AMPK/ULK1-mediated phosphorylation of Parkin ACT domain mediates an early step in mitophagy

Spatiotemporal Control of ULK1 Activation by NDP52 and TBK1 during Selective Autophagy

(2019) Jose Norberto S. Vargas et al.   MOLECULAR CELL

ULK1‐mediated phosphorylation of ATG16L1 promotes xenophagy, but destabilizes the ATG16L1 Crohn's mutant

(2019) Reham M Alsaadi et al.   EMBO REPORTS

ULK1 and ULK2 Regulate Stress Granule Disassembly Through Phosphorylation and Activation of VCP/p97

(2019) Bo Wang et al.   MOLECULAR CELL

The AMPK–Parkin axis negatively regulates necroptosis and tumorigenesis by inhibiting the necrosome

(2019) Seung Baek Lee et al.   NATURE CELL BIOLOGY

Mechanism of parkin activation by PINK1

(2018) Christina Gladkova et al.   NATURE

Building and decoding ubiquitin chains for mitophagy

(2018) J. Wade Harper et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondria-derived ROS activate AMP-activated protein kinase (AMPK) indirectly

(2018) Elizabeth C Hinchy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance

(2017) Daniel Garcia et al.   MOLECULAR CELL

A fluorescence-based imaging method to measure in vitro and in vivo mitophagy using mt-Keima

(2017) Nuo Sun et al.   Nature Protocols

Rapid immunopurification of mitochondria for metabolite profiling and absolute quantification of matrix metabolites

(2017) Walter W Chen et al.   Nature Protocols

AMPK: guardian of metabolism and mitochondrial homeostasis

(2017) Sébastien Herzig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiac hypertrophy

(2017) Robert W. Myers et al.   SCIENCE

Autophagy-Independent Lysosomal Targeting Regulated by ULK1/2-FIP200 and ATG9

(2017) Jonathan M. Goodwin et al.   Cell Reports

AMP-activated protein kinase mediates mitochondrial fission in response to energy stress

(2016) E. Q. Toyama et al.   SCIENCE

AMPK: An Energy-Sensing Pathway with Multiple Inputs and Outputs

(2016) D. Grahame Hardie et al.   TRENDS IN CELL BIOLOGY

Phosphorylation of ULK1 by AMPK regulates translocation of ULK1 to mitochondria and mitophagy

(2015) Weili Tian et al.   FEBS LETTERS

The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy

(2015) Jin-Mi Heo et al.   MOLECULAR CELL

Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates

(2015) Daniel F. Egan et al.   MOLECULAR CELL

The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease

(2015) Alicia M. Pickrell et al.   NEURON

Defining roles of PARKIN and ubiquitin phosphorylation by PINK1 in mitochondrial quality control using a ubiquitin replacement strategy

(2015) Alban Ordureau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65

(2014) Agne Kazlauskaite et al.   BIOCHEMICAL JOURNAL

A Redox-Dependent Mechanism for Regulation of AMPK Activation by Thioredoxin1 during Energy Starvation

(2014) Dan Shao et al.   Cell Metabolism

Oxidative stress activates AMPK in cultured cells primarily by increasing cellular AMP and/or ADP

(2014) F. Romana Auciello et al.   FEBS LETTERS

PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

(2014) Lesley A. Kane et al.   JOURNAL OF CELL BIOLOGY

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

Ulk1-mediated Atg5-independent macroautophagy mediates elimination of mitochondria from embryonic reticulocytes

(2014) Shinya Honda et al.   Nature Communications

PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding

(2013) Michael Lazarou et al.   JOURNAL OF CELL BIOLOGY

VCP Is Essential for Mitochondrial Quality Control by PINK1/Parkin and this Function Is Impaired by VCP Mutations

(2013) Nam Chul Kim et al.   NEURON

PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy

(2012) Kahori Shiba-Fukushima et al.   Scientific Reports

A Tissue-Specific Atlas of Mouse Protein Phosphorylation and Expression

(2010) Edward L. Huttlin et al.   CELL

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

(2010) Sven Geisler et al.   NATURE CELL BIOLOGY

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation

(2008) M. Kundu et al.   BLOOD

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL