Sestrin2 as a gatekeeper of cellular homeostasis: Physiological effects for the regulation of hypoxia‐related diseases

AMPK and TOR: The Yin and Yang of Cellular Nutrient Sensing and Growth Control

(2020) Asier González et al.   Cell Metabolism

Oxidative stress and the cardiovascular effects of air pollution

(2020) Mark R. Miller   FREE RADICAL BIOLOGY AND MEDICINE

Sestrin2 protects dendritic cells against endoplasmic reticulum stress-related apoptosis induced by high mobility group box-1 protein

(2020) Li-Xue Wang et al.   Cell Death & Disease

Liraglutide ameliorates obesity-related nonalcoholic fatty liver disease by regulating Sestrin2-mediated Nrf2/HO-1 pathway

(2020) Xue Han et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Nrf2 activation through the inhibition of Keap1–Nrf2 protein–protein interaction

(2020) Sumi Lee et al.   MEDICINAL CHEMISTRY RESEARCH

Pathophysiology of atherothrombosis: Mechanisms of thrombus formation on disrupted atherosclerotic plaques

(2020) Yujiro Asada et al.   PATHOLOGY INTERNATIONAL

Regulation of metabolism by mitochondrial enzyme acetylation in cardiac ischemia-reperfusion injury

(2020) Daniel J. Herr et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Hypoxia and pancreatic ductal adenocarcinoma

(2020) Akio Yamasaki et al.   CANCER LETTERS

Sestrin2 overexpression alleviates hydrogen peroxide-induced apoptosis and oxidative stress in retinal ganglion cells by enhancing Nrf2 activation via Keap1 downregulation

(2020) Yazhi Fan et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Bamboo Stems (Phyllostachys nigra variety henosis) Containing Polyphenol Mixtures Activate Nrf2 and Attenuate Phenylhydrazine-Induced Oxidative Stress and Liver Injury

(2019) Ji Yang et al.   Nutrients

Investigation of Urinary Sestrin2 in Patients with Obstructive Sleep Apnea

(2019) Lu Bai et al.   LUNG

Pentamethylquercetin protects against cardiac remodeling via activation of Sestrin2

(2019) Jing-Xia Du et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sestrin2 overexpression attenuates focal cerebral ischemic injury in rat by increasing Nrf2/HO-1 pathway-mediated angiogenesis

(2019) Peng Wang et al.   NEUROSCIENCE

The interaction of Hemin and Sestrin2 modulates oxidative stress and colon tumor growth

(2019) Hyeoncheol Kim et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Increased plasma sestrin2 concentrations in patients with chronic heart failure and predicted the occurrence of major adverse cardiac events: A 36-month follow-up cohort study

(2019) Haixiong Wang et al.   CLINICA CHIMICA ACTA

Sestrin2 is involved in asthma: a case–control study

(2019) Yanfang Kang et al.   Allergy Asthma and Clinical Immunology

Cancer and ER stress: Mutual crosstalk between autophagy, oxidative stress and inflammatory response

(2019) Yuning Lin et al.   BIOMEDICINE & PHARMACOTHERAPY

Ageing, age-related diseases and oxidative stress: What to do next?

(2019) Jiao Luo et al.   AGEING RESEARCH REVIEWS

Inhibition of microRNA‐148b‐3p alleviates oxygen‐glucose deprivation/reoxygenation‐induced apoptosis and oxidative stress in HT22 hippocampal neuron via reinforcing Sestrin2/Nrf2 signalling

(2019) Yin Du et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Crocin attenuates acute hypobaric hypoxia-induced cognitive deficits of rats

(2018) Xiao-yan Zhang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Sestrin2 facilitates glutamine-dependent transcription of PGC-1α and survival of liver cancer cells under glucose limitation

(2018) Ashish Kumar et al.   FEBS Journal

Sestrin2 prevents age-related intolerance to post myocardial infarction via AMPK/PGC-1α pathway

(2018) Nanhu Quan et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Sestrin2 regulates monocyte activation through AMPK-mTOR nexus under high-glucose and dyslipidemic conditions

(2018) Saravanakumar Sundararajan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The multifaceted role of autophagy in cancer and the microenvironment

(2018) Hendrik Folkerts et al.   MEDICINAL RESEARCH REVIEWS

Research advances in pathogenesis and prophylactic measures of acute high altitude illness

(2018) Yunhong Li et al.   RESPIRATORY MEDICINE

Sestrin 2 confers primary resistance to sorafenib by simultaneously activating AKT and AMPK in hepatocellular carcinoma

(2018) Jimin Dai et al.   Cancer Medicine

Sestrin2 prevents age-related intolerance to ischemia and reperfusion injury by modulating substrate metabolism

(2017) Nanhu Quan et al.   FASEB JOURNAL

Carbon monoxide protects against hepatic steatosis in mice by inducing sestrin-2 via the PERK-eIF2α-ATF4 pathway

(2017) Hyo Jeong Kim et al.   FREE RADICAL BIOLOGY AND MEDICINE

Polyphenolics from mango (Mangifera indica L.) suppress breast cancer ductal carcinoma in situ proliferation through activation of AMPK pathway and suppression of mTOR in athymic nude mice

(2017) Matthew J. Nemec et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Lysine-specific demethylase LSD1 regulates autophagy in neuroblastoma through SESN2-dependent pathway

(2017) S Ambrosio et al.   ONCOGENE

Nocturnal blood pressure fluctuations measured by using pulse transit time in patients with severe obstructive sleep apnea syndrome

(2017) Jennifer Gehring et al.   Sleep and Breathing

Air particulate matter induced oxidative stress and inflammation in cardiovascular disease and atherosclerosis: The role of Nrf2 and AhR-mediated pathways

(2017) Akeem O. Lawal   TOXICOLOGY LETTERS

Sestrin2 and sestrin3 suppress NK-92 cell-mediated cytotoxic activity on ovarian cancer cells through AMPK and mTORC1 signaling

(2017) Xuejin Wang et al.   Oncotarget

Sestrin2 Suppresses Classically Activated Macrophages-Mediated Inflammatory Response in Myocardial Infarction through Inhibition of mTORC1 Signaling

(2017) Keping Yang et al.   Frontiers in Immunology

5-Fluorouracil inhibits cell migration by induction of Sestrin2 in colon cancer cells

(2016) Kyuhwa Seo et al.   ARCHIVES OF PHARMACAL RESEARCH

SESN2/sestrin 2 induction-mediated autophagy and inhibitory effect of isorhapontigenin (ISO) on human bladder cancers

(2016) Yuguang Liang et al.   Autophagy

Sestrin2 inhibits hypoxia-inducible factor-1α accumulation via AMPK-mediated prolyl hydroxylase regulation

(2016) Kyuhwa Seo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Exposure to electromagnetic field attenuates oxygen-glucose deprivation-induced microglial cell death by reducing intracellular Ca2+and ROS

(2016) Cao Nguyen Duong et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Sestrin2, as a negative feedback regulator of mTOR, provides neuroprotection by activation AMPK phosphorylation in neonatal hypoxic-ischemic encephalopathy in rat pups

(2016) Xudan Shi et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Protein misfolding in the endoplasmic reticulum as a conduit to human disease

(2016) Miao Wang et al.   NATURE

Sestrin2 induced by hypoxia inducible factor1 alpha protects the blood-brain barrier via inhibiting VEGF after severe hypoxic-ischemic injury in neonatal rats

(2016) Xudan Shi et al.   NEUROBIOLOGY OF DISEASE

Distinct Role of Sesn2 in Response to UVB-Induced DNA Damage and UVA-Induced Oxidative Stress in Melanocytes

(2016) Baozhong Zhao et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

AMP-activated protein kinase mediates mitochondrial fission in response to energy stress

(2016) E. Q. Toyama et al.   SCIENCE

Exendin-4 Inhibits Matrix Metalloproteinase-9 Activation and Reduces Infarct Growth After Focal Cerebral Ischemia in Hyperglycemic Mice

(2016) Takuma Kuroki et al.   STROKE

Cardiac-Specific Deletion of thePdha1Gene Sensitizes Heart to Toxicological Actions of Ischemic Stress

(2016) Wanqing Sun et al.   TOXICOLOGICAL SCIENCES

CX-5461 induces autophagy and inhibits tumor growth via mammalian target of rapamycin-related signaling pathways in osteosarcoma

(2016) Xu Li et al.   OncoTargets and Therapy

Tumor suppressive role of sestrin2 during colitis and colon carcinogenesis

(2016) Seung-Hyun Ro et al.   eLife

Dexmedetomidine Protects against Transient Global Cerebral Ischemia/Reperfusion Induced Oxidative Stress and Inflammation in Diabetic Rats

(2016) Xianzhang Zeng et al.   PLoS One

Sestrin2 is induced by glucose starvation via the unfolded protein response and protects cells from non-canonical necroptotic cell death

(2016) Boxiao Ding et al.   Scientific Reports

Sestrin2 Silencing Exacerbates Cerebral Ischemia/Reperfusion Injury by Decreasing Mitochondrial Biogenesis through the AMPK/PGC-1α Pathway in Rats

(2016) Lingyu Li et al.   Scientific Reports

Sestrin2 facilitates death receptor-induced apoptosis in lung adenocarcinoma cells through regulation of XIAP degradation

(2015) Boxiao Ding et al.   CELL CYCLE

Roles of Sestrin2 and Ribosomal Protein S6 in Transient Global Ischemia-Induced Hippocampal Neuronal Injury

(2015) Yao-Chung Chuang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The role for autophagy in cancer

(2015) Eileen White   JOURNAL OF CLINICAL INVESTIGATION

Hypoxia-Ischemia and Therapeutic Hypothermia in the Neonatal Mouse Brain – A Longitudinal Study

(2015) Jennifer C. Burnsed et al.   PLoS One

Sestrins Function as Guanine Nucleotide Dissociation Inhibitors for Rag GTPases to Control mTORC1 Signaling

(2014) Min Peng et al.   CELL

DNA Damage Response and Metabolic Disease

(2014) Ippei Shimizu et al.   Cell Metabolism

Sestrin2 inhibits uncoupling protein 1 expression through suppressing reactive oxygen species

(2014) S.-H. Ro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

(2014) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

Stem cells for brain repair in neonatal hypoxia–ischemia

(2013) L. Chicha et al.   CHILDS NERVOUS SYSTEM

Nelfinavir and bortezomib inhibit mTOR activity via ATF4-mediated sestrin-2 regulation

(2013) Ansgar Brüning et al.   Molecular Oncology

Sestrin2 integrates Akt and mTOR signaling to protect cells against energetic stress-induced death

(2012) I Ben-Sahra et al.   CELL DEATH AND DIFFERENTIATION

Sestrins Activate Nrf2 by Promoting p62-Dependent Autophagic Degradation of Keap1 and Prevent Oxidative Liver Damage

(2012) Soo Han Bae et al.   Cell Metabolism

Nrf2-ARE pathway regulates induction of Sestrin-2 expression

(2012) Bo Yeon Shin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sestrin2 Modulates AMPK Subunit Expression and Its Response to Ionizing Radiation in Breast Cancer Cells

(2012) Toran Sanli et al.   PLoS One

The Inhibition of Autophagy Sensitises Colon Cancer Cells with Wild-Type p53 but Not Mutant p53 to Topotecan Treatment

(2012) Dan-Dan Li et al.   PLoS One

Activation of hypoxia-inducible factor-1 protects airway epithelium against oxidant-induced barrier dysfunction

(2011) Nels Olson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Stress-Responsive Sestrins Link p53 with Redox Regulation and Mammalian Target of Rapamycin Signaling

(2010) Andrei V. Budanov   ANTIOXIDANTS & REDOX SIGNALING

Stimulation of autophagy by the p53 target gene Sestrin2

(2010) Maria Chiara Maiuri et al.   CELL CYCLE

Stressin' Sestrins take an aging fight

(2010) Andrei V. Budanov et al.   EMBO Molecular Medicine

p53-dependent regulation of autophagy protein LC3 supports cancer cell survival under prolonged starvation

(2010) R. Scherz-Shouval et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sestrin as a Feedback Inhibitor of TOR That Prevents Age-Related Pathologies

(2010) J. H. Lee et al.   SCIENCE

Hypoxia-induced autophagy: cell death or cell survival?

(2009) Nathalie M Mazure et al.   CURRENT OPINION IN CELL BIOLOGY

Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

(2009) Nao Hosokawa et al.   MOLECULAR BIOLOGY OF THE CELL

A protective role of nuclear factor-erythroid 2-related factor-2 (Nrf2) in inflammatory disorders

(2009) Jiyoung Kim et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling

(2008) Andrei V. Budanov et al.   CELL