标题
Epigenetic mechanisms in breast cancer therapy and resistance
作者
关键词
-
出版物
Nature Communications
Volume 12, Issue 1, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2021-03-19
DOI
10.1038/s41467-021-22024-3
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- ARID1A determines luminal identity and therapeutic response in estrogen-receptor-positive breast cancer
- (2020) Guotai Xu et al. NATURE GENETICS
- Author Correction: Drug-induced PD-L1 expression and cell stress response in breast cancer cells can be balanced by drug combination
- (2020) Yosi Gilad et al. Scientific Reports
- Inhibition of EZH2 Catalytic Activity Selectively Targets a Metastatic Subpopulation in Triple-Negative Breast Cancer
- (2020) Shira Yomtoubian et al. Cell Reports
- Neurofibromin Is an Estrogen Receptor-α Transcriptional Co-repressor in Breast Cancer
- (2020) Ze-Yi Zheng et al. CANCER CELL
- Overcoming Endocrine Resistance in Breast Cancer
- (2020) Ariella B. Hanker et al. CANCER CELL
- Epigenetic switch-induced viral mimicry evasion in chemotherapy resistant breast cancer
- (2020) Genevieve Deblois et al. Cancer Discovery
- Estrogen induces dynamic ERα and RING1B recruitment to control gene and enhancer activities in luminal breast cancer
- (2020) Yusheng Zhang et al. Science Advances
- Systemic Therapy for Estrogen Receptor–Positive, HER2-Negative Breast Cancer
- (2020) Harold J. Burstein NEW ENGLAND JOURNAL OF MEDICINE
- Targeting epigenetic modifications in cancer therapy: erasing the roadmap to cancer
- (2019) Helai P. Mohammad et al. NATURE MEDICINE
- Cyclin E mRNA: Assessing Cyclin-Dependent Kinase (CDK) Activation State to Elucidate Breast Cancer Resistance to CDK4/6 Inhibitors
- (2019) Sarat Chandarlapaty et al. JOURNAL OF CLINICAL ONCOLOGY
- Genomic characterization of metastatic breast cancers
- (2019) François Bertucci et al. NATURE
- Estrogen receptor signaling is reprogrammed during breast tumorigenesis
- (2019) David Chi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Emerging role of PI3K/AKT in tumor-related epigenetic regulation
- (2019) Qi Yang et al. SEMINARS IN CANCER BIOLOGY
- Emerging Roles for Polycomb-Group Proteins in Stem Cells and Cancer
- (2019) Ho Lam Chan et al. TRENDS IN BIOCHEMICAL SCIENCES
- Therapeutic Ligands Antagonize Estrogen Receptor Function by Impairing Its Mobility
- (2019) Jane Guan et al. CELL
- Targeting enhancer switching overcomes non-genetic drug resistance in acute myeloid leukaemia
- (2019) Charles C. Bell et al. Nature Communications
- Combining epigenetic drugs with other therapies for solid tumours — past lessons and future promise
- (2019) Daphné Morel et al. Nature Reviews Clinical Oncology
- Reading, writing and erasing mRNA methylation
- (2019) Sara Zaccara et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Re-programing Chromatin with a Bifunctional LSD1/HDAC Inhibitor Induces Therapeutic Differentiation in DIPG
- (2019) Jamie N. Anastas et al. CANCER CELL
- Inactivating NF1 mutations are enriched in advanced breast cancer and contribute to endocrine therapy resistance
- (2019) Alex Pearson et al. CLINICAL CANCER RESEARCH
- Immune Checkpoint Profiles in Luminal B Breast Cancer (Alliance)
- (2019) Meenakshi Anurag et al. JNCI-Journal of the National Cancer Institute
- Single-cell transcriptomics reveals multi-step adaptations to endocrine therapy
- (2019) Sung Pil Hong et al. Nature Communications
- FOXA1 upregulation promotes enhancer and transcriptional reprogramming in endocrine-resistant breast cancer
- (2019) Xiaoyong Fu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Allele-Specific Chromatin Recruitment and Therapeutic Vulnerabilities of ESR1 Activating Mutations
- (2018) Rinath Jeselsohn et al. CANCER CELL
- Epigenetic regulation of the Hedgehog and Wnt pathways in cancer
- (2018) Leon J Wils et al. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
- Targeting Transcription Factors for Cancer Treatment
- (2018) Mélanie Lambert et al. MOLECULES
- Proteomic profiling identifies key coactivators utilized by mutant ERα proteins as potential new therapeutic targets
- (2018) Leah A. Gates et al. ONCOGENE
- KMT2C mediates the estrogen dependence of breast cancer through regulation of ERα enhancer function
- (2018) Kinisha Gala et al. ONCOGENE
- Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors
- (2018) Jay H. Kalin et al. Nature Communications
- p38-mediated phosphorylation at T367 induces EZH2 cytoplasmic localization to promote breast cancer metastasis
- (2018) Talha Anwar et al. Nature Communications
- Crosstalk between the RNA Methylation and Histone-Binding Activities of MePCE Regulates P-TEFb Activation on Chromatin
- (2018) Samantha B. Shelton et al. Cell Reports
- Repurposing Pan-HDAC Inhibitors for ARID1A -Mutated Ovarian Cancer
- (2018) Takeshi Fukumoto et al. Cell Reports
- The Genomic Landscape of Endocrine-Resistant Advanced Breast Cancers
- (2018) Pedram Razavi et al. CANCER CELL
- Polycomb complexes associate with enhancers and promote oncogenic transcriptional programs in cancer through multiple mechanisms
- (2018) Ho Lam Chan et al. Nature Communications
- Functional Annotation of ESR1 Gene Fusions in Estrogen Receptor-Positive Breast Cancer
- (2018) Jonathan T. Lei et al. Cell Reports
- Human ALKBH3-induced m1A demethylation increases the CSF-1 mRNA stability in breast and ovarian cancer cells
- (2018) Ho-Hyung Woo et al. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms
- Loss of the FAT1 Tumor Suppressor Promotes Resistance to CDK4/6 Inhibitors via the Hippo Pathway
- (2018) Zhiqiang Li et al. CANCER CELL
- KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance
- (2018) Kunihiko Hinohara et al. CANCER CELL
- Clinical epigenetics: seizing opportunities for translation
- (2018) María Berdasco et al. NATURE REVIEWS GENETICS
- Y-box binding protein YBX1 and its correlated genes as biomarkers for poor outcomes in patients with breast cancer
- (2018) Tomohiro Shibata et al. Oncotarget
- The role of histone deacetylase inhibitors in metastatic breast cancer
- (2018) Bruna Zucchetti et al. BREAST
- Dynamic assembly and activation of estrogen receptor α enhancers through coregulator switching
- (2017) Shino Murakami et al. GENES & DEVELOPMENT
- Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours
- (2017) Loren M. Lasko et al. NATURE
- Synthetic lethality and cancer
- (2017) Nigel J. O'Neil et al. NATURE REVIEWS GENETICS
- PI3K pathway regulates ER-dependent transcription in breast cancer through the epigenetic regulator KMT2D
- (2017) Eneda Toska et al. SCIENCE
- Discovery of naturally occurring ESR1 mutations in breast cancer cell lines modelling endocrine resistance
- (2017) Lesley-Ann Martin et al. Nature Communications
- Single-molecule analysis of steroid receptor and cofactor action in living cells
- (2017) Ville Paakinaho et al. Nature Communications
- Inhibitor of H3K27 demethylase JMJD3/UTX GSK-J4 is a potential therapeutic option for castration resistant prostate cancer
- (2017) Viacheslav M. Morozov et al. Oncotarget
- Inhibition of histone deacetylases in cancer therapy: lessons from leukaemia
- (2016) Elena Ceccacci et al. BRITISH JOURNAL OF CANCER
- Prognostic Impact of Discordance in Hormone Receptor Status Between Primary and Recurrent Sites in Patients With Recurrent Breast Cancer
- (2016) Sho Shiino et al. Clinical Breast Cancer
- HDAC Inhibitors Enhance T-Cell Chemokine Expression and Augment Response to PD-1 Immunotherapy in Lung Adenocarcinoma
- (2016) Hong Zheng et al. CLINICAL CANCER RESEARCH
- PlasmaESR1Mutations and the Treatment of Estrogen Receptor–Positive Advanced Breast Cancer
- (2016) Charlotte Fribbens et al. JOURNAL OF CLINICAL ONCOLOGY
- Elp3 links tRNA modification to IRES-dependent translation of LEF1 to sustain metastasis in breast cancer
- (2016) Sylvain Delaunay et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Fulvestrant 500 mg versus anastrozole 1 mg for hormone receptor-positive advanced breast cancer (FALCON): an international, randomised, double-blind, phase 3 trial
- (2016) John F R Robertson et al. LANCET
- Regulation of epithelial-mesenchymal transition through epigenetic and post-translational modifications
- (2016) Silvia Juliana Serrano-Gomez et al. Molecular Cancer
- Blockade of AP-1 Potentiates Endocrine Therapy and Overcomes Resistance
- (2016) L. Malorni et al. MOLECULAR CANCER RESEARCH
- Treating cancer with selective CDK4/6 inhibitors
- (2016) Ben O'Leary et al. Nature Reviews Clinical Oncology
- Palbociclib and Letrozole in Advanced Breast Cancer
- (2016) Richard S. Finn et al. NEW ENGLAND JOURNAL OF MEDICINE
- Genomic modelling of the ESR1 Y537S mutation for evaluating function and new therapeutic approaches for metastatic breast cancer
- (2016) A Harrod et al. ONCOGENE
- Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m6A-demethylation of NANOG mRNA
- (2016) Chuanzhao Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Heterogeneity and clinical significance of ESR1 mutations in ER-positive metastatic breast cancer patients receiving fulvestrant
- (2016) Jill M. Spoerke et al. Nature Communications
- Tumor Cell–Independent Estrogen Signaling Drives Disease Progression through Mobilization of Myeloid-Derived Suppressor Cells
- (2016) Nikolaos Svoronos et al. Cancer Discovery
- Inhibitors of histone deacetylase 1 reverse the immune evasion phenotype to enhance T-cell mediated lysis of prostate and breast carcinoma cells
- (2016) Sofia R. Gameiro et al. Oncotarget
- Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation
- (2016) Sean W Fanning et al. eLife
- The interplay of epigenetic therapy and immunity in locally recurrent or metastatic estrogen receptor-positive breast cancer: Correlative analysis of ENCORE 301, a randomized, placebo-controlled phase II trial of exemestane with or without entinostat
- (2016) Yusuke Tomita et al. OncoImmunology
- DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts
- (2015) David Roulois et al. CELL
- MEL-18 loss mediates estrogen receptor–α downregulation and hormone independence
- (2015) Jeong-Yeon Lee et al. JOURNAL OF CLINICAL INVESTIGATION
- Estrogen receptor alpha phosphorylation and its functional impact in human breast cancer
- (2015) Muralidharan Anbalagan et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Structure of a Biologically Active Estrogen Receptor-Coactivator Complex on DNA
- (2015) Ping Yi et al. MOLECULAR CELL
- Synthetic lethality by targeting EZH2 methyltransferase activity in ARID1A-mutated cancers
- (2015) Benjamin G Bitler et al. NATURE MEDICINE
- ESR1 mutations—a mechanism for acquired endocrine resistance in breast cancer
- (2015) Rinath Jeselsohn et al. Nature Reviews Clinical Oncology
- Challenges in the management of advanced, ER-positive, HER2-negative breast cancer
- (2015) Christopher D. Hart et al. Nature Reviews Clinical Oncology
- Mutation tracking in circulating tumor DNA predicts relapse in early breast cancer
- (2015) Isaac Garcia-Murillas et al. Science Translational Medicine
- Differential epigenetic reprogramming in response to specific endocrine therapies promotes cholesterol biosynthesis and cellular invasion
- (2015) Van T. M. Nguyen et al. Nature Communications
- HDAC Inhibition Upregulates PD-1 Ligands in Melanoma and Augments Immunotherapy with PD-1 Blockade
- (2015) D. M. Woods et al. Cancer Immunology Research
- Episensitization: Therapeutic Tumor Resensitization by Epigenetic Agents: A Review and Reassessment
- (2014) Bryan Oronsky et al. Anti-Cancer Agents in Medicinal Chemistry
- H3K4me3 Breadth Is Linked to Cell Identity and Transcriptional Consistency
- (2014) Bérénice A. Benayoun et al. CELL
- Directed Phenotype Switching as an Effective Antimelanoma Strategy
- (2013) Magalí Sáez-Ayala et al. CANCER CELL
- Epigenetic silencing of the WNT antagonist Dickkopf 3 disrupts normal Wnt/β-catenin signalling and apoptosis regulation in breast cancer cells
- (2013) Tingxiu Xiang et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- The structural biology of oestrogen metabolism
- (2013) Mark P. Thomas et al. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
- Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation
- (2013) Wenbo Li et al. NATURE
- Impact of Breast Cancer Subtypes and Treatment on Survival: An Analysis Spanning Two Decades
- (2012) R. Haque et al. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
- Mammary gland development
- (2012) Hector Macias et al. Wiley Interdisciplinary Reviews-Developmental Biology
- Addition of a histone deacetylase inhibitor redirects tamoxifen-treated breast cancer cells into apoptosis, which is opposed by the induction of autophagy
- (2011) Scott Thomas et al. BREAST CANCER RESEARCH AND TREATMENT
- A phase II study of the histone deacetylase inhibitor vorinostat combined with tamoxifen for the treatment of patients with hormone therapy-resistant breast cancer
- (2011) P N Munster et al. BRITISH JOURNAL OF CANCER
- Mammary Development and Breast Cancer: The Role of Stem Cells
- (2011) C. Ercan et al. CURRENT MOLECULAR MEDICINE
- Steroid receptor coactivators 1, 2, and 3: Critical regulators of nuclear receptor activity and steroid receptor modulator (SRM)-based cancer therapy
- (2011) Amber B. Johnson et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Genome-Wide Analysis of Estrogen Receptor DNA Binding and Tethering Mechanisms Identifies Runx1 as a Novel Tethering Factor in Receptor-Mediated Transcriptional Activation
- (2010) J. D. Stender et al. MOLECULAR AND CELLULAR BIOLOGY
- Protein arginine methylation in estrogen signaling and estrogen-related cancers
- (2009) Catherine Teyssier et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer
- (2008) H Suzuki et al. BRITISH JOURNAL OF CANCER
- Epigenetic alterations of CDH1 and APC genes: Relationship with activation of Wnt/β-catenin Pathway in invasive ductal carcinoma of breast
- (2008) Chandra P. Prasad et al. LIFE SCIENCES
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started