Multimodal Functional Imaging for Cancer/Tumor Microenvironments Based on MRI, EPRI, and PET

Cellular adaptation to hypoxia through hypoxia inducible factors and beyond

(2020) Pearl Lee et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Quantitative and Dynamic MRI Measures of Peripheral Vascular Function

(2020) Erin K. Englund et al.   Frontiers in Physiology

Role of metabolic imaging in diagnosis of primary, metastatic, and recurrent prostate cancer

(2020) Mohammad Amin Hadavand et al.   CURRENT OPINION IN ONCOLOGY

Association between myocardial hypoxia and fibrosis in hypertrophic cardiomyopathy: analysis by T2* BOLD and T1 mapping MRI

(2020) Kiyoe Ando et al.   EUROPEAN RADIOLOGY

Human Serum Albumin Labelled with Sterically-Hindered Nitroxides as Potential MRI Contrast Agents

(2020) Sergey Dobrynin et al.   MOLECULES

Feasibility of 4D T2* quantification in the lung with oxygen gas challenge in patients with non-small cell lung cancer

(2020) Kathrin Breuer et al.   Physica Medica-European Journal of Medical Physics

Whole gamma imaging: a new concept of PET combined with Compton imaging

(2020) Eiji Yoshida et al.   PHYSICS IN MEDICINE AND BIOLOGY

Imaging of Tumor Hypoxia for Radiotherapy: Current Status and Future Directions

(2020) Morten Busk et al.   SEMINARS IN NUCLEAR MEDICINE

Oxygen sensing ability of positronium atom for tumor hypoxia imaging

(2020) Kengo Shibuya et al.   Communications Physics

In Situ Labeling and Distance Measurements of Membrane Proteins in E. coli Using Finland and OX063 Trityl Labels

(2020) Sophie Ketter et al.   CHEMISTRY-A EUROPEAN JOURNAL

Reversible Dimerization of Human Serum Albumin

(2020) Alexey Chubarov et al.   MOLECULES

In vivo hypoxia characterization using blood oxygen level dependent magnetic resonance imaging in a preclinical glioblastoma mouse model

(2020) Needa Virani et al.   MAGNETIC RESONANCE IMAGING

Strategies and prospects for cortical depth dependent T2 and T2* weighted BOLD fMRI studies

(2019) Peter J. Koopmans et al.   NEUROIMAGE

Imaging tumor acidosis: a survey of the available techniques for mapping in vivo tumor pH

(2019) Annasofia Anemone et al.   CANCER AND METASTASIS REVIEWS

“Redox Imaging” to Distinguish Cells with Different Proliferative Indexes: Superoxide, Hydroperoxides, and Their Ratio as Potential Biomarkers

(2019) Zhivko Zhelev et al.   Oxidative Medicine and Cellular Longevity

An integrated physico-chemical approach for explaining the differential impact of FLASH versus conventional dose rate irradiation on cancer and normal tissue responses

(2019) Douglas R. Spitz et al.   RADIOTHERAPY AND ONCOLOGY

Functional MRI and resting state connectivity in white matter - a mini-review

(2019) John C. Gore et al.   MAGNETIC RESONANCE IMAGING

Renal perfusion imaging by MRI

(2019) Jeff L. Zhang et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Radiation-induced redox alteration in the mouse brain

(2019) Mizuki Nakamura et al.   FREE RADICAL BIOLOGY AND MEDICINE

Utility of Preoperative Blood-Oxygen-Level–Dependent Functional MR Imaging in Patients with a Central Nervous System Neoplasm

(2019) Ammar A. Chaudhry et al.   RADIOLOGIC CLINICS OF NORTH AMERICA

Probing renal blood volume with magnetic resonance imaging

(2019) Thoralf Niendorf et al.   Acta Physiologica

Methanethiosulfonate Derivative of OX063 Trityl: A Promising and Efficient Reagent for Side‐Directed Spin Labeling of Proteins

(2019) Victor M. Tormyshev et al.   CHEMISTRY-A EUROPEAN JOURNAL

In Vivo Application of Proton-Electron Double-Resonance Imaging

(2018) Shun Kishimoto et al.   ANTIOXIDANTS & REDOX SIGNALING

Pulsed Electron Paramagnetic Resonance Imaging: Applications in the Studies of Tumor Physiology

(2018) Shun Kishimoto et al.   ANTIOXIDANTS & REDOX SIGNALING

EPR-based oximetric imaging: a combination of single point-based spatial encoding and T1 weighting

(2018) Ken-ichiro Matsumoto et al.   MAGNETIC RESONANCE IN MEDICINE

Nitroxyl Modified Tobacco Mosaic Virus as a Metal-Free High-Relaxivity MRI and EPR Active Superoxide Sensor

(2018) Madushani Dharmarwardana et al.   MOLECULAR PHARMACEUTICS

Synthesis, Stability and Relaxivity of TEEPO-Met: An Organic Radical as a Potential Tumour Targeting Contrast Agent for Magnetic Resonance Imaging

(2018) Maiju Soikkeli et al.   MOLECULES

Co-imaging of the tumor oxygenation and metabolism using electron paramagnetic resonance imaging and 13-C hyperpolarized magnetic resonance imaging before and after irradiation

(2018) Masayuki Matsuo et al.   Oncotarget

Synthesis and Evaluation as a Blood–Brain Barrier-Permeable Probe of 7-N-(PROXYL-3-yl-methyl)theophylline

(2018) Miho C. Emoto et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Reactivity of redox sensitive paramagnetic nitroxyl contrast agents with reactive oxygen species

(2018) Minako Nyui et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Triply Loaded Nitroxide Brush-Arm Star Polymers Enable Metal-Free Millimetric Tumor Detection by Magnetic Resonance Imaging

(2018) Hung V.-T. Nguyen et al.   ACS Nano

Imaging tumour hypoxia with oxygen-enhanced MRI and BOLD MRI

(2018) James O'Connor et al.   BRITISH JOURNAL OF RADIOLOGY

Effects of oxygen challenging to tissue redox and pO2 status

(2018) Ken-ichiro Matsumoto et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nitroxide-radicals–modified gold nanorods for in vivo CT/MRI-guided photothermal cancer therapy

(2018) Luyao Xia et al.   International Journal of Nanomedicine

Non-invasive mapping of glutathione levels in mouse brains by in vivo electron paramagnetic resonance (EPR) imaging: Applied to a kindling mouse model

(2018) Miho C. Emoto et al.   NEUROSCIENCE LETTERS

Nitroxides as Antioxidants and Anticancer Drugs

(2017) Marcin Lewandowski et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Implications of neurovascular uncoupling in functional magnetic resonance imaging (fMRI) of brain tumors

(2017) Rebecca W Pak et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Oxygen breathing challenge- the simplest theranostic

(2017) Ralph P. Mason   Theranostics

Nitroxide-Based Macromolecular Contrast Agents with Unprecedented Transverse Relaxivity and Stability for Magnetic Resonance Imaging of Tumors

(2017) Hung V.-T. Nguyen et al.   ACS Central Science

Development of nitroxide-based theranostic compounds that act both as anti-inflammatory drugs and brain redox imaging probes in MRI

(2016) Miho C. Emoto et al.   MAGNETIC RESONANCE IN CHEMISTRY

In vivo evaluation of different alterations of redox status by studying pharmacokinetics of nitroxides using magnetic resonance techniques

(2016) Goran Bačić et al.   Redox Biology

Evaluation of oxidative stress in the brain of a transgenic mouse model of Alzheimer disease by in vivo electron paramagnetic resonance imaging

(2015) Akihiro Matsumura et al.   FREE RADICAL BIOLOGY AND MEDICINE

Feasibility and reproducibility of BOLD and TOLD measurements in the liver with oxygen and carbogen gas challenge in healthy volunteers and patients with hepatocellular carcinoma

(2015) Octavia Bane et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Brain contrasting ability of blood-brain-barrier-permeable nitroxyl contrast agents for magnetic resonance redox imaging

(2015) Ken-ichiro Matsumoto et al.   MAGNETIC RESONANCE IN MEDICINE

Brain redox imaging in the pentylenetetrazole (PTZ)-induced kindling model of epilepsy by using in vivo electron paramagnetic resonance and a nitroxide imaging probe

(2015) Miho C. Emoto et al.   NEUROSCIENCE LETTERS

Oxidative stress in oral diseases

(2015) AH Kesarwala et al.   ORAL DISEASES

In Vivo Imaging of Tumor Physiological, Metabolic, and Redox Changes in Response to the Anti-Angiogenic Agent Sunitinib: Longitudinal Assessment to Identify Transient Vascular Renormalization

(2014) Shingo Matsumoto et al.   ANTIOXIDANTS & REDOX SIGNALING

A highly sensitive, cell-membrane-permeable fluorescent probe for glutathione

(2014) Masafumi Yoshida et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

In vivoOverhauser-enhanced MRI of proteolytic activity

(2014) Neha Koonjoo et al.   Contrast Media & Molecular Imaging

Redox-responsive branched-bottlebrush polymers for in vivo MRI and fluorescence imaging

(2014) Molly A. Sowers et al.   Nature Communications

Imaging Tumor Hypoxia to Advance Radiation Oncology

(2013) Chen-Ting Lee et al.   ANTIOXIDANTS & REDOX SIGNALING

Radiation Damage to DNA: The Indirect Effect of Low-Energy Electrons

(2013) Elahe Alizadeh et al.   Journal of Physical Chemistry Letters

Quantitative 17O imaging towards oxygen consumption study in tumor bearing mice at 7T

(2013) Michiko Narazaki et al.   MAGNETIC RESONANCE IMAGING

OH Radicals from the Indirect Actions of X-Rays Induce Cell Lethality and Mediate the Majority of the Oxygen Enhancement Effect

(2013) Ryoichi Hirayama et al.   RADIATION RESEARCH

Nitroxides as Cancer Imaging Agents

(2012) Ryan M. Davis et al.   Anti-Cancer Agents in Medicinal Chemistry

Tissue redox activity as a sensing platform for imaging of cancer based on nitroxide redox cycle

(2012) Zhivko Zhelev et al.   EUROPEAN JOURNAL OF CANCER

The relationship between tissue oxygenation and redox status using magnetic resonance imaging

(2012) FUMINORI HYODO et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Organic Radical Contrast Agents for Magnetic Resonance Imaging

(2012) Andrzej Rajca et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Electron Paramagnetic Resonance Imaging of Tumor pO2

(2012) Murali C. Krishna et al.   RADIATION RESEARCH

In Vivo Magnetic Resonance Imaging to Detect Biliary Excretion of 19F-Labeled Drug in Mice

(2011) J.-P. Raufman et al.   DRUG METABOLISM AND DISPOSITION

A novel nitroxide is an effective brain redox imaging contrast agent and in vivo radioprotector

(2011) Ryan M. Davis et al.   FREE RADICAL BIOLOGY AND MEDICINE

Comparison of 250 MHz electron spin echo and continuous wave oxygen EPR imaging methods forin vivoapplications

(2011) Boris Epel et al.   MEDICAL PHYSICS

Imaging pH and metastasis

(2011) Arig Ibrahim Hashim et al.   NMR IN BIOMEDICINE

Low-Field Magnetic Resonance Imaging to Visualize Chronic and Cycling Hypoxia in Tumor-Bearing Mice

(2010) H. Yasui et al.   CANCER RESEARCH

PET imaging of hypoxia using [18F]HX4: a phase I trial

(2010) Judith van Loon et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

EPR signal reduction kinetic of several nitroxyl derivatives in blood in vitro and in vivo

(2010) Z. Zhelev et al.   GENERAL PHYSIOLOGY AND BIOPHYSICS

Multiparametric imaging of tumor oxygenation, redox status, and anatomical structure using overhauser-enhanced MRI-prepolarized MRI system

(2010) Kang-Hyun Ahn et al.   MAGNETIC RESONANCE IN MEDICINE

Radioprotectors and Mitigators of Radiation-Induced Normal Tissue Injury

(2010) D. Citrin et al.   ONCOLOGIST

Quantitative19F imaging of nmol-level F-nucleotides/-sides from 5-FU withT2mapping in mice at 9.4T

(2009) Yoshihiro Doi et al.   MAGNETIC RESONANCE IN MEDICINE

Radioprotection by DMSO in nitrogen-saturated mammalian cells exposed to helium ion beams

(2009) Ryoichi Hirayama et al.   RADIATION PHYSICS AND CHEMISTRY

Contributions of Direct and Indirect Actions in Cell Killing by High-LET Radiations

(2009) Ryoichi Hirayama et al.   RADIATION RESEARCH

Nitroxyl radicals as low toxic spin-labels for non-invasive magnetic resonance imaging of blood–brain barrier permeability for conventional therapeutics

(2008) Zhivko Zhelev et al.   CHEMICAL COMMUNICATIONS

Brain Redox Imaging Using Blood—Brain Barrier-Permeable Nitroxide MRI Contrast Agent

(2008) Fuminori Hyodo et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Low-field paramagnetic resonance imaging of tumor oxygenation and glycolytic activity in mice

(2008) Shingo Matsumoto et al.   JOURNAL OF CLINICAL INVESTIGATION

Assessment of tissue redox status using metabolic responsive contrast agents and magnetic resonance imaging

(2008) Fuminori Hyodo et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY