Article
Food Science & Technology
Chloe Robert, Armelle Penhoat, Leslie Couedelo, Magali Monnoye, Dominique Rainteau, Emmanuelle Meugnier, Sofia Bary, Helene Abrous, Emmanuelle Loizon, Pranvera Krasniqi, Stephanie Chanon, Aurekie Vieille-Marchiset, Francois Caillet, Sabine Danthine, Hubert Vidal, Nicolas Guillot, Philippe Gerard, Carole Vaysse, Marie-Caroline Michalski
Summary: The study found that natural emulsifiers such as plant lecithins, including those from rapeseed and soy, do not promote obesity and inflammation induced by high-fat diet. These lecithins also have no effect on gut barrier markers and caecal bile acids, and contribute to the status of n-3 PUFA. Moreover, they can improve gut microbiota diversity and increase the abundance of beneficial bacteria.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Review
Cell Biology
Zhihui Wu, Chengfei Xu, Tenghui Zheng, Qihui Li, Siwang Yang, Jiayuan Shao, Wutai Guan, Shihai Zhang
Summary: This review summarizes the role of AMPK in regulating intestinal nutrient absorption, barrier function, and intestinal diseases, providing a promising therapeutic target for the treatment of intestinal diseases.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Review
Food Science & Technology
Anayansi Escalante-Aburto, Grissel Trujillo-de Santiago, Mario M. Alvarez, Cristina Chuck-Hernandez
Summary: Three-dimensional food printing (3DFP) utilizes additive manufacturing to create customized food products, using a variety of ingredients and additives. Recent research shows potential for 3DFP in personalized nutrition, health applications, and aesthetic food improvement, indicating promising future developments.
COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY
(2021)
Review
Toxicology
Frederick Barreau, Celine Tisseyre, Sandrine Menard, Audrey Ferrand, Marie Carriere
Summary: The intestinal barrier function is crucial for protecting the body from harmful substances and its dysfunction is associated with various human diseases. In addition to genetic factors, environmental influences such as the use of food additives may also impact the intestinal barrier function.
PARTICLE AND FIBRE TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Caitlin K. Fung, Ningning Zhao
Summary: ZIP14 is a manganese transporter highly expressed in the small intestine and liver. Loss-of-function mutations in ZIP14 can lead to systemic manganese overload. Deletion of both intestinal and hepatic ZIP14 exacerbates the body's manganese burden.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Multidisciplinary
Ludivine Delon, Rachel J. Gibson, Clive A. Prestidge, Benjamin Thierry
Summary: Micro- and nano-scale particulate formulations can improve the oral bioavailability of biologics and drugs with low solubility and/or low intestinal permeability. Understanding absorption pathways and the role of intestinal cells is crucial for enhancing oral bioavailability.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Agriculture, Multidisciplinary
Qi Yang, Siwen Lyu, Menglei Xu, Shengrao Li, Zhiyang Du, Xuanting Liu, Xiaomin Shang, Zhipeng Yu, Jingbo Liu, Ting Zhang
Summary: The study aims to review the effects of egg white protein (EWP) and its bioactive peptides on intestinal structural repair. The potential modulation mechanisms by which EWP and their peptides regulate the gut microbiota and intestinal barrier include restoring the structure of the intestinal barrier, enhancing the intestinal immune system, alleviating inflammation and oxidative damage, and increasing the abundance of beneficial bacteria and metabolites. Further research is needed to understand the coregulation of multiple signaling pathways and evaluate the combined effects of these mechanisms in experimental models. Human trials can provide new directions for development.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Nutrition & Dietetics
Ao Liu, Aixi Han, Li Chai
Summary: Nutritional intake is crucial for human health, and while most nutrients are sufficiently supplied in China's current food system, some such as calcium and zinc still need further enlargement to improve the nutrition condition of the population. Supply-side regulation like fortification and enrichment is also necessary to enhance nutrient availability. This study provides insights into the development and current status of nutrient adequacy in China's food supply, offering valuable information for policymakers.
Review
Food Science & Technology
Antonietta Baiano
Summary: Three-dimensional printing has been successfully applied in the food sector to create complex-shaped, custom-textured, and nutritionally tailored 3D foods. The technology first emerged in the early 2000s and primarily utilizes extrusion methods with materials such as cereal derivatives and chocolate. Alternative ingredients derived from insects, algae, microorganisms, and agri-food residues have also shown promising applications. Safety concerns, including microbiological contamination and migration of toxic substances from printer elements, can be addressed through effective cleaning protocols and the use of authorized materials. However, acceptance of 3D printed foods can be hindered by their unconventional appearance. From a legal perspective, 3D printed foods should be considered as novel foods. There is potential for 3D food printing to drive new business strategies and enhance the sustainability of the food supply chain. Future prospects include the integration of cooking and 3D food printing on a single machine, as well as the development of 4D printing.
FOOD REVIEWS INTERNATIONAL
(2022)
Article
Food Science & Technology
Gina Kennedy, Zeyuan Wang, Danny Hunter, Patrick Maundu
Summary: This article discusses how food biodiversity can improve human and planetary health. Through case studies, it demonstrates various approaches to integrate food biodiversity into food systems, which contribute to improved food composition, dietary diversification, and agro-ecological resilience, as well as livelihoods, income, and socio-cultural wellbeing.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2022)
Review
Food Science & Technology
Tao Ma, Xinna Hu, Shuyu Lu, Xiaojun Liao, Yi Song, Xiaosong Hu
Summary: The synthesis of novel functional materials from abundant food waste resources has great potential for applications and ecological benefits. Nanocellulose, with its modifiable surface, excellent mechanical strength, and high aspect ratio, is a renewable and sustainable polymer that shows promise in various applications, including the food industry. This review focuses on the structural characteristics and extraction approaches of nanocellulose, as well as recent advancements in its use in the food industry. Environmental and human health concerns related to nanocellulose production are also evaluated. The extraction and production of nanocellulose from food waste provide a platform for the sustainable utilization of biomass, and its application in green food packaging materials, emulsion stabilizers, dietary fiber, nutrition delivery, and 3D printing hydrogels have shown excellent performance. Validated standards for characterizing the structure and evaluating toxicity are essential for the commercialization of nanocellulose in the food industry.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Food Science & Technology
Cameron Faustman, Daniel Aaron, Nicole Negowetti, Emily Broad Leib
Summary: The Government Accountability Office (GAO) criticized FDA's oversight of GRAS food ingredients and provided recommendations, but FDA only addressed a few criticisms and some important recommendations remain unaddressed. FDA has chosen to remain uninformed about food substances self-determined as GRAS by manufacturers.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Article
Nutrition & Dietetics
Jonathan Cantor, Bonnie Ghosh-Dastidar, Gerald Hunter, Matthew Baird, Andrea S. Richardson, Sameer Siddiqi, Tamara Dubowitz
Summary: Lack of geographic access to foods has been suggested as a cause for food insecurity, and for low-income individuals, food secure individuals tend to travel further for their major food shopping.
Article
Nutrition & Dietetics
Hao Wei, Ke Jiang, Boya Liu, Zhichuan Hu, Yong Zhao, Hong Xu, Manoj Sharma, Chuan Pu
Summary: This study evaluates the understanding and use of nutrition labels of prepackaged food by university students in Chongqing, China. The results show that the understanding and use of nutrition labels for prepackaged food by university students in Chongqing are unsatisfactory, with only 21.3% of students having a good understanding. Students' major is a significant influencing factor, with medical students having the greatest understanding.
Article
Nutrition & Dietetics
Tiffany Wesley Ardoin, Elizabeth Perry, Chelsea Morgan, Jared Hymowitz, Donald Mercante
Summary: The study examines the impact of the GGHOLOL program on food insecurity and finds that it improves food security scores, healthy eating, cooking and shopping behaviors, as well as depression scores. These improvements are sustained even 6 months after enrollment.
Editorial Material
Transplantation
Alberto Ortiz, Francesco Mattace-Raso, Maria Jose Soler, Denis Fouque
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Gastroenterology & Hepatology
Thomas Aparicio, Olivier Bouche, Pierre-Luc Etienne, Emilie Barbier, Laurent Mineur, Romain Desgrippes, Veronique Guerin-Meyer, Faycal Hocine, Jean Martin, Valerie Le Brun-Ly, Jacques Cretin, Jerome Desrame, Yves Rinaldi, Laurent Cany, Claire Falandry, Leila Bengrine Lefevre, Miguelle Marous, Eric Terrebonne, Laurent Mosser, Justine Turpin, Anthony Turpin, Lucille Bauguion, Cynthia Reichling, Marc Van den Eynde, Elisabeth Carola, Sandrine Hiret
Summary: In the preliminary tolerance analysis of the ADAGE-PRODIGE 34 trial, it was found that in patients over 70 years old, the group of patients treated with oxaliplatin and fluoropyrimidine had more grade 3-5 toxicities compared to the group treated with fluoropyrimidine alone in the fit patients.
DIGESTIVE AND LIVER DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Diana Santos-Ribeiro, Marylene Lecocq, Michele de Beukelaer, Stijn Verleden, Caroline Bouzin, Jerome Ambroise, Peter Dorfmuller, Yousef Yakoub, Francois Huaux, Rozenn Quarck, Harry Karmouty-Quintana, Maria-Rosa Ghigna, Juliette Bignard, Sophie Nadaud, Florent Soubrier, Sandrine Horman, Frederic Perros, Laurent Godinas, Charles Pilette
Summary: This study examined the involvement of the GCN2/eIF2 alpha pathway in the development of both pulmonary fibrosis (PF) and pulmonary hypertension (PH). The researchers found that GCN2 expression was reduced in lung tissue from PF and PH patients, as well as in endothelial cells. Animal experiments showed that GCN2 mutations led to increased fibrosis and vascular remodeling, as well as elevated right ventricular systolic pressure. These findings suggest a potential role for GCN2 dysregulation in the development of PF and PH.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2023)
Article
Surgery
Emma Wischlen, Olivier Boillot, Christine Rivet, Alain Lachaux, Raymonde Bouvier, Valerie Hervieu, Jean-Yves Scoazec, Sophie Collardeau-Frachon, Jerome Dumortier, Noemie Laverdure
Summary: This retrospective study reviewed 351 protocol liver biopsies (PLB) performed on pediatric liver transplant recipients. The results showed that 21.7% of patients had signs of rejection and 26.5% had moderate to severe fibrosis. The study suggests that PLB could be performed 1, 5, and 10 years after transplantation and then every 10 years for patients with normal results and no complications.
CLINICAL TRANSPLANTATION
(2023)
Article
Food Science & Technology
Charline Buisson, Valentin Leuzy, Emmanuelle Loizon, Emmanuelle Meugnier, Magali Monnoye, Catherine Philippe, Philippe Gerard, Marie-Caroline Michalski, Fabienne Laugerette
Summary: This study investigates the effects of rapeseed oil enriched with soy lecithin (SPL) on white adipose tissue (WAT) inflammation, ileum permeability, and microbiota composition in mice. The results show that rapeseed oil with SPL leads to increased gene expression of leptin and inflammation in WAT, and decreased expression of TLR4, IAP, and tight junction proteins in the ileum. However, it also increases the expression of antimicrobial activity proteins and promotes the growth of certain bacterial species.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Nutrition & Dietetics
Anais Alves, Frederic Lamarche, Remy Lefebvre, Eva Drevet Mulard, Arthur Bassot, Stephanie Chanon, Emmanuelle Loizon, Claudie Pinteur, Aline Maria Nunes de Lira Gomes Bloise, Murielle Godet, Gilles J. P. Rautureau, Baptiste Panthu, Beatrice Morio
Summary: The interactions between mitochondria and the endoplasmic reticulum, known as MAMs, are altered in the liver in obesity, which leads to disruption of the insulin signaling pathway. The plasma level of glycine is decreased in obesity, and the decrease is strongly correlated with the severity of insulin resistance. Glycine supplementation can promote MAM integrity and improve insulin response in hepatocytes, but it does not have a beneficial effect on the overall metabolic profile in obese mice.
Review
Nutrition & Dietetics
Catherine Calzada, Cecile Vors, Armelle Penhoat, David Cheillan, Marie-Caroline Michalski
Summary: Sphingolipids, as structural components and signaling molecules, play important roles in cell membranes and lipoproteins, and are implicated in metabolic and cardiovascular diseases. Dietary lipids can modulate circulating sphingolipids and lipid-related cardiovascular risk markers. Saturated fatty acids may increase ceramide concentrations, while milk polar lipids may decrease certain species of sphingomyelins and ceramides in plasma and chylomicrons. Understanding the impact of different dietary fatty acids and lipid species on circulating sphingolipids can guide the development of nutritional strategies for preventing cardiovascular diseases.
FRONTIERS IN NUTRITION
(2023)
Article
Physiology
Juliette Bignard, Fabrice Atassi, Olivier Claude, Maria-Rosa Ghigna, Nathalie Mougenot, Bahgat Soilih Abdoulkarim, Florence Deknuydt, Aurelle Gestin, Virginie Monceau, David Montani, Sophie Nadaud, Florent Soubrier, Frederic Perros
Summary: Hereditary pulmonary veno-occlusive disease (hPVOD) is a severe autosomal recessive pulmonary hypertension caused by loss of function of the EIF2AK4 gene. Researchers generated rat models with biallelic Gcn2 mutation to study the molecular and cellular response of the lungs under amino acid deprivation. The study revealed that Gcn2-/- rats displayed increased apoptosis, overexpression of proinflammatory genes, and infiltration of inflammatory cells, suggesting a potential role of Gcn2 in immune homeostasis and hPVOD development.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2023)
Review
Surgery
Robin Bayoux, Benoit Gignoux, Camille Barani, Jean-Yves Mabrut, Ali Mojallal
Summary: A training method for endoscopic treatment of diastasis rectus abdominis was developed and evaluated on fresh cadaver models. The results showed that laparoscopic surgery is an efficient and safe approach to correct diastasis of the rectus muscles.
ANNALES DE CHIRURGIE PLASTIQUE ESTHETIQUE
(2023)
Review
Clinical Neurology
Paul Clottes, Nicolas Benech, Chloe Dumot, Sophie Jarraud, Hubert Vidal, Laura Mechtouff
Summary: Despite recent advances in stroke therapy, it remains a leading cause of disability and death, necessitating the identification of new therapeutic targets. Increasingly, dysbiosis of gut microbiota has been recognized as playing a detrimental role in cardiovascular diseases, including stroke. The metabolites produced by gut microbiota, such as trimethylamine-N-oxide, short chain fatty acids, and tryptophan, have been found to be key players. There is evidence linking gut microbiota alteration to cardiovascular risk factors, supported by preclinical studies. Additionally, observational studies have shown that stroke patients with altered gut microbiota experience more complications, larger infarct sizes, and worse clinical outcomes. Various microbiota-targeted strategies, including prebiotics/probiotics and inhibitors of metabolites, have been developed. However, the timing and endpoints of these studies have varied, resulting in different outcomes. Based on available evidence, it is believed that further research on microbiota-targeted strategies, in conjunction with conventional stroke care, should be conducted within three therapeutic time windows: primary prevention or secondary prevention to control cardiovascular risk factors, acute phase to minimize infarct size and systemic complications, and subacute phase to prevent recurrence and promote neurological recovery.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Nutrition & Dietetics
Laure Meiller, Valerie Sauvinet, Anne-Esther Breyton, Harimalala Ranaivo, Christelle Machon, Anne Mialon, Alexandra Meynier, Stephan C. Bischoff, Jens Walter, Audrey M. Neyrinck, Martine Laville, Nathalie M. Delzenne, Sophie Vinoy, Julie-Anne Nazare
Summary: This pilot study aimed to analyze the kinetics of C-13-labeled gut-derived metabolites from C-13-labeled wheat bran in breath, plasma, and stools. The study found differential fermentation profiles among subjects and identified distinct excretion patterns of gases in high-CH4 producers compared to low-CH4 producers. The study also revealed different kinetics of C-13-labelled short-chain fatty acids in plasma.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Farhang Aminfar, Vladimir Rubimbura, Luc Maillard, Stephane Noble, Gregoire Range, Loic Belle, Francois Derimay, Anne Bellemain-Appaix, Alexis Al Karaky, Jean-Francois Morelle, Georgios Sideris, Pascal Motreff, Olivier Muller, Julien Adjedj
Article
Gastroenterology & Hepatology
Sarah Duponchel, Lea Monnier, Jennifer Molle, Nadia Bendridi, Muhammad Rizwan Alam, Ahmed Gaballah, Boyan Grigorov, Alexander Ivanov, Marcel Schmiel, Margarete Odenthal, Michel Ovize, Jennifer Rieusset, Fabien Zoulim, Birke Bartosch
Summary: Chronic HCV infection causes cellular stress, fibrosis, and predisposes to hepatocarcinogenesis. Mitochondria play key roles in orchestrating stress responses. The study revealed that HCV proteins associate with mitochondria and alter the composition of mitochondrial subdomains, which are crucial for efficient viral replication.
Article
Pediatrics
Tania Perrin, Pierre Pradat, Julie Larcade, Marion Masclef-Imbert, Blandine Pastor-Diez, Jean-Charles Picaud
Summary: This cohort study aimed to evaluate the impact of an individualised nutritional care approach combining standardised fortification with adjustable fortification on postnatal growth and body composition in extremely low birth weight (ELBW) infants. The study found that the individualised nutritional care approach prevented postnatal weight loss in most infants, limited length growth deficit, and supported excellent head circumference growth.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Clinical Neurology
Anke Wouters, Lauranne Scheldeman, Hannelore Liessens, Patrick Dupont, Florent Boutitie, Bastian Cheng, Martin Ebinger, Matthias Endres, Jochen B. Fiebach, Christian Gerloff, Keith W. Muir, Norbert Nighoghossian, Salvador Pedraza, Claus Z. Simonsen, Vincent Thijs, Goetz Thomalla, Robin Lemmens
Summary: This study aimed to explore the differences between women and men in acute ischemic stroke. The results showed that although there were more men in the WAKE-UP trial, sex did not modify the treatment effect of alteplase.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)