Exploiting synthetic lethality to target BRCA1/2-deficient tumors: where we stand

ALC1 links chromatin accessibility to PARP inhibitor response in homologous recombination-deficient cells

(2021) Priyanka Verma et al.   NATURE CELL BIOLOGY

RNF168 regulates R-loop resolution and genomic stability in BRCA1/2-deficient tumors

(2021) Parasvi S. Patel et al.   JOURNAL OF CLINICAL INVESTIGATION

The SF3b complex: splicing and beyond

(2020) Chengfu Sun   CELLULAR AND MOLECULAR LIFE SCIENCES

Upregulation of FEN1 Is Associated with the Tumor Progression and Prognosis of Hepatocellular Carcinoma

(2020) Yingying Zhang et al.   DISEASE MARKERS

RNF168-mediated ubiquitin signaling inhibits the viability of BRCA1 null cancers

(2020) John J. Krais et al.   CANCER RESEARCH

Homologous recombination DNA repair deficiency and PARP inhibition activity in primary triple negative breast cancer

(2020) Neha Chopra et al.   Nature Communications

Methodology for the identification of small molecule inhibitors of the Fanconi Anaemia ubiquitin E3 ligase complex

(2020) Michael F. Sharp et al.   Scientific Reports

Therapeutic Potential of Combining PARP Inhibitor and Immunotherapy in Solid Tumors

(2020) Praveen Vikas et al.   Frontiers in Oncology

Germline RBBP8 variants associated with early-onset breast cancer compromise replication fork stability

(2020) Reihaneh Zarrizi et al.   JOURNAL OF CLINICAL INVESTIGATION

Endogenous DNA 3′ Blocks Are Vulnerabilities for BRCA1 and BRCA2 Deficiency and Are Reversed by the APE2 Nuclease

(2020) Alejandro Álvarez-Quilón et al.   MOLECULAR CELL

FEN1 endonuclease as a therapeutic target for human cancers with defects in homologous recombination

(2020) Elaine Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Oncogenic Helicase ALC1 Regulates PARP Inhibitor Potency by Trapping PARP2 at DNA Breaks

(2020) Charlotte Blessing et al.   MOLECULAR CELL

Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD

(2020) Graeme Hewitt et al.   MOLECULAR CELL

The chromatin remodeler ALC1 underlies resistance to PARP inhibitor treatment

(2020) Szilvia Juhász et al.   Science Advances

BRCA1 Haploinsufficiency Is Masked by RNF168-Mediated Chromatin Ubiquitylation

(2019) Dali Zong et al.   MOLECULAR CELL

Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets

(2019) Kristen E. Mengwasser et al.   MOLECULAR CELL

Polo-like Kinase 1 Inhibition as a Therapeutic Approach to Selectively Target BRCA1-Deficient Cancer Cells by Synthetic Lethality Induction

(2019) Sofía Carbajosa et al.   CLINICAL CANCER RESEARCH

A decade of clinical development of PARP inhibitors in perspective

(2019) J Mateo et al.   ANNALS OF ONCOLOGY

Severe Fanconi Anemia phenotypes in Fancd2 depletion mice

(2019) Qiao Yang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

EXD2 Protects Stressed Replication Forks and Is Required for Cell Viability in the Absence of BRCA1/2

(2019) Jadwiga Nieminuszczy et al.   MOLECULAR CELL

Maintenance Olaparib for Germline BRCA-Mutated Metastatic Pancreatic Cancer

(2019) Talia Golan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mechanisms of DNA Replication and Repair: Insights from the Study of G-Quadruplexes

(2019) Tracy M. Bryan   MOLECULES

MiR223-3p promotes synthetic lethality in BRCA1-deficient cancers

(2019) Gayathri Srinivasan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Class I histone deacetylase inhibition is synthetic lethal with BRCA1 deficiency in breast cancer cells

(2019) Baoyuan Zhang et al.   Acta Pharmaceutica Sinica B

PARP Inhibitor Resistance: A Tug-of-War in BRCA-Mutated Cells

(2019) Sylvie M. Noordermeer et al.   TRENDS IN CELL BIOLOGY

Simultaneous Targeting of PARP1 and RAD52 Triggers Dual Synthetic Lethality in BRCA-Deficient Tumor Cells

(2018) Katherine Sullivan-Reed et al.   Cell Reports

Role of apurinic/apyrimidinic nucleases in the regulation of homologous recombination in myeloma: mechanisms and translational significance

(2018) Subodh Kumar et al.   Blood Cancer Journal

Association Between BRCA Status and Triple-Negative Breast Cancer: A Meta-Analysis

(2018) Haixia Chen et al.   Frontiers in Pharmacology

USP1 Is Required for Replication Fork Protection in BRCA1-Deficient Tumors

(2018) Kah Suan Lim et al.   MOLECULAR CELL

CtIP-Mediated Fork Protection Synergizes with BRCA1 to Suppress Genomic Instability upon DNA Replication Stress

(2018) Sara Przetocka et al.   MOLECULAR CELL

FANCD2 and DNA Damage

(2017) Manoj Nepal et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Human RAD52 interactions with replication protein A and the RAD51 presynaptic complex

(2017) Chu Jian Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FEN1 promotes tumor progression and confers cisplatin resistance in non-small-cell lung cancer

(2017) Lingfeng He et al.   Molecular Oncology

HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures

(2017) Helen Davies et al.   NATURE MEDICINE

The helicase domain of Polθ counteracts RPA to promote alt-NHEJ

(2017) Pedro A Mateos-Gomez et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

PARP inhibitors: Synthetic lethality in the clinic

(2017) Christopher J. Lord et al.   SCIENCE

DNA Damage and Repair Biomarkers of Immunotherapy Response

(2017) Kent W. Mouw et al.   Cancer Discovery

The helicase domain of Polθ counteracts RPA to promote alt-NHEJ

(2017) Pedro A Mateos-Gomez et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

BRCA mutation in ovarian cancer: testing, implications and treatment considerations

(2017) Robert T. Neff et al.   Therapeutic Advances in Medical Oncology

DNA polymerase θ (POLQ), double-strand break repair, and cancer

(2016) Richard D. Wood et al.   DNA REPAIR

Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds

(2016) Jutta Zimmer et al.   MOLECULAR CELL

Targeting BRCA1- and BRCA2-deficient cells with RAD52 small molecule inhibitors

(2016) Fei Huang et al.   NUCLEIC ACIDS RESEARCH

Laying a trap to kill cancer cells: PARP inhibitors and their mechanisms of action

(2016) Y. Pommier et al.   Science Translational Medicine

Regulation of Single-Strand Annealing and its Role in Genome Maintenance

(2016) Ragini Bhargava et al.   TRENDS IN GENETICS

FANCD2 Maintains Fork Stability in BRCA1/2-Deficient Tumors and Promotes Alternative End-Joining DNA Repair

(2016) Zeina Kais et al.   Cell Reports

Reappearance from Obscurity: Mammalian Rad52 in Homologous Recombination

(2016) Kritika Hanamshet et al.   Genes

Targeting DNA Flap Endonuclease 1 to Impede Breast Cancer Progression

(2016) Lingfeng He et al.   EBioMedicine

Functional characterization of RAD52 as a lung cancer susceptibility gene in the 12p13.33 locus

(2015) Rachel Lieberman et al.   MOLECULAR CARCINOGENESIS

The Fanconi Anemia Pathway Maintains Genome Stability by Coordinating Replication and Transcription

(2015) Rebekka A. Schwab et al.   MOLECULAR CELL

The Replication Checkpoint Prevents Two Types of Fork Collapse without Regulating Replisome Stability

(2015) Huzefa Dungrawala et al.   MOLECULAR CELL

Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair

(2015) Raphael Ceccaldi et al.   NATURE

Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination

(2015) Pedro A. Mateos-Gomez et al.   NATURE

Mechanism of microhomology-mediated end-joining promoted by human DNA polymerase θ

(2015) Tatiana Kent et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer

(2015) Joaquin Mateo et al.   NEW ENGLAND JOURNAL OF MEDICINE

DNA damage during the G0/G1 phase triggers RNA-templated, Cockayne syndrome B-dependent homologous recombination

(2015) Leizhen Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of microhomology-mediated end-joining promoted by human DNA polymerase θ

(2015) Tatiana Kent et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cancers associated withBRCA1andBRCA2mutations other than breast and ovarian

(2014) Jacqueline Mersch et al.   CANCER

Pharmacogenetics of DNA repair gene polymorphisms in non-small-cell lung carcinoma patients on platinum-based chemotherapy

(2014) L. Zhang et al.   GENETICS AND MOLECULAR RESEARCH

Base Excision Repair Defects Invoke Hypersensitivity to PARP Inhibition

(2014) Julie K. Horton et al.   MOLECULAR CANCER RESEARCH

Genomic and protein expression analysis reveals flap endonuclease 1 (FEN1) as a key biomarker in breast and ovarian cancer

(2014) Tarek M.A. Abdel-Fatah et al.   Molecular Oncology

Protein dynamics during presynaptic-complex assembly on individual single-stranded DNA molecules

(2014) Bryan Gibb et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A role for DNA polymerase θ in the timing of DNA replication

(2014) Anne Fernandez-Vidal et al.   Nature Communications

Mechanism of Suppression of Chromosomal Instability by DNA Polymerase POLQ

(2014) Matthew J. Yousefzadeh et al.   PLoS Genetics

Personalized synthetic lethality induced by targeting RAD52 in leukemias identified by gene mutation and expression profile

(2013) K. Cramer-Morales et al.   BLOOD

Review of Poly (ADP-ribose) Polymerase (PARP) Mechanisms of Action and Rationale for Targeting in Cancer and Other Diseases

(2013) Julio Morales et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Stereospecific PARP Trapping by BMN 673 and Comparison with Olaparib and Rucaparib

(2013) J. Murai et al.   MOLECULAR CANCER THERAPEUTICS

FANCD2 Binds MCM Proteins and Controls Replisome Function upon Activation of S Phase Checkpoint Signaling

(2013) Gérald Lossaint et al.   MOLECULAR CELL

FANC Pathway Promotes UV-Induced Stalled Replication Forks Recovery by Acting Both Upstream and Downstream Polη and Rev1

(2013) Emilie Renaud et al.   PLoS One

APE2 is required for ATR-Chk1 checkpoint activation in response to oxidative stress

(2013) J. Willis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Base Excision Repair

(2013) H. E. Krokan et al.   Cold Spring Harbor Perspectives in Biology

Correction: An Evolutionarily Conserved Synthetic Lethal Interaction Network Identifies FEN1 as a Broad-Spectrum Target for Anticancer Therapeutic Development

(2013) Derek M. van Pel et al.   PLoS Genetics

A Distinct Replication Fork Protection Pathway Connects Fanconi Anemia Tumor Suppressors to RAD51-BRCA1/2

(2012) Katharina Schlacher et al.   CANCER CELL

Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors

(2012) J. Murai et al.   CANCER RESEARCH

PARP1 promotes nucleotide excision repair through DDB2 stabilization and recruitment of ALC1

(2012) Alex Pines et al.   JOURNAL OF CELL BIOLOGY

Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: The molecular choreography

(2012) Larry H. Thompson   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

RAD52 inactivation is synthetically lethal with deficiencies in BRCA1 and PALB2 in addition to BRCA2 through RAD51-mediated homologous recombination

(2012) B H Lok et al.   ONCOGENE

BRCA1 contributes to transcription-coupled repair of DNA damage through polyubiquitination and degradation of Cockayne syndrome B protein

(2011) Leizhen Wei et al.   CANCER SCIENCE

Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11

(2011) Katharina Schlacher et al.   CELL

Homology-directed Fanconi anemia pathway cross-link repair is dependent on DNA replication

(2011) Koji Nakanishi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the FANCI-FANCD2 Complex: Insights into the Fanconi Anemia DNA Repair Pathway

(2011) Woo Joo et al.   SCIENCE

Unpairing and gating: sequence-independent substrate recognition by FEN superfamily nucleases

(2011) Jane A. Grasby et al.   TRENDS IN BIOCHEMICAL SCIENCES

Toxicity modelling of Plk1-targeted therapies in genetically engineered mice and cultured primary mammalian cells

(2011) Monika Raab et al.   Nature Communications

Regulation of centrosomes by the BRCA1-dependent ubiquitin ligase

(2010) Zeina Kais et al.   CANCER BIOLOGY & THERAPY

FEN1 Ensures Telomere Stability by Facilitating Replication Fork Re-initiation

(2010) Abhishek Saharia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Purified human BRCA2 stimulates RAD51-mediated recombination

(2010) Ryan B. Jensen et al.   NATURE

Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70

(2010) C. Boboila et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rad52 inactivation is synthetically lethal with BRCA2 deficiency

(2010) Z. Feng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of PCNA-dependent stimulation of 3'-phosphodiesterase and 3'-5' exonuclease activities of human Ape2 in repair of oxidative DNA damage

(2009) P. Burkovics et al.   NUCLEIC ACIDS RESEARCH

Lack of DNA Polymerase θ (POLQ) Radiosensitizes Bone Marrow Stromal CellsIn Vitroand Increases Reticulocyte Micronuclei after Total-Body Irradiation

(2009) Julie P. Goff et al.   RADIATION RESEARCH

The Fanconi Anemia Pathway Promotes Replication-Dependent DNA Interstrand Cross-Link Repair

(2009) P. Knipscheer et al.   SCIENCE