A selective NLRP3 inflammasome inhibitor attenuates behavioral deficits and neuroinflammation in a mouse model of Parkinson's disease

Activation of NLRP3 in microglia exacerbates diesel exhaust particles-induced impairment in learning and memory in mice

(2020) Xiaobo Li et al.   ENVIRONMENT INTERNATIONAL

Therapeutic modulation of inflammasome pathways

(2020) Dhruv Chauhan et al.   IMMUNOLOGICAL REVIEWS

Microglia Gone Awry: Linking Immunometabolism to Neurodegeneration

(2020) Ruqayya Afridi et al.   Frontiers in Cellular Neuroscience

MCC950, a selective NLPR3 inflammasome inhibitor, improves neurologic function and survival after cardiac arrest and resuscitation

(2020) Maorong Jiang et al.   Journal of Neuroinflammation

Role of inflammasomes in multiple sclerosis and their potential as therapeutic targets

(2020) Vaidya Govindarajan et al.   Journal of Neuroinflammation

Tracking Cortical Changes Throughout Cognitive Decline in Parkinson's Disease

(2020) Massimo Filippi et al.   MOVEMENT DISORDERS

Mechanisms of NLRP3 Inflammasome Activation: Its Role in the Treatment of Alzheimer’s Disease

(2020) Yidan Zhang et al.   NEUROCHEMICAL RESEARCH

Protection of MCC950 against Alzheimer's disease via inhibiting neuronal pyroptosis in SAMP8 mice

(2020) Jie Li et al.   EXPERIMENTAL BRAIN RESEARCH

Inflammation, Infectious Triggers, and Parkinson's Disease

(2019) Elisa Caggiu et al.   Frontiers in Neurology

LRRK2 modifies α-syn pathology and spread in mouse models and human neurons

(2019) Gregor Bieri et al.   ACTA NEUROPATHOLOGICA

Drug treatment strategies for depression in Parkinson disease

(2019) Melody Ryan et al.   EXPERT OPINION ON PHARMACOTHERAPY

MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition

(2019) Rebecca C. Coll et al.   Nature Chemical Biology

MCC950 closes the active conformation of NLRP3 to an inactive state

(2019) Ana Tapia-Abellán et al.   Nature Chemical Biology

Introduction and classical environmental risk factors for Parkinson

(2019) C. Tranchant   REVUE NEUROLOGIQUE

Hippocampal damage and white matter lesions contribute to cognitive impairment in MPTP-lesioned mice with chronic cerebral hypoperfusion

(2019) Yuyuan Gao et al.   BEHAVIOURAL BRAIN RESEARCH

MPTP-driven NLRP3 inflammasome activation in microglia plays a central role in dopaminergic neurodegeneration

(2018) Eunju Lee et al.   CELL DEATH AND DIFFERENTIATION

Hoehn and Yahr staging of Parkinson rsquo s disease in relation to neuropsychological measures

(2018) Edward Justin Modestino   Frontiers in Bioscience-Landmark

Parkin deficiency modulates NLRP3 inflammasome activation by attenuating an A20-dependent negative feedback loop

(2018) François Mouton-Liger et al.   GLIA

Inhibition of the hepatic Nlrp3 protects dopaminergic neurons via attenuating systemic inflammation in a MPTP/p mouse model of Parkinson’s disease

(2018) Chen Qiao et al.   Journal of Neuroinflammation

MCC950, the Selective Inhibitor of Nucleotide Oligomerization Domain-Like Receptor Protein-3 Inflammasome, Protects Mice against Traumatic Brain Injury

(2018) Saifudeen Ismael et al.   JOURNAL OF NEUROTRAUMA

Role of Inflammasomes in Neuroimmune and Neurodegenerative Diseases: A Systematic Review

(2018) Yue Lang et al.   MEDIATORS OF INFLAMMATION

Selective NLRP3 inflammasome inhibitor reduces neuroinflammation and improves long-term neurological outcomes in a murine model of traumatic brain injury

(2018) Xin Xu et al.   NEUROBIOLOGY OF DISEASE

OUP accepted manuscript

(2018)   BRAIN

The inflammasomes, immune guardians at defence barriers

(2018) Pablo Palazon-Riquelme et al.   IMMUNOLOGY

Rapamycin combined with MCC950 to treat multiple sclerosis in experimental autoimmune encephalomyelitis

(2018) Ling Xu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice

(2018) Richard Gordon et al.   Science Translational Medicine

Cognitive changes in prodromal Parkinson's disease: A review

(2017) Sophie Fengler et al.   MOVEMENT DISORDERS

Microglial phenotypes in Parkinson’s disease and animal models of the disease

(2017) Valerie Joers et al.   PROGRESS IN NEUROBIOLOGY

Pharmacological inhibition of the NLRP3 inflammasome as a potential target for multiple sclerosis induced central neuropathic pain

(2017) Nemat Khan et al.   INFLAMMOPHARMACOLOGY

Parkinson disease

(2017) Werner Poewe et al.   Nature Reviews Disease Primers

The epidemiology of Parkinson's disease: risk factors and prevention

(2016) Alberto Ascherio et al.   LANCET NEUROLOGY

Dopamine Controls Systemic Inflammation through Inhibition of NLRP3 Inflammasome

(2015) Yiqing Yan et al.   CELL

Brain region-dependent differential expression of alpha-synuclein

(2015) Katsutoshi Taguchi et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Parkinson's disease

(2015) Lorraine V Kalia et al.   LANCET