The AMPK–Parkin axis negatively regulates necroptosis and tumorigenesis by inhibiting the necrosome

Hypoxia-inducible factor-1 alpha is involved in RIP-induced necroptosis caused by in vitro and in vivo ischemic brain injury

(2017) Xiao-Sa Yang et al.   Scientific Reports

Deubiquitination and Activation of AMPK by USP10

(2016) Min Deng et al.   MOLECULAR CELL

The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression

(2016) Lena Seifert et al.   NATURE

Cancer-type-specific crosstalk between autophagy, necroptosis and apoptosis as a pharmacological target

(2015) Flavia Radogna et al.   BIOCHEMICAL PHARMACOLOGY

Suppression of RIP3-dependent Necroptosis by Human Cytomegalovirus

(2015) Shinya Omoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Apoptosis, autophagy, necroptosis, and cancer metastasis

(2015) Zhenyi Su et al.   Molecular Cancer

Parkin Regulates Mitosis and Genomic Stability through Cdc20/Cdh1

(2015) Seung Baek Lee et al.   MOLECULAR CELL

Necroptosis and its role in inflammation

(2015) Manolis Pasparakis et al.   NATURE

The molecular relationships between apoptosis, autophagy and necroptosis

(2015) Najoua Lalaoui et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Pore-Forming Toxins Induce Macrophage Necroptosis during Acute Bacterial Pneumonia

(2015) Norberto González-Juarbe et al.   PLoS Pathogens

Distinct roles of RIP1–RIP3 hetero- and RIP3–RIP3 homo-interaction in mediating necroptosis

(2014) X-N Wu et al.   CELL DEATH AND DIFFERENTIATION

PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

(2014) Lesley A. Kane et al.   JOURNAL OF CELL BIOLOGY

RIP3 Induces Apoptosis Independent of Pronecrotic Kinase Activity

(2014) Pratyusha Mandal et al.   MOLECULAR CELL

Ubiquitin is phosphorylated by PINK1 to activate parkin

(2014) Fumika Koyano et al.   NATURE

Colorectal cancer in inflammatory bowel disease: The risk, pathogenesis, prevention and diagnosis

(2014) Eun Ran Kim   WORLD JOURNAL OF GASTROENTEROLOGY

Crosstalk between apoptosis, necrosis and autophagy

(2013) Vassiliki Nikoletopoulou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Parkin-catalyzed Ubiquitin-Ester Transfer Is Triggered by PINK1-dependent Phosphorylation

(2013) Masahiro Iguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

The RIP1/RIP3 Necrosome Forms a Functional Amyloid Signaling Complex Required for Programmed Necrosis

(2012) Jixi Li et al.   CELL

New frontiers in promoting tumour cell death: targeting apoptosis, necroptosis and autophagy

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Inflammation and colorectal cancer: colitis-associated neoplasia

(2012) Sergei I. Grivennikov   Seminars in Immunopathology

Chronic intestinal inflammation: inflammatory bowel disease and colitis-associated colon cancer

(2012) Deborah C. Rubin et al.   Frontiers in Immunology

FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation

(2011) Patrick-Simon Welz et al.   NATURE

Parkin Mono-ubiquitinates Bcl-2 and Regulates Autophagy

(2010) Dong Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice

(2010) G. Poulogiannis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

(2009) YoungSik Cho et al.   CELL

Parkin protects mitochondrial genome integrity and supports mitochondrial DNA repair

(2009) Oliver Rothfuss et al.   HUMAN MOLECULAR GENETICS

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

Somatic mutations of the Parkinson's disease–associated gene PARK2 in glioblastoma and other human malignancies

(2009) Selvaraju Veeriah et al.   NATURE GENETICS

Regional variation in gene expression in the healthy colon is dysregulated in ulcerative colitis

(2008) C L Noble et al.   GUT

Parkin mediates the degradation-independent ubiquitination of Hsp70

(2008) Darren J. Moore et al.   JOURNAL OF NEUROCHEMISTRY

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

Parkin as a tumor suppressor gene for hepatocellular carcinoma

(2008) M Fujiwara et al.   ONCOGENE