Neuropeptide Y Y2 and Y5 receptors as potential targets for neuroprotective and antidepressant therapies: Evidence from preclinical studies

Nose-to-brain Delivery of Natural Compounds for the Treatment of Central Nervous System Disorders

(2020) Joana Bicker et al.   CURRENT PHARMACEUTICAL DESIGN

Are neuropeptides relevant for the mechanism of action of SSRIs?

(2019) Miłosz Gołyszny et al.   NEUROPEPTIDES

Characterization of the Brain Penetrant Neuropeptide Y Y2 Receptor Antagonist SF-11

(2019) Helena Domin et al.   ACS Chemical Neuroscience

Activation of NPY-Y2 receptors ameliorates disease pathology in the R6/2 mouse and PC12 cell models of Huntington's disease

(2018) Oluwaseun Fatoba et al.   EXPERIMENTAL NEUROLOGY

Excitotoxicity in the pathogenesis of neurological and psychiatric disorders: Therapeutic implications

(2018) Jordi Olloquequi et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Mechanism of intranasal drug delivery directly to the brain

(2018) Tyler P. Crowe et al.   LIFE SCIENCES

Polarization effect in tip-enhanced infrared nanospectroscopy studies of the selective Y5 receptor antagonistLu AA33810

(2018) Natalia Piergies et al.   Nano Research

Intranasal administration of progesterone: A potential efficient route of delivery for cerebroprotection after acute brain injuries

(2018) Rachida Guennoun et al.   NEUROPHARMACOLOGY

The Role of Neuropeptide Y in Cardiovascular Health and Disease

(2018) Cheryl M. J. Tan et al.   Frontiers in Physiology

Monitoring the Interfacial Behavior of Selective Y5 Receptor Antagonist on Colloidal Gold Nanoparticle Surfaces: Surface-Enhanced Vibrational Spectroscopy Studies

(2017) Ewa Pięta et al.   Journal of Physical Chemistry C

Neuropeptide Y Y2 and Y5 receptors as promising targets for neuroprotection in primary neurons exposed to oxygen-glucose deprivation and in transient focal cerebral ischemia in rats

(2017) Helena Domin et al.   NEUROSCIENCE

The Effects of Antidepressants on Neuropeptide Y in Patients with Depression and Anxiety

(2016) S. Ozsoy et al.   PHARMACOPSYCHIATRY

Antidepressant-like activity of the neuropeptide Y Y5 receptor antagonist Lu AA33810: behavioral, molecular, and immunohistochemical evidence

(2016) Helena Domin et al.   PSYCHOPHARMACOLOGY

Neuropeptide Y and its C -terminal fragments acting on Y 2 receptor: Raman and SERS spectroscopy studies

(2015) Helena Domin et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Neuropeptide Y: An Anti-Aging Player?

(2015) Mariana Botelho et al.   TRENDS IN NEUROSCIENCES

Peptide YY: more than just an appetite regulator

(2014) Shanta J. Persaud et al.   DIABETOLOGIA

Neuropeptide Y1 and Y5 Receptor Antagonists as Potential Anti-Obesity Drugs: Current Status

(2014) Antonio Moreno-Herrera et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Importance of Preclinical Research in the Development of Neuroprotective Strategies for Ischemic Stroke

(2014) Ain A. Neuhaus et al.   JAMA Neurology

Neuroactive Peptides as Putative Mediators of Antiepileptic Ketogenic Diets

(2014) Carmela Giordano et al.   Frontiers in Neurology

Neuropeptide Y (NPY) prevents depressive-like behavior, spatial memory deficits and oxidative stress following amyloid-β (Aβ1–40) administration in mice

(2013) Vanessa V. dos Santos et al.   BEHAVIOURAL BRAIN RESEARCH

Ligands of the neuropeptide Y Y2 receptor

(2013) Gopi Kumar Mittapalli et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Insights into direct nose to brain delivery: current status and future perspective

(2013) Deepti Mittal et al.   DRUG DELIVERY

Association of age at onset in Huntington disease with functional promoter variations in NPY and NPY2R

(2013) Eugen Kloster et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

NPY modulates miR-30a-5p and BDNF in opposite direction in an in vitro model of Alzheimer disease: a possible role in neuroprotection?

(2013) Nicoletta Croce et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Neuropeptides in learning and memory

(2013) Éva Borbély et al.   NEUROPEPTIDES

Neuropeptides in epilepsy

(2013) Stjepana Kovac et al.   NEUROPEPTIDES

Role of neuropeptides in anxiety, stress, and depression: From animals to humans

(2013) Viktória Kormos et al.   NEUROPEPTIDES

Neuropeptide Y receptors activation protects rat retinal neural cells against necrotic and apoptotic cell death induced by glutamate

(2013) A Santos-Carvalho et al.   Cell Death & Disease

Neuropeptide Y Protects Rat Cortical Neurons against β-Amyloid Toxicity and Re-establishes Synthesis and Release of Nerve Growth Factor

(2012) Nicoletta Croce et al.   ACS Chemical Neuroscience

Protective role of neuropeptide Y Y2receptors in cell death and microglial response following methamphetamine injury

(2012) Joana Gonçalves et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Chronic administration of the Y2 receptor antagonist, JNJ-31020028, induced anti-depressant like-behaviors in olfactory bulbectomized rat

(2012) J.C. Morales-Medina et al.   NEUROPEPTIDES

Multifaces of neuropeptide Y in the brain – Neuroprotection, neurogenesis and neuroinflammation

(2012) J.O. Malva et al.   NEUROPEPTIDES

Intranasal Treatment of Central Nervous System Dysfunction in Humans

(2012) Colin D. Chapman et al.   PHARMACEUTICAL RESEARCH

Discovery of Lu AA33810: A highly selective and potent NPY5 antagonist with in vivo efficacy in a model of mood disorder

(2011) Mathivanan Packiarajan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Central functions of neuropeptide Y in mood and anxiety disorders

(2011) Gang Wu et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Neuropeptide Y receptors: ligand binding and trafficking suggest novel approaches in drug development

(2011) Cornelia Walther et al.   JOURNAL OF PEPTIDE SCIENCE

Neuroprotection by neuropeptide Y in cell and animal models of Parkinson's disease

(2011) Mickael Decressac et al.   NEUROBIOLOGY OF AGING

Neuroprotective Effect of Neuropeptide Y against Beta-Amyloid 25–35 Toxicity in SH-SY5Y Neuroblastoma Cells Is Associated with Increased Neurotrophin Production

(2011) Nicoletta Croce et al.   Neurodegenerative Diseases

Role of neuropeptide Y Y1 and Y2 receptors on behavioral despair in a rat model of depression with co-morbid anxiety

(2011) Julio César Morales-Medina et al.   NEUROPHARMACOLOGY

Therapeutic potential of neuropeptide Y (NPY) receptor ligands

(2010) Shaun P. Brothers et al.   EMBO Molecular Medicine

Neuropeptide Y modifies the disease course in the R6/2 transgenic model of Huntington's disease

(2010) M. Decressac et al.   EXPERIMENTAL NEUROLOGY

A possible role of neuropeptide Y in depression and stress

(2009) Julio César Morales-Medina et al.   BRAIN RESEARCH

Neuropeptide Y Fragments Derived from Neprilysin Processing Are Neuroprotective in a Transgenic Model of Alzheimer's Disease

(2009) J. B. Rose et al.   JOURNAL OF NEUROSCIENCE

Selective and Brain Penetrant Neuropeptide Y Y2 Receptor Antagonists Discovered by Whole-Cell High-Throughput Screening

(2009) S. P. Brothers et al.   MOLECULAR PHARMACOLOGY

Neuroprotective effects of neuropeptide Y-Y2 and Y5 receptor agonists in vitro and in vivo

(2009) Maria Śmiałowska et al.   NEUROPEPTIDES

In vitro and in vivo characterization of JNJ-31020028 (N-(4-{4-[2-(diethylamino)-2-oxo-1-phenylethyl]piperazin-1-yl}-3-fluorophenyl)-2-pyridin-3-ylbenzamide), a selective brain penetrant small molecule antagonist of the neuropeptide Y Y2 receptor

(2009) James R. Shoblock et al.   PSYCHOPHARMACOLOGY

Interaction between neuropeptide Y (NPY) and brain-derived neurotrophic factor in NPY-mediated neuroprotection against excitotoxicity: a role for microglia

(2008) S. Xapelli et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

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(2008) M. W. Walker et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Implication of neuropeptide-Y Y2 receptors in the effects of immune stress on emotional, locomotor and social behavior of mice

(2008) Evelin Painsipp et al.   NEUROPHARMACOLOGY

Molecular recognition of the NPY hormone family by their receptors

(2008) Diana Lindner et al.   NUTRITION

Modulation of intracellular calcium changes and glutamate release by neuropeptide Y1 and Y2 receptors in the rat hippocampus: differential effects in CA1, CA3 and dentate gyrus

(2003) Ana P. Silva et al.   JOURNAL OF NEUROCHEMISTRY