Differential role of sphingomyelin in influenza virus, rhinovirus and SARS-CoV-2 infection of Calu-3 cells

Improved molecular diagnosis of COVID-19 by the novel, highly sensitive and specific COVID-19-RdRp/Hel real-time reverse transcription-polymerase chain reaction assay validated in vitro and with clinical specimens

(2020) Jasper Fuk-Woo Chan et al.   JOURNAL OF CLINICAL MICROBIOLOGY

A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster

(2020) Jasper Fuk-Woo Chan et al.   LANCET

Proteomic and Metabolomic Characterization of COVID-19 Patient Sera

(2020) Bo Shen et al.   CELL

Depletion of Host and Viral Sphingomyelin Impairs Influenza Virus Infection

(2020) Amani Audi et al.   Frontiers in Microbiology

Omics-Driven Systems Interrogation of Metabolic Dysregulation in COVID-19 Pathogenesis

(2020) Jin-Wen Song et al.   Cell Metabolism

Comparative Transcriptomic Analysis of Rhinovirus and Influenza Virus Infection

(2020) Thrimendra Kaushika Dissanayake et al.   Frontiers in Microbiology

A broad-spectrum virus- and host-targeting peptide against respiratory viruses including influenza virus and SARS-CoV-2

(2020) Hanjun Zhao et al.   Nature Communications

Clinical and Virological Characteristics of Acute Sinusitis in Children

(2019) Gregory P DeMuri et al.   CLINICAL INFECTIOUS DISEASES

Characterization of the Lipidomic Profile of Human Coronavirus-Infected Cells: Implications for Lipid Metabolism Remodeling upon Coronavirus Replication

(2019) Bingpeng Yan et al.   Viruses-Basel

SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target

(2019) Shuofeng Yuan et al.   Nature Communications

Ceramide Suppresses Influenza A Virus Replication In Vitro

(2019) Nadia Soudani et al.   JOURNAL OF VIROLOGY

Respiratory virus infection among hospitalized adult patients with or without clinically apparent respiratory infection: a prospective cohort study

(2019) K.K.W. To et al.   CLINICAL MICROBIOLOGY AND INFECTION

Innate Immune Response to Influenza Virus at Single-Cell Resolution in Human Epithelial Cells Revealed Paracrine Induction of Interferon Lambda 1

(2019) Irene Ramos et al.   JOURNAL OF VIROLOGY

Virological and Immunological Outcomes of Coinfections

(2018) Naveen Kumar et al.   CLINICAL MICROBIOLOGY REVIEWS

Rhinovirus respiratory tract infection in hospitalized adult patients is associated with T H 2 response irrespective of asthma

(2018) Kelvin K.W. To et al.   JOURNAL OF INFECTION

Host lipidome analysis during rhinovirus replication in human bronchial epithelial cells identifies potential therapeutic targets

(2018) An Nguyen et al.   JOURNAL OF LIPID RESEARCH

MetaboAnalyst 4.0: towards more transparent and integrative metabolomics analysis

(2018) Jasmine Chong et al.   NUCLEIC ACIDS RESEARCH

The role of sphingolipid metabolism disruption on lipopolysaccharide-induced lung injury in mice

(2018) Renata Tiemi Okuro et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Prostaglandin E2-mediated impairment of innate immune response to A(H1N1)pdm09 infection in diet-induced obese mice could be restored by paracetamol

(2018) Anna J X Zhang et al.   JOURNAL OF INFECTIOUS DISEASES

Targeting host lipid flows: Exploring new antiviral and antibiotic strategies

(2018) Alberto Fernández-Oliva et al.   CELLULAR MICROBIOLOGY

Role of sphingomyelin in alphaherpesvirus entry

(2018) Gabrielle Pastenkos et al.   JOURNAL OF VIROLOGY

Unexpectedly Higher Morbidity and Mortality of Hospitalized Elderly Patients Associated with Rhinovirus Compared with Influenza Virus Respiratory Tract Infection

(2017) Ivan Hung et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

B Cell Activity Is Impaired in Human and Mouse Obesity and Is Responsive to an Essential Fatty Acid upon Murine Influenza Infection

(2017) Rasagna Kosaraju et al.   JOURNAL OF IMMUNOLOGY

Rhinovirus – From bench to bedside

(2017) Kelvin K.W. To et al.   JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION

Both Sphingomyelin and Cholesterol in the Host Cell Membrane Are Essential for Rubella Virus Entry

(2017) Noriyuki Otsuki et al.   JOURNAL OF VIROLOGY

PLA2G16 represents a switch between entry and clearance of Picornaviridae

(2017) Jacqueline Staring et al.   NATURE

Additional molecular testing of saliva specimens improves the detection of respiratory viruses

(2017) Kelvin KW To et al.   Emerging Microbes & Infections

Lipid metabolites as potential diagnostic and prognostic biomarkers for acute community acquired pneumonia

(2016) Kelvin K.W. To et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

Colon-derived uremic biomarkers induced by the acute toxicity of Kansui radix: A metabolomics study of rat plasma and intestinal contents by UPLC-QTOF-MS E

(2016) Zhou Yang et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Pulmonary and extrapulmonary complications of human rhinovirus infection in critically ill patients

(2016) Kelvin K.W. To et al.   JOURNAL OF CLINICAL VIROLOGY

Mycophenolic acid, an immunomodulator, has potent and broad-spectrum in vitro antiviral activity against pandemic, seasonal and avian influenza viruses affecting humans

(2016) Kelvin K. W. To et al.   JOURNAL OF GENERAL VIROLOGY

Human H7N9 virus induces a more pronounced pro-inflammatory cytokine but an attenuated interferon response in human bronchial epithelial cells when compared with an epidemiologically-linked chicken H7N9 virus

(2016) Kelvin K. W. To et al.   Virology Journal

Sphingolipids in viral infection

(2015) Jürgen Schneider-Schaulies et al.   BIOLOGICAL CHEMISTRY

UHPLC-LTQ-Orbitrap MS combined with spike-in method for plasma metabonomics analysis of acute myocardial ischemia rats and pretreatment effect of Danqi Tongmai tablet

(2015) Bingpeng Yan et al.   Molecular BioSystems

MS-DIAL: data-independent MS/MS deconvolution for comprehensive metabolome analysis

(2015) Hiroshi Tsugawa et al.   NATURE METHODS

Community-Acquired Pneumonia Requiring Hospitalization among U.S. Adults

(2015) Seema Jain et al.   NEW ENGLAND JOURNAL OF MEDICINE

Rhinovirus Uses a Phosphatidylinositol 4-Phosphate/Cholesterol Counter-Current for the Formation of Replication Compartments at the ER-Golgi Interface

(2014) Pascal S. Roulin et al.   Cell Host & Microbe

Variable influence on projection (VIP) for orthogonal projections to latent structures (OPLS)

(2014) Beatriz Galindo-Prieto et al.   JOURNAL OF CHEMOMETRICS

Lipidomics identifies a requirement for peroxisomal function during influenza virus replication

(2014) Lukas Bahati Tanner et al.   JOURNAL OF LIPID RESEARCH

H7N9 and Other Pathogenic Avian Influenza Viruses Elicit a Three-Pronged Transcriptomic Signature That Is Reminiscent of 1918 Influenza Virus and Is Associated with Lethal Outcome in Mice

(2014) J. Morrison et al.   JOURNAL OF VIROLOGY

Avian Influenza A H7N9 Virus Induces Severe Pneumonia in Mice without Prior Adaptation and Responds to a Combination of Zanamivir and COX-2 Inhibitor

(2014) Can Li et al.   PLoS One

Human Rhinovirus Induced Cytokine/Chemokine Responses in Human Airway Epithelial and Immune Cells

(2014) Devi Rajan et al.   PLoS One

A comprehensive collection of systems biology data characterizing the host response to viral infection

(2014) Brian D. Aevermann et al.   Scientific Data

Measurement of DNA Concentration as a Normalization Strategy for Metabolomic Data from Adherent Cell Lines

(2013) Leslie P. Silva et al.   ANALYTICAL CHEMISTRY

The Lipid Mediator Protectin D1 Inhibits Influenza Virus Replication and Improves Severe Influenza

(2013) Masayuki Morita et al.   CELL

Lipidomic Profiling of Influenza Infection Identifies Mediators that Induce and Resolve Inflammation

(2013) Vincent C. Tam et al.   CELL

LipidBlast in silico tandem mass spectrometry database for lipid identification

(2013) Tobias Kind et al.   NATURE METHODS

Liquid chromatography quadrupole time-of-flight mass spectrometry characterization of metabolites guided by the METLIN database

(2013) Zheng-Jiang Zhu et al.   Nature Protocols

Intact sphingomyelin biosynthetic pathway is essential for intracellular transport of influenza virus glycoproteins

(2013) F. G. Tafesse et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biological functions of sphingomyelins

(2013) J. Peter Slotte   PROGRESS IN LIPID RESEARCH

Role of Sphingomyelin Synthesis in Pulmonary Endothelial Cell Cytoskeletal Activation and Endotoxin-Induced Lung Injury

(2012) Fatima Anjum et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Ebolavirus Requires Acid Sphingomyelinase Activity and Plasma Membrane Sphingomyelin for Infection

(2012) M. E. Miller et al.   JOURNAL OF VIROLOGY

D225G mutation in hemagglutinin of pandemic influenza H1N1 (2009) virus enhances virulence in mice

(2011) Bojian Zheng et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Delayed Clearance of Viral Load and Marked Cytokine Activation in Severe Cases of Pandemic H1N1 2009 Influenza Virus Infection

(2010) Kelvin K. W. To et al.   CLINICAL INFECTIOUS DISEASES

Rhinoviruses delayed the circulation of the pandemic influenza A (H1N1) 2009 virus in France

(2010) J.S. Casalegno et al.   CLINICAL MICROBIOLOGY AND INFECTION

Sphingomyelin Activates Hepatitis C Virus RNA Polymerase in a Genotype-Specific Manner

(2010) L. Weng et al.   JOURNAL OF VIROLOGY

SARS coronavirus entry into host cells through a novel clathrin- and caveolae-independent endocytic pathway

(2008) Hongliang Wang et al.   CELL RESEARCH

Critical Role of Virion-Associated Cholesterol and Sphingolipid in Hepatitis C Virus Infection

(2008) H. Aizaki et al.   JOURNAL OF VIROLOGY