Article
Biochemistry & Molecular Biology
Daniela D. Herrera-Balandrano, Zhi Chai, Ruth P. Hutabarat, Trust Beta, Jin Feng, Kaiyang Ma, Dajing Li, Wuyang Huang
Summary: Blueberries are rich in bioactive anthocyanins, such as malvidin, which have antioxidant benefits and can reduce the risk of diabetes. Studies have shown that blueberry anthocyanin extract can help lower oxidative stress, increase cell viability, inhibit hyperglycemia and hyperlipidemia, and enhance AMPK signaling pathway, making it a promising functional food or medicine for diabetes treatment.
Article
Biochemistry & Molecular Biology
Ruth Iban-Arias, Maria Sebastian-Valverde, Henry Wu, Weiting Lyu, Qingli Wu, Jim Simon, Giulio Maria Pasinetti
Summary: Long-term exposure to mental stress increases the risk of developing neuropsychiatric disorders. This study explores the therapeutic potential of malvidin-3-O-glucoside (MG), a natural compound found in grapes, in reducing inflammation induced by inflammasomes. The findings suggest that MG can target and reduce the levels of inflammasomes, leading to a decrease in anxiety and depression.
Article
Chemistry, Applied
Mamatha Chandra Singh, Yasmine Probst, William E. Price, Celine Kelso
Summary: This study demonstrated that the solubility of anthocyanin compounds is affected by the solvent composition and extraction methods. The most effective homogenization and maximal extraction yield of anthocyanins was achieved using ultra-sonication with methanol/water (80/20 v/v) at pH 3.0.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2022)
Article
Agriculture, Multidisciplinary
Barbara Torres-Rochera, Elvira Manjon, Natercia F. Bras, Maria Teresa Escribano-Bailon, Ignacio Garcia-Estevez
Summary: This study investigates the supramolecular interactions between the major wine anthocyanin, malvidin-3-O-glucoside, and different wine phenolic compounds under acidic conditions. The color variations of the anthocyanin are evaluated, and the interaction constants with the phenolic compounds are determined. Hydrophobic interactions and hydrogen bonds play important roles in the pigment/copigment aggregation, while hydrophobic interactions are more significant when caffeic acid is involved.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Review
Plant Sciences
Ponnuvel Deepa, Minji Hong, Kandhasamy Sowndhararajan, Songmun Kim
Summary: Obesity is a major health issue worldwide and is associated with various chronic diseases. Cyanidin-3-O-beta-glucoside (C3G), an anthocyanin compound, has shown potential health benefits in reducing obesity-related complications.
Article
Nutrition & Dietetics
Shuer Liang, Xusheng Li, Ruijing Liu, Jun Hu, Yue Li, Jianxia Sun, Weibin Bai
Summary: This study investigated the protective effects of malvidin-3-O-glucoside (M3G) against cadmium-induced toxicity on female reproduction in KGN cells. M3G was found to reduce Cd-induced cytotoxicity, reactive oxygen species generation, G2/M cell cycle arrest, and promote estradiol (E2) production. Transcriptomic results revealed that M3G controlled the abnormal expression of estrogen-responsive genes. These findings suggest that M3G has great potential as a dietary supplement to prevent Cd-induced female reproductive impairment.
Article
Engineering, Environmental
Dacheng Yang, Yanhong Ran, Xusheng Li, Xinwei Jiang, Jiali Chen, Jianxia Sun, Lingmin Tian, Katia Teerds, Weibin Bai
Summary: The study demonstrated that C3G could mitigate the negative effects of Cd exposure on uterine epithelial cells, potentially preventing Cd-induced female reproductive toxicity. C3G exerts anti-estrogenic effects through various mechanisms to protect the uterus from the harm caused by Cd.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Nutrition & Dietetics
Ruilin Hao, Shuhua Shan, Dandan Yang, Huimin Zhang, Yi Sun, Zhuoyu Li
Summary: Nonalcoholic fatty liver disease (NAFLD), a common chronic liver condition worldwide, is primarily caused by oxidative stress resulting from lipid accumulation. Anthocyanins, such as peonidin 3-O-glucoside (P3G), can effectively inhibit reactive oxygen species (ROS) production and improve oxidative stress. In this study, six major anthocyanins were separated from purple corncob and their effects on NAFLD were investigated. Results showed that P3G significantly reduced lipid accumulation in a NAFLD cell model and inhibited oxidative stress by regulating ROS levels and antioxidant enzyme activities. Additionally, P3G alleviated inflammation and improved mitochondrial damage in the cell model. It also upregulated lysosomal function and activated peroxisomal lipid oxidation possibly by interacting with PPAR alpha. This study enhances our understanding of the protective effects of purple corn anthocyanins against NAFLD and suggests their potential use in functional foods.
Article
Biochemistry & Molecular Biology
Didier Fraisse, Alexis Bred, Catherine Felgines, Francois Senejoux
Summary: The study found that cyanidin-3-O-glucoside has poor stability under intestinal conditions, but shows persistent antioxidant and antiglycation effects, and even inhibits alpha-glucosidase activity in the intestinal phase. This suggests that classical in vitro evaluations may underestimate its potential for managing diabetes.
Article
Agriculture, Multidisciplinary
Cristina Alcalde-Eon, Maria-Teresa Escribano-Bailon, Ignacio Garcia-Estevez
Summary: Recent studies have shown the influence of oak ellagitannins on astringency and color in wine. This study evaluates the different roles of castalagin and vescalagin in the synthesis of vitisin A and the degradation of malvidin 3-O-glucoside in wine-like model systems. The presence of pyruvic acid leads to the synthesis of vitisin A, while its absence results in degradation reactions. Overall, ellagitannins increase vitisin A synthesis, decrease the total content of degradation products, and alter the degradation profile.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Food Science & Technology
Ping Zhou, Ying Pan, Wei Yang, Baoru Yang, Shiyi Ou, Pengzhan Liu, Jie Zheng
Summary: Acylation of anthocyanin with fatty acid can enhance their lipophilicity and stability, and also provide protective effect against oxidative stress.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Chemistry, Multidisciplinary
Wan-jun Zhao, Yang-ping Bian, Qiu-hui Wang, Fei Yin, Li Yin, Yong-lan Zhang, Jian-hui Liu
Summary: The study demonstrates that blueberry-derived exosomes-like nanoparticles can ameliorate oxidative stress, improve the pathogenesis of NAFLD, regulate cell apoptosis and lipid metabolism, enhance antioxidant capacity, and may serve as a novel approach for the treatment of NAFLD.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Chemistry, Applied
Lili Li, Ping Zhou, Yidi Wang, Ying Pan, Min Chen, Ye Tian, Hua Zhou, Baoru Yang, Hecheng Meng, Jie Zheng
Summary: Enzymatic acylation of anthocyanin with fatty acid improves its lipophilic solubility and this study demonstrates that the resulting acylated anthocyanin, C3G-LA, exhibits strong antibacterial activity against Staphylococcus aureus and moderate activity against Escherichia coli. The mechanism of action involves disruption of cell membrane integrity, intracellular ATP concentration, intracellular pH, and changes in cellular morphology.
Article
Food Science & Technology
Rui Li, Zhan Ye, Yong-jiang Xu, Yuanfa Liu
Summary: This study investigates the protective role of blueberry anthocyanin extracts (BAEs), particularly its anti-oxidant constituent, cyanidin-3-O-glucoside (C3G), against damage to retinal pigment epithelium (RPE) cells induced by high glucose (HG) levels. The findings suggest that BAEs mitigated damage to HG-induced RPE cells by decreasing intracellular reactive oxygen species (ROS) levels and improving cell morphology and viability. The underlying mechanism involves C3G interrupting ROS generation feedback loop, downregulating REDD1 expression, enhancing retinal Nrf2 antioxidant response, and suppressing VEGFA expression to prevent an increase in vascular permeability.
Article
Chemistry, Applied
A. S. Marquez-Rodriguez, M. Guimaraes, N. Mateus, V de Freitas, M. L. Ballinas-Casarrubias, M. E. Fuentes-Montero, E. Salas, L. Cruz
Summary: Enzymatic lipophilization of delphinidin 3-O-sambubioside with octanoic acid was studied in this research, leading to the formation of a new lipophilic pigment with improved solubility and stability, which showed potential applications in various industries requiring lipo-soluble formulations.
Review
Chemistry, Applied
Vemana Gowd, Hongming Su, Petr Karlovsky, Wei Chen
Review
Food Science & Technology
Lianghua Xie, Hongming Su, Chongde Sun, Xiaodong Zheng, Wei Chen
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Hongming Su, Yuting Li, Dongwen Hu, Lianghua Xie, Huihui Ke, Xiaodong Zheng, Wei Chen
FREE RADICAL BIOLOGY AND MEDICINE
(2018)
Article
Multidisciplinary Sciences
Wei Chen, Hongming Su, Yang Xu, Chao Jin
SCIENTIFIC REPORTS
(2017)
Article
Agriculture, Multidisciplinary
Hongming Su, Lianghua Xie, Yang Xu, Huihui Ke, Tao Bao, Yuting Li, Wei Chen
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2020)
Article
Agriculture, Multidisciplinary
Dongwen Hu, Tao Bao, Yang Lu, Hongming Su, Huihui Ke, Wei Chen
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2020)
Article
Food Science & Technology
Hongming Su, Tao Bao, Lianghua Xie, Yang Xu, Wei Chen
JOURNAL OF FUNCTIONAL FOODS
(2020)
Article
Cell Biology
Hongming Su, Jianling Mo, Jingdan Ni, Huihui Ke, Tao Bao, Jiahong Xie, Yang Xu, Lianghua Xie, Wei Chen
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2020)
Meeting Abstract
Endocrinology & Metabolism
Hongming Su, Hong Guo, Xiaoxue Qiu, Te-Yueh Lin, Xiaoli Chen
Editorial Material
Biochemistry & Molecular Biology
Wei Chen, Hongming Su
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2023)
Article
Multidisciplinary Sciences
Hongming Su, Hong Guo, Xiaoxue Qiu, Te-Yueh Lin, Chao Qin, Gail Celio, Peter Yong, Mark Senders, Xianlin Han, David A. Bernlohr, Xiaoli Chen
Summary: The authors find that LCN2 plays a critical role as a phosphatidic acid binding protein in phospholipid acyl chain remodeling and mitochondrial bioenergetics, influencing signaling pathway activation.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Lianghua Xie, Jianling Mo, Jingdan Ni, Yang Xu, Hongming Su, Jiahong Xie, Wei Chen
Meeting Abstract
Chemistry, Multidisciplinary
Hongming Su, Wei Chen
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2019)
Meeting Abstract
Chemistry, Multidisciplinary
Wei Chen, Hongming Su
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2019)