postmortem State Calls Into Question Past Conclusions About the Lack of Turnover of Adult Human β-Cells

(2014) Brooke A. Sullivan et al.   DIABETES

Human  -Cell Proliferation and Intracellular Signaling Part 2: Still Driving in the Dark Without a Road Map

(2014) E. Bernal-Mizrachi et al.   DIABETES

Exendin-4 stimulates islet cell replication via the IGF1 receptor activation of mTORC1/S6K1

(2014) J. Xie et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Generation of Insulin-Producing Cells from the Mouse Liver Using β Cell-Related Gene Transfer Including Mafa and Mafb

(2014) Haruka Nagasaki et al.   PLoS One

FOXO1 inhibition yields functional insulin-producing cells in human gut organoid cultures

(2014) Ryotaro Bouchi et al.   Nature Communications

De Novo Formation of Insulin-Producing “Neo-β Cell Islets” from Intestinal Crypts

(2014) Yi-Ju Chen et al.   Cell Reports

Biology of the RANKL–RANK–OPG System in Immunity, Bone, and Beyond

(2014) Matthew C. Walsh et al.   Frontiers in Immunology

Pharmacology, Physiology, and Mechanisms of Incretin Hormone Action

(2013) Jonathan E. Campbell et al.   Cell Metabolism

Birth and Death of Human β-Cells in Pancreases from Cadaver Donors, Autopsies, Surgical Specimens, and Islets Transplanted into Mice

(2013) Francisco Caballero et al.   CELL TRANSPLANTATION

Soluble Factors Secreted by T Cells Promote  -Cell Proliferation

(2013) E. Dirice et al.   DIABETES

Human Pancreatic  -Cell G1/S Molecule Cell Cycle Atlas

(2013) N. M. Fiaschi-Taesch et al.   DIABETES

Cytoplasmic-Nuclear Trafficking of G1/S Cell Cycle Molecules and Adult Human  -Cell Replication: A Revised Model of Human  -Cell G1/S Control

(2013) N. M. Fiaschi-Taesch et al.   DIABETES

The majority of patients with long-duration type 1 diabetes are insulin microsecretors and have functioning beta cells

(2013) Richard A. Oram et al.   DIABETOLOGIA

Small-Molecule Inducer of β Cell Proliferation Identified by High-Throughput Screening

(2013) Weijun Shen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice

(2013) Luc Baeyens et al.   NATURE BIOTECHNOLOGY

The Inactivation of Arx in Pancreatic α-Cells Triggers Their Neogenesis and Conversion into Functional β-Like Cells

(2013) Monica Courtney et al.   PLoS Genetics

Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

(2012) Chutima Talchai et al.   CELL

Human  -Cell Proliferation and Intracellular Signaling: Driving in the Dark Without a Road Map

(2012) R. N. Kulkarni et al.   DIABETES

 -Cell Mass and Turnover in Humans: Effects of obesity and aging

(2012) Y. Saisho et al.   DIABETES CARE

Generation of functional insulin-producing cells in the gut by Foxo1 ablation

(2012) Chutima Talchai et al.   NATURE GENETICS

TGFβ signalling in context

(2012) Joan Massagué   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Normal Glucagon Signaling and β-Cell Function After Near-Total α-Cell Ablation in Adult Mice

(2011) Fabrizio Thorel et al.   DIABETES

Longevity of human islet α- and β-cells

(2011) M. Cnop et al.   DIABETES OBESITY & METABOLISM

Immunohistochemical analysis of the relationship between islet cell proliferation and the production of the enteroviral capsid protein, VP1, in the islets of patients with recent-onset type 1 diabetes

(2011) A. Willcox et al.   DIABETOLOGIA

Skp2 Is Required for Incretin Hormone-Mediated β-Cell Proliferation

(2011) Shuen-Ing Tschen et al.   MOLECULAR ENDOCRINOLOGY

Comparison of exendin-4 on beta-cell replication in mouse and human islet grafts

(2011) Lei Tian et al.   TRANSPLANT INTERNATIONAL

Gastrointestinal hormones and the regulation of β-cell mass

(2010) Jeremy A. Lavine et al.   Annals of the New York Academy of Sciences

Residual Insulin Production and Pancreatic  -Cell Turnover After 50 Years of Diabetes: Joslin Medalist Study

(2010) H. A. Keenan et al.   DIABETES

Beta cell adaptation in pregnancy: a major difference between humans and rodents?

(2010) M. Genevay et al.   DIABETOLOGIA

Evidence of increased islet cell proliferation in patients with recent-onset type 1 diabetes

(2010) A. Willcox et al.   DIABETOLOGIA

Adaptive changes in pancreatic beta cell fractional area and beta cell turnover in human pregnancy

(2010) A. E. Butler et al.   DIABETOLOGIA

Conditional ablation of Gsk-3β in islet beta cells results in expanded mass and resistance to fat feeding-induced diabetes in mice

(2010) Y. Liu et al.   DIABETOLOGIA

Glucagon Deficiency Reduces Hepatic Glucose Production and Improves Glucose Tolerance In Adult Mice

(2010) Aidan S. Hancock et al.   MOLECULAR ENDOCRINOLOGY

Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss

(2010) Fabrizio Thorel et al.   NATURE

Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine

(2010) Kenichiro Furuyama et al.   NATURE GENETICS

Serotonin regulates pancreatic beta cell mass during pregnancy

(2010) Hail Kim et al.   NATURE MEDICINE

Pancreatic β-Cell Neogenesis by Direct Conversion from Mature α-Cells

(2010) Cheng-Ho Chung et al.   STEM CELLS

Genetic influences on the association between fetal growth and susceptibility to type 2 diabetes

(2010) B. M. Shields et al.   Journal of Developmental Origins of Health and Disease

The Ectopic Expression of Pax4 in the Mouse Pancreas Converts Progenitor Cells into α and Subsequently β Cells

(2009) Patrick Collombat et al.   CELL

Pancreatic Exocrine Duct Cells Give Rise to Insulin-Producing β Cells during Embryogenesis but Not after Birth

(2009) Myriam Solar et al.   DEVELOPMENTAL CELL

Gestational Diabetes Mellitus Resulting From Impaired  -Cell Compensation in the Absence of FoxM1, a Novel Downstream Effector of Placental Lactogen

(2009) H. Zhang et al.   DIABETES

The Transcriptional Response of the Islet to Pregnancy in Mice

(2009) Sebastian Rieck et al.   MOLECULAR ENDOCRINOLOGY

Expansion of β-cell mass in response to pregnancy

(2009) Sebastian Rieck et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Glycogen Synthase Kinase-3 and Mammalian Target of Rapamycin Pathways Contribute to DNA Synthesis, Cell Cycle Progression, and Proliferation in Human Islets

(2008) H. Liu et al.   DIABETES

Pregnancy outcome in patients with raised blood glucose due to a heterozygous glucokinase gene mutation

(2008) G. Spyer et al.   DIABETIC MEDICINE

Mice with beta cell overexpression of glycogen synthase kinase-3β have reduced beta cell mass and proliferation

(2008) Z. Liu et al.   DIABETOLOGIA

Insulin protein and proliferation in ductal cells in the transplanted pancreas of patients with type 1 diabetes and recurrence of autoimmunity

(2008) A. Martin-Pagola et al.   DIABETOLOGIA

In vivo reprogramming of adult pancreatic exocrine cells to β-cells

(2008) Qiao Zhou et al.   NATURE

Growth factor control of pancreatic islet regeneration and function

(2008) Anke Assmann et al.   PEDIATRIC DIABETES

Genetic Deficiency of Glycogen Synthase Kinase-3β Corrects Diabetes in Mouse Models of Insulin Resistance

(2008) Katsuya Tanabe et al.   PLOS BIOLOGY