Pharmacological inhibition of the NLRP3 inflammasome as a potential target for multiple sclerosis induced central neuropathic pain

Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammation

(2017) Weiqiang Chen et al.   Nature Microbiology

Pain in autoimmune disorders

(2016) Katherine A. Mifflin et al.   JOURNAL OF NEUROSCIENCE RESEARCH

MicroRNA-7 targets Nod-like receptor protein 3 inflammasome to modulate neuroinflammation in the pathogenesis of Parkinson’s disease

(2016) Yan Zhou et al.   Molecular Neurodegeneration

Cortical relapses in multiple sclerosis

(2016) Marco Puthenparampil et al.   Multiple Sclerosis Journal

Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activation

(2016) Peter M. Grace et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cortical relapses in multiple sclerosis

(2016) Marco Puthenparampil et al.   Multiple Sclerosis Journal

NLRP3 inflammasome is associated with the response to IFN-β in patients with multiple sclerosis

(2015) Sunny Malhotra et al.   BRAIN

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

(2015) Rebecca C Coll et al.   NATURE MEDICINE

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

Neuropathic Pain Phenotype Does Not Involve the NLRP3 Inflammasome and Its End Product Interleukin-1β in the Mice Spared Nerve Injury Model

(2015) Verdad Curto-Reyes et al.   PLoS One

Chemical stimulation of the intracranial dura activates NALP3 inflammasome in trigeminal ganglia neurons

(2014) Lingzhi Chen et al.   BRAIN RESEARCH

Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes

(2014) Alvin Lu et al.   CELL

Doliroside A attenuates monosodium urate crystals-induced inflammation by targeting NLRP3 inflammasome

(2014) Han Wei et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cytosolic Double-Stranded RNA Activates the NLRP3 Inflammasome via MAVS-Induced Membrane Permeabilization and K+Efflux

(2014) Luigi Franchi et al.   JOURNAL OF IMMUNOLOGY

Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis

(2014) Lieselotte Vande Walle et al.   NATURE

Establishment and characterization of an optimized mouse model of multiple sclerosis-induced neuropathic pain using behavioral, pharmacologic, histologic and immunohistochemical methods

(2014) Nemat Khan et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

NLRP3 Inflammasome Is Activated in Fibromyalgia: The Effect of Coenzyme Q10

(2013) Mario D. Cordero et al.   ANTIOXIDANTS & REDOX SIGNALING

Cytokine profile in relapsing-remitting multiple sclerosis patients and the association between progression and activity of the disease

(2013) ANA PAULA KALLAUR et al.   Molecular Medicine Reports

Multiple sclerosis-induced neuropathic pain: pharmacological management and pathophysiological insights from rodent EAE models

(2013) Nemat Khan et al.   INFLAMMOPHARMACOLOGY

Pain and Multiple Sclerosis: Pathophysiology and Treatment

(2012) Claudio Solaro et al.   Current Neurology and Neuroscience Reports

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

NLRP3 inflammasome induces chemotactic immune cell migration to the CNS in experimental autoimmune encephalomyelitis

(2012) M. Inoue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Animal research: Reporting in vivo experiments: The ARRIVE guidelines

(2010) Carol Kilkenny et al.   BRITISH JOURNAL OF PHARMACOLOGY

NLRP3 Plays a Critical Role in the Development of Experimental Autoimmune Encephalomyelitis by Mediating Th1 and Th17 Responses

(2010) D. Gris et al.   JOURNAL OF IMMUNOLOGY

The Inflammasome Sensor, NLRP3, Regulates CNS Inflammation and Demyelination via Caspase-1 and Interleukin-18

(2010) S. Jha et al.   JOURNAL OF NEUROSCIENCE

Recommendations for the Pharmacological Management of Neuropathic Pain: An Overview and Literature Update

(2010) Robert H. Dworkin et al.   MAYO CLINIC PROCEEDINGS

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Multiple sclerosis

(2008) Alastair Compston et al.   LANCET

Pain associated with multiple sclerosis: Systematic review and proposed classification

(2007) Alec B. O’Connor et al.   PAIN