Network medicine framework for identifying drug-repurposing opportunities for COVID-19

Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro

(2020) Manli Wang et al.   CELL RESEARCH

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

(2020) David E. Gordon et al.   NATURE

Remdesivir for the Treatment of Covid-19 — Preliminary Report

(2020) John H. Beigel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Molecular networks in Network Medicine: Development and applications

(2020) Edwin K. Silverman et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2

(2020) Yadi Zhou et al.   Cell Discovery

Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing

(2020) Laura Riva et al.   NATURE

Exploring the SARS-CoV-2 virus-host-drug interactome for drug repurposing

(2020) Sepideh Sadegh et al.   Nature Communications

Effect of hydroxychloroquine with or without azithromycin on the mortality of coronavirus disease 2019 (COVID-19) patients: a systematic review and meta-analysis

(2020) Thibault Fiolet et al.   CLINICAL MICROBIOLOGY AND INFECTION

Network-based prediction of drug combinations

(2019) Feixiong Cheng et al.   Nature Communications

From single drug targets to synergistic network pharmacology in ischemic stroke

(2019) Ana I. Casas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modeling polypharmacy side effects with graph convolutional networks

(2018) Marinka Zitnik et al.   BIOINFORMATICS

Prioritizing network communities

(2018) Marinka Zitnik et al.   Nature Communications

Network-based approach to prediction and population-based validation of in silico drug repurposing

(2018) Feixiong Cheng et al.   Nature Communications

Repurposing Auranofin, Ebselen, and PX-12 as Antimicrobial Agents Targeting the Thioredoxin System

(2018) Holly C. May et al.   Frontiers in Microbiology

Machine Learning for Integrating Data in Biology and Medicine: Principles, Practice, and Opportunities

(2018) Marinka Zitnik et al.   Information Fusion

The Drug Repurposing Hub: a next-generation drug library and information resource

(2017) Steven M Corsello et al.   NATURE MEDICINE

DrugBank 5.0: a major update to the DrugBank database for 2018

(2017) David S Wishart et al.   NUCLEIC ACIDS RESEARCH

Proteome-Scale Human Interactomics

(2017) Katja Luck et al.   TRENDS IN BIOCHEMICAL SCIENCES

A large-scale benchmark of gene prioritization methods

(2017) Dimitri Guala et al.   Scientific Reports

Pathway and network-based strategies to translate genetic discoveries into effective therapies

(2016) Casey S. Greene et al.   HUMAN MOLECULAR GENETICS

Network-based in silico drug efficacy screening

(2016) Emre Guney et al.   Nature Communications

A disease module in the interactome explains disease heterogeneity, drug response and captures novel pathways and genes in asthma

(2015) Amitabh Sharma et al.   HUMAN MOLECULAR GENETICS

Uncovering disease-disease relationships through the incomplete interactome

(2015) J. Menche et al.   SCIENCE

Repurpose terbutaline sulfate for amyotrophic lateral sclerosis using electronic medical records

(2015) Hyojung Paik et al.   Scientific Reports

Curing a viral infection by targeting the host: The example of cyclophilin inhibitors

(2013) Kai Lin et al.   ANTIVIRAL RESEARCH

Going the Distance for Protein Function Prediction: A New Distance Metric for Protein Interaction Networks

(2013) Mengfei Cao et al.   PLoS One

Predicting New Indications for Approved Drugs Using a Proteochemometric Method

(2012) Sivanesan Dakshanamurthy et al.   JOURNAL OF MEDICINAL CHEMISTRY

Viral Perturbations of Host Networks Reflect Disease Etiology

(2012) Natali Gulbahce et al.   PLoS Computational Biology

Computational Repositioning of the Anticonvulsant Topiramate for Inflammatory Bowel Disease

(2011) J. T. Dudley et al.   Science Translational Medicine

Predicting new molecular targets for known drugs

(2009) Michael J. Keiser et al.   NATURE

Drug Target Identification Using Side-Effect Similarity

(2008) M. Campillos et al.   SCIENCE