Article
Biochemistry & Molecular Biology
Ting-Yang Hsieh, Yi Chang, Su-Jane Wang
Summary: This study found that piperine can protect hippocampal neurons against excitotoxicity induced by kainic acid by modulating the nerve growth factor signaling pathway.
Article
Biochemistry & Molecular Biology
Urszula Hohmann, Chalid Ghadban, Tim Hohmann, Joshua Kleine, Miriam Schmidt, Christian Scheller, Christian Strauss, Faramarz Dehghani
Summary: During injuries in the central nervous system, nimodipine, a lipophilic L-type calcium channel blocking agent, has neuroprotective effects on neurons and affects the survival of glia cells. The protective actions of nimodipine are time-dependent.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Yeonggwang Hwang, Hyoung-Chun Kim, Eun-Joo Shin
Summary: Repeated exposure to MCLR enhances KA-induced seizures and neurodegeneration in the hippocampus by increasing membrane GluK2 expression and enhancing oxidative stress and neuroinflammation.
Article
Biochemistry & Molecular Biology
Cheng-Wei Lu, Chen-Jung Lin, Pei-Wen Hsieh, Kuan-Ming Chiu, Ming-Yi Lee, Tzu-Yu Lin, Su-Jane Wang
Summary: This study investigates the role of HFP034, a synthesized anthranilate derivative, in the central glutamatergic system. The results show that HFP034 inhibits excessive release of glutamate and has neuroprotective effects. The study suggests that the inhibitory effect of HFP034 is achieved through the suppression of P/Q-type Ca2+ channels and PKC/MARCKS pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Yihyun Roh, Su Bin Lee, Minseo Kim, Mi-Hye Kim, Hee Jung Kim, Kyung-Ok Cho
Summary: This study investigated the therapeutic effects of a novel small molecule, NecroX-7, in temporal lobe epilepsy (TLE) and found that it has neuroprotective, anti-inflammatory, and anti-necroptotic effects, making it a potential novel medication for TLE.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Immunology
Hui Liang, Nathanael Matei, Devin W. McBride, Yang Xu, Zhenhua Zhou, Jiping Tang, Benyan Luo, John H. Zhang
Summary: Activation of TGR5 mitigates brain injury by inhibiting neuroinflammation after MCAO, potentially mediated by Pellino3 inhibition of caspase-8/NLRP3.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Biochemistry & Molecular Biology
Yuanyuan Yao, Yang Hu, Jiurong Yang, Canyu Zhang, Yuqi He, Honggang Qi, Yu Zeng, Aifeng Zhang, Xiufang Liu, Xinjian Zhu
Summary: nNOS plays a crucial role in the pathological process of neuronal injury in the development of epilepsy. NPY expression is regulated by nNOS, and the regulation of NPY by nNOS is associated with hippocampal neuronal injuries in the epileptic brain. Targeting the nNOS-NPY signaling pathway may provide clinical benefits in epilepsy patients by attenuating neuronal injuries and preventing cognitive deficits.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Cell Biology
Yu-Jeong Ahn, Hyun-Joo Shin, Eun-Ae Jeong, Hyeong-Seok An, Jong-Youl Lee, Hye-Min Jang, Kyung-Eun Kim, Jaewoong Lee, Meong-Cheol Shin, Gu-Seob Roh
Summary: Exendin-4 (Ex-4) pretreatment showed neuroprotective effects in a mouse model of kainic acid (KA)-induced seizures, reversing the reduction of GLP-1R expression and attenuating seizure score, hippocampal neuronal death, and neuroinflammation. It also significantly reduced hippocampal lipocalin-2 protein levels and alleviated blood-brain barrier leakage, while stimulating the expression of phosphorylated cyclic adenosine monophosphate response element-binding protein (p-CREB). These findings suggest that Ex-4 pretreatment may protect against KA-induced neuronal damage by regulating GLP-1R/CREB-mediated signaling pathways.
Article
Neurosciences
Shuang Wu, Yan-Feng Zhang, Yue Gui, Tian Jiang, Cheng-Mei Zhou, Jing-Yi Li, Jia-Le Suo, Yong-Nan Li, Rui-Lin Jin, Shu-Lei Li, Jia-Yue Cui, Bai-Hong Tan, Yan-Chao Li
Summary: In this study, a new method for detecting neuronal death using two membrane-bound dyes, rhodamine R6 and DiOC6(3), was reported. The staining pattern produced by this method is similar to Fluoro-Jade B in kainic acid-damaged brains in mice. The increased staining of rhodamine R6 and DiOC6(3) is associated with increased levels of phospholipids and free cholesterol in the perinuclear cytoplasm of damaged neurons.
PROGRESS IN NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tzu-Yu Lin, Chih-Yu Hung, Kuan-Ming Chiu, Ming-Yi Lee, Cheng-Wei Lu, Su-Jane Wang
Summary: Neferine pretreatment showed positive effects in increasing seizure latency, reducing seizure scores, preventing glutamate elevation and neuronal loss, as well as decreasing neuroinflammation in rats with KA-induced seizures, indicating its potential as a therapeutic option in epilepsy treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Ming -Shang Pai, Kaw-Chen Wang, Kun-Chieh Yeh, Su-Jane Wang
Summary: The study found that chlorogenic acid can protect rats from kainic acid-induced neurotoxicity and seizures by reducing glutamate levels and maintaining mitochondrial balance.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Neurosciences
V. Rodriguez-Chavez, E. Flores-Soto, G. Molina-Salinas, L. D. Martinez-Razo, L. M. Montano, M. Cerbon
Summary: The aim of this study was to examine the role of prolactin (PRL) in protecting hippocampal neurons against excitotoxicity induced by kainic acid (KA). The results showed that PRL administration significantly increased neuronal viability and decreased intracellular calcium concentrations induced by KA treatment. The study also revealed the presence of ionotropic glutamatergic receptors (iGluRs) in hippocampal neurons, although no significant changes in iGluRs subunit expression were observed due to excitotoxicity or PRL treatment.
NEUROSCIENCE LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Xenia Puig-Bosch, Markus Ballmann, Stefan Bieletzki, Bernd Antkowiak, Uwe Rudolph, Hanns Ulrich Zeilhofer, Gerhard Rammes
Summary: Neurosteroids and benzodiazepines are GABA(A) receptor modulators with anxiolytic effects. This study aimed to investigate the effects of neurosteroids and their synthesis using a synthetic compound called XBD173, which promotes neurosteroidogenesis by binding to the translocator protein 18 kDa (TSPO). The results showed that XBD173 induced neurosteroidogenesis and the application of potentially synthesized neurosteroids did not impair hippocampal CA1-LTP, which is important for learning and memory. Therefore, TSPO ligands could be promising candidates for post-ischemic recovery with neuroprotection and without detrimental effects on synaptic plasticity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Konstantinos M. Themistoklis, Themistoklis I. Papasilekas, Konstantinos S. Melanis, Konstantinos A. Boviatsis, Stefanos I. Korfias, Konstaninos Vekrellis, Damianos E. Sakas
Summary: The tifMCAO stroke model in rats is widely used and has been proven to reliably mimic human stroke. The surgical technique has been detailed with stepwise instructions and visual aids provided.
WORLD NEUROSURGERY
(2022)
Article
Engineering, Electrical & Electronic
Ye Chen, Bingyan Yang, Yuqing Liu, Lixin Xu, Zhongfang Shi, Yixiao Liu, Ruoyu Han, Fang Yuan, Jiting Ouyang, Xu Yan, Kostya (Ken) Ostrikov
Summary: This study found that treatment with atmospheric pressure plasma jet (APPJ) could improve neurological function, enhance blood flow, reduce brain infarction, and decrease brain cell apoptosis in a rat model of ischemic stroke (IS). These findings provide a novel potential strategy for IS treatment using atmospheric pressure plasma inhalation.
Article
Neurosciences
Paulina Cieslik, Helena Domin, Agnieszka Chocyk, Piotr Gruca, Ewa Litwa, Agata Ploska, Adrianna Radulska, Iwona Pelikant-Malecka, Piotr Branski, Leszek Kalinowski, Joanna M. Wieronska
Article
Environmental Sciences
M. Kajta, J. Rzemieniec, A. Wnuk, W. Lason
SCIENCE OF THE TOTAL ENVIRONMENT
(2020)
Article
Neurosciences
Agnieszka Wnuk, Karolina Przepiorska, Joanna Rzemieniec, Bernadeta Pietrzak, Malgorzata Kajta
NEUROTOXICITY RESEARCH
(2020)
Article
Clinical Neurology
Helena Domin
Summary: Currently, there is no effective treatment for neurological and psychiatric disorders in which the Glu/GABA balance is disturbed. Recent studies suggest that the neuropeptide Y (NPY)-ergic system could be a potential therapeutic target for these disorders. Research on the neuroprotective roles of Y2 and Y5 receptors (YRs) could lead to the development of novel therapeutic strategies for these diseases.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Review
Biochemistry & Molecular Biology
Agnieszka Wnuk, Malgorzata Kajta
Summary: Benzophenone-3 is commonly used as a sunscreen filter, but it can penetrate the skin and affect the nervous system when absorbed by the body. Recent research has shown that it can induce neurotoxicity and affect the development and function of neuronal cells.
ACTA BIOCHIMICA POLONICA
(2021)
Article
Chemistry, Medicinal
Edyta Proniewicz, Grzegorz Burnat, Helena Domin, Izabela Maluch, Marta Makowska, Adam Prahl
Summary: The article discusses the application of alanine-scanning technique combined with various spectroscopic methods to study the role of individual amino acid residues in the adsorption process of a peptide fragment on metal nanoparticles. By analyzing spectral profiles and conducting bioactivity studies, conclusions were drawn on the specific interactions between peptides and metal nanoparticles as well as peptide-G protein-coupled receptors (GPCRs).
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Endocrinology & Metabolism
Maria Smialowska, Barbara Zieba, Helena Domin
Summary: CRF is a neuropeptide that plays various roles in the brain, including activating stress and anxiety, but its specific role in the cortex remains unclear. Studies have shown that high doses of CRF injected into the Fr2 area can have an anxiolytic-like effect, primarily through activation of CRF1 receptors. The involvement of alpha1 and alpha2 adrenergic receptors in the noradrenergic system seems to play a key role in these anxiolytic effects, while beta receptors do not appear to have a significant impact.
Review
Clinical Neurology
Lukasz Przykaza, Ewa Kozniewska
Summary: Ischemic stroke is a major global health issue with limited treatment options. Current treatments focus on reperfusion methods, but a small percentage of patients are eligible. Basic research suggests that neuropeptide Y activation may have potential protective effects against stroke.
TRANSLATIONAL STROKE RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Agnieszka Wnuk, Karolina Przepiorska, Bernadeta A. Pietrzak, Malgorzata Kajta
Summary: Amorfrutin B exhibits neuroprotective effects by modulating the PPARγ receptor, promoting mitochondrial integrity, and inhibiting ROS activity and DNA damage. The compound's actions on the PPARγ gene methylation and protein expression vary under hypoxic and ischemic conditions, suggesting complex regulatory mechanisms involved in its neuroprotective effects. Amorfrutin B also affects other epigenetic parameters, making it a promising therapeutic option for stroke treatment with a wide treatment window.
Article
Biochemistry & Molecular Biology
Agnieszka Wnuk, Joanna Rzemieniec, Karolina Przepiorska, Bernadeta Angelika Pietrzak, Marzena Mackowiak, Malgorzata Kajta
Summary: Triclocarban is identified as a neurodevelopmental risk factor that targets ESR1, affects apoptosis and autophagy in a sex-specific manner, and disrupts the epigenetic status of brain tissue while dysregulating the postnatal expression of neurogenesis- and neurotransmitter-related genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
A. Wnuk, K. Przepiorska, B. A. Pietrzak, M. Kajta
Summary: The study demonstrates that PaPE-1 can inhibit hypoxia/ischemia-induced neuronal death in a delayed posttreatment, with a reduction in neurotoxicity and neurodegeneration. The neuroprotective effect is achieved through reducing ROS formation and restoring cellular metabolic activity.
NEUROTOXICITY RESEARCH
(2021)
Article
Neurosciences
Karolina Przepiorska, Agnieszka Wnuk, Cordian Beyer, Malgorzata Kajta
Summary: Amorfrutin B is identified as a selective modulator of the PPAR gamma receptor with neuroprotective properties against hypoxic and ischemic damage in brain neurons. The delayed post-treatment with amorfrutin B prevents neuronal apoptosis by preserving mitochondrial function, inhibiting heterochromatin foci formation, and modulating the expression of specific genes and proteins. The protective mechanisms of amorfrutin B involve the inhibition of autophagy and the regulation of apoptosis-focused and autophagy-related miRNAs. Amorfrutin B shows promise as an anti-stroke therapeutic with a wide treatment window.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Behavioral Sciences
Helena Domin
Summary: This review examines the specific role of group III mGluRs in neuroprotection and highlights the importance of therapeutic time windows and potential mechanisms underlying the neuroprotective activity of these ligands.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2022)
Article
Multidisciplinary Sciences
Edyta Proniewicz, Grzegorz Burnat, Helena Domin, Adam Roman, Adam Prahl, Emilia Llowska
Summary: This study synthesized multiple analogs of bradykinin and examined their biological activity on cell lines expressing B1 or B2 receptors. The mRNA expression of B1R and B2R in tumor cell lines was also determined. In addition, the adsorption of five B1R antagonists at the liquid/solid interface was discussed.
SCIENTIFIC REPORTS
(2022)
Article
Environmental Sciences
Agnieszka Wnuk, Joanna Rzemieniec, Karolina Przepiorska, Julita Wesolowska, Anna Katarzyna Wojtowicz, Malgorzata Kajta
SCIENCE OF THE TOTAL ENVIRONMENT
(2020)
Article
Endocrinology & Metabolism
Andreia Biolchi Mayer, Henrique de Oliveira Amaral, Danilo Gustavo R. de Oliveira, Gabriel Avohay Alves Campos, Priscilla Galante Ribeiro, Solange Cristina Rego Fernandes, Adolfo Carlos Barros de Souza, Raffael Hinio Araijo de Castro, Anamelia Lorenzetti Bocca, Marcia Renata Mortari
Summary: This study synthesized three bioinspired peptides based on fraternine and tested their effects in a Parkinson's disease model. The peptides fra-10 and fra-14 improved motor coordination, but most of the peptides were toxic at the applied doses. All three peptides reduced the intensity of lesion-induced rotations. The peptide fra-24 increased the number of TH+ neurons in the substantia nigra and reduced the concentration of the cytokine TNF-alpha, suggesting it has neuroprotective effects in Parkinson's disease.