Temporal increase in thymocyte negative selection parallels enhanced thymic SIRPα+DC function

Central tolerance spares the private high-avidity CD4+T-cell repertoire specific for an islet antigen in NOD mice

(2015) Laurent Serre et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The T Cell Repertoire–Diversifying Enzyme TSSP Contributes to Thymic Selection of Diabetogenic CD4 T Cell Specificities Reactive to ChgA and IAPP Autoantigens

(2015) Christophe Viret et al.   JOURNAL OF IMMUNOLOGY

 -Cell-Specific IL-2 Therapy Increases Islet Foxp3+Treg and Suppresses Type 1 Diabetes in NOD Mice

(2013) M. C. Johnson et al.   DIABETES

Thymic Development of Autoreactive T Cells in NOD Mice Is Regulated in an Age-Dependent Manner

(2013) Q. He et al.   JOURNAL OF IMMUNOLOGY

Plasmacytoid Dendritic Cells Transport Peripheral Antigens to the Thymus to Promote Central Tolerance

(2012) Husein Hadeiba et al.   IMMUNITY

Dendritic Cell-Specific Ablation of the Protein Tyrosine Phosphatase Shp1 Promotes Th1 Cell Differentiation and Induces Autoimmunity

(2012) T. Kaneko et al.   JOURNAL OF IMMUNOLOGY

Aire regulates the transfer of antigen from mTECs to dendritic cells for induction of thymic tolerance

(2011) F.-X. Hubert et al.   BLOOD

Thymic but not splenic CD8+ DCs can efficiently cross-prime T cells in the absence of licensing factors

(2011) Christiane Dresch et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Thymus-specific serine protease controls autoreactive CD4 T cell development and autoimmune diabetes in mice

(2011) Christophe Viret et al.   JOURNAL OF CLINICAL INVESTIGATION

Autonomous versus dendritic cell-dependent contributions of medullary thymic epithelial cells to central tolerance

(2011) Ludger Klein et al.   TRENDS IN IMMUNOLOGY

Thymus transplantation

(2010) M. Louise Markert et al.   CLINICAL IMMUNOLOGY

Functional Redundancy between Thymic CD8 + and Sirp + Conventional Dendritic Cells in Presentation of Blood-Derived Lysozyme by MHC Class II Proteins

(2010) D. F. Atibalentja et al.   JOURNAL OF IMMUNOLOGY

Distinct kinetics and dynamics of cross-presentation in liver sinusoidal endothelial cells compared to dendritic cells

(2009) Anna Schurich et al.   HEPATOLOGY

The thymic medulla: a unique microenvironment for intercellular self-antigen transfer

(2009) Christian Koble et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity

(2009) Caspar Ohnmacht et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Thymus-homing peripheral dendritic cells constitute two of the three major subsets of dendritic cells in the steady-state thymus

(2009) JiChu Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neonatal tolerance revisited: a perinatal window for Aire control of autoimmunity

(2009) Mireia Guerau-de-Arellano et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Autoimmunity during Thymectomy-Induced Lymphopenia: Role of Thymus Ablation and Initial Effector T Cell Activation Timing in Nonobese Diabetic Mice

(2009) M.-C. Gagnerault et al.   JOURNAL OF IMMUNOLOGY

Thymus-Blood Protein Interactions Are Highly Effective in Negative Selection and Regulatory T Cell Induction

(2009) D. F. Atibalentja et al.   JOURNAL OF IMMUNOLOGY

Crucial Contribution of Thymic Sirp + Conventional Dendritic Cells to Central Tolerance against Blood-Borne Antigens in a CCR2-Dependent Manner

(2009) T. Baba et al.   JOURNAL OF IMMUNOLOGY

Targeting proteins to distinct subcellular compartments reveals unique requirements for MHC class I and II presentation

(2009) R. Belizaire et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dendritic cells in the thymus contribute to T-regulatory cell induction

(2008) A. I. Proietto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA