NLRP3 inflammasome as a potential treatment in ischemic stroke concomitant with diabetes

Early TLR4 blockade reduces ROS and inflammation triggered by microglial pro‐inflammatory phenotype in rodents and human brain ischemia models

(2019) E. Parada et al.   BRITISH JOURNAL OF PHARMACOLOGY

NLRP3 inflammasome inhibition with MCC950 improves diabetes-mediated cognitive impairment and vasoneuronal remodeling after ischemia

(2019) Rebecca Ward et al.   PHARMACOLOGICAL RESEARCH

Nrf2 inhibits NLRP3 inflammasome activation through regulating Trx1/TXNIP complex in cerebral ischemia reperfusion injury

(2018) Yanghao Hou et al.   BEHAVIOURAL BRAIN RESEARCH

Heart Disease and Stroke Statistics—2018 Update: A Report From the American Heart Association

(2018) Emelia J. Benjamin et al.   CIRCULATION

SCIL-STROKE (Subcutaneous Interleukin-1 Receptor Antagonist in Ischemic Stroke)

(2018) Craig J. Smith et al.   STROKE

Oxidative Stress and NLRP3-Inflammasome Activity as Significant Drivers of Diabetic Cardiovascular Complications: Therapeutic Implications

(2018) Arpeeta Sharma et al.   Frontiers in Physiology

Interaction of Sex and Diabetes on Outcome After Ischemic Stroke

(2018) Maria Montserrat Soriano-Reixach et al.   Frontiers in Neurology

Combined NADPH and the NOX inhibitor apocynin provides greater anti-inflammatory and neuroprotective effects in a mouse model of stroke

(2017) Yuan-Yuan Qin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Association Between Diabetes and Cause-Specific Mortality in Rural and Urban Areas of China

(2017) Fiona Bragg et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Evidence that NF-κB and MAPK Signaling Promotes NLRP Inflammasome Activation in Neurons Following Ischemic Stroke

(2017) David Yang-Wei Fann et al.   MOLECULAR NEUROBIOLOGY

Stroke is treatable, but prevention is the key

(2017) Ale Algra et al.   Nature Reviews Neurology

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Selective NLRP3 (Pyrin Domain–Containing Protein 3) Inflammasome Inhibitor Reduces Brain Injury After Intracerebral Hemorrhage

(2017) Honglei Ren et al.   STROKE

A novel indication of platonin, a therapeutic immunomodulating medicine, on neuroprotection against ischemic stroke in mice

(2017) Joen-Rong Sheu et al.   Scientific Reports

Mitochondria and the NLRP3 inflammasome: physiological and pathological relevance

(2016) Je-Wook Yu et al.   ARCHIVES OF PHARMACAL RESEARCH

Hexokinase Is an Innate Immune Receptor for the Detection of Bacterial Peptidoglycan

(2016) Andrea J. Wolf et al.   CELL

NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria

(2016) Zhenyu Zhong et al.   CELL

Cerebrovascular Safety of Sulfonylureas: The Role of KATPChannels in Neuroprotection and the Risk of Stroke in Patients With Type 2 Diabetes

(2016) Rui Liu et al.   DIABETES

The selective NLRP3-inflammasome inhibitor MCC950 reduces infarct size and preserves cardiac function in a pig model of myocardial infarction

(2016) Gerardus P.J. van Hout et al.   EUROPEAN HEART JOURNAL

NLRP3 inflammasome: a promising target in ischemic stroke

(2016) Li Gao et al.   INFLAMMATION RESEARCH

The neuroprotection of Sinomenine against ischemic stroke in mice by suppressing NLRP3 inflammasome via AMPK signaling

(2016) Jing Qiu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Early High-dosage Atorvastatin Treatment Improved Serum Immune-inflammatory Markers and Functional Outcome in Acute Ischemic Strokes Classified as Large Artery Atherosclerotic Stroke

(2016) Antonino Tuttolomondo et al.   MEDICINE

A casein hydrolysate protects mice against high fat diet induced hyperglycemia by attenuating NLRP3 inflammasome-mediated inflammation and improving insulin signaling

(2016) Niamh P. Healy et al.   MOLECULAR NUTRITION & FOOD RESEARCH

ROS-Mediated NLRP3 Inflammasome Activation in Brain, Heart, Kidney, and Testis Ischemia/Reperfusion Injury

(2016) Letteria Minutoli et al.   Oxidative Medicine and Cellular Longevity

Obesity and Type 2 Diabetes Alters the Immune Properties of Human Adipose Derived Stem Cells

(2016) Carolina Serena et al.   STEM CELLS

Diabetes

(2015) David M. Nathan   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Suppression of NLRP3 inflammasome by γ-tocotrienol ameliorates type 2 diabetes

(2015) Yongeun Kim et al.   JOURNAL OF LIPID RESEARCH

Inhibiting the Inflammasome: A Chemical Perspective

(2015) Alex G. Baldwin et al.   JOURNAL OF MEDICINAL CHEMISTRY

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

(2015) Rebecca C Coll et al.   NATURE MEDICINE

Innate immunity in diabetes and diabetic nephropathy

(2015) Jun Wada et al.   Nature Reviews Nephrology

Umbelliferone ameliorates cerebral ischemia–reperfusion injury via upregulating the PPAR gamma expression and suppressing TXNIP/NLRP3 inflammasome

(2015) Xiangxiang Wang et al.   NEUROSCIENCE LETTERS

Synthetic Oligodeoxynucleotides Containing Multiple Telemeric TTAGGG Motifs Suppress Inflammasome Activity in Macrophages Subjected to Oxygen and Glucose Deprivation and Reduce Ischemic Brain Injury in Stroke-Prone Spontaneously Hypertensive Rats

(2015) Jing Zhao et al.   PLoS One

Anti-inflammatory effects of grape seed procyanidin B2 on a diabetic pancreas

(2015) Wenbin Yin et al.   Food & Function

Sodium butyrate alleviates adipocyte inflammation by inhibiting NLRP3 pathway

(2015) Xukai Wang et al.   Scientific Reports

NLRP3 inflammasome: From a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases

(2015) Amna Abderrazak et al.   Redox Biology

Is immunity a mechanism contributing to statin-induced diabetes?

(2015) Brandyn D Henriksbo et al.   Adipocyte

NLRP3 Inflammasome Is Expressed and Functional in Mouse Brain Microglia but Not in Astrocytes

(2015) Audrey Gustin et al.   PLoS One

Autophagy in microglia degrades extracellular β-amyloid fibrils and regulates the NLRP3 inflammasome

(2014) Mi-Hyang Cho et al.   Autophagy

T Cell–Derived IL-22 Amplifies IL-1β–Driven Inflammation in Human Adipose Tissue: Relevance to Obesity and Type 2 Diabetes

(2014) Elise Dalmas et al.   DIABETES

Intermittent fasting attenuates inflammasome activity in ischemic stroke

(2014) David Yang-Wei Fann et al.   EXPERIMENTAL NEUROLOGY

Lysosomes Integrate Metabolic-Inflammatory Cross-talk in Primary Macrophage Inflammasome Activation

(2014) Kassandra Weber et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NLRP3 Deficiency Ameliorates Neurovascular Damage in Experimental Ischemic Stroke

(2014) Fan Yang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cutting Edge: Inflammasome Activation by Alum and Alum's Adjuvant Effect Are Mediated by NLRP3

(2014) H. Li et al.   JOURNAL OF IMMUNOLOGY

Isoliquiritigenin is a potent inhibitor of NLRP3 inflammasome activation and diet-induced adipose tissue inflammation

(2014) Hiroe Honda et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Deregulation of inflammatory response in the diabetic condition is associated with increased ischemic brain injury

(2014) Eunhee Kim et al.   Journal of Neuroinflammation

Thioredoxin-Interacting Protein: a Novel Target for Neuroprotection in Experimental Thromboembolic Stroke in Mice

(2014) Tauheed Ishrat et al.   MOLECULAR NEUROBIOLOGY

Cardiovascular Risk and Events in 17 Low-, Middle-, and High-Income Countries

(2014) Salim Yusuf et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pathogenesis of acute stroke and the role of inflammasomes

(2013) David Yang-Wei Fann et al.   AGEING RESEARCH REVIEWS

Autophagy regulates inflammation following oxidative injury in diabetes

(2013) Yang Wang et al.   Autophagy

Ambiguities in NLRP3 inflammasome regulation: Is there a role for mitochondria?

(2013) Kate E. Lawlor et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Rosuvastatin Alleviates Diabetic Cardiomyopathy by Inhibiting NLRP3 Inflammasome and MAPK Pathways in a Type 2 Diabetes Rat Model

(2013) Beibei Luo et al.   CARDIOVASCULAR DRUGS AND THERAPY

Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock

(2013) Kairui Mao et al.   CELL RESEARCH

Modulatory mechanisms controlling the NLRP3 inflammasome in inflammation: recent developments

(2013) Moritz Haneklaus et al.   CURRENT OPINION IN IMMUNOLOGY

Sustained Inflammasome Activity in Macrophages Impairs Wound Healing in Type 2 Diabetic Humans and Mice

(2013) R. E. Mirza et al.   DIABETES

Double-Blind, Randomized Study Evaluating the Glycemic and Anti-inflammatory Effects of Subcutaneous LY2189102, a Neutralizing IL-1  Antibody, in Patients With Type 2 Diabetes

(2013) J. Sloan-Lancaster et al.   DIABETES CARE

Omega-3 Fatty Acids Prevent Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome Activation

(2013) Yiqing Yan et al.   IMMUNITY

Mechanisms of NOD-like Receptor-Associated Inflammasome Activation

(2013) Haitao Wen et al.   IMMUNITY

ATP-P2X4 signaling mediates NLRP3 inflammasome activation: A novel pathway of diabetic nephropathy

(2013) Kehong Chen et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

3,4-Methylenedioxy-β-nitrostyrene Inhibits NLRP3 Inflammasome Activation by Blocking Assembly of the Inflammasome

(2013) Yuan He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MFGE8 inhibits inflammasome-induced IL-1β production and limits postischemic cerebral injury

(2013) Nicolas Deroide et al.   JOURNAL OF CLINICAL INVESTIGATION

CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation

(2013) Frederick J Sheedy et al.   NATURE IMMUNOLOGY

Treating inflammation by blocking interleukin-1 in humans

(2013) Charles A. Dinarello et al.   SEMINARS IN IMMUNOLOGY

Intravenous immunoglobulin suppresses NLRP1 and NLRP3 inflammasome-mediated neuronal death in ischemic stroke

(2013) D Yang-Wei Fann et al.   Cell Death & Disease

Negative regulation of NLRP3 inflammasome signaling

(2013) Shuzhen Chen et al.   Protein & Cell

Mechanisms of disease: inflammasome activation and the development of type 2 diabetes

(2013) Ryan W. Grant et al.   Frontiers in Immunology

Autoinflammatory syndromes and cellular responses to stress: pathophysiology, diagnosis and new treatment perspectives

(2012) Sinisa Savic et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

The Inflammasome Puts Obesity in the Danger Zone

(2012) Rinke Stienstra et al.   Cell Metabolism

Thioredoxin-Interacting Protein Mediates ER Stress-Induced β Cell Death through Initiation of the Inflammasome

(2012) Christine M. Oslowski et al.   Cell Metabolism

Biochemical regulation of the inflammasome

(2012) Jennifer K. Dowling et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Upregulated NLRP3 Inflammasome Activation in Patients With Type 2 Diabetes

(2012) Hye-Mi Lee et al.   DIABETES

Effect of anti-IL-1β antibody (canakinumab) on insulin secretion rates in impaired glucose tolerance or type 2 diabetes: results of a randomized, placebo-controlled trial

(2012) A. Rissanen et al.   DIABETES OBESITY & METABOLISM

Inflammation links excess fat to insulin resistance: the role of the interleukin-1 family

(2012) Cees J. Tack et al.   IMMUNOLOGICAL REVIEWS

NLRP3 Inflammasome Activity Is Negatively Controlled by miR-223

(2012) F. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Intravenous immunoglobulin protects neurons against amyloid beta-peptide toxicity and ischemic stroke by attenuating multiple cell death pathways

(2012) Alexander Widiapradja et al.   JOURNAL OF NEUROCHEMISTRY

Diabetes, hyperglycaemia, and acute ischaemic stroke

(2012) Merel JA Luitse et al.   LANCET NEUROLOGY

Interleukin-1β inhibition and the prevention of recurrent cardiovascular events: Rationale and Design of the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS)

(2011) Paul M Ridker et al.   AMERICAN HEART JOURNAL

Elimination of the NLRP3-ASC Inflammasome Protects against Chronic Obesity-Induced Pancreatic Damage

(2011) Yun-Hee Youm et al.   ENDOCRINOLOGY

Mitochondria: Sovereign of inflammation?

(2011) Jürg Tschopp   EUROPEAN JOURNAL OF IMMUNOLOGY

Type I Interferon Inhibits Interleukin-1 Production and Inflammasome Activation

(2011) Greta Guarda et al.   IMMUNITY

The inflammasome: an integrated view

(2011) Olaf Gross et al.   IMMUNOLOGICAL REVIEWS

Autophagy Controls IL-1β Secretion by Targeting Pro-IL-1β for Degradation

(2011) James Harris et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inflammasome activation and IL-1β/IL-18 processing are influenced by distinct pathways in microglia

(2011) Richa Hanamsagar et al.   JOURNAL OF NEUROCHEMISTRY

Measles Virus V Protein Inhibits NLRP3 Inflammasome-Mediated Interleukin-1  Secretion

(2011) N. Komune et al.   JOURNAL OF VIROLOGY

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

Inflammasome is a central player in the induction of obesity and insulin resistance

(2011) R. Stienstra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NLRP3 inflammasomes link inflammation and metabolic disease

(2011) Dominic De Nardo et al.   TRENDS IN IMMUNOLOGY

Role of Innate Immunity in Diabetes and Metabolism: Recent Progress in the Study of Inflammasomes

(2011) Myung-Shik Lee   Immune Network

The Inflammasomes

(2010) Kate Schroder et al.   CELL

The Inflammasome-Mediated Caspase-1 Activation Controls Adipocyte Differentiation and Insulin Sensitivity

(2010) Rinke Stienstra et al.   Cell Metabolism

Anti-inflammatory Compounds Parthenolide and Bay 11-7082 Are Direct Inhibitors of the Inflammasome

(2010) Christine Juliana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hyperglycaemia and Infarct Size in Animal Models of Middle Cerebral Artery Occlusion: Systematic Review and Meta-Analysis

(2010) Niall J J MacDougall et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Exacerbated brain damage, edema and inflammation in type-2 diabetic mice subjected to focal ischemia

(2010) Kudret Tureyen et al.   JOURNAL OF NEUROCHEMISTRY

Stroke Prevention and Treatment

(2010) James D. Marsh et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies

(2010) The Emerging Risk Factors Collaboration   LANCET

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Hyperglycemia in acute ischemic stroke: pathophysiology and clinical management

(2010) Nyika D. Kruyt et al.   Nature Reviews Neurology

The NLRP3 Inflammasome: A Sensor for Metabolic Danger?

(2010) K. Schroder et al.   SCIENCE

Immunological and Inflammatory Functions of the Interleukin-1 Family

(2009) Charles A. Dinarello   Annual Review of Immunology

Sustained Effects of Interleukin-1 Receptor Antagonist Treatment in Type 2 Diabetes

(2009) C. M. Larsen et al.   DIABETES CARE

Glyburide inhibits the Cryopyrin/Nalp3 inflammasome

(2009) Mohamed Lamkanfi et al.   JOURNAL OF CELL BIOLOGY

Worldwide stroke incidence and early case fatality reported in 56 population-based studies: a systematic review

(2009) Valery L Feigin et al.   LANCET NEUROLOGY

T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes

(2009) Greta Guarda et al.   NATURE

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome

(2009) S. S. Iyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The NLR Gene Family: A Standard Nomenclature

(2008) Jenny P.-Y. Ting et al.   IMMUNITY

Inhibition of the Inflammasome Complex Reduces the Inflammatory Response after Thromboembolic Stroke in Mice

(2008) Denise P Abulafia et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Hyperglycemia and cognitive outcome after ischemic stroke

(2008) N.D. Kruyt et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE

Dynamic of Hyperglycemia as a Predictor of Stroke Outcome in the ECASS-II Trial

(2008) Mei Yong et al.   STROKE