Compound- and fiber type-selective requirement of AMPKγ3 for insulin-independent glucose uptake in skeletal muscle

Single-nucleus RNA-seq and FISH identify coordinated transcriptional activity in mammalian myofibers

(2020) Matthieu Dos Santos et al.   Nature Communications

AMP-activated protein kinase: the current landscape for drug development

(2019) Gregory R. Steinberg et al.   NATURE REVIEWS DRUG DISCOVERY

AMPK promotes induction of the tumor suppressor FLCN through activation of TFEB independently of mTOR

(2019) Caterina Collodet et al.   FASEB JOURNAL

AMPK in skeletal muscle function and metabolism

(2018) Rasmus Kjøbsted et al.   FASEB JOURNAL

AMP-activated protein kinase selectively inhibited by the type II inhibitor SBI-0206965

(2018) Toby A. Dite et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMP-Activated Protein Kinase (AMPK) Regulates Energy Metabolism through Modulating Thermogenesis in Adipose Tissue

(2018) Lingyan Wu et al.   Frontiers in Physiology

Skeletal muscle O-GlcNAc transferase is important for muscle energy homeostasis and whole-body insulin sensitivity

(2018) Hao Shi et al.   Molecular Metabolism

Emerging Role of AMPK in Brown and Beige Adipose Tissue (BAT): Implications for Obesity, Insulin Resistance, and Type 2 Diabetes

(2018) Eric M. Desjardins et al.   Current Diabetes Reports

Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase

(2018) Roger W. Hunter et al.   NATURE MEDICINE

AMPK: guardian of metabolism and mitochondrial homeostasis

(2017) Sébastien Herzig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiac hypertrophy

(2017) Robert W. Myers et al.   SCIENCE

A high-throughput, image-based screen to identify kinases involved in brown adipocyte development

(2017) Aliki Perdikari et al.   Science Signaling

A high-throughput, image-based screen to identify kinases involved in brown adipocyte development

(2017) Aliki Perdikari et al.   Science Signaling

Benzimidazole derivative small-molecule 991 enhances AMPK activity and glucose uptake induced by AICAR or contraction in skeletal muscle

(2016) Laurent Bultot et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function

(2016) Emilio P. Mottillo et al.   Cell Metabolism

A Tbc1d1 Ser231Ala-knockin mutation partially impairs AICAR- but not exercise-induced muscle glucose uptake in mice

(2016) Qiaoli Chen et al.   DIABETOLOGIA

Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding

(2016) Christopher G. Langendorf et al.   Nature Communications

Probing the enzyme kinetics, allosteric modulation and activation of  1- and  2-subunit-containing AMP-activated protein kinase (AMPK) heterotrimeric complexes by pharmacological and physiological activators

(2015) F. Rajamohan et al.   BIOCHEMICAL JOURNAL

Differential regulation by AMP and ADP of AMPK complexes containing different   subunit isoforms

(2015) F. A. Ross et al.   BIOCHEMICAL JOURNAL

Inhibition of AMP-Activated Protein Kinase at the Allosteric Drug-Binding Site Promotes Islet Insulin Release

(2015) John W. Scott et al.   CHEMISTRY & BIOLOGY

AMPKα is critical for enhancing skeletal muscle fatty acid utilization during in vivo exercise in mice

(2015) Joachim Fentz et al.   FASEB JOURNAL

A small-molecule benzimidazole derivative that potently activates AMPK to increase glucose transport in skeletal muscle: comparison with effects of contraction and other AMPK activators

(2014) Yu-Chiang Lai et al.   BIOCHEMICAL JOURNAL

Mechanism of Action of Compound-13: An α1-Selective Small Molecule Activator of AMPK

(2014) Roger W. Hunter et al.   CHEMISTRY & BIOLOGY

AMPK controls exercise endurance, mitochondrial oxidative capacity, and skeletal muscle integrity

(2014) Louise Lantier et al.   FASEB JOURNAL

Structural Basis for AMPK Activation: Natural and Synthetic Ligands Regulate Kinase Activity from Opposite Poles by Different Molecular Mechanisms

(2014) Matthew F. Calabrese et al.   STRUCTURE

A standardized infrared imaging technique that specifically detects UCP1-mediated thermogenesis in vivo

(2014) Justin D. Crane et al.   Molecular Metabolism

AMP Is a True Physiological Regulator of AMP-Activated Protein Kinase by Both Allosteric Activation and Enhancing Net Phosphorylation

(2013) Graeme J. Gowans et al.   Cell Metabolism

Molecular mechanism of action of metformin: old or new insights?

(2013) Graham Rena et al.   DIABETOLOGIA

Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin

(2013) Morgan D Fullerton et al.   NATURE MEDICINE

Structural basis of AMPK regulation by small molecule activators

(2013) Bing Xiao et al.   Nature Communications

The AMPK  2 Subunit Is Required for Energy Homeostasis during Metabolic Stress

(2012) B. Dasgupta et al.   MOLECULAR AND CELLULAR BIOLOGY

AMP-activated protein kinase--an energy sensor that regulates all aspects of cell function

(2011) D. G. Hardie   GENES & DEVELOPMENT

Structure of mammalian AMPK and its regulation by ADP

(2011) Bing Xiao et al.   NATURE

AMP-activated protein kinase (AMPK)  1 2 muscle null mice reveal an essential role for AMPK in maintaining mitochondrial content and glucose uptake during exercise

(2011) H. M. O'Neill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AMPK Is a Direct Adenylate Charge-Regulated Protein Kinase

(2011) J. S. Oakhill et al.   SCIENCE

The AMPKγ1 subunit plays an essential role in erythrocyte membrane elasticity, and its genetic inactivation induces splenomegaly and anemia

(2010) Marc Foretz et al.   FASEB JOURNAL

Whole Body Deletion of AMP-activated Protein Kinase β2 Reduces Muscle AMPK Activity and Exercise Capacity

(2010) Gregory R. Steinberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

(2010) Marc Foretz et al.   JOURNAL OF CLINICAL INVESTIGATION

Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells

(2010) Daisuke Nakada et al.   NATURE

A-769662 activates AMPK β1-containing complexes but induces glucose uptake through a PI3-kinase-dependent pathway in mouse skeletal muscle

(2009) Jonas T. Treebak et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Thienopyridone Drugs Are Selective Activators of AMP-Activated Protein Kinase β1-Containing Complexes

(2008) John W. Scott et al.   CHEMISTRY & BIOLOGY

Beyond AICA riboside: In search of new specific AMP-activated protein kinase activators

(2008) Bruno Guigas et al.   IUBMB LIFE

Gain-of-function R225Q Mutation in AMP-activated Protein Kinase γ3 Subunit Increases Mitochondrial Biogenesis in Glycolytic Skeletal Muscle

(2008) Pablo M. Garcia-Roves et al.   JOURNAL OF BIOLOGICAL CHEMISTRY