Review
Neurosciences
Xiaoxue Xu, Bowen Sun, Chuansheng Zhao
Summary: This review discusses the biological functions of PARP-1 in neural cell proliferation and differentiation, memory formation, brain ageing, and epigenetic regulation. It also elaborates on the involvement of PARP-1 in various neuropathological processes, such as oxidative stress, neuroinflammation, mitochondrial dysfunction, excitotoxicity, autophagy damage, and endoplasmic reticulum (ER) stress. Additionally, it highlights the implications of PARP-1 in different neurological illnesses and explores the potential therapeutic opportunities for neurological diseases using PARP inhibitors.
NEUROBIOLOGY OF DISEASE
(2023)
Review
Biochemistry & Molecular Biology
Shuiqiao Liu, Weibo Luo, Yingfei Wang
Summary: Cell death is a crucial feature in neurological diseases, with PARP-1 and PARthanatos playing key roles in ischemic neuronal cell death and disease progression. Inhibition of PARP-1 shows potential therapeutic effects in stroke by reducing infarct volume and improving neurological recovery.
JOURNAL OF NEUROCHEMISTRY
(2022)
Article
Neurosciences
Xue Wang, Wuqiong Zhang, Pengfei Ge, Miaomiao Yu, Hongmei Meng
Summary: This study found that Parthanatos mechanism is involved in hippocampal neuronal death following seizures, possibly initiated by ROS.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Surgery
Sanae Haga, Akira Kanno, Naoki Morita, Shigeki Jin, Kotaro Matoba, Takeaki Ozawa, Michitaka Ozaki
Summary: PARP, activated by ischemic damage and/or oxidative stress, may play a critical role in post-ischemic liver injury by inducing programmed necrosis (parthanatos and necroptosis). PARP inhibition may be one of the promising strategies against post-ischemic liver injury.
JOURNAL OF SURGICAL RESEARCH
(2022)
Review
Cell Biology
Chuwen Tian, Yifan Liu, Zhuoshu Li, Ping Zhu, Mingyi Zhao
Summary: Mitochondria play a key role in cell death, not only generating ATP but also controlling cell death through various mechanisms. These mitochondria-associated modes of cell death are related to various diseases, and mitochondria-based treatments have shown effectiveness.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Zsofia Lengyel-Zhand, Laura N. Puentes, Robert H. Mach
Summary: This paper discusses the role of poly (ADP-ribose) polymerase 1 (PARP-1) and poly (ADP-ribose) (PAR) in the pathological process of Parkinson's disease (PD). It also suggests the potential of PARP-1 inhibitors as disease-modifying therapeutics for PD and outlines important considerations for repurposing PARP-1 inhibitors for use in PD.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Chemistry, Multidisciplinary
Liguo Zhu, Zhuo Xie, Guang Yang, Gaoshi Zhou, Li Li, Shenghong Zhang
Summary: This study found that STC1 is upregulated in Crohn's disease patients and chemically-induced mice colitis models. Intestinal-specific Stc1 knockout mice showed resistance to DSS-induced colitis. STC1 mediates oxidative stress-associated parthanatos and aggravates inflammation via the STC1-PARP1-JNK interactions and subsequent JNK pathway activation.
Review
Physiology
Tong Zhang, Minh D. A. Luu, Amalia M. M. Dolga, Ulrich L. M. Eisel, Martina Schmidt
Summary: Alzheimer's disease (AD) and Parkinson's disease (PD) are the most prevalent neurodegenerative disorders worldwide, impacting millions of people's life expectancy and quality. Recent research suggests overlapping mechanisms may underlie AD and PD, with novel cell death mechanisms, such as parthanatos, netosis, lysosome-dependent cell death, senescence, and ferroptosis, being modulated by cAMP signaling via PKA and Epac. This review focuses on the overlapping mechanisms between AD and PD, specifically in relation to cAMP signaling and the pharmacology of cAMP signaling pathways.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Fisheries
Francisco J. Martinez-Morcillo, Joaquin Canton-Sandoval, Teresa Martinez-Menchon, Rail Corbalan-Velez, Pablo Mesa-del-Castillo, Ana B. Perez-Oliva, Diana Garcia-Moreno, Victoriano Mulero
Summary: NAD(+) is a crucial hydrogen carrier involved in various biological processes, and increasing its levels can improve health and longevity. NAMPT and PARP play important roles as NAD(+) biosynthetic enzyme and consuming enzyme, respectively, in the occurrence of inflammation.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Keun-Yeong Jeong, Min Hee Park
Summary: Genome-wide studies have identified a subpopulation of pancreatic cancer cells with unstable genomic characteristics, leading to a focus on the deleterious effects of PARP-1 in oncology. PARP-1 plays a crucial role in DNA repair, oxidative stress regulation, and mitosis in cancer cells, impacting their survival and growth. Targeting PARP-1 in the treatment of pancreatic cancer through recent approaches may offer promising prospects for clinical and non-clinical research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biology
Anastasia S. S. Frolova, Olga E. E. Chepikova, Anna S. S. Deviataikina, Alena D. D. Solonkina, Andrey A. A. Zamyatnin
Summary: Cell death is an important process for multicellular organisms, and proteases play a crucial role in breaking down proteins and maintaining a healthy cellular environment. The activity of nuclear proteins determines the fate of the cell during certain types of cell death, making the regulation of nuclear proteases crucial. Understanding the roles and regulation of nuclear proteases in cell death could lead to new therapeutic targets for improving treatment outcomes.
Review
Neurosciences
Yan Zhang, Suliman Khan, Yang Liu, Ruiyi Zhang, Hongmin Li, Guofeng Wu, Zhouping Tang, Mengzhou Xue, V. Wee Yong
Summary: This review summarizes the knowledge of cell death induced by intracerebral hemorrhage (ICH), with a focus on apoptosis and necrosis. It also discusses the involvement of recently described modes of cell death including necroptosis, pyroptosis, ferroptosis, autophagy, and parthanatos in ICH. Treatment strategies to mitigate brain injury based on specific cell death pathways after ICH are also summarized.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Cong Wang, Qian Jiang, Ping Zhao
Summary: This study aimed to investigate the potential mechanism of neurotoxicity in offspring rats after sevoflurane exposure during the second trimester of pregnancy. The results showed that sevoflurane exposure led to excessive activation of PARP-1 via the STEP61/Pyk2 pathway, resulting in neurotoxicity in the offspring rats. In addition, the inhibitors 3-AB and TC-2153 alleviated cell death and improved sevoflurane-induced spatial learning and memory impairment.
PSYCHOPHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Chun-Yan Kong, Zhen Guo, Peng Song, Xin Zhang, Yu-Pei Yuan, Teng Teng, Ling Yan, Qi-Zhu Tang
Summary: This review provides a comprehensive overview of the mechanisms underlying the oxidative stress and cell death pathways induced by doxorubicin, which are the major factors responsible for the acute cardiotoxicity. The authors aim to offer new insights for researchers to discover potential therapeutic strategies to prevent or reverse doxorubicin-induced cardiotoxicity.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Neurosciences
Chenghe Fan, Yu Tian, Yilin Zhang, Junfang Teng, Xinyu Zhao
Summary: The study found that ceramide induced neuronal parthanatos by increasing ROS levels, and MIF may play a crucial role in this pathway. Knocking down MIF expression may be a potential therapeutic strategy for nervous system diseases.
NEUROSCIENCE LETTERS
(2022)
Article
Biochemistry & Molecular Biology
Felix Breyer, Anetta Hartlova, Teresa Thurston, Helen R. Flynn, Probir Chakravarty, Julia Janzen, Julien Peltier, Tiaan Heunis, Ambrosius P. Snijders, Matthias Trost, Steven C. Ley
Summary: TPL-2 kinase mediates TLR activation of MAP kinases to modulate cytokine expression in myeloid cells, and also plays a crucial role in regulating phagosome maturation for efficient killing of phagocytosed microbes.
Article
Multidisciplinary Sciences
Daniela Ivanova, Katharine L. Dobson, Akshada Gajbhiye, Elizabeth C. Davenport, Daniela Hacker, Sila K. Ultanir, Matthias Trost, Michael A. Cousin
Summary: The study reveals that regulating the copy number of the noncanonical vesicular SNARE protein VAMP4 on synaptic vesicles is crucial for controlling neurotransmitter release probability. VAMP4, with high synaptic turnover, is selectively sorted to endolysosomes during activity-dependent bulk endocytosis, disrupting which can lead to an increase in VAMP4 abundance in the SV pool and inhibition of SV fusion.
Article
Biology
Rachel E. Heap, Jose Luis Marin-Rubio, Julien Peltier, Tiaan Heunis, Abeer Dannoura, Adam Moore, Matthias Trost
Summary: The study revealed that L929 cell-conditioned media (LCCM) contains abundant M-CSF and other immunomodulatory proteins, impacting the differentiation of BMDMs, resulting in a stronger anti-inflammatory M1 phenotype.
LIFE SCIENCE ALLIANCE
(2021)
Article
Biochemistry & Molecular Biology
Ivana Rubic, Richard Burchmore, Stefan Weidt, Clement Regnault, Josipa Kules, Renata Baric Rafaj, Tomislav Masek, Anita Horvatic, Martina Crnogaj, Peter David Eckersall, Predrag Novak, Vladimir Mrljak
Summary: This study aimed to explore and characterize the serum metabolome of dogs naturally infected with Babesia canis. By using different analytical platforms, 295 metabolites were detected and various metabolic pathways were found to be involved in canine babesiosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Santhasiri Orrapin, Sittiruk Roytrakul, Narumon Phaonakrop, Siriwan Thaisakun, Khajornsak Tragoolpua, Amornrat Intorasoot, Suzanne McGill, Richard Burchmore, Sorasak Intorasoot
Summary: The study evaluated the biological activities of recombinant javanicin against the human fungal pathogen Cryptococcus neoformans, showing concentration- and time-dependent antifungal activity. Microscopic and proteomics analysis indicated that javanicin may inhibit fungal growth by interfering with carbohydrate metabolism and energy production pathways.
Article
Pharmacology & Pharmacy
Jitkasem Meewan, Sukrut Somani, Partha Laskar, Craig Irving, Margaret Mullin, Stuart Woods, Craig W. Roberts, Abdullah R. Alzahrani, Valerie A. Ferro, Suzanne McGill, Stefan Weidt, Richard Burchmore, Christine Dufes
Summary: The protein corona formed on the nanoparticle surface has a strong influence on cell interactions and uptake of nanomedicines. This study shows that the protein corona affects the uptake of PEGylated zein micelles by cancer cells, macrophages, and dendritic cells. PEGylation gives stealth effects to the zein micelles and makes them promising drug delivery systems for cancer therapy.
Article
Biochemical Research Methods
Heather Hulme, Lynsey M. Meikle, Nicole Strittmatter, John Swales, Gregory Hamm, Sheila L. Brown, Simon Milling, Andrew S. MacDonald, Richard J. A. Goodwin, Richard Burchmore, Daniel M. Wall
Summary: Microbes have significant effects on the levels of neurotransmitters and their precursors in the brain. Antibiotic treatment does not cause significant changes in these metabolites in the brain.
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
(2022)
Article
Biology
Pornchai Anuntasomboon, Suradej Siripattanapipong, Sasimanas Unajak, Kiattawee Choowongkomon, Richard Burchmore, Saovanee Leelayoova, Mathirut Mungthin, Teerasak E-kobon
Summary: This study successfully sequenced the draft genomes of two Leishmania species in southern Thailand and found species-level similarity and genetic variation compared to the northern isolates. The unique proteins identified in these strains could be targeted for further experimental characterization. These findings indicate the need for more genetic and population genomic investigation and close monitoring of these Leishmania species in Thailand and neighboring regions.
Article
Biochemistry & Molecular Biology
Mustafa M. Aldfer, Tahani A. AlSiari, Hamza A. A. Elati, Manal J. Natto, Ibrahim A. Alfayez, Gustavo D. Campagnaro, Bashiru Sani, Richard J. S. Burchmore, George Diallinas, Harry P. De Koning
Summary: The study of transporters, specifically nucleoside transporters, presents unique challenges and requires specific systems for analysis. This study describes the development of a system, using CRISPR/Cas9 technology, to delete and reintroduce nucleoside transporters in Leishmania mexicana, providing a null background for the expression and characterization of individual transporter genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Pornchai Anuntasomboon, Suradej Siripattanapipong, Sasimanas Unajak, Kiattawee Choowongkomon, Richard Burchmore, Saovanee Leelayoova, Mathirut Mungthin, Teerasak E-kobon
Summary: This study presents an integrative bioinformatic workflow for assembling the high-quality genome of Leishmania orientalis strain PCM2 from Thailand using short-read data. The workflow provides extensive information for identifying strain-specific markers and virulence-associated genes, which is useful for drug and vaccine development.
Article
Biochemistry & Molecular Biology
Jose Luis Marin-Rubio, Laura Vela-Martin, Jack Gudgeon, Eduardo Perez-Gomez, Frances R. Sidgwick, Matthias Trost, Debbie L. Cunningham, Javier Santos, Jose Fernandez-Piqueras, Maria Villa-Morales
Summary: A reduction in FADD levels has been found in precursor T-cell neoplasms, which may affect tumor cell apoptosis and lead to poor clinical outcomes. FADD is involved in both apoptotic and non-apoptotic functions, and its expression could serve as a prognostic marker and guide targeted therapeutic strategies in these tumors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Marzuq A. Ungogo, Mustafa M. Aldfer, Manal J. Natto, Hainan Zhuang, Robyn Chisholm, Katy Walsh, MarieClaire McGee, Kayhan Ilbeigi, Jamal Ibrahim Asseri, Richard J. S. Burchmore, Guy Caljon, Serge Van Calenbergh, Harry P. De Koning
Summary: African Animal Trypanosomiasis (AAT) is a fatal livestock disease in Sub-Saharan Africa caused by Trypanosoma brucei brucei, T. vivax, and T. congolense. Limited treatment options and resistance threaten the control of this disease. In this study, the adenosine transporters of T. vivax (TvxNT3) and T. congolense (TcoAT1/NT10) were characterized and their functional expression was demonstrated. The findings suggest that nucleoside chemotherapy for AAT is viable based on the similarities in nucleoside sensitivity among different parasite species and the interactions with nucleoside transporters.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ivana Rubic, Stefan Weidt, Richard Burchmore, Alan Kovacevic, Josipa Kules, Peter David Eckersall, Marin Torti, Ines Jovic, Mislav Kovacic, Jelena Gotic, Renata Baric Rafaj, Predrag Novak, Marko Samardzija, Vladimir Mrljak
Summary: This study utilized mass spectrometry-based analysis to compare changes in plasma metabolites between dogs with idiopathic dilated cardiomyopathy (iDCM) and healthy dogs. The findings revealed altered concentrations of various metabolites involved in the development of iDCM. These results will contribute to the detection and monitoring of pathophysiological mechanisms in the development of iDCM in the future.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Biochemistry & Molecular Biology
Roland Hjerpe, Thimo Kurz
Summary: This study discusses a method for targeted protein degradation, where targets are delivered to E3 ubiquitin ligases, leading to proteasomal degradation. The authors demonstrate that CAND1 can modulate cullin-RING ubiquitin ligase (CRL) and may be utilized for protein degradation.
Article
Biochemistry & Molecular Biology
Martha Lucia Diaz, Karl Burgess, Richard Burchmore, Maria Adelaida Gomez, Sergio Alejandro Gomez-Ochoa, Luis Eduardo Echeverria, Carlos Morillo, Clara Isabel Gonzalez
Summary: This exploratory study used metabolomic profiling to investigate the underlying pathogenic mechanisms in the failing myocardium of patients with end-stage heart failure secondary to chronic Chagas cardiomyopathy (CCC). The results revealed altered metabolite profiles associated with energy deficit, changes in substrate availability, and increased production of reactive oxygen species in the affected myocardium.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)