Tumor‐Targeted Disruption of Lactate Transport with Reactivity‐Reversible Nanocatalysts to Amplify Oxidative Damage

Self-assembled single-atom nanozyme for enhanced photodynamic therapy treatment of tumor

(2020) Dongdong Wang et al.   Nature Communications

Tumor microenvironment-activatable Fe-doxorubicin preloaded amorphous CaCO3 nanoformulation triggers ferroptosis in target tumor cells

(2020) Chen-Cheng Xue et al.   Science Advances

Openwork@Dendritic Mesoporous Silica Nanoparticles for Lactate Depletion and Tumor Microenvironment Regulation

(2020) Jie Tang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cancer Cells Don’t Live Alone: Metabolic Communication within Tumor Microenvironments

(2020) Fuming Li et al.   DEVELOPMENTAL CELL

Magnetic field boosted ferroptosis-like cell death and responsive MRI using hybrid vesicles for cancer immunotherapy

(2020) Bo Yu et al.   Nature Communications

Synergistic tumor immunological strategy by combining tumor nanovaccine with gene-mediated extracellular matrix scavenger

(2020) Yingying Hu et al.   BIOMATERIALS

Multifunctional Prussian blue-based nanomaterials: Preparation, modification, and theranostic applications

(2020) Xianwen Wang et al.   COORDINATION CHEMISTRY REVIEWS

HCAR1/MCT1 Regulates Tumor Ferroptosis through the Lactate-Mediated AMPK-SCD1 Activity and Its Therapeutic Implications

(2020) Youbo Zhao et al.   Cell Reports

Causes, consequences, and therapy of tumors acidosis

(2019) Smitha R. Pillai et al.   CANCER AND METASTASIS REVIEWS

Proteogenomic Analysis of Human Colon Cancer Reveals New Therapeutic Opportunities

(2019) Suhas Vasaikar et al.   CELL

Nanozymes: From New Concepts, Mechanisms, and Standards to Applications

(2019) Minmin Liang et al.   ACCOUNTS OF CHEMICAL RESEARCH

Nanocatalytic Medicine

(2019) Bowen Yang et al.   ADVANCED MATERIALS

Recent progress in the design fabrication of metal-organic frameworks-based nanozymes and their applications to sensing and cancer therapy

(2019) Xianlong Zhang et al.   BIOSENSORS & BIOELECTRONICS

NQO1 targeting prodrug triggers innate sensing to overcome checkpoint blockade resistance

(2019) Xiaoguang Li et al.   Nature Communications

Enhanced Antitumor Efficacy by a Cascade of Reactive Oxygen Species Generation and Drug Release

(2019) Sheng Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Targeted inhibition of MCT4 disrupts intracellular pH homeostasis and confers self-regulated apoptosis on hepatocellular carcinoma

(2019) Youbo Zhao et al.   EXPERIMENTAL CELL RESEARCH

Lactate in the Regulation of Tumor Microenvironment and Therapeutic Approaches

(2019) Karen G. de la Cruz-López et al.   Frontiers in Oncology

Cancer Cell Sensitivity to Redox-Cycling Quinones is Influenced by NAD(P)H: Quinone Oxidoreductase 1 Polymorphism

(2019) Glorieux et al.   Antioxidants

Emerging Strategies of Cancer Therapy Based on Ferroptosis

(2018) Zheyu Shen et al.   ADVANCED MATERIALS

Engineering Multifunctional RNAi Nanomedicine To Concurrently Target Cancer Hallmarks for Combinatorial Therapy

(2018) Yanlan Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Metabolic changes in tumor cells and tumor-associated macrophages: A mutual relationship

(2018) Romana T. Netea-Maier et al.   CANCER LETTERS

Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR

(2018) Zandra E. Walton et al.   CELL

Increased Tumor Glycolysis Characterizes Immune Resistance to Adoptive T Cell Therapy

(2018) Tina Cascone et al.   Cell Metabolism

Nanoparticle-triggered in situ catalytic chemical reactions for tumour-specific therapy

(2018) Han Lin et al.   CHEMICAL SOCIETY REVIEWS

Hypoxia and acidosis: immune suppressors and therapeutic targets

(2018) Sultan Damgaci et al.   IMMUNOLOGY

Exploiting Metabolic Vulnerabilities of Cancer with Precision and Accuracy

(2018) Adam J. Wolpaw et al.   TRENDS IN CELL BIOLOGY

In vivo guiding nitrogen-doped carbon nanozyme for tumor catalytic therapy

(2018) Kelong Fan et al.   Nature Communications

Hollow Structures Based on Prussian Blue and Its Analogs for Electrochemical Energy Storage and Conversion

(2018) Jianwei Nai et al.   ADVANCED MATERIALS

Binary Cooperative Prodrug Nanoparticles Improve Immunotherapy by Synergistically Modulating Immune Tumor Microenvironment

(2018) Bing Feng et al.   ADVANCED MATERIALS

Catalytically Synthesized Prussian Blue Nanoparticles Defeating Natural Enzyme Peroxidase

(2018) Maria A. Komkova et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release

(2018) Sho Morioka et al.   NATURE

Mannose impairs tumour growth and enhances chemotherapy

(2018) Pablo Sierra Gonzalez et al.   NATURE

In situ sprayed bioresponsive immunotherapeutic gel for post-surgical cancer treatment

(2018) Qian Chen et al.   Nature Nanotechnology

Dual Inhibition of the Lactate Transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD+ Depletion in Cancer Cells

(2018) Don Benjamin et al.   Cell Reports

Metal-Organic Framework-Based Stimuli-Responsive Systems for Drug Delivery

(2018) Wen Cai et al.   Advanced Science

Lactate: A Metabolic Driver in the Tumour Landscape

(2018) Luigi Ippolito et al.   TRENDS IN BIOCHEMICAL SCIENCES

Dual-Ratiometric Target-Triggered Fluorescent Probe for Simultaneous Quantitative Visualization of Tumor Microenvironment Protease Activity and pH in Vivo

(2017) Tiancong Ma et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nanoparticle orientation to control RNA loading and ligand display on extracellular vesicles for cancer regression

(2017) Fengmei Pi et al.   Nature Nanotechnology

MCT1 Modulates Cancer Cell Pyruvate Export and Growth of Tumors that Co-express MCT1 and MCT4

(2016) Candice Sun Hong et al.   Cell Reports

Implications of NQO1 in cancer therapy

(2015) Eun-Taex Oh et al.   BMB Reports

Synthesis of Prussian Blue Nanoparticles with a Hollow Interior by Controlled Chemical Etching

(2011) Ming Hu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mitochondrial and plasma membrane lactate transporter and lactate dehydrogenase isoform expression in breast cancer cell lines

(2010) Rajaa Hussien et al.   PHYSIOLOGICAL GENOMICS