Article
Biochemistry & Molecular Biology
Giuliano Cutolo, Blanka Didak, Josip Tomas, Benoit Roubinet, Pierre Lafite, Reine Nehm, Marie Schuler, Ludovic Landemarre, Arnaud Tatibouet
Summary: A convenient 'one-pot' synthesis strategy for neoglycoproteins (NGP) was developed using myrosinaseglucosinolate couple, allowing the generation of multivalent glycoproteins without the use of harmful chemical reagents. Lectin binding screening showed that the NGPs synthesized exhibited similar or better affinities towards mannose-specific lectins compared to commercial approaches.
CARBOHYDRATE RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Rahul Rimal, Prachi Desai, Rasika Daware, Aisa Hosseinnejad, Jai Prakash, Twan Lammers, Smriti Singh
Summary: The tumor microenvironment, specifically cancer-associated fibroblasts (CAF), plays a critical role in tumor progression and drug resistance. This review presents imaging techniques for visualizing CAF and CAF-induced fibrosis, as well as compounds known to modulate CAF activity. Additionally, CAF-targeted therapies and CAF-modulating nanocarriers are discussed, along with the challenges and prospects for these treatments.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Chemistry, Multidisciplinary
Viktoria Heine, Tom Kremers, Nora Menzel, Uwe Schnakenberg, Lothar Elling
Summary: The study presents a novel electrochemical impedance spectroscopy sensor for real-time monitoring of bacterial fucosyltransferase binding kinetics. By immobilizing a multivalent neoglycoprotein on the sensor, the researchers were able to detect glycosyltransferase activities and protein-glycan interactions, which could be valuable for detecting pathogenic bacteria and cancer cells in future biomedical applications.
Article
Chemistry, Multidisciplinary
David Goyard, Benoit Roubinet, Federica Vena, Ludovic Landemarre, Olivier Renaudet
Summary: Click chemistry allows for the creation of a diverse range of multivalent glycoconjugates to study carbohydrate-protein interactions and discover high affinity ligands. The study shows that multivalent and multispecific neoGPs have the potential to effectively interact with specific lectins and combat resistant pathogens.
Article
Biochemistry & Molecular Biology
Libo Zhang, Hai Yu, Yuanyuan Bai, Bijoyananda Mishra, Xiaoxiao Yang, Jing Wang, Evan B. Yu, Riyao Li, Xi Chen
Summary: Carbohydrate-protein conjugates have diverse applications, from vaccines to high-throughput assays. A process combining chemoenzymatic synthesis, squarate linker conjugation, and neoglycoprotein immobilization on fluorescent magnetic beads was developed for a suspension multiplex array platform. This platform allowed for analysis of glycan and GBP interactions, providing useful insights into human galectins' multivalent glycan-binding properties.
Article
Engineering, Biomedical
Xue Zhou, Ning Yan, Erik J. Cornel, Haidong Cai, Shaobo Xue, Hao Xi, Zhen Fan, Shisheng He, Jianzhong Du
Summary: This bone-targeting polymer vesicle offers a new platform for the real-time diagnosis and therapy of malignant bone tumors, showing excellent imaging capability and high drug delivery efficiency. The vesicle can be self-assembled in water without the need for a cosolvent, and effectively reduces tumor size while inducing tumor cell necrosis and apoptosis.
Article
Environmental Sciences
M. Dara, M. G. Parisi, C. La Corte, G. Benenati, D. Parrinello, D. Piazzese, M. Cammarata
Summary: We report the mucus bacterial agglutination response of Sabella spallanzanii after exposure to inorganic arsenic (As). High concentrations of As inhibit pathogen recognition, but the response to As concentrations remains similar across seasons. This suggests that Sabella spallanzanii may adapt to high As concentrations and it is related to predation defense.
MARINE POLLUTION BULLETIN
(2022)
Article
Multidisciplinary Sciences
Lixue Wang, Guosheng Wang, Wenjun Mao, Yundi Chen, Md. Mofizur Rahman, Chuandong Zhu, Peter M. Prisinzano, Bo Kong, Jing Wang, Luke P. Lee, Yuan Wan
Summary: Researchers have developed a bioinspired material called eFT-CNV, which can be used as a drug delivery vehicle. They have demonstrated that eFT-CNV can efficiently and selectively bind to target cells and achieve cytosolic drug delivery through membrane fusion. Compared to other similar drug delivery systems, eFT-CNV significantly improves the treatment efficacy of drugs targeting the cytosol. Researchers believe that this bioinspired eFT-CNV holds great promise as a tool in nanomedicine and precision medicine.
NATURE COMMUNICATIONS
(2023)
Review
Chemistry, Organic
Vinod Khatri, Badri Parshad, Ashok K. Prasad, Sumati Bhatia
Summary: In the past few decades, efforts have been made to synthesize optimized glycotripods for targeting trimeric glycoproteins. These glycoproteins have selective sugar binding pockets, and the optimized glycotripods serve as high affinity binders for drug delivery and drug candidates. This review discusses important design parameters such as the selection of tripodal base scaffold and the length and flexibility of the linker between the scaffold and sugar residue.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Philipp von Hundelshausen, Kanin Wichapong, Hans-Joachim Gabius, Kevin H. Mayo
Summary: The trafficking and local activity of leukocytes are essential for various physiological processes. Microenvironments are complex due to the multiple mediators from diverse cell types playing regulated roles. Chemokines and galectins represent important effector molecules involved in inflammatory processes and have the capacity to form various molecular interactions in response to inflammation.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Chemistry, Multidisciplinary
Behnaz Lahooti, Racheal G. Akwii, Fatema Tuz Zahra, Md Sanaullah Sajib, Margarita Lamprou, Ahmed Alobaida, Michail S. Lionakis, George Mattheolabakis, Constantinos M. Mikelis
Summary: The review focuses on the characteristics and regulation of vascular permeability in tumor microenvironment, especially the impact of endothelial cells. It discusses the challenges and approaches of targeting vascular permeability for clinical translation, the effects of immune cells on the tumor vessels and nanomedicine delivery, and desirable nanoparticle design approaches.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Biophysics
Parimala Devi Ganthala, Sateesh Alavala, Naveen Chella, Sai Balaji Andugulapati, Nagendra Babu Bathini, Ramakrishna Sistla
Summary: Erlotinib-based EGFR targeted therapy has shown significant clinical improvement against non-small cell lung cancer. However, the development of drug resistance limits its effectiveness. In this study, the combination of Erlotinib and Quercetin was found to be more synergistic against certain lung cancer cells compared to other natural products. By preparing drug-loaded nanoparticles, the encapsulation efficiency and release performance of the drugs were improved. The nanoparticles could reduce the expression of drug-resistant proteins, increase drug uptake, and induce apoptosis in drug-resistant cells. In vivo experiments also showed increased uptake of nanoparticles in lung tissue and decreased expression of cancer-related genes.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Wen-Fang Song, Diwei Zheng, Si-Min Zeng, Xuan Zeng, Xian-Zheng Zhang
Summary: The special bacteria-enriched tumor environment can be utilized as a target for drug delivery, leading to an efficient cancer treatment strategy.
Article
Chemistry, Multidisciplinary
Homan Kang, Md Shamim, Xiaoran Yin, Eeswar Adluru, Takeshi Fukuda, Shinya Yokomizo, Hyejin Chang, Seung Hun Park, Yanan Cui, Austin J. Moy, Satoshi Kashiwagi, Maged Henary, Hak Soo Choi
Summary: The strategy of structure-inherent tumor targeting with cyanine-based fluorophores has gained attention due to its targetability of tumor microenvironments without the need for additional targeting ligands. This study demonstrates that heptamethine-cyanine-based fluorophores not only possess targetability but also provide second near-infrared spectral window imaging capabilities. The new mechanism of structure-inherent tumor targeting suggests that immune cells derived from bone marrow or residing in tissues/tumors can be principal targets for cancer detection.
ADVANCED MATERIALS
(2022)
Review
Chemistry, Multidisciplinary
Xinyuan Shen, Chaojie Zhu, Qing Wu, Jiaqi Shi, Wei Wu, Xiao Zhao, Jie Sun, Hongjun Li, Zhen Gu
Summary: This review explores the rational design of nanomodulators to target tumor-resident immunosuppressive cells and provides an overview of the basic functions and therapeutic strategies for each cell type. Challenges and future research perspectives are also discussed.
Article
Biochemistry & Molecular Biology
Katarina Kopcova, Ludmila Blascakova, Tibor Kozar, Daniel Jancura, Marian Fabian
Article
Biophysics
Katarina Siposova, Erik Sedlak, Tibor Kozar, Michal Nemergut, Andrey Musatov
COLLOIDS AND SURFACES B-BIOINTERFACES
(2019)
Article
Biochemistry & Molecular Biology
Katarina Siposova, Tibor Kozar, Veronika Huntosova, Silvia Tomkova, Andrey Musatov
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
(2019)
Article
Oncology
Katarina Stroffekova, Silvia Tomkova, Veronika Huntosova, Tibor Kozar
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2019)
Article
Multidisciplinary Sciences
Martina Petrencakova, Frantisek Filandr, Andrej Hovan, Ghazaleh Yassaghi, Petr Man, Tibor Kozar, Marc-Simon Schwer, Daniel Jancura, Andreas Pluckthun, Petr Novak, Pavol Miskovsky, Gregor Bano, Erik Sedlak
SCIENTIFIC REPORTS
(2020)
Article
Biochemistry & Molecular Biology
Martina Petrencakova, Rastislav Varhac, Tibor Kozar, Michal Nemergut, Daniel Jancura, Marc-Simon Schwer, Erik Sedlak
BIOPHYSICAL CHEMISTRY
(2020)
Biographical-Item
Biochemistry & Molecular Biology
Hans-Christian Siebert, Tibor Kozar, Athanasios K. Petridis
GLYCOCONJUGATE JOURNAL
(2020)
Article
Biophysics
Katarina Siposova, Tibor Kozar, Michaela Stupakova, Andrey Musatov
Summary: The study found that certain detergents (such as DDM) and selected phospholipids are not always interchangeable in their use to investigate the effect of amphiphilic compounds on the behavior of amyloid-prone proteins.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Review
Cell Biology
Erik Sedlak, Tibor Kozar, Andrey Musatov
Article
Biochemistry & Molecular Biology
Natasa Tomaskova, Petr Novak, Tibor Kozar, Martina Petrencakova, Daniel Jancura, Ghazaleh Yassaghi, Petr Man, Erik Sedlak
Summary: Cytochrome c plays a critical role in apoptosis, and incubation with hydrogen peroxide can lead to its inactivation and protein modification, while early oxidation of amino acids triggers accelerated destruction of cytochrome c.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Medicinal
Thomas Eckert, Mahena Jahrling-Butkus, Helen Louton, Monika Burg-Roderfeld, Ruiyan Zhang, Ning Zhang, Karsten Hesse, Athanasios K. Petridis, Tibor Kozar, Juergen Steinmeyer, Roland Schauer, Peter Engelhard, Anna Kozarova, John W. Hudson, Hans-Christian Siebert
Summary: The study investigated the potential therapeutic effects of collagen hydrolysates, sulfated glucosamine, and a special fatty acid enriched dog-food in early osteoarthritis in 52 dogs, suggesting they may act as effective nutraceuticals. Biophysical, biochemical, cell biological, and molecular modeling methods supported these substances, with a focus on intermolecular interactions and key proteins involved in cartilage health and immunity. The beneficial effects of these components, especially collagen hydrolysates and sulfated glycans, on biochemical and physiological processes in human and veterinary medicine were discussed.
Article
Spectroscopy
Zuzana Jurasekova, Annamaria Jutkova, Tibor Kozar, Jana Stanicova
Summary: Pesticide use has positive effects on agricultural production globally but may have negative impacts on organisms and human health. Preliminary studies, continuous monitoring, and the use of Raman spectroscopy for rapid and selective pollutant detection are essential.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Biochemistry & Molecular Biology
Erik Sedlak, Tibor Kozar, Rastislav Varhac, Andrej Musatov, Natasa Tomaskova
Summary: The specific effects of anions on the structure, thermal stability, and peroxidase activity of cytochrome c in native and alkaline states were studied. It was found that the alkaline state of cytochrome c showed lower stability and different acid-base isomerization properties compared to the native state. Additionally, the peroxidase activity of cytochrome c was influenced by the salt present in the solution, with the alkaline state lacking peroxidase activity regardless of the anion type.
BIOCHEMISTRY-MOSCOW
(2021)
Article
Chemistry, Multidisciplinary
Ruiyan Zhang, Ning Zhang, Marzieh Mohri, Lisha Wu, Thomas Eckert, Vadim B. Krylov, Andrea Antosova, Slavomira Ponikova, Zuzana Bednarikova, Philipp Markart, Andreas Guenther, Bengt Norden, Martin Billeter, Roland Schauer, Axel J. Scheidig, Bhisma N. Ratha, Anirban Bhunia, Karsten Hesse, Mushira Abdelaziz Enani, Juergen Steinmeyer, Athanasios K. Petridis, Tibor Kozar, Zuzana Gazova, Nikolay E. Nifantiev, Hans-Christian Siebert
Proceedings Paper
Physics, Mathematical
Jozef Ulicny, Tibor Kozar
MATHEMATICAL MODELING AND COMPUTATIONAL PHYSICS 2017 (MMCP 2017)
(2018)