A STING antagonist modulating the interaction with STIM1 blocks ER-to-Golgi trafficking and inhibits lupus pathology

Mutations in COPA lead to abnormal trafficking of STING to the Golgi and interferon signaling

(2020) Alice Lepelley et al.   JOURNAL OF EXPERIMENTAL MEDICINE

STEEP mediates STING ER exit and activation of signaling

(2020) Bao-cun Zhang et al.   NATURE IMMUNOLOGY

Autophagy induction via STING trafficking is a primordial function of the cGAS pathway

(2019) Xiang Gui et al.   NATURE

The cGAS-STING pathway is a therapeutic target in a preclinical model of hepatocellular carcinoma

(2019) Martin K. Thomsen et al.   ONCOGENE

Trial of Anifrolumab in Active Systemic Lupus Erythematosus

(2019) Eric F. Morand et al.   NEW ENGLAND JOURNAL OF MEDICINE

Apoptosis-derived membrane vesicles drive the cGAS–STING pathway and enhance type I IFN production in systemic lupus erythematosus

(2018) Yasuhiro Kato et al.   ANNALS OF THE RHEUMATIC DISEASES

Type-1 interferons prolong the lifespan of neutrophils by interfering with members of the apoptotic cascade

(2018) Eresso Aga et al.   CYTOKINE

Attenuation of cGAS‐STING signaling is mediated by a p62/SQSTM1‐dependent autophagy pathway activated by TBK1

(2018) Thaneas Prabakaran et al.   EMBO JOURNAL

The Lectin Pathway of Complement Activation in Patients with Systemic Lupus Erythematosus

(2018) Anne Troldborg et al.   JOURNAL OF RHEUMATOLOGY

An open-label trial of JAK 1/2 blockade in progressive IFIH1 -associated neuroinflammation

(2018) Kavitha Kothur et al.   NEUROLOGY

Optimization of protein and peptide drugs based on the mechanisms of kidney clearance

(2018) Jiaguo Huang et al.   PROTEIN AND PEPTIDE LETTERS

UBXN3B positively regulates STING-mediated antiviral immune responses

(2018) Long Yang et al.   Nature Communications

STING-Activating Adjuvants Elicit a Th17 Immune Response and Protect against Mycobacterium tuberculosis Infection

(2018) Erik Van Dis et al.   Cell Reports

B-Cell-Intrinsic Type 1 Interferon Signaling Is Crucial for Loss of Tolerance and the Development of Autoreactive B Cells

(2018) Phillip P. Domeier et al.   Cell Reports

The common HAQ STING variant impairs cGAS-dependent antibacterial responses and is associated with susceptibility to Legionnaires’ disease in humans

(2018) Juan S. Ruiz-Moreno et al.   PLoS Pathogens

Targeting STING with covalent small-molecule inhibitors

(2018) Simone M. Haag et al.   NATURE

Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling

(2018) Anne Louise Hansen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Ca2+ sensor STIM1 regulates the type I interferon response by retaining the signaling adaptor STING at the endoplasmic reticulum

(2018) Sonal Srikanth et al.   NATURE IMMUNOLOGY

New therapeutic strategies in systemic lupus erythematosus management

(2018) Mariele Gatto et al.   Nature Reviews Rheumatology

Discovery of a Novel cGAMP Competitive Ligand of the Inactive Form of STING

(2018) Tony Siu et al.   ACS Medicinal Chemistry Letters

TMED2 Potentiates Cellular IFN Responses to DNA Viruses by Reinforcing MITA Dimerization and Facilitating Its Trafficking

(2018) Ming-Shun Sun et al.   Cell Reports

The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING

(2018) Senlin Li et al.   Cell Reports

SNX8 modulates innate immune response to DNA virus by mediating trafficking and activation of MITA

(2018) Jin Wei et al.   PLoS Pathogens

Type I interferon-mediated autoinflammation due to DNase II deficiency

(2017) Mathieu P. Rodero et al.   Nature Communications

Signalling strength determines proapoptotic functions of STING

(2017) Muhammet F. Gulen et al.   Nature Communications

Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice

(2017) Jessica Vincent et al.   Nature Communications

Expression of Cyclic GMP-AMP Synthase in Patients With Systemic Lupus Erythematosus

(2017) Jie An et al.   Arthritis & Rheumatology

Familial chilblain lupus due to a gain-of-function mutation in STING

(2016) Nadja König et al.   ANNALS OF THE RHEUMATIC DISEASES

Personalized Immunomonitoring Uncovers Molecular Networks that Stratify Lupus Patients

(2016) Romain Banchereau et al.   CELL

iRhom2 is essential for innate immunity to DNA viruses by mediating trafficking and stability of the adaptor STING

(2016) Wei-Wei Luo et al.   NATURE IMMUNOLOGY

Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses

(2016) Christian K. Holm et al.   Nature Communications

Activation of STING requires palmitoylation at the Golgi

(2016) Kojiro Mukai et al.   Nature Communications

Sensing of HSV-1 by the cGAS–STING pathway in microglia orchestrates antiviral defence in the CNS

(2016) Line S. Reinert et al.   Nature Communications

STING Activation by Translocation from the ER Is Associated with Infection and Autoinflammatory Disease

(2015) Nicole Dobbs et al.   Cell Host & Microbe

STING Negatively Regulates Double-Stranded DNA-Activated JAK1-STAT1 Signaling via SHP-1/2 in B Cells

(2015) Guanjun Dong et al.   MOLECULES AND CELLS

Suppression of systemic autoimmunity by the innate immune adaptor STING

(2015) Shruti Sharma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases

(2015) Daxing Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors

(2014) Seng-Ryong Woo et al.   IMMUNITY

STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors

(2014) Liufu Deng et al.   IMMUNITY

Inherited STING-activating mutation underlies a familial inflammatory syndrome with lupus-like manifestations

(2014) Nadia Jeremiah et al.   JOURNAL OF CLINICAL INVESTIGATION

Activated STING in a Vascular and Pulmonary Syndrome

(2014) Yin Liu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Immune Sensing of DNA

(2013) Søren R. Paludan et al.   IMMUNITY

STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease

(2013) J. Petrasek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects

(2013) X.-D. Li et al.   SCIENCE

Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses

(2013) D. Gao et al.   SCIENCE

Interleukin-17 Cytokines Are Critical in Development of Fatal Lupus Glomerulonephritis

(2012) Prapaporn Pisitkun et al.   IMMUNITY

Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING

(2012) Christian K Holm et al.   NATURE IMMUNOLOGY

STING Specifies IRF3 Phosphorylation by TBK1 in the Cytosolic DNA Signaling Pathway

(2012) Y. Tanaka et al.   Science Signaling

Activation of Autophagy by α-Herpesviruses in Myeloid Cells Is Mediated by Cytoplasmic Viral DNA through a Mechanism Dependent on Stimulator of IFN Genes

(2011) Simon B. Rasmussen et al.   JOURNAL OF IMMUNOLOGY

Systemic Lupus Erythematosus

(2011) George C. Tsokos   NEW ENGLAND JOURNAL OF MEDICINE

Type I IFN enhances follicular B cell contribution to the T cell–independent antibody response

(2010) Cristina L. Swanson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IFI16 is an innate immune sensor for intracellular DNA

(2010) Leonie Unterholzner et al.   NATURE IMMUNOLOGY

Novel Reporter Mouse Reveals Constitutive and Inflammatory Expression of IFN-  In Vivo

(2009) S. Lienenklaus et al.   JOURNAL OF IMMUNOLOGY

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

(2009) Hiroki Ishikawa et al.   NATURE

Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response

(2009) T. Saitoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IFIH1 polymorphisms are significantly associated with type 1 diabetes and IFIH1 gene expression in peripheral blood mononuclear cells

(2008) S. Liu et al.   HUMAN MOLECULAR GENETICS

Association of elevated transcript levels of interferon-inducible chemokines with disease activity and organ damage in systemic lupus erythematosus patients

(2008) Qiong Fu et al.   ARTHRITIS RESEARCH & THERAPY