Stereoselective and Regioselective Assembly of Spirooxindole [2,1-b]furan Motifs through a Tandem Friedel-Crafts Alkylation/5-exo-dig-Cyclization

From Complex Natural Products to Simple Synthetic Mimetics by Computational De Novo Design

(2016) Lukas Friedrich et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Desilylation-Activated Propargylic Transformation: Enantioselective Copper-Catalyzed [3+2] Cycloaddition of Propargylic Esters with β-Naphthol or Phenol Derivatives

(2016) Long Shao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Natural Product-Derived Spirooxindole Fragments Serve as Privileged Substructures for Discovery of New Anticancer Agents

(2016) Bin Yu et al.   Anti-Cancer Agents in Medicinal Chemistry

Organocatalytic cascade Michael/Michael reaction for the asymmetric synthesis of spirooxindoles containing five contiguous stereocenters

(2016) Bo-Liang Zhao et al.   CHEMICAL COMMUNICATIONS

Lewis Acid Catalyzed [4 + 3] Cycloaddition of Propargylic Alcohols with Azides

(2016) Ya-Ping Han et al.   ORGANIC LETTERS

Synthetic Study of Rubriflordilactone B: Highly Stereoselective Construction of the C-5-epi ABCDE Ring System

(2016) Yong Wang et al.   ORGANIC LETTERS

Dual Catalysis: Proton/Metal-Catalyzed Tandem Benzofuran Annulation/Carbene Transfer Reaction

(2016) Jun Ma et al.   ORGANIC LETTERS

Enantioselective Synthesis of Dihydrospiro[indoline-3,4′-pyrano[2,3-c]pyrazole] Derivatives via Michael/Hemiketalization Reaction

(2016) Nandarapu Kumarswamyreddy et al.   ORGANIC LETTERS

Pd(ii)-catalyzed formal [4+1] cycloaddition reactions of diazoacetates and aryl propargyl alcohols to form 2,5-dihydrofurans

(2015) Taoda Shi et al.   CHEMICAL COMMUNICATIONS

Suzuki-Miyaura Reactions of Halospirooxindole Derivatives

(2015) Abderrahman El Bouakher et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Discovery and Synthesis of Boletopsins 13 and 14, Brominated Fungal Metabolites of Terrestrial Origin

(2015) Andrew M. Beekman et al.   JOURNAL OF NATURAL PRODUCTS

Synthesis of Azepines via a [6 + 1] Annulation of Ynenitriles with Reformatsky Reagents

(2015) Mitsuhiro Yoshimatsu et al.   JOURNAL OF ORGANIC CHEMISTRY

Pd-Catalyzed Isocyanide Assisted Reductive Cyclization of 1-(2-Hydroxyphenyl)-propargyl Alcohols for 2-Alkyl/Benzyl Benzofurans and Their Useful Oxidative Derivatization

(2015) Manda Rajesh et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of 5,6-Dihydrodibenzo[b,h][1,6]naphthyridines via Copper Bromide Catalyzed Intramolecular [4 + 2] Hetero-Diels–Alder Reactions

(2015) Isravel Muthukrishnan et al.   JOURNAL OF ORGANIC CHEMISTRY

A strategic approach to the synthesis of functionalized spirooxindole pyrrolidine derivatives: in vitro antibacterial, antifungal, antimalarial and antitubercular studies

(2015) Saoussen Haddad et al.   NEW JOURNAL OF CHEMISTRY

Divergent Cyclization Reactions of Morita–Baylis–Hillman Carbonates of 2-Cyclohexenone and Isatylidene Malononitriles

(2015) Jing Peng et al.   ORGANIC LETTERS

The [2 + 2] Cycloaddition–Retroelectrocyclization and [4 + 2] Hetero-Diels–Alder Reactions of 2-(Dicyanomethylene)indan-1,3-dione with Electron-Rich Alkynes: Influence of Lewis Acids on Reactivity

(2015) Etienne J. Donckele et al.   ORGANIC LETTERS

Cascade Synthesis of 3-Alkylidene Dihydrobenzofuran Derivatives via Rhodium(III)-Catalyzed Redox-Neutral C–H Functionalization/Cyclization

(2015) Zhi Zhou et al.   ORGANIC LETTERS

Synthesis of 2,5-Dihydrofurans via a Gold(I)-Catalyzed Formal [4 + 1] Cycloaddition of α-Diazoesters and Propargyl Alcohols

(2015) Jing Wang et al.   ORGANIC LETTERS

Synthesis of Fused Carbazoles by Gold-Catalyzed Tricyclization of Conjugated Diynes via Rearrangement of an N-Propargyl Group

(2015) Masamitsu Taguchi et al.   ORGANIC LETTERS

Assembly of 3-allyl-3-ethynyl-oxindole motifs via palladium(ii)-catalyzed quaternary allylation of 3-ethynyl-3-OBoc-oxindoles

(2015) Nandarapu Kumarswamyreddy et al.   RSC Advances

Four-component reaction between naphthols, substituted β-nitrostyrenes, substituted benzaldehydes and ammonium acetate in water–PEG-400: an approach to construct polysubstituted naphthofuranamines

(2015) Jungui Zhang et al.   RSC Advances

Lewis Acid Catalyzed Unprecedented [3 + 2] Cycloaddition Yields 3,3′-Pyrrolidinyldispirooxindoles Containing Four Contiguous Chiral Stereocenters with Two Contiguous Quaternary Spirostereocenters

(2014) Koorathota Suman et al.   ORGANIC LETTERS

Modular Synthesis of Sulfonyl Benzoheteroles by Silver-Catalyzed Heteroaromatization of Propargylic Alcohols with p-Toluenesulfonylmethyl Isocyanide (TosMIC): Dual Roles of TosMIC

(2014) Jianquan Liu et al.   ORGANIC LETTERS

Lewis Acid Catalyzed Intramolecular [3 + 2] Cross Cycloadditions of Cobalt-Alkynylcyclopropane 1,1-Diesters with Carbonyls for Construction of Medium-Sized and Polycyclic Skeletons

(2014) Junhui Zhang et al.   ORGANIC LETTERS

Stereoselective Synthesis of Spiro[tetrahydropyran-3,3′-oxindole] Derivatives Employing Prins Cascade Strategy

(2014) B. V. Subba Reddy et al.   ORGANIC LETTERS

Organocatalytic Asymmetric Assembly Reactions: Synthesis of Spirooxindoles via Organocascade Strategies

(2014) Daojuan Cheng et al.   ACS Catalysis

Synthesis of Substituted Tetrahydrocyclobuta[b]benzofurans by Palladium-Catalyzed Substitution/[2+2] Cycloaddition of Propargylic Carbonates with 2-Vinylphenols

(2013) Masahiro Yoshida et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Controlling the Molecular Topology of Vinylogous Iminium Ions by Logical Substrate Design: Highly Regio- and Stereoselective Aminocatalytic 1,6-Addition to Linear 2,4-Dienals

(2013) Mattia Silvi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cinchona-based squaramide-catalysed cascade aza-Michael–Michael addition: enantioselective construction of functionalized spirooxindole tetrahydroquinolines

(2013) Wen Yang et al.   CHEMICAL COMMUNICATIONS

Highly diastereo- and enantioselective [3+2] annulation of isatin-derived Morita–Baylis–Hillman carbonates with trifluoropyruvate catalyzed by tertiary amines

(2013) Neng-Jun Zhong et al.   CHEMICAL COMMUNICATIONS

Stereoselective Synthesis of the Butyrolactone and the Oxazoline/Furan Fragment of Leupyrrin A1

(2013) Thomas Debnar et al.   ORGANIC LETTERS

Synthesis of 3-Alkyl- or 3-Allenyl-2-amidobenzofurans via Electrophilic Cyclization of o-Anisole-Substituted Ynamides with Carbocations

(2013) Yulong Kong et al.   ORGANIC LETTERS

A Simple and Efficient Synthesis of 2,3-Diarylnaphthofurans Using Sequential Hydroarylation/Heck Oxyarylation

(2013) V. Kameshwara Rao et al.   ORGANIC LETTERS

Asymmetric synthesis of a structurally and stereochemically complex spirooxindole pyran scaffold through an organocatalytic multicomponent cascade reaction

(2012) Xin Xie et al.   CHEMICAL COMMUNICATIONS

Approach to Construct Polysubstituted 1,2-Dihydronaphtho[2,1-b]furans and Their Aerobic Oxidative Aromatization

(2012) Congde Huo et al.   JOURNAL OF ORGANIC CHEMISTRY

Tetracyclic spirooxindole blockers of hNaV1.7: activity in vitro and in CFA-induced inflammatory pain model

(2012) Sultan Chowdhury et al.   MEDICINAL CHEMISTRY RESEARCH

Inhibition of EGF/EGFR activation with naphtho[1,2-b]furan-4,5-dione blocks migration and invasion of MDA-MB-231 cells

(2012) Chi-Ying Hsieh et al.   TOXICOLOGY IN VITRO

Discovery of XEN907, a spirooxindole blocker of NaV1.7 for the treatment of pain

(2011) Sultan Chowdhury et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Highly Stereoselective Brønsted Acid Catalyzed Synthesis of Spirooxindole Pyrans

(2011) Jingqi Wang et al.   ORGANIC LETTERS

A Concise Route to Dihydrobenzo[b]furans: Formal Total Synthesis of (+)-Lithospermic Acid

(2011) Joshua Fischer et al.   ORGANIC LETTERS

Flexible Strategy for Syntheses of Spirooxindoles using Palladium-Catalyzed Carbosilylation and Sakurai-Type Cyclization

(2011) Sudhir M. Hande et al.   ORGANIC LETTERS

Synthesis of regioisomeric naphtho-furans via naphthyloxyalkanals

(2010) H. Kwiecień et al.   Chemistry of Heterocyclic Compounds

Highly enantioselective synthesis and cellular evaluation of spirooxindoles inspired by natural products

(2010) Andrey P. Antonchick et al.   Nature Chemistry

The influence of a 1,1-diarylvinyl moiety on the photochromism of naphthopyrans

(2010) Christopher D. Gabbutt et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Applications of NHC-mediated O- to C-carboxyl transfer: synthesis of (±)-N-benzyl-coerulescine and (±)-horsfiline

(2010) Jennifer E. Thomson et al.   TETRAHEDRON

Iron-Catalyzed Regioselective Hydroaryloxylation of CC Triple Bonds: An Efficient Synthesis of 2H-1-Benzopyran Derivatives

(2009) Xiaobing Xu et al.   ADVANCED SYNTHESIS & CATALYSIS

Solvent-free synthesis of naphthopyrans under ball-milling conditions

(2008) Ya-Wei Dong et al.   TETRAHEDRON