Article
Behavioral Sciences
Ericks Sousa Soares, Felipe Vanz, Vagner Fagnani Linartevichi, Helena Cimarosti, Thereza Christina Monteiro de Lima
Summary: Memory is the ability to store, retrieve and use information, and it relies on a time-dependent consolidation process. The hippocampus plays a crucial role in processing all types of information, particularly spatial memory. This study investigates the involvement and recruitment of neuropeptide Y (NPY) receptors in the consolidation of spatial memory. The results demonstrate that NPY injection impairs memory consolidation, and previous stress enhances this effect. Additionally, selective antagonists for NPY receptors Y-1 and Y-2 show that both receptors are key players in spatial memory consolidation. The findings suggest that NPY modulates aversive and adaptive memory formation through receptor activation.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Oncology
Sydney A. Pascetta, Sarah M. Kirsh, Makenna Cameron, James Uniacke
Summary: In breast carcinomas, neuropeptide Y (NPY) acts on NPY1R and NPY5R, and their interaction is associated with enhanced migration and proliferation. Inhibiting NPY1R and NPY5R under hypoxia conditions greatly reduces signaling, proliferation, migration, invasion, and spheroid growth. In breast tumor tissue, NPY5R levels and colocalization with hypoxia correlate with advanced cancer, while NPY1R correlates with adverse outcomes.
Review
Biochemistry & Molecular Biology
Masaki Tanaka, Shunji Yamada, Yoshihisa Watanabe
Summary: Neuropeptide Y (NPY) plays a significant role in the brain, mainly mediating physiological and behavioral effects through Y1, Y2, and Y5 receptors in regions regulating various functions. The nucleus accumbens (NAc) has high levels of NPY concentration, contributing to functions like alcohol intake and emotional behavior. NPY in the NAc affects physiological and pathophysiological actions through neuroendocrine mechanisms and the autonomic nervous system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Manuel Lisardo Sanchez, Francisco D. Rodriguez, Rafael Covenas
Summary: This study updates the current knowledge on the involvement of neuropeptide Y (NPY), peptide YY (PYY), and pancreatic polypeptide (PP) and their receptors (YRs) in cancer. The roles played by these peptides in different cancer types are reviewed, and their potential as diagnostic markers and therapeutic targets is discussed. NPY promotes tumor growth and metastasis in some tumors, while exerting an antitumor effect in others. PYY or its fragments can block tumor cell growth, migration, and invasion in several cancer types.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Ines C. F. Fonseca, Miguel Castelo-Branco, Claudia Cavadas, Antero J. Abrunhosa
Summary: This article provides a systematic review of imaging biomarkers developed as PET tracers to study the functions and molecular mechanisms of the NPY receptor family.
Article
Neurosciences
Devika S. Bodas, Aditi Maduskar, Tarun Kaniganti, Debia Wakhloo, Akilandeswari Balasubramanian, Nishikant Subhedar, Aurnab Ghose
Summary: The internal energy stores adaptively regulate feeding-associated behaviors and integrate opposing hunger and satiety signals at the level of neural circuits. The activities of the neuropeptides CART and NPY converge on a population of neurons in the Dm to generate nutritional state-dependent circuit plasticity. CART facilitates glutamatergic neurotransmission, while NPY dampens the response to glutamate. The opposing actions of satiety and hunger signals induce a behavioral switch correlated with the convergent integration of CART and NPY inputs by the Dm neurons.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Clinical Neurology
Shuntaro Natsume, Hajime Baba, Hitoshi Maeshima, Takao Saida, Naoto Yoshinari, Kentaro Shimizu, Toshihito Suzuki
Summary: Depression is a risk factor for Alzheimer's disease, and changes in A13 protein metabolism may contribute to the transition from depression to AD. This study found that elderly patients with depression had decreased A1342 levels at admission, but these levels recovered to healthy levels 1 year after remission.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Neurosciences
Caleigh A. Findley, Samuel A. McFadden, MaKayla F. Cox, Lindsey N. Sime, Mackenzie R. Peck, Kathleen Quinn, Andrzej Bartke, Kevin N. Hascup, Erin R. Hascup
Summary: This study investigates the relationship between Alzheimer's disease and metabolic dysfunction, and finds that modulation of glutamatergic activity can improve glucose metabolism and spatial cognition, providing a new therapeutic approach for cognitive decline.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Physiology
Caitlin S. Mitchell, Elisabeth K. Goodman, Caitlin R. Tedesco, Kathy Nguyen, Lei Zhang, Herbert Herzog, Denovan P. Begg
Summary: This study investigated the effect of disrupted insulin signaling in NPY neurons on diet-induced deficits in hippocampal-dependent memory. The results showed that obesogenic diets can lead to hippocampal insulin resistance and impairments to hippocampal-dependent cognition. However, chronic sucrose intake did not have adverse effects on metabolic outcomes or hippocampal-dependent memory. These findings suggest that the effects of high-fat diet on hippocampal-dependent memory may depend on insulin signaling in hippocampal NPY cells.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yue Liu, Zheng Chen, Ben Li, Hua Yao, Martin Zarka, Jeffrey Welch, Perminder Sachdev, Wallace Bridge, Nady Braidy
Summary: Supplementation with gamma-GC decreased brain lipid peroxidation, protein carbonyls, and apoptosis, while increasing total GSH levels and enhancing antioxidant enzyme activities. Additionally, gamma-GC improved Aβ pathology and cognitive function in APP/PS1 mice.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Article
Neurosciences
Thalia T. Dimopoulos, Stephen L. P. Lippi, Jorge Fernandez Davila, Rachel E. Barkey, Erin N. Doherty, Jane M. Flinn
Summary: This study assessed the effects of white button mushroom supplementation on spatial memory and plaque formation in mice with A beta mutations. The results showed that mice on the WBM diet had improved spatial memory and fewer amyloid plaques.
Review
Biochemistry & Molecular Biology
Elena Tamagno, Michela Guglielmotto, Valeria Vasciaveo, Massimo Tabaton
Summary: The pathogenesis of Alzheimer's disease involves the accumulation of beta amyloid and vulnerability of the brain to oxidative stress, which are linked to each other. It is difficult to determine which comes first, Aβ or oxidative stress. Evidence suggests that oxidative stress occurs early in the development of Alzheimer's disease and plays a crucial role in the manifestation of clinical and pathological symptoms.
Article
Biochemistry & Molecular Biology
Sarah Bonk, Kevin Kirchner, Sabine Ameling, Linda Garvert, Henry Volzke, Matthias Nauck, Uwe Voelker, Hans J. Grabe, Sandra Van der Auwera
Summary: This study aimed to replicate the interaction between APOE epsilon 4 status and depression on memory function and explore the role of circulating plasma miRNAs. The results confirmed the effect of depressive symptoms and APOE epsilon 4 status on memory performance and identified hsa-miR-107 as a possible biological link between APOE epsilon 4, depressive symptoms, and cognitive impairment.
Article
Chemistry, Analytical
Shuai Huang, Haiyang Wang, Xinxin Liu, Lanxiang Liu, Dan Liu, Xiaozhe Zhang, Lihua Zhang, Peng Xie, Yukui Zhang
Summary: This study presents a mass spectrometry imaging (MSI) approach for mapping thiol compounds on brain tissue sections. The developed method allows for selective and rapid detection of glutathione (GSH) synthesis and metabolic pathway related metabolites. The method also enables quantitative detection of exogenous N-acetylcysteine tissue sections, with a detection limit of 0.05 ng. The capabilities of the method are demonstrated through mapping thiol compounds on brain tissue from a chronic social defeat stress (CSDS) depression model mice.
ANALYTICA CHIMICA ACTA
(2023)
Review
Behavioral Sciences
Marta Mendez-Couz, Denise Manahan-Vaughan, Ana Paula Silva, Hector Gonzalez-Pardo, Jorge Luis Arias, Nelida Maria Conejo
Summary: The neuropeptide Y2 receptors play a significant role in hippocampus-dependent spatial memory, with receptor expression dynamically regulated by learning experiences. Antagonism of the receptors in the dorsal intrahippocampal area improves spatial reference memory.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Review
Neurosciences
Luana M. Manosso, Anderson Camargo, Alcir L. Dafre, Ana Lucia S. Rodrigues
Summary: Vitamin E has been found to play a role in the prevention and/or treatment of major depressive disorder (MDD) by modulating oxidative stress and neuroinflammation. This narrative review presents evidence from clinical and preclinical studies showing the relationship between low vitamin E status and MDD symptoms. More research is needed to determine the efficacy of vitamin E for alleviating depressive symptoms.
NUTRITIONAL NEUROSCIENCE
(2022)
Article
Behavioral Sciences
Angela Patricia Franca, Marissa Giovanna Schamne, Bruna Soares de Souza, Thiago Correa, Jose E. Da Silva-Santos, Geison Souza Izidio, Rui Daniel Prediger
Summary: The study provides evidence that agmatine treatment can improve olfactory and cognitive impairments observed in an animal model of ADHD, particularly in olfactory discrimination, object recognition, and social recognition memory tasks. Additionally, agmatine enhances cognitive flexibility in SHR in the water maze test.
BEHAVIORAL NEUROSCIENCE
(2022)
Review
Food Science & Technology
Flavia Barbosa Schappo, Camila Duarte Ferreira Ribeiro, Marcelo Farina, Itaciara Larroza Nunes
Summary: This research provides an overview of the toxicity of oil nanocapsules (ONP) for food applications. It suggests that while ONP may have potential beneficial effects such as antioxidant and anti-cancer properties, there is limited knowledge about its safety. Further studies are needed to ensure the safe use of this innovative technology.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Pharmacology & Pharmacy
Nair C. F. Castro, Izabelle S. Silva, Sabrina C. Cartagenes, Luanna M. P. Fernandes, Paula C. Ribera, Mayara A. Barros, Rui D. Prediger, Eneas A. Fontes-Junior, Cristiane S. F. Maia
Summary: This study evaluated the long-lasting neurobehavioral and nociceptive consequences in adult rats and mice exposed to morphine during pregnancy and lactation periods. The results showed that both male and female rats exhibited anxiety- and depressive-like behaviors, while mice displayed alterations in nociceptive responses. These findings suggest that intrauterine and lactation exposure to morphine can have long-lasting effects on psychological and pain responses in adulthood.
Review
Neurosciences
Ericks S. Soares, Rui D. Prediger, Patricia S. Brocardo, Helena Cimarosti
Summary: SUMOs are proteins that regulate the functions of target substrates through a post-translational modification called SUMOylation. In addition to their physiological roles, SUMOylation has been implicated in neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's diseases. This review focuses on the role of Htt SUMOylation in cellular processes involved in the pathogenesis of HD.
IBRO NEUROSCIENCE REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Anderson Camargo, Luis E. B. Bettio, Priscila B. Rosa, Julia M. Rosa, Glorister A. Alte, Ana Lucia S. Rodrigues
Summary: This study reveals the antidepressant-like effect of Guanosine and the modulation of A(1)R and A(2A)R in its antidepressant action. Guanosine interacts with A(1)R and A(2A)R at the adenosine binding site.
PURINERGIC SIGNALLING
(2023)
Article
Biochemistry & Molecular Biology
Mauricio Tavares Jacques, Luciano Saso, Marcelo Farina
Summary: Neuron-glia interactions are crucial for maintaining the central nervous system's stability. Microglial cells, as important support cells in the brain, play a role in responding to disruptions in this stability. In this study, the researchers investigated the potential protective effects of activated microglia on neuronal cells against ferroptosis, an iron-dependent form of cell death. The findings suggest that activated microglial cell-derived molecules may contribute to the protection of neuronal cells against ferroptosis, highlighting the potential for controlling this cell death mechanism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
German Josuet Lapo-Talledo, Jorge Andres Talledo-Delgado, Diego Portalanza, Ana Lucia S. Rodrigues, Aline Siteneski
Summary: Suicide rates and choice of suicide method have increased in Ecuador after natural disasters such as earthquakes and the COVID-19 confinement. Hanging accounted for the majority of suicide cases in the country. The province most severely affected by the 2016 earthquake saw an increased suicide rate.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Endocrinology & Metabolism
Bruna R. Kouba, Ana Clara N. C. Torra, Anderson Camargo, Ana Lucia S. Rodrigues
Summary: Vitamin D-3 has shown antidepressant-like responses in mice, possibly through increasing BDNF levels and synaptic protein synthesis.
METABOLIC BRAIN DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Anderson Camargo, Ana P. Dalmagro, Glorister A. Alte, Ana Lucia B. Zeni, Carla I. Tasca, Ana Lucia S. Rodrigues
Summary: This study investigated the antidepressant-like and neuroprotective effects of guanosine and ketamine in mice and found that both substances showed protective effects against glutamate-induced damage. The combination of guanosine and ketamine exhibited enhanced antidepressant-like effects and increased glutamine synthetase activity and GLT-1 levels. The findings suggest that guanosine has potential as a treatment for depression and should be further studied.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Environmental Sciences
Mauricio Tavares Jacques, Marcell Valandro Soares, Marcelo Farina, Julia Bornhorst, Tanja Schwerdtle, Daiana Silva Avila
Summary: The excessive and indiscriminate use of agrochemicals has raised great concerns due to its toxic consequences on the environment and human health. This study compared the toxicity of pure chlorpyrifos (CPF) with that of a commercial formulation containing supposedly inert ingredients (CBCF) using Caenorhabditis elegans as a model organism. The results showed that after a 48-hour exposure, CBCF was 14 times more lethal than CPF, with significantly greater negative effects on hatching, brood size, body length, and motor-related behavioral parameters in worms exposed to CBCF. Additionally, CBCF induced morphological changes in cholinergic neurons associated with motor-related behavioral parameters, and the analysis of CBCF also revealed the presence of potentially toxic metals not specified on the label.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2023)
Review
Endocrinology & Metabolism
Bruna R. Kouba, Anderson Camargo, Ana Lucia S. Rodrigues
Summary: Alzheimer's disease is primarily caused by neuroinflammation, as evidenced by the co-localization of amyloid-beta plaques with activated glial cells and increased levels of inflammatory cytokines. Current pharmacological treatments are challenging, hence compounds with anti-inflammatory and antioxidant properties are being explored as potential therapies. Vitamin D, due to its neuroprotective effects and high prevalence of deficiency, has emerged as a promising candidate. This review highlights the antioxidant and anti-inflammatory properties of vitamin D, and its potential effects on the neuroinflammatory process in Alzheimer's disease.
METABOLIC BRAIN DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Mauricio Tavares Jacques, Viviane de Souza, Flavio Augusto Rocha Barbosa, Romulo Faria Santos Canto, Samantha Cristiane Lopes, Rui Daniel Prediger, Antonio Luiz Braga, Michael Aschner, Marcelo Farina
Summary: Oxidative glutamate toxicity is a harmful mechanism in ischemic stroke. Two new probucol analogues (C1 and C2) were designed and synthesized, and their effects against glutamate-induced neuronal oxidative toxicity were investigated. C2 showed the lowest toxicity and provided significant protection against glutamate-induced cytotoxicity both in vitro and in vivo. This study presents a promising neuroprotective drug for ischemic stroke.
ACS CHEMICAL NEUROSCIENCE
(2023)
Review
Behavioral Sciences
Juliete Palandi, Josiel Mileno Mack, Isabela Longo de Araujo, Marcelo Farina, Franciane Bobinski
Summary: This study provides a comprehensive framework of animal models used to investigate CRPS by reviewing 93 preclinical studies. The results show that the main objective of the included studies was to understand the CRPS model, with the most common characteristics being rats, males, and adults exposed to ischemia/reperfusion or tibia fracture. The most widely adopted method for nociceptive evaluation was the use of von Frey monofilaments. However, future studies should include more heterogeneous animals, multiple assessment tools, and improve measures to reduce bias for better translational science between animal models and individuals with CRPS.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Environmental Sciences
Maria Vitoria Takemura Mariano, Luana Paganotto Leandro, Karen Kich Gomes, Ana Beatriz dos Santos, Vitor Oliveira de Rosso, Alcir Luiz Dafre, Marcelo Farina, Thais Posser, Jeferson Luis Franco
Summary: This study evaluated the toxicity of copper at environmentally relevant concentrations on zebrafish larvae and found adverse effects on morphology, biochemistry, and behavior. Therefore, the permissible copper concentrations in Brazil need to be reevaluated.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
(2024)
Article
Behavioral Sciences
Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy
Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik
Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu
Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang
Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri
Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo
Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao
Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning
Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral
Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan
Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.
BEHAVIOURAL BRAIN RESEARCH
(2024)