Ku70 suppresses alternative end joining in G1-arrested progenitor B cells

Loop extrusion mediates physiological Igh locus contraction for RAG scanning

(2021) Hai-Qiang Dai et al.   NATURE

BCR selection and affinity maturation in Peyer’s patch germinal centres

(2020) Huan Chen et al.   NATURE

CTCF orchestrates long-range cohesin-driven V(D)J recombinational scanning

(2020) Zhaoqing Ba et al.   NATURE

Wapl repression by Pax5 promotes V gene recombination by Igh loop extrusion

(2020) Louisa Hill et al.   NATURE

Repair of G1 induced DNA double-strand breaks in S-G2/M by alternative NHEJ

(2020) Wei Yu et al.   Nature Communications

DNA double-strand break repair-pathway choice in somatic mammalian cells

(2019) Ralph Scully et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The fundamental role of chromatin loop extrusion in physiological V(D)J recombination

(2019) Yu Zhang et al.   NATURE

A Mechanism to Minimize Errors during Non-homologous End Joining

(2019) Benjamin M. Stinson et al.   MOLECULAR CELL

CTCF-Binding Elements Mediate Accessibility of RAG Substrates During Chromatin Scanning

(2018) Suvi Jain et al.   CELL

Regulation of DNA repair in the absence of classical non-homologous end joining

(2018) Youn-Jung Kang et al.   DNA REPAIR

CRISPR/Cas9 cleavages in budding yeast reveal templated insertions and strand-specific insertion/deletion profiles

(2018) Brenda R. Lemos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Non-homologous DNA end joining and alternative pathways to double-strand break repair

(2017) Howard H. Y. Chang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Rad52 competes with Ku70/Ku86 for binding to S-region DSB ends to modulate antibody class-switch DNA recombination

(2017) Hong Zan et al.   Nature Communications

Long Neural Genes Harbor Recurrent DNA Break Clusters in Neural Stem/Progenitor Cells

(2016) Pei-Chi Wei et al.   CELL

Orientation-specific RAG activity in chromosomal loop domains contributes toTcrdV(D)J recombination during T cell development

(2016) Lijuan Zhao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Detecting DNA double-stranded breaks in mammalian genomes by linear amplification–mediated high-throughput genome-wide translocation sequencing

(2016) Jiazhi Hu et al.   Nature Protocols

PAXX and XLF DNA repair factors are functionally redundant in joining DNA breaks in a G1-arrested progenitor B-cell line

(2016) Vipul Kumar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RAG2 and XLF/Cernunnos interplay reveals a novel role for the RAG complex in DNA repair

(2016) Chloé Lescale et al.   Nature Communications

WRN regulates pathway choice between classical and alternative non-homologous end joining

(2016) Raghavendra A. Shamanna et al.   Nature Communications

Impaired 53BP1/RIF1 DSB mediated end-protection stimulates CtIP-dependent end resection and switches the repair to PARP1-dependent end joining in G1

(2016) Ali Bakr et al.   Oncotarget

Chromosomal Loop Domains Direct the Recombination of Antigen Receptor Genes

(2015) Jiazhi Hu et al.   CELL

Molecular Mechanism of V(D)J Recombination from Synaptic RAG1-RAG2 Complex Structures

(2015) Heng Ru et al.   CELL

Structural basis for a novel mechanism of DNA bridging and alignment in eukaryotic DSB DNA repair

(2015) J. Gouge et al.   EMBO JOURNAL

Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair

(2015) Raphael Ceccaldi et al.   NATURE

Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination

(2015) Pedro A. Mateos-Gomez et al.   NATURE

Crystal structure of the V(D)J recombinase RAG1–RAG2

(2015) Min-Sung Kim et al.   NATURE

Essential role for polymerase specialization in cellular nonhomologous end joining

(2015) John M. Pryor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases

(2014) Richard L Frock et al.   NATURE BIOTECHNOLOGY

RAG2 mutants alter DSB repair pathway choice in vivo and illuminate the nature of ‘alternative NHEJ’

(2014) Vered Gigi et al.   NUCLEIC ACIDS RESEARCH

Requirement for Parp-1 and DNA ligases 1 or 3 but not of Xrcc1 in chromosomal translocation formation by backup end joining

(2014) Aashish Soni et al.   NUCLEIC ACIDS RESEARCH

Mechanisms of Programmed DNA Lesions and Genomic Instability in the Immune System

(2013) Frederick W. Alt et al.   CELL

The absence of Ku but not defects in classical non-homologous end-joining is required to trigger PARP1-dependent end-joining

(2013) Wael Y. Mansour et al.   DNA REPAIR

Functional Intersection of ATM and DNA-Dependent Protein Kinase Catalytic Subunit in Coding End Joining during V(D)J Recombination

(2013) B.-S. Lee et al.   MOLECULAR AND CELLULAR BIOLOGY

Microhomology-mediated End Joining and Homologous Recombination share the initial end resection step to repair DNA double-strand breaks in mammalian cells

(2013) L. N. Truong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Robust chromosomal DNA repair via alternative end-joining in the absence of X-ray repair cross-complementing protein 1 (XRCC1)

(2012) C. Boboila et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Removal of Shelterin Reveals the Telomere End-Protection Problem

(2012) A. Sfeir et al.   SCIENCE

V(D)J Recombination: Mechanisms of Initiation

(2011) David G. Schatz et al.   Annual Review of Genetics

Genome-wide Translocation Sequencing Reveals Mechanisms of Chromosome Breaks and Rearrangements in B Cells

(2011) Roberto Chiarle et al.   CELL

The RAG2 C terminus suppresses genomic instability and lymphomagenesis

(2011) Ludovic Deriano et al.   NATURE

Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4

(2010) Cristian Boboila et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70

(2010) C. Boboila et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracts of proliferating and non-proliferating human cells display different base excision pathways and repair fidelity

(2009) Mansour Akbari et al.   DNA REPAIR

Alternative endings

(2008) J. E. Haber   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA