A disease module in the interactome explains disease heterogeneity, drug response and captures novel pathways and genes in asthma

Unifying immunology with informatics and multiscale biology

(2014) Brian A Kidd et al.   NATURE IMMUNOLOGY

Gene expression analysis uncovers novel hedgehog interacting protein (HHIP) effects in human bronchial epithelial cells

(2013) Xiaobo Zhou et al.   GENOMICS

MetaRanker 2.0: a web server for prioritization of genetic variation data

(2013) Tune H. Pers et al.   NUCLEIC ACIDS RESEARCH

Linkage-Disequilibrium-Based Binning Affects the Interpretation of GWASs

(2012) Andrea Christoforou et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A genome-wide signature of glucocorticoid receptor binding in neuronal PC12 cells

(2012) J Annelies E Polman et al.   BMC NEUROSCIENCE

Systems analysis of eleven rodent disease models reveals an inflammatome signature and key drivers

(2012) I.-M. Wang et al.   Molecular Systems Biology

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

Computational tools for prioritizing candidate genes: boosting disease gene discovery

(2012) Yves Moreau et al.   NATURE REVIEWS GENETICS

Evaluation of Gene Association Methods for Coexpression Network Construction and Biological Knowledge Discovery

(2012) Sapna Kumari et al.   PLoS One

Viral Perturbations of Host Networks Reflect Disease Etiology

(2012) Natali Gulbahce et al.   PLoS Computational Biology

Molecular signatures database (MSigDB) 3.0

(2011) A. Liberzon et al.   BIOINFORMATICS

Interactome Networks and Human Disease

(2011) Marc Vidal et al.   CELL

Costs of asthma in the United States: 2002-2007

(2011) Sarah Beth L. Barnett et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population

(2011) Tomomitsu Hirota et al.   NATURE GENETICS

Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations

(2011) Carole Ober et al.   NATURE GENETICS

Genomewide Association betweenGLCCI1and Response to Glucocorticoid Therapy in Asthma

(2011) Kelan G. Tantisira et al.   NEW ENGLAND JOURNAL OF MEDICINE

Lebrikizumab Treatment in Adults with Asthma

(2011) Jonathan Corren et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genome-wide association studies for discovery of genes involved in asthma

(2011) LOUBNA AKHABIR et al.   RESPIROLOGY

Proteins Encoded in Genomic Regions Associated with Immune-Mediated Disease Physically Interact and Suggest Underlying Biology

(2011) Elizabeth J. Rossin et al.   PLoS Genetics

DA DA: Degree-Aware Algorithms for Network-Based Disease Gene Prioritization

(2011) Sinan Erten et al.   BioData Mining

Addressing the Complexity of Chronic Obstructive Pulmonary Disease

(2010) Alvar Agusti et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Clld7, A Candidate Tumor Suppressor on Chromosome 13q14, Regulates Pathways of DNA Damage/Repair and Apoptosis

(2010) X. Zhou et al.   CANCER RESEARCH

Scaffolding Adaptor Protein Gab1 Is Required for TLR3/4- and RIG-I-Mediated Production of Proinflammatory Cytokines and Type I IFN in Macrophages

(2010) Y. Zheng et al.   JOURNAL OF IMMUNOLOGY

Link communities reveal multiscale complexity in networks

(2010) Yong-Yeol Ahn et al.   NATURE

Network medicine: a network-based approach to human disease

(2010) Albert-László Barabási et al.   NATURE REVIEWS GENETICS

A Large-Scale, Consortium-Based Genomewide Association Study of Asthma

(2010) Miriam F. Moffatt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Associating Genes and Protein Complexes with Disease via Network Propagation

(2010) Oron Vanunu et al.   PLoS Computational Biology

Integrating siRNA and protein-protein interaction data to identify an expanded insulin signaling network

(2009) Z. Tu et al.   GENOME RESEARCH

Pathway and network-based analysis of genome-wide association studies in multiple sclerosis

(2009) S. E. Baranzini et al.   HUMAN MOLECULAR GENETICS

A Dynamic Network Approach for the Study of Human Phenotypes

(2009) César A. Hidalgo et al.   PLoS Computational Biology

Walking the Interactome for Prioritization of Candidate Disease Genes

(2008) Sebastian Köhler et al.   AMERICAN JOURNAL OF HUMAN GENETICS

CANDID: a flexible method for prioritizing candidate genes for complex human traits

(2008) Janna E. Hutz et al.   GENETIC EPIDEMIOLOGY

Protein networks in disease

(2008) T. Ideker et al.   GENOME RESEARCH

A protein interaction network associated with asthma

(2008) Sohyun Hwang et al.   JOURNAL OF THEORETICAL BIOLOGY

Variations in DNA elucidate molecular networks that cause disease

(2008) Yanqing Chen et al.   NATURE

An empirical framework for binary interactome mapping

(2008) Kavitha Venkatesan et al.   NATURE METHODS

Detecting shared pathogenesis from the shared genetics of immune-related diseases

(2008) Alexandra Zhernakova et al.   NATURE REVIEWS GENETICS

A Functional and Regulatory Map of Asthma

(2007) Noa Novershtern et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The nerve growth factor and its receptors in airway inflammatory diseases

(2007) V. Freund-Michel et al.   PHARMACOLOGY & THERAPEUTICS