Site-Selective Chemoenzymatic Modification on the Core Fucose of an Antibody Enhances Its Fcγ Receptor Affinity and ADCC Activity
出版年份 2021 全文链接
标题
Site-Selective Chemoenzymatic Modification on the Core Fucose of an Antibody Enhances Its Fcγ Receptor Affinity and ADCC Activity
作者
关键词
-
出版物
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume -, Issue -, Pages -
出版商
American Chemical Society (ACS)
发表日期
2021-05-12
DOI
10.1021/jacs.1c03174
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Structure and dynamics of an α-fucosidase reveal a mechanism for highly efficient IgG transfucosylation
- (2020) Erik H. Klontz et al. Nature Communications
- Antibody fucosylation lowers FcγRIIIa/CD16a affinity by limiting the conformations sampled by the N162-glycan
- (2018) Daniel J. Falconer et al. ACS Chemical Biology
- Site-selective chemoenzymatic glycoengineering of Fab and Fc glycans of a therapeutic antibody
- (2018) John P. Giddens et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Polymorphisms of immunoglobulin receptors and the effects on clinical outcome in cancer immunotherapy and other immune diseases: a general review
- (2017) Tomonori Kaifu et al. INTERNATIONAL IMMUNOLOGY
- Designer α1,6-Fucosidase Mutants Enable Direct Core Fucosylation of Intact N-Glycopeptides and N-Glycoproteins
- (2017) Chao Li et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Arabinosylation of recombinant human immunoglobulin-based protein therapeutics
- (2017) Patrick Hossler et al. mAbs
- Modulating IgG effector function by Fc glycan engineering
- (2017) Tiezheng Li et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- OpenMM 7: Rapid development of high performance algorithms for molecular dynamics
- (2017) Peter Eastman et al. PLoS Computational Biology
- Conformational effects of N-glycan core fucosylation of immunoglobulin G Fc region on its interaction with Fcγ receptor IIIa
- (2017) Yoshitake Sakae et al. Scientific Reports
- Glycosynthase Mutants of Endoglycosidase S2 Show Potent Transglycosylation Activity and Remarkably Relaxed Substrate Specificity for Antibody Glycosylation Remodeling
- (2016) Tiezheng Li et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- CHARMM36m: an improved force field for folded and intrinsically disordered proteins
- (2016) Jing Huang et al. NATURE METHODS
- Enhanced Conformational Sampling Using Replica Exchange with Concurrent Solute Scaling and Hamiltonian Biasing Realized in One Dimension
- (2015) Mingjun Yang et al. Journal of Chemical Theory and Computation
- Conformational Sampling of Oligosaccharides Using Hamiltonian Replica Exchange with Two-Dimensional Dihedral Biasing Potentials and the Weighted Histogram Analysis Method (WHAM)
- (2015) Mingjun Yang et al. Journal of Chemical Theory and Computation
- Analysis of in vitro ADCC and clinical response to trastuzumab: possible relevance of FcγRIIIA/FcγRIIA gene polymorphisms and HER-2 expression levels on breast cancer cell lines
- (2015) Silvia Boero et al. Journal of Translational Medicine
- Fc-Gamma receptor polymorphism and gene expression of peripheral blood mononuclear cells in patients with HER2-positive metastatic breast cancer receiving single-agent trastuzumab
- (2015) Chikako Shimizu et al. Breast Cancer
- Development of a robust reporter-based ADCC assay with frozen, thaw-and-use cells to measure Fc effector function of therapeutic antibodies
- (2014) Zhijie Jey Cheng et al. JOURNAL OF IMMUNOLOGICAL METHODS
- Trisulfide Modification Impacts the Reduction Step in Antibody–Drug Conjugation Process
- (2013) Katherine Cumnock et al. BIOCONJUGATE CHEMISTRY
- A prominent lack of IgG1-Fc fucosylation of platelet alloantibodies in pregnancy
- (2013) R. Kapur et al. BLOOD
- Development of orally active inhibitors of protein and cellular fucosylation
- (2013) N. M. Okeley et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Automation of the CHARMM General Force Field (CGenFF) II: Assignment of Bonded Parameters and Partial Atomic Charges
- (2012) K. Vanommeslaeghe et al. Journal of Chemical Information and Modeling
- Automation of the CHARMM General Force Field (CGenFF) I: Bond Perception and Atom Typing
- (2012) K. Vanommeslaeghe et al. Journal of Chemical Information and Modeling
- Optimization of the Additive CHARMM All-Atom Protein Force Field Targeting Improved Sampling of the Backbone ϕ, ψ and Side-Chain χ1 and χ2 Dihedral Angles
- (2012) Robert B. Best et al. Journal of Chemical Theory and Computation
- Chemoenzymatic Glycoengineering of Intact IgG Antibodies for Gain of Functions
- (2012) Wei Huang et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- dbOGAP - An Integrated Bioinformatics Resource for Protein O-GlcNAcylation
- (2011) Jinlian Wang et al. BMC BIOINFORMATICS
- Structural basis for improved efficacy of therapeutic antibodies on defucosylation of their Fc glycans
- (2011) Tsunehiro Mizushima et al. GENES TO CELLS
- CHARMM Additive All-Atom Force Field for Carbohydrate Derivatives and Its Utility in Polysaccharide and Carbohydrate–Protein Modeling
- (2011) Olgun Guvench et al. Journal of Chemical Theory and Computation
- Enhanced potency of a fucose-free monoclonal antibody being developed as an Ebola virus immunoprotectant
- (2011) L. Zeitlin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Unique carbohydrate-carbohydrate interactions are required for high affinity binding between Fc RIII and antibodies lacking core fucose
- (2011) C. Ferrara et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- From structural to functional glycomics: core substitutions as molecular switches for shape and lectin affinity of N-glycans
- (2009) Sabine André et al. BIOLOGICAL CHEMISTRY
- CHARMM-GUI: A web-based graphical user interface for CHARMM
- (2008) Sunhwan Jo et al. JOURNAL OF COMPUTATIONAL CHEMISTRY
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