Article
Cell Biology
Jana Petrusova, Jasper Manning, Dominik Filipp
Summary: This article discusses the potential role of the autoimmune regulator AIRE in male infertility. The authors found that Aire is exclusively expressed in Sertoli cells in the testes and propose an unknown mechanism by which testicular Aire regulates fertility. This challenges the current perception of Aire's function in the testes.
Article
Immunology
Gustaaf G. van Laar, Jan Piet van Hamburg, Sander W. Tas
Summary: Auto-immune regulator (AIRE) is a transcription factor mainly found in the thymus, but recent studies have identified its expression in other tissues as well. The exact function of these extrathymic AIRE expressing cells (eTACs) is still unknown, but they have the potential to modulate or inhibit immune responses, making them promising targets for restoring tolerance in autoimmune diseases or improving immuno-therapy in cancer settings.
AUTOIMMUNITY REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Jonathan Charaix, Alexia Borelli, Jeremy C. Santamaria, Lionel Chasson, Matthieu Giraud, Arnauld Serge, Magali Irla
Summary: This study reveals that Aire regulates the suppressive signature of recirculating T-reg in the thymus. Specifically, Aire controls the suppressive function of recirculating T-reg by regulating the expression of mTEC, which are responsible for restimulating T-reg.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Immunology
Nina Pilat, Jonathan Sprent
Summary: Inducing immune tolerance is crucial in transplantation medicine and autoimmune diseases. Increasing Treg numbers or function may provide a comprehensive solution for tolerance induction without the unwanted side effects of general immunosuppression. Current therapies lack specificity and the potential for successful long-term results, but Treg expansion has shown promise in animal models for effective tolerance induction.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Elif Soyak Aytekin, Deniz Cagdas
Summary: In the past 20 years, research on the autoimmune regulator (AIRE) protein has provided important insights into the molecular basis of autoimmunity. This review focuses on the role of AIRE in immune tolerance and the characteristics of autoimmune diseases caused by AIRE mutations. A better understanding of AIRE deficiency may contribute to the development of new diagnostic and treatment strategies for autoimmune diseases. Unfortunately, there is currently no curative therapy available for these diseases.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2023)
Review
Immunology
Veronika Niederlova, Oksana Tsyklauri, Tereza Chadimova, Ondrej Stepanek
Summary: The article revisits the concept of CD8(+) regulatory T cells by evaluating different subsets with proposed regulatory capacity, to determine their potential as bona fide Tregs.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Jason A. Carter, Leonie Stroemich, Matthew Peacey, Sarah R. Chapin, Lars Velten, Lars M. Steinmetz, Benedikt Brors, Sheena Pinto, Hannah Meyer
Summary: This study reveals the transcriptomic diversity of mTECs in the thymus and establishes a web portal for querying their transcriptome, which may aid in identifying the drivers of autoimmune diseases.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Daniel A. Michelson, Christophe Benoist, Diane Mathis
Summary: Medullary thymic epithelial cells (mTECs) are crucial for T cell central tolerance. In addition to the transcription factor Aire, we found that mTECs express the inhibitory receptor CTLA-4. CTLA-4(+) mTECs have a distinct gene signature associated with antigen presentation and interferon-gamma signaling, complementing the role of Aire.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Pharmacology & Pharmacy
Yang Yang, Pere Santamaria
Summary: In the past two decades, research on nanoparticle/microparticle-based compounds for treating autoimmune diseases has experienced explosive growth. Compounds have been evaluated using a variety of materials with different shapes, sizes, surface chemistries, and structures, incorporating various active pharmaceutical ingredients. These compounds can be categorized into four groups based on their intended mechanisms of action.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Review
Immunology
Naomi Benne, Danielle ter Braake, Arie Jan Stoppelenburg, Femke Broere
Summary: This article discusses the strategy of using nanoparticles to deliver antigens and restore immune tolerance. It highlights potential cell targets and application methods for nanoparticles, as well as how nanoparticles carrying immunomodulators can activate tolerance in other antigen-presenting cell types. It also emphasizes the importance of considering relevant factors when translating animal studies to clinical applications.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Erin Strachan, Xavier Clemente-Casares, Sue Tsai
Summary: Maternal influences on the immune health and development of an infant begin in utero and continue after birth, shaping and educating the child's immune system. Two important provisions from the mother include early microbial colonizers and the transfer of antibodies. These provisions help educate the developing neonatal immune system, connecting with the microbiota and influencing disease development.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Ranjeny Thomas, Jose M. Carballido, Johnna D. Wesley, Simi T. Ahmed
Summary: Antigen-specific immunotherapy shows promise for treating type 1 diabetes, but faces obstacles in clinical translation. The key to overcoming these challenges lies in collaboration and cooperation among various stakeholders.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Jeffrey A. Bluestone, Brent S. McKenzie, Joshua Beilke, Fred Ramsdell
Summary: Regulatory T (Treg) cells play a crucial role in maintaining peripheral tolerance and preventing various immune-related diseases. They are able to develop in both the thymus and peripheral tissues through the expression of a transcription factor called FOXP3. Treg cells exert their tolerogenic effects by using multiple mechanisms, such as producing inhibitory cytokines, suppressing T effector cells, and modulating antigen-presenting cell function. Recently, there has been a focus on genetically engineering Treg cells to enhance their therapeutic potential, leading to ongoing clinical trials. This review highlights the advancements and challenges in harnessing Treg cells as a new approach for treating diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Lakshmipriya Perincherry, Lukasz Stepien, Soniya Eppurathu Vasudevan
Summary: Plants utilize a variety of defense mechanisms when facing stress, with continuous activation of defense pathways potentially leading to abnormal phenotypes. Self-immunity can cause tissue damage, but the possibility of engineered protective autoimmunity requires further investigation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Multidisciplinary
Sean T. Carey, Christopher Bridgeman, Christopher M. Jewell
Summary: Autoimmunity and allergies are widespread diseases with current approaches unable to differentiate between healthy and disease-causing cells. New immunotherapies offer potential cures without immunosuppressive side effects, but translation to patients remains challenging. Biomaterials can maximize tolerance mechanisms through unique capabilities, although their clinical development is still in early stages. This review provides insights into recent advances and the current state of antigen-specific tolerance technologies.
Article
Immunology
Marianne M. Martinic, Irina Caminschi, Meredith O'Keeffe, Therese C. Thinnes, Raelene Grumont, Steve Gerondakis, Dianne B. McKay, David Nemazee, Amanda L. Gavin
JOURNAL OF IMMUNOLOGY
(2017)
Review
Immunology
Marianne M. Martinic, Matthias G. von Herrath
IMMUNOLOGICAL REVIEWS
(2008)
Article
Immunology
Marianne M. Martinic, Christoph Huber, Ken Coppieters, Janine E. Oldham, Amanda L. Gavin, Matthias G. von Herrath
JOURNAL OF AUTOIMMUNITY
(2010)
Article
Multidisciplinary Sciences
Ken Coppieters, Marianne M. Martinic, William B. Kiosses, Natalie Amirian, Matthias von Herrath
Review
Immunology
Marianne M. Martinic, Matthias G. von Herrath
TRENDS IN IMMUNOLOGY
(2008)
Article
Biochemistry & Molecular Biology
Laetitia Pouzol, Nadege Baumlin, Anna Sassi, Melanie Tunis, Julia Marrie, Enrico Vezzali, Herve Farine, Ulrich Mentzel, Marianne M. Martinic
Summary: Current strategies for treating demyelinating diseases like multiple sclerosis focus on anti-inflammatory or immunomodulatory drugs. The CXCR7 receptor antagonist ACT-1004-1239 shows promise in reducing disease severity, decreasing neuroinflammation, and promoting myelin repair in experimental models.
Article
Rheumatology
Daniel S. Strasser, Sylvie Froidevaux, Virginie Sippel, Estelle Gerossier, Ursula Grieder, Gabin M. Pierlot, Andrea Kieninger-Graefitsch, Enrico Vezzali, Anna K. Stalder, Berengere Renault, Jesper Ryge, Aaron Hart, Ulrich Mentzel, Peter M. A. Groenen, Marcel P. Keller, Marten Trendelenburg, Marianne M. Martinic, Mark J. Murphy
Article
Endocrinology & Metabolism
Marianne M. Martinic, Amy E. Juedes, Damien Bresson, Dirk Homann, Kresten Skak, Christoph Huber, Eleanor Ling, Mette Ejrnaes, Tom Wolfe, Lisa Togher, Urs Christen, Matthias G. von Herrath
Article
Immunology
Mette Ejrnaes, Christophe M. Filippi, Marianne M. Martinic, Eleanor M. Ling, Lisa M. Togher, Shane Crotty, Matthias G. von Herrath
JOURNAL OF EXPERIMENTAL MEDICINE
(2006)
Article
Multidisciplinary Sciences
Marianne M. Martinic, Maries F. van den Broek, Thomas Ruelicke, Christoph Huber, Bernhard Odermatt, Walter Reith, Edit Horvath, Raphael Zellweger, Katja Fink, Mike Recher, Bruno Eschli, Hans Hengartner, Rolf M. Zinkernagel
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2006)
Article
Immunology
Evelyne Jouvin-Marche, Valerie Attuil-Audenis, Catherine Aude-Garcia, Walid Rachidi, Mark Zabel, Valerie Podevin-Dimster, Carole Siret, Christoph Huber, Marianne Martinic, Jacqueline Riondel, Christian L. Villiers, Alain Favier, Philippe Naquet, Jean-Yves Cesbron, Patrice N. Marche
JOURNAL OF IMMUNOLOGY
(2006)
Article
Hematology
ME Blais, G Gérard, MM Martinic, G Roy-Proulx, RM Zinkernagel, C Perreault
Article
Immunology
MM Martinic, B Rocha, KD McCoy, H Hengartner, RM Zinkernagel
EUROPEAN JOURNAL OF IMMUNOLOGY
(2004)
Article
Immunology
HC Probst, K Tschannen, A Gallimore, M Martinic, M Basler, T Dumrese, E Jones, MF van den Broek
JOURNAL OF IMMUNOLOGY
(2003)