Structure-Based Discovery of Pyrimidine Aminobenzene Derivatives as Potent Oral Reversal Agents against P-gp- and BCRP-Mediated Multidrug Resistance

Medicinal chemistry strategies to discover P-glycoprotein inhibitors: An update

(2020) Jinyun Dong et al.   DRUG RESISTANCE UPDATES

Short-chain fatty acids exert opposite effects on the expression and function of p-glycoprotein and breast cancer resistance protein in rat intestine

(2020) Qiu-shi Xie et al.   ACTA PHARMACOLOGICA SINICA

One molecule two goals: A selective P-glycoprotein modulator increases drug transport across gastro-intestinal barrier and recovers doxorubicin toxicity in multidrug resistant cancer cells

(2020) Marialessandra Contino et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structure-guided probing of the leukotriene C4 binding site in human multidrug resistance protein 1 (MRP1; ABCC1)

(2019) Gwenaëlle Conseil et al.   FASEB JOURNAL

The multi-factorial nature of clinical multidrug resistance in cancer

(2019) Yehuda G. Assaraf et al.   DRUG RESISTANCE UPDATES

PSMP/MSMP promotes hepatic fibrosis through CCR2 and represents a novel therapeutic target

(2019) Shaoping She et al.   JOURNAL OF HEPATOLOGY

Understanding of human ATP binding cassette superfamily and novel multidrug resistance modulators to overcome MDR

(2018) Imran Shair Mohammad et al.   BIOMEDICINE & PHARMACOTHERAPY

Redundant angiogenic signaling and tumor drug resistance

(2018) Rajesh N. Gacche et al.   DRUG RESISTANCE UPDATES

Molecular structure of human P-glycoprotein in the ATP-bound, outward-facing conformation

(2018) Youngjin Kim et al.   SCIENCE

Overcoming ABC transporter-mediated multidrug resistance: The dual role of tyrosine kinase inhibitors as multitargeting agents

(2017) Giovanni Luca Beretta et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

9-Deazapurines as Broad-Spectrum Inhibitors of the ABC Transport Proteins P-Glycoprotein, Multidrug Resistance-Associated Protein 1, and Breast Cancer Resistance Protein

(2017) Katja Stefan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Toward a Better Understanding of the Complexity of Cancer Drug Resistance

(2016) Michael M. Gottesman et al.   Annual Review of Pharmacology and Toxicology

ABC transporters as mediators of drug resistance and contributors to cancer cell biology

(2016) Jamie I. Fletcher et al.   DRUG RESISTANCE UPDATES

ABCG2/BCRP: Specific and Nonspecific Modulators

(2016) Diana Peña-Solórzano et al.   MEDICINAL RESEARCH REVIEWS

Patient-reported outcomes in the evaluation of toxicity of anticancer treatments

(2016) Massimo Di Maio et al.   Nature Reviews Clinical Oncology

Design of inhibitors of BCRP/ABCG2

(2015) Kapil Juvale et al.   Future Medicinal Chemistry

Determining the optimal dose in the development of anticancer agents

(2014) Ron H. J. Mathijssen et al.   Nature Reviews Clinical Oncology

Three Decades of P-gp Inhibitors: Skimming Through Several Generations and Scaffolds

(2012) A. Palmeira et al.   CURRENT MEDICINAL CHEMISTRY

Tyrosine kinase inhibitors as modulators of ABC transporter-mediated drug resistance

(2012) Suneet Shukla et al.   DRUG RESISTANCE UPDATES

Amine Linked Flavonoid Dimers as Modulators for P-Glycoprotein-Based Multidrug Resistance: Structure–Activity Relationship and Mechanism of Modulation

(2012) Kin-Fai Chan et al.   JOURNAL OF MEDICINAL CHEMISTRY

ABC multidrug transporters: structure, function and role in chemoresistance

(2007) Frances J Sharom   PHARMACOGENOMICS