Molecular mechanisms of APC/C release from spindle assembly checkpoint inhibition by APC/C SUMOylation

A unique binding mode of Nek2A to the APC /C allows its ubiquitination during prometaphase

(2020) Claudio Alfieri et al.   EMBO REPORTS

Cyclin A2 degradation during the spindle assembly checkpoint requires multiple binding modes to the APC/C

(2019) Suyang Zhang et al.   Nature Communications

Role of ubiquitylation of components of mitotic checkpoint complex in their dissociation from anaphase-promoting complex/cyclosome

(2018) Danielle Sitry-Shevah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SUMO targets the APC/C to regulate transition from metaphase to anaphase

(2018) Karolin Eifler et al.   Nature Communications

Sumoylation promotes optimal APC/C activation and timely anaphase

(2018) Christine C Lee et al.   eLife

New tools for automated high-resolution cryo-EM structure determination in RELION-3

(2018) Jasenko Zivanov et al.   eLife

Posing the APC/C E3 Ubiquitin Ligase to Orchestrate Cell Division

(2018) Edmond R. Watson et al.   TRENDS IN CELL BIOLOGY

UCSF ChimeraX: Meeting modern challenges in visualization and analysis

(2017) Thomas D. Goddard et al.   PROTEIN SCIENCE

Visualizing the complex functions and mechanisms of the anaphase promoting complex/cyclosome (APC/C)

(2017) Claudio Alfieri et al.   Open Biology

Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C

(2016) Nicholas G. Brown et al.   CELL

Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin Ligation

(2016) Masaya Yamaguchi et al.   MOLECULAR CELL

Molecular mechanism of APC/C activation by mitotic phosphorylation

(2016) Suyang Zhang et al.   NATURE

Molecular basis of APC/C regulation by the spindle assembly checkpoint

(2016) Claudio Alfieri et al.   NATURE

A comprehensive compilation of SUMO proteomics

(2016) Ivo A. Hendriks et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanism of APC/CCDC20activation by mitotic phosphorylation

(2016) Renping Qiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Spindle Assembly Checkpoint Is Not Essential for Viability of Human Cells with Genetically Lowered APC/C Activity

(2016) Thomas Wild et al.   Cell Reports

The Molecular Biology of Spindle Assembly Checkpoint Signaling Dynamics

(2015) Andrea Musacchio   CURRENT BIOLOGY

Atomic structure of the APC/C and its mechanism of protein ubiquitination

(2015) Leifu Chang et al.   NATURE

RING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complex

(2015) Nicholas G. Brown et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of SUMO-2/3-modified proteins associated with mitotic chromosomes

(2015) Caelin Cubeñas-Potts et al.   PROTEOMICS

SUMOylation-Mediated Regulation of Cell Cycle Progression and Cancer

(2015) Karolin Eifler et al.   TRENDS IN BIOCHEMICAL SCIENCES

Uncovering SUMOylation Dynamics during Cell-Cycle Progression Reveals FoxM1 as a Key Mitotic SUMO Target Protein

(2014) Joost Schimmel et al.   MOLECULAR CELL

Mechanism of Polyubiquitination by Human Anaphase-Promoting Complex: RING Repurposing for Ubiquitin Chain Assembly

(2014) Nicholas G. Brown et al.   MOLECULAR CELL

Comprehensive Identification of SUMO2/3 Targets and Their Dynamics during Mitosis

(2014) Julie Schou et al.   PLoS One

Disassembly of mitotic checkpoint complexes by the joint action of the AAA-ATPase TRIP13 and p31comet

(2014) E. Eytan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recombinant expression, reconstitution and structure of human anaphase-promoting complex (APC/C)

(2012) Ziguo Zhang et al.   BIOCHEMICAL JOURNAL

Protein Group Modification and Synergy in the SUMO Pathway as Exemplified in DNA Repair

(2012) Ivan Psakhye et al.   CELL

The APC/C Subunit Mnd2/Apc15 Promotes Cdc20 Autoubiquitination and Spindle Assembly Checkpoint Inactivation

(2012) Scott A. Foster et al.   MOLECULAR CELL

APC15 mediates CDC20 autoubiquitylation by APC/CMCC and disassembly of the mitotic checkpoint complex

(2012) Kristina Uzunova et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

UCSF Chimera, MODELLER, and IMP: An integrated modeling system

(2011) Zheng Yang et al.   JOURNAL OF STRUCTURAL BIOLOGY

APC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachment

(2011) Jörg Mansfeld et al.   NATURE CELL BIOLOGY

p31comet promotes disassembly of the mitotic checkpoint complex in an ATP-dependent process

(2011) A. Teichner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Site-Specific Identification of SUMO-2 Targets in Cells Reveals an Inverted SUMOylation Motif and a Hydrophobic Cluster SUMOylation Motif

(2010) Ivan Matic et al.   MOLECULAR CELL

The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition

(2010) Jaclyn R. Gareau et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ATP is required for the release of the anaphase-promoting complex/cyclosome from inhibition by the mitotic checkpoint

(2010) S. Miniowitz-Shemtov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Jalview Version 2--a multiple sequence alignment editor and analysis workbench

(2009) A. M. Waterhouse et al.   BIOINFORMATICS

The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction

(2008) Jakob Nilsson et al.   NATURE CELL BIOLOGY