Topological DNA damage, telomere attrition and T cell senescence during chronic viral infections

Structural, functional, and stability change predictions in human telomerase upon specific point mutations

(2019) U. Kalathiya et al.   Scientific Reports

Disruption of Telomere Integrity and DNA Repair Machineries by KML001 Induces T Cell Senescence, Apoptosis, and Cellular Dysfunctions

(2019) Dechao Cao et al.   Frontiers in Immunology

Insufficiency of DNA repair enzyme ATM promotes naive CD4 T-cell loss in chronic hepatitis C virus infection

(2018) Juan Zhao et al.   Cell Discovery

Inhibition of TRF2 accelerates telomere attrition and DNA damage in naïve CD4 T cells during HCV infection

(2018) Lam Nhat Nguyen et al.   Cell Death & Disease

Viral Persistence and Chronicity in Hepatitis C Virus Infection: Role of T-Cell Apoptosis, Senescence and Exhaustion

(2018) Muttiah Barathan et al.   Cells

The PARP inhibitor ABT-888 potentiates dacarbazine-induced cell death in carcinoids

(2016) Y Somnay et al.   CANCER GENE THERAPY

Telomeres in aging and disease: lessons from zebrafish

(2016) Madalena C. Carneiro et al.   Disease Models & Mechanisms

T-Cell Activation Independently Associates With Immune Senescence in HIV-Infected Recipients of Long-term Antiretroviral Treatment

(2016) Viviana Cobos Jiménez et al.   JOURNAL OF INFECTIOUS DISEASES

Protection of CD4 + T cells from hepatitis C virus infection-associated senescence via ΔNp63–miR-181a–Sirt1 pathway

(2016) Yun Zhou et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Methylome-wide Analysis of Chronic HIV Infection Reveals Five-Year Increase in Biological Age and Epigenetic Targeting of HLA

(2016) Andrew M. Gross et al.   MOLECULAR CELL

Immunodetection of human topoisomerase I-DNA covalent complexes

(2016) Anand G. Patel et al.   NUCLEIC ACIDS RESEARCH

HCV monoinfection and HIV/HCV coinfection enhance T-cell immune senescence in injecting drug users early during infection

(2016) Bart P. X. Grady et al.   Immunity & Ageing

DNA damage foci: Meaning and significance

(2015) Kai Rothkamm et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Hepatitis C virus-induced reduction in miR-181a impairs CD4+T-cell responses through overexpression of DUSP6

(2015) Guang Y. Li et al.   HEPATOLOGY

ATM and ATR signaling at a glance

(2015) P. Awasthi et al.   JOURNAL OF CELL SCIENCE

DNA-PK triggers histone ubiquitination and signaling in response to DNA double-strand breaks produced during the repair of transcription-blocking topoisomerase I lesions

(2015) Agnese Cristini et al.   NUCLEIC ACIDS RESEARCH

Association Between Short Leukocyte Telomere Length and HIV Infection in a Cohort Study: No Evidence of a Relationship With Antiretroviral Therapy

(2014) DeAnna L. Zanet et al.   CLINICAL INFECTIOUS DISEASES

PARP1–TDP1 coupling for the repair of topoisomerase I–induced DNA damage

(2014) Benu Brata Das et al.   NUCLEIC ACIDS RESEARCH

Neuroprotection and repair of 3'-blocking DNA ends by glaikit (gkt) encoding Drosophila tyrosyl-DNA phosphodiesterase 1 (TDP1)

(2014) D. Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immune Exhaustion and Immune Senescence: Two Distinct Pathways for HBV Vaccine Failure During HCV and/or HIV Infection

(2013) Zhi Q. Yao et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

KLRG1 Impairs CD4+ T Cell Responses via p16ink4a and p27kip1 Pathways: Role in Hepatitis B Vaccine Failure in Individuals with Hepatitis C Virus Infection

(2013) L. Shi et al.   JOURNAL OF IMMUNOLOGY

One Identity or More for Telomeres?

(2013) Marie-Josèphe Giraud-Panis et al.   Frontiers in Oncology

Drugging Topoisomerases: Lessons and Challenges

(2012) Yves Pommier   ACS Chemical Biology

Expression ofp16INK4aas a biomarker of T-cell aging in HIV-infected patients prior to and during antiretroviral therapy

(2012) Julie A. E. Nelson et al.   AGING CELL

HIV Infection-Related Premature Immunosenescence: High Rates of Immune Exhaustion After Short Time of Infection

(2011) Sara Ferrando-Martinez et al.   CURRENT HIV RESEARCH

Monoubiquitination of H2AX Protein Regulates DNA Damage Response Signaling

(2011) Mei-Ren Pan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

All tangled up: how cells direct, manage and exploit topoisomerase function

(2011) Seychelle M. Vos et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs

(2010) Yves Pommier et al.   CHEMISTRY & BIOLOGY

CD4+ T-lymphocyte telomere length is related to fibrosis stage, clinical outcome and treatment response in chronic hepatitis C virus infection

(2010) Matthew Hoare et al.   JOURNAL OF HEPATOLOGY

ATM Activation by Oxidative Stress

(2010) Z. Guo et al.   SCIENCE