Epilepsy channelopathies go neddy: stabilizing NaV1.1 channels by neddylation

Neddylation stabilizes Nav1.1 to maintain interneuron excitability and prevent seizures in murine epilepsy models

(2021) Wenbing Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Neddylation mediates ventricular chamber maturation through repression of Hippo signaling

(2018) Jianqiu Zou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Transient Developmental Window of Fast-Spiking Interneuron Dysfunction in a Mouse Model of Dravet Syndrome

(2018) Morgana Favero et al.   JOURNAL OF NEUROSCIENCE

Dissecting the phenotypes of Dravet syndrome by gene deletion

(2015) Moran Rubinstein et al.   BRAIN

Neddylation inhibition impairs spine development, destabilizes synapses and deteriorates cognition

(2015) Annette M Vogl et al.   NATURE NEUROSCIENCE

Strain- and age-dependent hippocampal neuron sodium currents correlate with epilepsy severity in Dravet syndrome mice

(2014) Akshitkumar M. Mistry et al.   NEUROBIOLOGY OF DISEASE

Nav1.1 haploinsufficiency in excitatory neurons ameliorates seizure-associated sudden death in a mouse model of Dravet syndrome

(2013) Ikuo Ogiwara et al.   HUMAN MOLECULAR GENETICS

H2O2Regulates Lung Epithelial Sodium Channel (ENaC) via Ubiquitin-like Protein Nedd8

(2013) Charles A. Downs et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Specific deletion of NaV1.1 sodium channels in inhibitory interneurons causes seizures and premature death in a mouse model of Dravet syndrome

(2012) C. S. Cheah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA