Endocannabinoids — at the crossroads between the gut microbiota and host metabolism

Endocannabinoids and their oxygenation by cyclo-oxygenases, lipoxygenases and other oxygenases

(2015) P. Urquhart et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Feeding-induced oleoylethanolamide mobilization is disrupted in the gut of diet-induced obese rodents

(2015) Miki Igarashi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Dynamics and Stabilization of the Human Gut Microbiome during the First Year of Life

(2015) Fredrik Bäckhed et al.   Cell Host & Microbe

A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents

(2015) Mayank Kumar Sharma et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

N-Acylethanolamine-hydrolyzing acid amidase inhibition increases colon N-palmitoylethanolamine levels and counteracts murine colitis

(2015) Mireille Alhouayek et al.   FASEB JOURNAL

Monitoring host responses to the gut microbiota

(2015) Joshua S Lichtman et al.   ISME Journal

Modulation of Glucagon-like Peptide-1 (GLP-1) Potency by Endocannabinoid-like Lipids Represents a Novel Mode of Regulating GLP-1 Receptor Signaling

(2015) Yu-Hong Cheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intestinal lipid–derived signals that sense dietary fat

(2015) Nicholas V. DiPatrizio et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation of inflammation by cannabinoids, the endocannabinoids 2-arachidonoyl-glycerol and arachidonoyl-ethanolamide, and their metabolites

(2015) Caroline Turcotte et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome

(2015) Benoit Chassaing et al.   NATURE

Towards a more comprehensive concept for prebiotics

(2015) Laure B. Bindels et al.   Nature Reviews Gastroenterology & Hepatology

Endocannabinoid signalling and the deteriorating brain

(2015) Vincenzo Di Marzo et al.   NATURE REVIEWS NEUROSCIENCE

Keeping gut lining at bay: impact of emulsifiers

(2015) Patrice D. Cani et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Endocannabinoid signaling at the periphery: 50 years after THC

(2015) Mauro Maccarrone et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Adipose tissue NAPE-PLD controls fat mass development by altering the browning process and gut microbiota

(2015) Lucie Geurts et al.   Nature Communications

The Gut Microbiota of Rural Papua New Guineans: Composition, Diversity Patterns, and Ecological Processes

(2015) Inés Martínez et al.   Cell Reports

Endocannabinoids and energy homeostasis: An update

(2014) Luigia Cristino et al.   BIOFACTORS

Palmitoylethanolamide, a naturally occurring lipid, is an orally effective intestinal anti-inflammatory agent

(2014) Francesca Borrelli et al.   BRITISH JOURNAL OF PHARMACOLOGY

Palmitoylethanolamide normalizes intestinal motility in a model of post-inflammatory accelerated transit: involvement of CB1receptors and TRPV1 channels

(2014) Raffaele Capasso et al.   BRITISH JOURNAL OF PHARMACOLOGY

Human Genetics Shape the Gut Microbiome

(2014) Julia K. Goodrich et al.   CELL

α/β-Hydrolase Domain-6-Accessible Monoacylglycerol Controls Glucose-Stimulated Insulin Secretion

(2014) Shangang Zhao et al.   Cell Metabolism

Optimization of 1,2,5-Thiadiazole Carbamates as Potent and Selective ABHD6 Inhibitors

(2014) Jayendra Z. Patel et al.   ChemMedChem

Acute Activation of Cannabinoid Receptors by Anandamide Reduces Gastrointestinal Motility and Improves Postprandial Glycemia in Mice

(2014) Stephanie Troy-Fioramonti et al.   DIABETES

Glucose metabolism: Focus on gut microbiota, the endocannabinoid system and beyond

(2014) P.D. Cani et al.   DIABETES & METABOLISM

Harnessing the anti-inflammatory potential of palmitoylethanolamide

(2014) Mireille Alhouayek et al.   DRUG DISCOVERY TODAY

Palmitoylethanolamide Prevents Metabolic Alterations and Restores Leptin Sensitivity in Ovariectomized Rats

(2014) G. Mattace Raso et al.   ENDOCRINOLOGY

Prospective therapeutic agents for obesity: Molecular modification approaches of centrally and peripherally acting selective cannabinoid 1 receptor antagonists

(2014) Mayank Kumar Sharma et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Silencing of mitochondrial Lon protease deeply impairs mitochondrial proteome and function in colon cancer cells

(2014) Lara Gibellini et al.   FASEB JOURNAL

Incorporation of therapeutically modified bacteria into gut microbiota inhibits obesity

(2014) Zhongyi Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Discovery of Glycine Sulfonamides as Dual Inhibitors of sn-1-Diacylglycerol Lipase α and α/β-Hydrolase Domain 6

(2014) Freek J. Janssen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Endocannabinoids, Related Compounds and Their Metabolic Routes

(2014) Filomena Fezza et al.   MOLECULES

Alterations of the human gut microbiome in liver cirrhosis

(2014) Nan Qin et al.   NATURE

An integrated catalog of reference genes in the human gut microbiome

(2014) Junhua Li et al.   NATURE BIOTECHNOLOGY

The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic

(2014) Colin Hill et al.   Nature Reviews Gastroenterology & Hepatology

Advances in the discovery of N-acylethanolamine acid amidase inhibitors

(2014) Tiziano Bandiera et al.   PHARMACOLOGICAL RESEARCH

A peripheral endocannabinoid mechanism contributes to glucocorticoid-mediated metabolic syndrome

(2014) Nicole P. Bowles et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gut microbiota and GLP-1

(2014) Amandine Everard et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Intestinal epithelial MyD88 is a sensor switching host metabolism towards obesity according to nutritional status

(2014) Amandine Everard et al.   Nature Communications

Proteome-Wide Reactivity Profiling Identifies Diverse Carbamate Chemotypes Tuned for Serine Hydrolase Inhibition

(2013) Jae Won Chang et al.   ACS Chemical Biology

Peripherally restricted CB1 receptor blockers

(2013) Robert J. Chorvat   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Peripheral selectivity of the novel cannabinoid receptor antagonist TM38837 in healthy subjects

(2013) Linda E. Klumpers et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

The Endocannabinoid System in Energy Homeostasis and the Etiopathology of Metabolic Disorders

(2013) Cristoforo Silvestri et al.   Cell Metabolism

Oleoylethanolamide enhances  -adrenergic-mediated thermogenesis and white-to-brown adipocyte phenotype in epididymal white adipose tissue in rat

(2013) J. Suarez et al.   Disease Models & Mechanisms

Inhibition of fatty acid amide hydrolase (FAAH) as a novel therapeutic strategy in the treatment of pain and inflammatory diseases in the gastrointestinal tract

(2013) Maciej Sałaga et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Metabolism of endocannabinoids and relatedN-acylethanolamines: Canonical and alternative pathways

(2013) Natsuo Ueda et al.   FEBS Journal

Palmitoylethanolamide improves colon inflammation through an enteric glia/toll like receptor 4-dependent PPAR-α activation

(2013) Giuseppe Esposito et al.   GUT

Richness of human gut microbiome correlates with metabolic markers

(2013) Emmanuelle Le Chatelier et al.   NATURE

Diet rapidly and reproducibly alters the human gut microbiome

(2013) Lawrence A. David et al.   NATURE

Gut metagenome in European women with normal, impaired and diabetic glucose control

(2013) Fredrik H. Karlsson et al.   NATURE

Chronic Endocannabinoid System Stimulation Induces Muscle Macrophage and Lipid Accumulation in Type 2 Diabetic Mice Independently of Metabolic Endotoxaemia

(2013) Lucie Geurts et al.   PLoS One

Implication of the anti-inflammatory bioactive lipid prostaglandin D2-glycerol ester in the control of macrophage activation and inflammation by ABHD6

(2013) M. Alhouayek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Obesity-driven synaptic remodeling affects endocannabinoid control of orexinergic neurons

(2013) L. Cristino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Animals in a bacterial world, a new imperative for the life sciences

(2013) Margaret McFall-Ngai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity

(2013) A. Everard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fat to treat fat: Emerging relationship between dietary PUFA, endocannabinoids, and obesity

(2013) Jeffrey Kim et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Analysis of the “endocannabinoidome” in peripheral tissues of obese Zucker rats

(2013) F.A. Iannotti et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

A fatty gut feeling

(2013) Daniele Piomelli   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The Serine Hydrolase ABHD6 Is a Critical Regulator of the Metabolic Syndrome

(2013) Gwynneth Thomas et al.   Cell Reports

Regulation of GPR119 receptor activity with endocannabinoid-like lipids

(2012) Samreen K. Syed et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

A novel fluorophosphonate inhibitor of the biosynthesis of the endocannabinoid 2-arachidonoylglycerol with potential anti-obesity effects

(2012) Tiziana Bisogno et al.   BRITISH JOURNAL OF PHARMACOLOGY

Defining a Healthy Human Gut Microbiome: Current Concepts, Future Directions, and Clinical Applications

(2012) Fredrik Bäckhed et al.   Cell Host & Microbe

Peripheral Cannabinoid-1 Receptor Inverse Agonism Reduces Obesity by Reversing Leptin Resistance

(2012) Joseph Tam et al.   Cell Metabolism

The therapeutic potential of GPR119 agonists for type 2 diabetes

(2012) Takahide Ohishi et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Structure, function and diversity of the healthy human microbiome

(2012)   NATURE

Host-Gut Microbiota Metabolic Interactions

(2012) J. K. Nicholson et al.   SCIENCE

A Crypt-Specific Core Microbiota Resides in the Mouse Colon

(2012) T. Pedron et al.   mBio

Cannabinoids mediate opposing effects on inflammation-induced intestinal permeability

(2011) A Alhamoruni et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cannabinoid receptor 1 (CB1) antagonism enhances glucose utilisation and activates brown adipose tissue in diet-induced obese mice

(2011) M. Bajzer et al.   DIABETOLOGIA

Altered endocannabinoid signalling after a high-fat diet in Apoe −/− mice: relevance to adipose tissue inflammation, hepatic steatosis and insulin resistance

(2011) A. Bartelt et al.   DIABETOLOGIA

Increasing endogenous 2-arachidonoylglycerol levels counteracts colitis and related systemic inflammation

(2011) Mireille Alhouayek et al.   FASEB JOURNAL

Proinflammatory Stimuli Control N-Acylphosphatidylethanolamine-Specific Phospholipase D Expression in Macrophages

(2011) C. Zhu et al.   MOLECULAR PHARMACOLOGY

Krill oil significantly decreases 2-arachidonoylglycerol plasma levels in obese subjects

(2011) Sebastiano Banni et al.   Nutrition & Metabolism

The gut microbiome as therapeutic target

(2011) Patrice D. Cani et al.   PHARMACOLOGY & THERAPEUTICS

Omega-3 N-acylethanolamines are endogenously synthesised from omega-3 fatty acids in different human prostate and breast cancer cell lines

(2011) I. Brown et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Linking Long-Term Dietary Patterns with Gut Microbial Enterotypes

(2011) G. D. Wu et al.   SCIENCE

Altered Gut Microbiota and Endocannabinoid System Tone in Obese and Diabetic Leptin-Resistant Mice: Impact on Apelin Regulation in Adipose Tissue

(2011) Lucie Geurts et al.   Frontiers in Microbiology

Prebiotic effects: metabolic and health benefits

(2010) Marcel Roberfroid et al.   BRITISH JOURNAL OF NUTRITION

Cannabinoid receptor-dependent and -independent anti-proliferative effects of omega-3 ethanolamides in androgen receptor-positive and -negative prostate cancer cell lines

(2010) Iain Brown et al.   CARCINOGENESIS

CB1 Signaling in Forebrain and Sympathetic Neurons Is a Key Determinant of Endocannabinoid Actions on Energy Balance

(2010) Carmelo Quarta et al.   Cell Metabolism

Endocannabinoids as Regulators of Transient Receptor Potential (TRP)Channels: a Further Opportunity to Develop New Endocannabinoid-Based Therapeutic Drugs

(2010) V. Marzo et al.   CURRENT MEDICINAL CHEMISTRY

Endocannabinoid biosynthesis and inactivation, from simple to complex

(2010) Giulio G. Muccioli   DRUG DISCOVERY TODAY

Endocannabinoids in liver disease

(2010) Joseph Tam et al.   HEPATOLOGY

Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity

(2010) Joseph Tam et al.   JOURNAL OF CLINICAL INVESTIGATION

Pharmacological Effects of Cannabinoids on the Caco-2 Cell Culture Model of Intestinal Permeability

(2010) A. Alhamoruni et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The endocannabinoid system links gut microbiota to adipogenesis

(2010) Giulio G Muccioli et al.   Molecular Systems Biology

A human gut microbial gene catalogue established by metagenomic sequencing

(2010) Junjie Qin et al.   NATURE

The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors

(2010) William R Marrs et al.   NATURE NEUROSCIENCE

A Common Haplotype in NAPEPLD Is Associated With Severe Obesity in a Norwegian Population-Based Cohort (the HUNT Study)

(2010) Teresia Wangensteen et al.   Obesity

International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2

(2010) R. G. Pertwee et al.   PHARMACOLOGICAL REVIEWS

Cannabinoids and the gut: New developments and emerging concepts

(2010) Angelo A. Izzo et al.   PHARMACOLOGY & THERAPEUTICS

The endocannabinoid system, eating behavior and energy homeostasis: The end or a new beginning?

(2010) F.J. Bermudez-Silva et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Peripheral endocannabinoid dysregulation in obesity: relation to intestinal motility and energy processing induced by food deprivation and re-feeding

(2009) Angelo A Izzo et al.   BRITISH JOURNAL OF PHARMACOLOGY

Synthesis and Pharmacological Activity of a Potent Inhibitor of the Biosynthesis of the Endocannabinoid 2-Arachidonoylglycerol

(2009) Tiziana Bisogno et al.   ChemMedChem

The Role of the Gut Microbiota in Energy Metabolism and Metabolic Disease

(2009) Patrice Cani et al.   CURRENT PHARMACEUTICAL DESIGN

GPR119 Is Essential for Oleoylethanolamide-Induced Glucagon-Like Peptide-1 Secretion From the Intestinal Enteroendocrine L-Cell

(2009) L. M. Lauffer et al.   DIABETES

Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability

(2009) P. D. Cani et al.   GUT

FAAH deficiency promotes energy storage and enhances the motivation for food

(2009) C Touriño et al.   INTERNATIONAL JOURNAL OF OBESITY

Non-CB1, Non-CB2 Receptors for Endocannabinoids, Plant Cannabinoids, and Synthetic Cannabimimetics: Focus on G-protein-coupled Receptors and Transient Receptor Potential Channels

(2009) Luciano De Petrocellis et al.   Journal of Neuroimmune Pharmacology

Anti-inflammatory Effect of Palmitoylethanolamide on Human Adipocytes

(2009) Laurence Hoareau et al.   Obesity

Synthesis and characterization of a peripherally restricted CB1 cannabinoid antagonist, URB447, that reduces feeding and body-weight gain in mice

(2008) Jesse LoVerme et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The role of endocannabinoids in the regulation of gastric emptying: alterations in mice fed a high-fat diet

(2008) V Di Marzo et al.   BRITISH JOURNAL OF PHARMACOLOGY

N-acylphosphatidylethanolamine, a Gut- Derived Circulating Factor Induced by Fat Ingestion, Inhibits Food Intake

(2008) Matthew P. Gillum et al.   CELL

GASTROINTESTINAL ENDOCANNABINOID SYSTEM: MULTIFACETED ROLES IN THE HEALTHY AND INFLAMED INTESTINE

(2008) Scott D Smid   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet-Induced Obesity and Diabetes in Mice

(2008) P. D. Cani et al.   DIABETES

Hepatic CB1 receptor is required for development of diet-induced steatosis, dyslipidemia, and insulin and leptin resistance in mice

(2008) Douglas Osei-Hyiaman et al.   JOURNAL OF CLINICAL INVESTIGATION

A core gut microbiome in obese and lean twins

(2008) Peter J. Turnbaugh et al.   NATURE

Worlds within worlds: evolution of the vertebrate gut microbiota

(2008) Ruth E. Ley et al.   NATURE REVIEWS MICROBIOLOGY

The orphan receptor GPR55 is a novel cannabinoid receptor

(2007) E Ryberg et al.   BRITISH JOURNAL OF PHARMACOLOGY