Article
Biochemistry & Molecular Biology
Mouna Mhamdi-Ghodbani, Christin Starzonek, Sarah Degenhardt, Marc Bender, Mohammed Said, Ruediger Greinert, Beate Volkmer
Summary: The study found that dermal stem cells have a similar DNA damage response to other skin cells after UVB radiation, but only fibroblasts showed significant changes in cell cycle distribution. Moreover, the UVB dose used in the experiment did not lead to UVB-induced apoptosis in any of the tested cell types.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Giovanna Pressi, Giovanna Rigillo, Paolo Governa, Vittoria Borgonetti, Giulia Baini, Raffaella Rizzi, Chiara Guarnerio, Oriana Bertaiola, Marco Frigo, Matilde Merlin, Stefania Paltrinieri, Roberto Zambonin, Stefano Pandolfo, Marco Biagi
Summary: In recent years, the medicinal plant Perilla frutescens has attracted scientific interest due to its potential anti-allergic and skin protective properties. However, the lack of standardized extracts has hindered its clinical applications. This study developed a standardized phytocomplex of P. frutescens enriched in rosmarinic acid and polyphenols using innovative cell culture biotechnology and evaluated its efficacy in inflammatory models and vaginal mucosal integrity. The results demonstrated that the P. frutescens phytocomplex had significant effects on epidermal barrier maintenance, anti-inflammatory activity, and preservation of vaginal mucosal integrity, suggesting its potential as an innovative ingredient for dermatological applications.
Review
Biochemistry & Molecular Biology
Gigi Adam, Silvia Robu, Mihaela-Magdalena Flutur, Oana Cioanca, Ingrid-Andrada Vasilache, Ana-Maria Adam, Cornelia Mircea, Aurel Nechita, Valeriu Harabor, AnaMaria Harabor, Monica Hancianu
Summary: This review aims to provide an updated understanding of the clinical applications of Perilla frutescens through human studies and outline potential directions for further research. The findings suggest significant clinical effects of Perilla frutescens extracts on allergic rhinoconjuctivitis, especially in young populations, as well as a potent hypolipemiant effect and potential improvements in cognitive function. Supplementary research in controlled clinical settings is needed to confirm these therapeutic effects.
Article
Agricultural Engineering
SuYun Ding, ZhiQian Yan, HuiPing Liu, Pei Chen, ShuYuan Shi, MengLi Chang
Summary: The polysaccharide PFP extracted from Perilla frutescens var. frutescens has antitumor activity by inhibiting tumor proliferation through blocking the cell cycle S phase, and also exhibits protective effects on mouse liver and thymus tissues.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Biochemistry & Molecular Biology
Wen-Fang Tang, Hui-Ping Tsai, Yu-Hsiu Chang, Tein-Yao Chang, Chung-Fan Hsieh, Chia-Yi Lin, Guan-Hua Lin, Yu-Li Chen, Jia-Rong Jheng, Ping-Cheng Liu, Chuen-Mi Yang, Yuan-Fan Chin, Cheng Cheung Chen, Jyh-Hwa Kau, Yi-Jen Hung, Po-Shiuan Hsieh, Jim-Tong Horng
Summary: The study found that Perilla leaf extract could inhibit SARS-CoV-2 replication by inactivating the virus, blocking viral infection steps, reducing viral replication and inflammation response. Moreover, it showed additive-to-synergistic efficacy when used in combination with remdesivir.
BIOMEDICAL JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Zhan Li, Ying Wang, Lili Yu, Yongzhe Gu, Lijuan Zhang, Jun Wang, Lijuan Qiu
Summary: The increasing problem of soil salinization has a severe impact on soybean growth and development, leading to reduced yields and posing a serious threat to global crop production. In this study, the PfFAD3a gene was isolated from perilla and overexpressed in soybeans to assess the salt tolerance of transgenic plants. The results showed that overexpression of PfFAD3a increased the expression of PfFAD3a and the content of ff-linolenic acid in transgenic soybean plants, significantly enhancing their salt tolerance. Physiological and biochemical analysis revealed that overexpression of PfFAD3a increased the chlorophyll content and maximum photochemical efficiency of transgenic soybean plants under salt stress, while reducing the accumulation of MDA, H2O2, and O-circle(2), and increasing the activities of SOD, POD, CAT, and APX, as well as the production of proline and soluble sugar. In conclusion, the overexpression of PfFAD3a enhances salt tolerance in transgenic soybean plants through improved membrane fluidity and increased antioxidant capacity induced by C18:3.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Hyeon Park, Kyu Jin Sa, Do Yoon Hyun, Sookyeong Lee, Ju Kyong Lee
Summary: Perilla seed oil, a popular health food in South Korea, contains various fatty acids. By using association analysis of SSR markers, several markers associated with fatty acid content in Perilla seed oil were identified, which can be useful for improving seed oil quality in Perilla crops through MAS breeding programs.
Article
Plant Sciences
Peina Zhou, Yongfang Shao, Zheng Jiang, Jingjie Dang, Cheng Qu, Qinan Wu
Summary: In this study, eight candidate genes encoding double bond reductases (DBRs) related to perilla ketone biosynthesis were identified in Perilla frutescens. These DBRs were found to catalyze the conversion of isoegoma ketone and egoma ketone into perilla ketone in vitro. In addition, genes and transcription factors associated with monoterpenoid biosynthesis were predicted and shown to be correlated with variations in perilla ketone abundance.
Review
Biochemistry & Molecular Biology
Tianyu Hou, Vasudeva Reddy Netala, Hongjiao Zhang, Yun Xing, Huizhen Li, Zhijun Zhang
Summary: This review summarizes the latest research findings on the phytochemistry and pharmacological activities of Perilla frutescens. The plant contains approximately 400 different bioactive compounds and exhibits various pharmacological properties such as anti-inflammatory, antidepressant, anticancer, and antioxidant effects. It has potential applications in the treatment of diabetes and its complications, prevention of hyperuricemia, and management of allergic conditions.
Article
Food Science & Technology
Yuan Li, Yue Zhang, Youyou Wang, Xiang Li, Li Zhou, Jian Yang, Lanping Guo
Summary: This study analyzed the components of Perilla samples from different origins and found differences in compound contents between red and green Perilla, particularly in anthocyanins and some metabolites. Additionally, the content of these compounds also varied between the north and south of China for each variety. This research provides a basis for distinguishing different varieties and sources of Perilla.
JOURNAL OF FOOD SCIENCE
(2022)
Article
Pharmacology & Pharmacy
NamHoon Kim, Si-Yeon Kim, Sang-Woo Kim, Jung Min Lee, Sung-Kyu Kim, Mi-Houn Park, Ki-Hwan Kim, Minseok Oh, Chang-Gue Son, In Chul Jung, Eun-Jung Lee
Summary: This study aimed to evaluate the clinical efficacy and safety of PE extracts on semi-healthy people with mild knee joint pain. The results showed that PE intake for eight weeks was more effective than placebo in reducing knee joint pain and improving knee joint function. It was concluded that PE extracts were effective and safe for relieving knee joint pain and improving knee joint function.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Plant Sciences
Ye Ju Ha, Kyu Jin Sa, Ju Kyong Lee
Summary: This study identified SSR markers associated with seed characteristics in cultivated and weedy types of Perilla crop, showing differences in seed traits between the two types. The correlation analysis among the seed traits of different accessions revealed positive and negative relationships between seed germination rate, hardness, and size. The results are valuable for understanding and improving the seed quality of Perilla crop through marker-assisted selection breeding programs.
PHYSIOLOGY AND MOLECULAR BIOLOGY OF PLANTS
(2021)
Article
Genetics & Heredity
Keita Tamura, Mika Sakamoto, Yasuhiro Tanizawa, Takako Mochizuki, Shuji Matsushita, Yoshihiro Kato, Takeshi Ishikawa, Keisuke Okuhara, Yasukazu Nakamura, Hidemasa Bono
Summary: Perilla frutescens is an important herbal plant with perillaldehyde and rosmarinic acid as its major bioactive compounds. By using genome editing technology, the production of valuable metabolites can be enhanced, improving the medicinal and nutritional uses of this plant. A high-quality genome assembly of red perilla domesticated in Japan was generated, which can serve as a valuable reference for selecting target genes in genome editing.
Review
Biochemistry & Molecular Biology
Shicong Huang, Yi Nan, Guoqing Chen, Na Ning, Yuhua Du, Doudou Lu, Yating Yang, Fandi Meng, Ling Yuan
Summary: Perilla frutescens is a widely grown herb in Asia with various medicinal uses. It has been found to have pharmacological effects such as anti-inflammatory, antibacterial, detoxifying, antioxidant, and hepatoprotective properties. This review summarizes the chemical composition and molecular mechanisms of Perilla frutescens for cancer treatment, with perilla aldehyde, rosmarinic acid, lignan, isoestrogen, and perilla seed oil identified as the main active components. This review also provides new ideas and thoughts for scientific innovation and clinical applications related to Perilla frutescens.
Article
Environmental Sciences
Silvina Acosta, Lucia Canclini, Juan Jose Marizcurrena, Susana Castro-Sowinski, Paola Hernandez
Summary: The recombinant CPD-photolyase PhrAHym from the Antarctic bacterium shows a highly efficient repair effect on DNA lesions induced by UVC light in human keratinocytes. This non-cytotoxic enzyme repairs CPD-photoproducts and reduces the formation of gamma H2AX, suggesting its potential as a biotherapeutic agent against UV-induced skin cancer, photoaging, and related diseases.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2022)
