Article
Automation & Control Systems
Lorenzo Castellino, Eugenio Alladio, Stefano Bertinetti, Gabriele Lando, Concetta De Stefano, Salvador Blasco, Enrique Garcia-Espana, Sofia Gama, Silvia Berto, Demetrio Milea
Summary: A new open-source Python application called PyES has been developed for concentrations calculation. It can handle both precipitation and solution equilibria and is the only open-source software that can perform calculations at variable ionic strength, taking into account the dependence of stability constants on it. The reliability of PyES has been verified through various tests with satisfying results. It is user-friendly, compatible with existing operative systems, and the data analysis results can be easily exported in different file formats.
CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS
(2023)
Article
Chemistry, Inorganic & Nuclear
Natalia G. Baranska, Alison Parkin, Anne -K. Duhme-Klair
Summary: We report the electrochemical study of iron(III) catecholate siderophores using a boron-doped diamond working electrode. Our results reveal the formation of coordinatively unsaturated tetracoordinate complexes of iron(III) azotochelin, contrary to other siderophore complexes which favor hexacoordinate environment. The reduction potential of iron(III) azotochelin shows notable pH and buffer composition dependence. The study also extends to the investigation of iron(III) hexadentate siderophores.
INORGANIC CHEMISTRY
(2022)
Article
Geochemistry & Geophysics
Xin Zhong, Marcin Dabrowski, Bjorn Jamtveit
Summary: Raman elastic thermobarometry has been widely used to determine the P-T conditions of mineral inclusion entrapment in petrological studies. This study introduces an analytical framework based on the Eshelby solution to calculate the residual stress and strain state of ellipsoidal inclusions in an isotropic host, showing that the effect of changing the aspect ratio varies for different mineral inclusions. Results indicate that quartz is the least affected by aspect ratio changes, while rutile is the most affected. Furthermore, the study demonstrates the possibility of fitting an effective ellipsoid to estimate the averaged residual stress or strain within faceted inclusions, expanding the applicability of the analytical solution in practical Raman measurements.
Article
Biochemistry & Molecular Biology
Sherin Abdelrahman, Mawadda Alghrably, Marcello Campagna, Charlotte Armgard Emma Hauser, Mariusz Jaremko, Joanna Izabela Lachowicz
Summary: Metformin forms stable complexes with copper ions, leading to enhanced antiproliferative effect in cancer cells. It reduces cell number and viability in SW1222 and K562 cells, as well as in K562-200 multidrug-resistant cells. Additionally, metformin has been noted to have lower cancer incidence in diabetic patients.
Article
Chemistry, Medicinal
Zhenlei Zhang, Juzheng Zhang, Tongfu Yang, Shanhe Li, Gang Xu, Hong Liang, Feng Yang
Summary: To develop a next-generation Pt drug with high activity and low toxicity, researchers optimized a Pt(II) thiosemicarbazone compound (C4) with remarkable cytotoxicity to SK N-MC cells and constructed a human serum albumin-C4 (HSA-C4) complex delivery system. In vivo experiments showed that both C4 and the HSA-C4 complex had excellent therapeutic efficiency and minimal toxicity, inducing apoptosis and inhibiting tumor angiogenesis. This system has the potential to become a practical Pt drug, paving the way for the development of next-generation dual-targeted Pt drugs for cancer targeting therapy.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Lily Southcott, Lily Li, Brian O. Patrick, Holger Stephan, Maria de Guadalupe Jaraquemada-Pelaez, Chris Orvig
Summary: This study reports a highly stable [Zr(pypa)] complex, synthesized and characterized using various techniques. The complex demonstrates excellent thermodynamic stability and radiolabeling efficiency in vivo, is antibody-compatible, and maintains stability under challenging conditions.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Marianna Tosato, Marco Dalla Tiezza, Nora May, Abdirisak Ahmed Isse, Sonia Nardella, Laura Orian, Marco Verona, Christian Vaccarin, Andre Alker, Helmut Macke, Paolo Pastore, Valerio Di Marco
Summary: A series of Cu2+ complexes formed by cyclen derivatives with sulfur pendant arms were studied for their potential as chelators for copper radioisotopes. Various experiments were conducted to evaluate the stoichiometry and stability of these complexes, demonstrating their promising application in copper-based radiopharmaceuticals. The high stability of both Cu2+ and Cu+ complexes suggests these sulfur-containing chelators may prevent in vivo demetalation after bioinduced reduction to Cu+.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Katarzyna Malarz, Dawid Zych, Robert Gawecki, Michal Kuczak, Robert Musiol, Anna Mrozek-Wilczkiewicz
Summary: Terpyridine derivatives, particularly the newly synthesized 4'-phenyl-2,2':6',2 ''-terpyridine group, exhibit high anti-proliferative activity and selective toxicity towards various types of cancer cells. Molecular biology studies have shown their impact on cell cycle inhibition, apoptosis, and autophagy pathways, with a specific focus on DNA and ROS-related targets.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Shivani Daksh, Ankur Kaul, Shashank Deep, Anupama Datta
Summary: Emerging non-invasive molecular imaging modalities can detect pathophysiological states before any anatomical changes are observed. Magnetic resonance imaging (MRI) is preferred due to its radiation-free approach, and the development of manganese-based contrast agents aims to overcome nephrogenic toxicity issues associated with gadolinium contrast agents.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Antonio Gigliuto, Rosalia Maria Cigala, Anna Irto, Maria Rosa Felice, Alberto Pettignano, Demetrio Milea, Stefano Materazzi, Concetta De Stefano, Francesco Crea
Summary: The study investigated the interactions of dopamine with methylmercury(II), magnesium(II), calcium(II), and tin(II) at different ionic strengths and temperatures, and evaluated the sequestering ability of dopamine towards these cations. The results showed that entropy is the driving force of the process, and the stoichiometry of the precipitates formed depends on the metal:ligand ratios and concentrations of the starting solutions.
Correction
Chemistry, Physical
Ravi D. O'Brien, Thomas J. Summers, Danil S. Kaliakin, David C. Cantu
Summary: Correction is made for the solution structures and relative stability constants of lanthanide-EDTA complexes predicted from computation in the study conducted by Ravi D. O'Brien et al.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Biochemical Research Methods
Lily Li, Julie Rousseau, Maria De Guadalupe Jaraquemada-Pelaez, Xiaozhu Wang, Andrew Robertson, Valery Radchenko, Paul Schaffer, Kuo-Shyan Lin, Francois Benard, Chris Orvig
Summary: The study focuses on the synthesis, characterization, and stability of a new undecadendate chelator H(4)py4pa and its bifunctional analog H(4)py4pa-phenyl-NCS conjugated with the monoclonal antibody Trastuzumab targeting HER2+ cancer. The complex showed excellent affinity for Ac-225 and a high thermodynamic stability, making it a promising candidate for targeted alpha therapy. Incorporation of a short phenyl-NCS linker allowed for easy attachment to Trastuzumab, resulting in excellent in vivo stability and tumor specificity.
BIOCONJUGATE CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Ranajit Das, Michael Claron, Colette Lebrun, Jacques Pecaut, Srinivas Ambala, Christelle Gateau, Gouriprasanna Roy, Pascale Delangle
Summary: Imidazole thiones are interesting building blocks for Cu(I) chelation and protection against Cu-mediated oxidative stress. Tripodal molecules derived from nitrilotriacetic acid appended with imidazole thiones show intermediate affinity for Cu(I), with non-alkylated tripods demonstrating significantly higher affinity and efficiency in reducing Cu-mediated oxidative stress than their alkylated counterparts.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2021)
Article
Automation & Control Systems
Filippo Fabiani, Kostas Margellos, Paul J. Goulart
Summary: We propose a data-driven approach to compute a-posteriori feasibility certificates for sets of solutions of variational inequalities affected by uncertainty. By quantifying the robustness properties of the solution set and providing probabilistic feasibility guarantees, we offer protection for any feasible solution of the underlying variational inequality. Additionally, we introduce a procedure to enumerate the support constraints without describing the solution set.
Article
Chemistry, Inorganic & Nuclear
Yuxiao Guo, Haiwang Liu, Hong Cao, Xue Dong, Zhipeng Wang, Jing Chen, Chao Xu
Summary: Investigation of the coordination chemistry between U(vi) and benzoic acid has been conducted through potentiometry, spectrometry and DFT calculations. Three successive complexes (UO2L+, UO2L2 and UO2L3-, L = benzoate ion) have been identified in aqueous solution, and their thermodynamic parameters have been determined. This study reports the previously missing 1:2 and 1:3 (U to L) complexes and their complexation thermodynamics, which contribute to a better understanding of the chemical behavior of U(vi) in the presence of benzoic acid. The coordination structures of the complexes have been elucidated using DFT calculations.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Matthew P. P. Sullivan, Muneebah Adams, Mie Riisom, Caitlin D. D. Herbert, Kelvin K. H. Tong, Jonathan W. W. Astin, Stephen M. F. Jamieson, Muhammad Hanif, David C. C. Goldstone, Christian G. G. Hartinger
Summary: Pt(terpyridine) complexes are known for their ability to intercalate with DNA. The addition of an NHC co-ligand significantly increased the anticancer activity of the complex compared to its chlorido derivative. While the compound showed high efficacy, it was well-tolerated by zebrafish embryos, especially when compared to cisplatin. DNA interaction studies suggest that the mode of action is related to intercalation.
DALTON TRANSACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Tamas Pivarcsik, Vivien Posa, Hilda Kovacs, Nora May, Gabriella Spengler, Szonja P. Posa, Szilard Toth, Zeinab Nezafat Yazdi, Csilla Ozvegy-Laczka, Imre Ugrai, Istvan Szatmari, Gergely Szakacs, Eva A. Enyedy
Summary: This article investigates a novel 5-nitro-8-hydroxyquinoline-proline hybrid and its Rh(eta(5)-C5Me5) and Ru(eta(6)-p-cymene) complexes, which have excellent solubility in water and show inhibitory effects on sensitive and multidrug-resistant cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Orsolya Domotor, Eva A. Enyedy
Summary: Uncertainties exist in plasma protein binding and blood distribution of the COVID-19 therapeutics favipiravir (FAVI), molnupiravir (MOLNU), and imatinib (IMA). This study investigated the proton dissociation processes, solubility, lipophilicity, and serum protein binding of these drugs. The results showed different degrees of lipophilicity at different pH values. MOLNU was hydrolyzed by blood serum proteins, while FAVI had weak binding to blood proteins and IMA showed high affinity binding to AGP.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Tatsiana Petrasheuskaya, Ferenc Kovacs, Nora Igaz, Andrea Ronavari, Balint Hajdu, Laura Bereczki, Nora May, Gabriella Spengler, Bela Gyurcsik, Monika Kiricsi, Eva Frank, Eva A. Enyedy
Summary: A series of novel estradiol-based salicylaldehyde (thio)semicarbazones and their Cu(II) complexes were synthesized and characterized. The Cu(II)-estradiol-semicarbazone complex structure was determined by X-ray crystallography. The Cu(II) complexes of estradiol-TSC and its N,N-dimethyl derivative showed high cytotoxicity against cancer cells and significant activity against Staphylococcus aureus bacteria strain. Estradiol-TSCs exhibited efficient antioxidant activity, which was decreased by complexation with Cu(II) ions. The exchange of estrone moiety to estradiol did not significantly affect the physicochemical and biological properties.
Article
Pharmacology & Pharmacy
Janos P. Meszaros, Wolfgang Kandioller, Gabriella Spengler, Alexander Prado-Roller, Bernhard K. Keppler, Eva A. Enyedy
Summary: This study introduces half-sandwich Rh complexes that can be activated in the acidic, extracellular pH of tumor tissue, reducing the side effects and improving the efficacy of chemotherapy.
Article
Pharmacology & Pharmacy
Nadia Ribeiro, Pedro F. Farinha, Jacinta O. Pinho, Hugo Luiz, Janos P. Meszaros, Adelino M. Galvao, Joao Costa Pessoa, Eva A. Enyedy, Catarina Pinto Reis, Isabel Correia, Maria Manuela Gaspar
Summary: The development of new metallodrugs for anticancer therapy has shown promising results in inhibiting colon cancer cell proliferation in vitro, with two metal complexes demonstrating superior efficacy compared to clinically approved drugs.
Article
Chemistry, Multidisciplinary
Karolina Kowalczyk, Andrzej Blauz, Daniel Moscoh Ayine-Tora, Christian G. Hartinger, Blazej Rychlik, Damian Plazuk
Summary: Derivatives of ispinesib and its (S) analogue, containing ferrocenyl moieties or bulky organic substituents, were prepared to combine multiple biologically-active components in a single molecule. Several of these compounds demonstrated higher antiproliferative activity than ispinesib, with nanomolar IC50 values against cell lines. The improved activity may be attributed to synergic effects of various factors such as KSP inhibitory activity due to the ispinesib core and ability to generate ROS and induce mitotic arrest.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Inorganic & Nuclear
William D. J. Tremlett, Tilo Soehnel, James D. Crowley, L. James Wright, Christian G. Hartinger
Summary: Using ferrocene-based ligand systems, a series of heterobimetallic architectures were designed to release and bind guest molecules. The complexes were characterized using various techniques and the disassembly and reassembly process of metallosupramolecular structures were investigated using NMR spectroscopy. Guest binding studies revealed interactions with anionic guests and the release of guests was induced by Cl- ions.
INORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Zahid Riaz, Betty Y. T. Lee, Julia Stjarnhage, Sanam Movassaghi, Tilo Sohnel, Stephen M. F. Jamieson, Muhammad Ashraf Shaheen, Muhammad Hanif, Christian G. Hartinger
Summary: The substitution of the labile chloride ligand with phosphorus donor ligands in half-sandwich MII(cym)Cl complexes showed that Ru and Os complexes with triphenylphosphine ligands exhibited the most potent anticancer activity in submicromolar range against four cancer cell lines. This suggests that the antiproliferative activity is mainly dependent on the lipophilic properties of the phosphine ligand.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Robin Vinck, Orsolya Domotor, Johannes Karges, Marta Jakubaszek, Johanne Seguin, Mickael Tharaud, Vincent Guerineau, Kevin Cariou, Nathalie Mignet, Eva A. Enyedy, Gilles Gasser
Summary: Maleimide-containing prodrugs can selectively react with circulating serum albumin, leading to longer blood circulation times and improved tumor accumulation. This study synthesized maleimide-functionalized complexes and investigated their interaction with albumin. The complexes showed lower cytotoxicity in noncancerous cells under dark conditions but did not result in a significant increase in tumor accumulation.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Saawan Kumar, Mie Riisom, Stephen M. F. Jamieson, Iman Kavianinia, Paul W. R. Harris, Nils Metzler-Nolte, Margaret A. Brimble, Christian G. Hartinger
Summary: Researchers conjugated a derivative of plecstatin-1 with peptides to enhance their targeting ability towards cancer cells. Metal-peptide conjugates were successfully synthesized and tested for their anticancer activity. Although the activity was relatively low, this study provides a potential strategy to design other metal complexes utilizing the targeting properties of peptides.
INORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Mie Riisom, Stephen M. F. Jamieson, Christian G. Hartinger
Summary: This study aimed to investigate different protocols for efficient and reproducible lysis of cancer cells and found that chemical lysis with the RIPA buffer was the most efficient method. Minimal differences were found for experiments measuring the overall cell uptake of the Ru complex.
Article
Chemistry, Multidisciplinary
Aston C. Pearcy, Lynn S. Lisboa, Dan Preston, Nick B. Page, Tristan Lawrence, L. James Wright, Christian G. Hartinger, James D. Crowley
Summary: A new sequential metalation strategy has been developed for the assembly of a more stable heterobimetallic [PdPtL4](4+) cage. By using a low-symmetry ditopic ligand (L) with imidazole and pyridine donor units, a [Pt(L)(4)](2+) open-cage complex was selectively formed and then reacted with Pd(ii) ions to assemble the cage C. Various spectroscopy and crystallography techniques confirmed the formation of the cage and its heterobimetallic structure. The cage C exhibited anionic guest molecule binding capability and demonstrated stimulus-responsive behavior.
Article
Chemistry, Inorganic & Nuclear
Christopher Wittmann, Orsolya Domotor, Irina Kuznetcova, Gabriella Spengler, Johannes Reynisson, Lauren Holder, Gavin J. J. Miller, Eva A. A. Enyedy, Ruoli Bai, Ernest Hamel, Vladimir B. B. Arion
Summary: A series of benzazocines and benzazonines, along with their copper(II) complexes, were synthesized and characterized. The compounds showed strong antiproliferative activity and selectivity towards malignant cell lines.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Guojun Hu, Ziyue Deng, Yanwei Wang, Dan Yuan, Yong Zhang, Yingming Yao
Summary: A series of rare-earth metal complexes were synthesized and used as efficient initiators for the polymerization of trimethylene carbonate (TMC) and (L)-lactide ((L)-LA).
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
Article
Chemistry, Inorganic & Nuclear
Van Ha Nguyen, John H. K. Yip
Summary: In this study, eight PtII-azulene complexes were synthesized to investigate the effect of metalation on the electronic structures, spectroscopy, and luminescence of organic chromophores. The results showed that the attachment of Pt substituents to azulene affected the HOMOs, LUMOs, and luminescence properties. The study provides insights into the role of metalation in modifying the properties of organic chromophores.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
Article
Chemistry, Inorganic & Nuclear
Moon Kedia, Virender Singh, Bhaskaran Shankar, Malaichamy Sathiyendiran
Summary: This study synthesized two types of neutral binuclear metallocycles using a one-pot solvothermal method and characterized their structures. The analysis revealed that these complexes adopt a binuclear heteroleptic cyclic architecture and belong to phosphine oxide donor (P=O)-based supramolecular coordination cyclic complexes.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
Article
Chemistry, Inorganic & Nuclear
Radhey S. Srivastava
Summary: This study demonstrates the effectiveness of zero-valent elements as reductants for the deoxydehydration reaction of polyols catalyzed by ONO-pincer ligated molybdenum dioxo. The insolubility and easy separability of the reductants and their oxidized products during the reaction are emphasized. Additionally, the choice of ligand has an impact on the catalytic performance of the reaction.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
Article
Chemistry, Inorganic & Nuclear
Hao Zhou, Yajun Sun, Li Deng, Weiran Yang, Yuehui Li
Summary: Efficient Ru-catalyzed hydrogenation of aldehydes was achieved using carbazole-derived phosphine ligands, with the crucial role of N-H moiety in promoting the catalytic reaction. The method was successfully applied in the Co/Ru-catalyzed hydroformylation process, resulting in the production of long-chain alcohols with excellent yields.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
Article
Chemistry, Inorganic & Nuclear
Theodor Danescu, Alexandru Lupan, Radu Silaghi-Dumitrescu, R. Bruce King
Summary: The structures and energies of complexes containing (Me2C2N2P)2Ru2(CO)n and (Me2C2N2P)2Fe2(CO)n have been studied. Low-energy structures are characterized by the presence of bridging diazaphospholyl rings, while higher-energy structures involve different ligand structures.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
Article
Chemistry, Inorganic & Nuclear
Savannah C. Kapper, Aamani Ponnekanti, Jonas Schaab, Tian-yi Li, Christine L. Chung, Gael Ung, Peter I. Djurovich, Mark E. Thompson
Summary: Organometallic iridium complexes with two cyclometalated ligands and one bis-oxazoline derived ancillary ligand were studied. These complexes have emission spanning across the visible and near-ultraviolet region, with moderate to high photoluminescence quantum yields. The (ppy)2Ir(BOX-CN) complexes were resolved into Delta- and Lambda-diastereomers based on solubility differences.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
Article
Chemistry, Inorganic & Nuclear
Zahra Karimi Sangari, Hossein Naeimi
Summary: In this research, a nanostructured CoCuFe2O4 catalyst was prepared using a brief and useful synthetic strategy. This catalyst was used for synthesizing 1,2,4,5-tetrasubstituted imidazole derivatives under ultrasonic irradiation. The approach offers advantages such as high efficiency, short reaction times, simplicity of the reaction medium, accelerated reaction rates, and easier separation and purification of products.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
Article
Chemistry, Inorganic & Nuclear
Rukhsana Gul, Wajid Munir, Ebraheem Abdu Musad Saleh, Shaukat Shujah, Muhammad Sirajuddin, Saira Tabassum, Khalil Ur Rehman, Dilfaraz Khan, Sameerah I. Al-Saeedi, Ehab A. Abdelrahman
Summary: Two new Schiff base ligands were synthesized and used to form copper, nickel, and cobalt complexes. The synthesized compounds were characterized and screened for various biological activities. The metal complexes showed better activities in antibacterial, antifungal, antidiabetic, and antioxidant assays.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
Review
Chemistry, Inorganic & Nuclear
Ahsan Nazir, Pengwei Huo, Ameena Tur Rasool
Summary: This review explores the potential of g-C3N4-based S-scheme heterojunctions in addressing environmental issues. It summarizes the mechanism and preparation techniques of S-scheme heterojunctions based on g-C3N4, and presents recent studies on their applications in pollutant removal, CO2 reduction, hydrogen production, and bacterial disinfection. The review concludes with an outlook on future challenges for g-C3N4-based S-scheme heterojunctions.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
Article
Chemistry, Inorganic & Nuclear
Francois Mazars, Koffi Senam Etse, Guillermo Zaragoza, Lionel Delaude
Summary: The activity of three Pd-PEPPSI catalyst precursors with N-heterocyclic carbene (NHC) ligands derived from caffeine and theophylline in Mizoroki-Heck reactions was tested. The results showed that the catalysts achieved high conversions and yields, especially in the presence of electron-withdrawing substituents.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
Article
Chemistry, Inorganic & Nuclear
Bo-Han Wu, Xue Zhou, Lin Liu, Zheng-Bo Han
Summary: Researching carbon dioxide removal from flue gas and natural gas is crucial. Metal-organic frameworks (MOFs) are commonly used in adsorption due to their high surface area, porosity, and chemical properties. An ultra-microporous MOF CPM-20(Co) with mixed ligand was synthesized using inexpensive ligands. The material exhibited high selectivities and low regenerative energy, making it a promising option for CO2 separation in industries.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
