Salvianolic Acids for Injection alleviates cerebral ischemia/reperfusion injury by switching M1/M2 phenotypes and inhibiting NLRP3 inflammasome/pyroptosis axis in microglia in vivo and in vitro

Modulation of Microglia Polarization through Silencing of NF-κB p65 by Functionalized Curdlan Nanoparticle-Mediated RNAi

(2020) Tsogzolmaa Ganbold et al.   ACS Applied Materials & Interfaces

Transforming Growth Factor Beta-Activated Kinase 1–Dependent Microglial and Macrophage Responses Aggravate Long-Term Outcomes After Ischemic Stroke

(2020) Rongrong Wang et al.   STROKE

Sweroside Prevents Non-Alcoholic Steatohepatitis by Suppressing Activation of the NLRP3 Inflammasome

(2020) Gabsik Yang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Melatonin attenuates choroidal neovascularization by regulating macrophage/microglia polarization via inhibition of RhoA/ROCK signaling pathway

(2020) Yue Xu et al.   JOURNAL OF PINEAL RESEARCH

Microglia and macrophage metabolism in CNS injury and disease: The role of immunometabolism in neurodegeneration and neurotrauma

(2020) Nicholas A. Devanney et al.   EXPERIMENTAL NEUROLOGY

Kv1.3 channel blockade alleviates cerebral ischemia/reperfusion injury by reshaping M1/M2 phenotypes and compromising the activation of NLRP3 inflammasome in microglia

(2020) Dai-Chao Ma et al.   EXPERIMENTAL NEUROLOGY

Gasdermin D serves as a key executioner of pyroptosis in experimental cerebral ischemia and reperfusion model both in vivo and in vitro

(2019) Dongping Zhang et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Effects of Betaine on LPS-Stimulated Activation of Microglial M1/M2 Phenotypes by Suppressing TLR4/NF-κB Pathways in N9 Cells

(2019) Hui Shi et al.   MOLECULES

Salvianolic Acids: Potential Source of Natural Drugs for the Treatment of Fibrosis Disease and Cancer

(2019) Lunkun Ma et al.   Frontiers in Pharmacology

NLRP3 inflammasome in ischemic stroke: As possible therapeutic target

(2019) Masoumeh Alishahi et al.   International Journal of Stroke

Dual Functions of Microglia in Ischemic Stroke

(2019) Chuan Qin et al.   Neuroscience Bulletin

NLRP3 inflammasome as a potential treatment in ischemic stroke concomitant with diabetes

(2019) Pu Hong et al.   Journal of Neuroinflammation

Hispidulin exhibits neuroprotective activities against cerebral ischemia reperfusion injury through suppressing NLRP3-mediated pyroptosis

(2019) Pengpeng An et al.   LIFE SCIENCES

Salvianolic Acids for Injection Combined with Conventional Treatment for Patients with Acute Cerebral Infarction: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

(2019) Jian Lyu et al.   MEDICAL SCIENCE MONITOR

Sal B Alleviates Myocardial Ischemic Injury by Inhibiting TLR4 and the Priming Phase of NLRP3 Inflammasome

(2019) Yang Hu et al.   MOLECULES

Cysteinyl Leukotriene Receptor 2 is Involved in Inflammation and Neuronal Damage by Mediating Microglia M1/M2 Polarization through NF-κB Pathway

(2019) Rui Zhao et al.   NEUROSCIENCE

Experimental colitis reduces microglial cell activation in the mouse brain without affecting microglial cell numbers

(2019) Hoda M. Sroor et al.   Scientific Reports

Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer’s disease

(2018) Srikant Rangaraju et al.   Molecular Neurodegeneration

Mild focal hypothermia regulates the dynamic polarization of microglia after ischemic stroke in mice

(2018) Liqiang Liu et al.   NEUROLOGICAL RESEARCH

A quality marker study on salvianolic acids for injection

(2018) Wei Li et al.   PHYTOMEDICINE

Inhibition of NLRP3 Inflammasome Ameliorates Cerebral Ischemia-Reperfusion Injury in Diabetic Mice

(2018) Pu Hong et al.   NEURAL PLASTICITY

Bidirectional Microglia–Neuron Communication in Health and Disease

(2018) Zsuzsanna Szepesi et al.   Frontiers in Cellular Neuroscience

Post-stroke DHA Treatment Protects Against Acute Ischemic Brain Injury by Skewing Macrophage Polarity Toward the M2 Phenotype

(2018) Wei Cai et al.   Translational Stroke Research

The Possibility and Molecular Mechanisms of Cell Pyroptosis After Cerebral Ischemia

(2018) Zhaofei Dong et al.   Neuroscience Bulletin

Microglia and Monocytes/Macrophages Polarization Reveal Novel Therapeutic Mechanism against Stroke

(2017) Masato Kanazawa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Depletion of microglia exacerbates postischemic inflammation and brain injury

(2017) Wei-Na Jin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Salvianolic Acids for Injection (SAFI) suppresses inflammatory responses in activated microglia to attenuate brain damage in focal cerebral ischemia

(2017) Pengwei Zhuang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Salvianolic acids enhance cerebral angiogenesis and neurological recovery by activating JAK2/STAT3 signaling pathway after ischemic stroke in mice

(2017) Yaoru Li et al.   JOURNAL OF NEUROCHEMISTRY

Salvianolic acid B protects against lipopolysaccharide-induced behavioral deficits and neuroinflammatory response: involvement of autophagy and NLRP3 inflammasome

(2017) Pei Jiang et al.   Journal of Neuroinflammation

Salvianolic Acids for Injection (SAFI) promotes functional recovery and neurogenesis via sonic hedgehog pathway after stroke in mice

(2017) Ye Zhang et al.   NEUROCHEMISTRY INTERNATIONAL

The biphasic function of microglia in ischemic stroke

(2017) Yuanyuan Ma et al.   PROGRESS IN NEUROBIOLOGY

NOSH-NBP, a Novel Nitric Oxide and Hydrogen Sulfide- Releasing Hybrid, Attenuates Ischemic Stroke-Induced Neuroinflammatory Injury by Modulating Microglia Polarization

(2017) Jing Ji et al.   Frontiers in Cellular Neuroscience

Gadd45b prevents autophagy and apoptosis against rat cerebral neuron oxygen-glucose deprivation/reperfusion injury

(2016) Guoqian He et al.   APOPTOSIS

IL-1β/NF-kb signaling promotes colorectal cancer cell growth through miR-181a/PTEN axis

(2016) Pei Hai ping et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

NLRP3 inflammasome: a promising target in ischemic stroke

(2016) Li Gao et al.   INFLAMMATION RESEARCH

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

Regulation of therapeutic hypothermia on inflammatory cytokines, microglia polarization, migration and functional recovery after ischemic stroke in mice

(2016) Jin Hwan Lee et al.   NEUROBIOLOGY OF DISEASE

Functions and mechanisms of microglia/macrophages in neuroinflammation and neurogenesis after stroke

(2016) Xiao-Yi Xiong et al.   PROGRESS IN NEUROBIOLOGY

Multiple therapeutic effects of progranulin on experimental acute ischaemic stroke

(2015) Masato Kanazawa et al.   BRAIN

A New Golden Age of Natural Products Drug Discovery

(2015) Ben Shen   CELL

Malibatol A regulates microglia M1/M2 polarization in experimental stroke in a PPARγ-dependent manner

(2015) Jie Pan et al.   Journal of Neuroinflammation

Calpain-Dependent ErbB4 Cleavage Is Involved in Brain Ischemia-Induced Neuronal Death

(2015) Ying-mei Lu et al.   MOLECULAR NEUROBIOLOGY

The Ischemic Environment Drives Microglia and Macrophage Function

(2015) Stefano Fumagalli et al.   Frontiers in Neurology

NLRP3 Deficiency Ameliorates Neurovascular Damage in Experimental Ischemic Stroke

(2014) Fan Yang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Role of NADPH Oxidase in Total Salvianolic Acid Injection Attenuating Ischemia-Reperfusion Impaired Cerebral Microcirculation and Neurons: Implication of AMPK/Akt/PKC

(2014) Hao Tang et al.   MICROCIRCULATION

Therapeutically Targeting Neuroinflammation and Microglia after Acute Ischemic Stroke

(2014) Youngjeon Lee et al.   Biomed Research International

Pathogenesis of acute stroke and the role of inflammasomes

(2013) David Yang-Wei Fann et al.   AGEING RESEARCH REVIEWS

Target identification and mechanism of action in chemical biology and drug discovery

(2013) Monica Schenone et al.   Nature Chemical Biology

Microglia/Macrophage Polarization Dynamics Reveal Novel Mechanism of Injury Expansion After Focal Cerebral Ischemia

(2012) Xiaoming Hu et al.   STROKE

Activation of Microglia Depends on Na+/H+ Exchange-Mediated H+ Homeostasis

(2010) Y. Liu et al.   JOURNAL OF NEUROSCIENCE

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY