Cationic Ru(η6-p-cymene) Complexes of 3-Hydroxy-4-pyr(id)ones - Lipophilic Triphenylphosphine as Co-Ligand Is Key to Highly Stable and Cytotoxic Anticancer Agents

The development of RAPTA compounds for the treatment of tumors

(2016) Benjamin S. Murray et al.   COORDINATION CHEMISTRY REVIEWS

RuII(η6-p-cymene) Complexes of Bioactive 1,2-Benzothiazines: Protein Binding vs. Antitumor Activity

(2016) Adnan Ashraf et al.   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

Biodistribution of the novel anticancer drug sodium trans -[tetrachloridobis(1 H -indazole)ruthenate(III)] KP-1339/IT139 in nude BALB/c mice and implications on its mode of action

(2016) Anna K. Bytzek et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Protein ruthenation and DNA alkylation: chlorambucil-functionalized RAPTA complexes and their anticancer activity

(2015) Alexey A. Nazarov et al.   DALTON TRANSACTIONS

Synthesis and Antiproliferative Activity of New Ruthenium Complexes with Ethacrynic-Acid-Modified Pyridine and Triphenylphosphine Ligands

(2015) Gabriele Agonigi et al.   INORGANIC CHEMISTRY

Impact of the Halogen Substitution Pattern on the Biological Activity of Organoruthenium 8-Hydroxyquinoline Anticancer Agents

(2015) Mario Kubanik et al.   ORGANOMETALLICS

Target profiling of an antimetastatic RAPTA agent by chemical proteomics: relevance to the mode of action

(2015) Maria V. Babak et al.   Chemical Science

Phase I/II study with ruthenium compound NAMI-A and gemcitabine in patients with non-small cell lung cancer after first line therapy

(2014) Suzanne Leijen et al.   INVESTIGATIONAL NEW DRUGS

Influence of PPh3 moiety in the anticancer activity of new organometallic ruthenium complexes

(2014) Rubén Sáez et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Anticancer Ruthenium(η6-p-cymene) Complexes of Nonsteroidal Anti-inflammatory Drug Derivatives

(2014) Farhana Aman et al.   ORGANOMETALLICS

In vivo anti-tumor activity of the organometallic ruthenium(ii)-arene complex [Ru(η6-p-cymene)Cl2(pta)] (RAPTA-C) in human ovarian and colorectal carcinomas

(2014) Andrea Weiss et al.   Chemical Science

NKP-1339, the first ruthenium-based anticancer drug on the edge to clinical application

(2014) Robert Trondl et al.   Chemical Science

Organometallic anticancer complexes of lapachol: metal centre-dependent formation of reactive oxygen species and correlation with cytotoxicity

(2013) Wolfgang Kandioller et al.   CHEMICAL COMMUNICATIONS

Targeting the DNA-topoisomerase complex in a double-strike approach with a topoisomerase inhibiting moiety and covalent DNA binder

(2012) Andrea Kurzwernhart et al.   CHEMICAL COMMUNICATIONS

Structure–Activity Relationships of Targeted RuII(η6-p-Cymene) Anticancer Complexes with Flavonol-Derived Ligands

(2012) Andrea Kurzwernhart et al.   JOURNAL OF MEDICINAL CHEMISTRY

Solution equilibrium studies on anticancer ruthenium(II)–η6-p-cymene complexes of 3-hydroxy-2(1H)-pyridones

(2012) Éva A. Enyedy et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Challenges and Opportunities in the Development of Organometallic Anticancer Drugs

(2012) Christian G. Hartinger et al.   ORGANOMETALLICS

Synthesis of [RuII(η6-p-cymene)(PPh3)(L)Cl]PF6 complexes with carbohydrate-derived phosphites, imidazole or indazole co-ligands

(2011) Muhammad Hanif et al.   INORGANICA CHIMICA ACTA

Physicochemical Studies and Anticancer Potency of Ruthenium η6-p-Cymene Complexes Containing Antibacterial Quinolones

(2011) Jakob Kljun et al.   ORGANOMETALLICS

Influence of the Arene Ligand and the Leaving Group on the Anticancer Activity of (Thio)maltol Ruthenium(II)?(η6-Arene) Complexes

(2010) Muhammad Hanif et al.   AUSTRALIAN JOURNAL OF CHEMISTRY

First Ruthenium Organometallic Complex of Antibacterial Agent Ofloxacin. Crystal Structure and Interactions with DNA

(2010) Iztok Turel et al.   INORGANIC CHEMISTRY

Is the Reactivity of M(II)−Arene Complexes of 3-Hydroxy-2(1H)-pyridones to Biomolecules the Anticancer Activity Determining Parameter?

(2010) Muhammad Hanif et al.   INORGANIC CHEMISTRY

Organometallic Anticancer Compounds

(2010) Gilles Gasser et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pyrone derivatives and metals: From natural products to metal-based drugs

(2010) Wolfgang Kandioller et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Rational Design of an Organometallic Glutathione Transferase Inhibitor

(2009) Wee Han Ang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Maltol-Derived Ruthenium-Cymene Complexes with Tumor Inhibiting Properties: The Impact of Ligand-Metal Bond Stability on Anticancer Activity In Vitro

(2009) Wolfgang Kandioller et al.   CHEMISTRY-A EUROPEAN JOURNAL

A categorization of metal anticancer compounds based on their mode of action

(2009) Teresa Gianferrara et al.   DALTON TRANSACTIONS

From Pyrone to Thiopyrone Ligands−Rendering Maltol-Derived Ruthenium(II)−Arene Complexes That Are Anticancer Active in Vitro

(2009) Wolfgang Kandioller et al.   ORGANOMETALLICS

In Vitro Anticancer Activity and Biologically Relevant Metabolization of Organometallic Ruthenium Complexes with Carbohydrate-Based Ligands

(2008) Isabella Berger et al.   CHEMISTRY-A EUROPEAN JOURNAL

Hydrolysis study of the bifunctional antitumour compound RAPTA-C, [Ru(η6-p-cymene)Cl2(pta)]

(2008) Claudine Scolaro et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Influence of the Spacer Length on thein VitroAnticancer Activity of Dinuclear Ruthenium−Arene Compounds

(2008) Maria-Grazia Mendoza-Ferri et al.   ORGANOMETALLICS

Antitumour metal compounds: more than theme and variations

(2007) Michael A. Jakupec et al.   DALTON TRANSACTIONS

Studies on the reactivity of organometallic Ru–, Rh– and Os–pta complexes with DNA model compounds

(2007) Antoine Dorcier et al.   JOURNAL OF INORGANIC BIOCHEMISTRY