Personalized synthetic lethality induced by targeting RAD52 in leukemias identified by gene mutation and expression profile

Genomic instability may originate from imatinib-refractory chronic myeloid leukemia stem cells

(2013) E. Bolton-Gillespie et al.   BLOOD

Rac2-MRC-cIII-generated ROS cause genomic instability in chronic myeloid leukemia stem cells and primitive progenitors

(2012) M. Nieborowska-Skorska et al.   BLOOD

Regulation of self-renewal in normal and cancer stem cells

(2012) Maria V. Verga Falzacappa et al.   FEBS Journal

Inhibition of Homologous Recombination in Human Cells by Targeting RAD51 Recombinase

(2012) Fei Huang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Rad51 Paralog Complexes BCDX2 and CX3 Act at Different Stages in the BRCA1-BRCA2-Dependent Homologous Recombination Pathway

(2012) J. Chun et al.   MOLECULAR AND CELLULAR BIOLOGY

Quantitative Live Cell Imaging Reveals a Gradual Shift between DNA Repair Mechanisms and a Maximal Use of HR in Mid S Phase

(2012) Ketki Karanam et al.   MOLECULAR CELL

Playing the End Game: DNA Double-Strand Break Repair Pathway Choice

(2012) J. Ross Chapman et al.   MOLECULAR CELL

Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors

(2012) Elisabet Wahlberg et al.   NATURE BIOTECHNOLOGY

Genome-wide profiles of H2AX and γ-H2AX differentiate endogenous and exogenous DNA damage hotspots in human cells

(2012) Jungmin Seo et al.   NUCLEIC ACIDS RESEARCH

RI-1: a chemical inhibitor of RAD51 that disrupts homologous recombination in human cells

(2012) Brian Budke et al.   NUCLEIC ACIDS RESEARCH

Synthetic lethality: exploiting the addiction of cancer to DNA repair

(2011) M. Shaheen et al.   BLOOD

Targeting RAD51 phosphotyrosine-315 to prevent unfaithful recombination repair in BCR-ABL1 leukemia

(2011) A. Slupianek et al.   BLOOD

Chronic myeloid leukemia stem cells are not dependent on Bcr-Abl kinase activity for their survival

(2011) A. Hamilton et al.   BLOOD

Persistence of leukemia stem cells in chronic myelogenous leukemia patients in prolonged remission with imatinib treatment

(2011) S. Chu et al.   BLOOD

Leukemic stem cell persistence in chronic myeloid leukemia patients with sustained undetectable molecular residual disease

(2011) J.-C. Chomel et al.   BLOOD

Poly(ADP-Ribose) polymerase (PARP) inhibitors: Exploiting a synthetic lethal strategy in the clinic

(2011) Timothy A. Yap et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Altered Hematopoietic Cell Gene Expression Precedes Development of Therapy-Related Myelodysplasia/Acute Myeloid Leukemia and Identifies Patients at Risk

(2011) Liang Li et al.   CANCER CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Tyrosine phosphorylation enhances RAD52-mediated annealing by modulating its DNA binding

(2011) Masayoshi Honda et al.   EMBO JOURNAL

Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity

(2010) Amie S. Corbin et al.   JOURNAL OF CLINICAL INVESTIGATION

Expression of Oncogenic Kinase Bcr-Abl Impairs Mitotic Checkpoint and Promotes Aberrant Divisions and Resistance to Microtubule-Targeting Agents

(2010) K. Wolanin et al.   MOLECULAR CANCER THERAPEUTICS

Widespread genomic breaks generated by activation-induced cytidine deaminase are prevented by homologous recombination

(2010) Muneer G Hasham et al.   NATURE IMMUNOLOGY

Who's who in human recombination: BRCA2 and RAD52

(2010) J. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rad52 inactivation is synthetically lethal with BRCA2 deficiency

(2010) Z. Feng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells

(2009) Andrea Viale et al.   NATURE

Genomic instability in myeloid malignancies: Increased reactive oxygen species (ROS), DNA double strand breaks (DSBs) and error-prone repair

(2008) Annahita Sallmyr et al.   CANCER LETTERS

Identification of a Second DNA Binding Site in the Human Rad52 Protein

(2008) Wataru Kagawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY