The crosstalk between DNA damage response components and DNA-sensing innate immune signaling pathways

Prevention of DNA Replication Stress by CHK1 Leads to Chemoresistance Despite a DNA Repair Defect in Homologous Recombination in Breast Cancer

(2020) Felix Meyer et al.   Cells

Human DNA-PK activates a STING-independent DNA sensing pathway

(2020) Katelyn Burleigh et al.   Science Immunology

BRD4 inhibition exerts anti-viral activity through DNA damage-dependent innate immune responses

(2020) Jiang Wang et al.   PLoS Pathogens

Anticancer drug and ionizing radiation-induced DNA damage differently influences transcription activity and DDR-related stress responses of an endothelial monolayer

(2020) Verena Ziegler et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Cryo-EM structures of herpes simplex virus type 1 portal vertex and packaged genome

(2019) Yun-Tao Liu et al.   NATURE

The MRE11–RAD50–NBS1 Complex Conducts the Orchestration of Damage Signaling and Outcomes to Stress in DNA Replication and Repair

(2018) Aleem Syed et al.   Annual Review of Biochemistry

Structure of the Human cGAS–DNA Complex Reveals Enhanced Control of Immune Surveillance

(2018) Wen Zhou et al.   CELL

DNA-induced liquid phase condensation of cGAS activates innate immune signaling

(2018) Mingjian Du et al.   SCIENCE

STAG2 deficiency induces interferon responses via cGAS-STING pathway and restricts virus infection

(2018) Siyuan Ding et al.   Nature Communications

Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage

(2018) Gillian Dunphy et al.   MOLECULAR CELL

TREX1 D18N mice fail to process erythroblast DNA resulting in inflammation and dysfunctional erythropoiesis

(2018) Stephen L. Rego et al.   AUTOIMMUNITY

The AIM2 inflammasome: Sensor of pathogens and cellular perturbations

(2017) Jérôme Lugrin et al.   IMMUNOLOGICAL REVIEWS

HEXIM1 and NEAT1 Long Non-coding RNA Form a Multi-subunit Complex that Regulates DNA-Mediated Innate Immune Response

(2017) Mehdi Morchikh et al.   MOLECULAR CELL

RAD51 interconnects between DNA replication, DNA repair and immunity

(2017) Souparno Bhattacharya et al.   NUCLEIC ACIDS RESEARCH

Novel insights into RAD51 activity and regulation during homologous recombination and DNA replication

(2016) Stephen K. Godin et al.   Biochemistry and Cell Biology

Fanconi Anemia Proteins Function in Mitophagy and Immunity

(2016) Rhea Sumpter et al.   CELL

The DNA Structure-Specific Endonuclease MUS81 Mediates DNA Sensor STING-Dependent Host Rejection of Prostate Cancer Cells

(2016) Samantha S.W. Ho et al.   IMMUNITY

Activation of STING-Dependent Innate Immune Signaling By S-Phase-Specific DNA Damage in Breast Cancer

(2016) Eileen E. Parkes et al.   JNCI-Journal of the National Cancer Institute

Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing

(2016) Qi Chen et al.   NATURE IMMUNOLOGY

AIM2 inflammasome is activated by pharmacological disruption of nuclear envelope integrity

(2016) Antonia Di Micco et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury

(2016) Bo Hu et al.   SCIENCE

RPA and Rad51 constitute a cell intrinsic mechanism to protect the cytosol from self DNA

(2016) Christine Wolf et al.   Nature Communications

Activation of STING-Dependent Innate Immune Signaling By S-Phase-Specific DNA Damage in Breast Cancer

(2016) Eileen E. Parkes et al.   JNCI-Journal of the National Cancer Institute

FANCD2 influences replication fork processes and genome stability in response to clustered DSBs

(2015) Jiayun Zhu et al.   CELL CYCLE

Cytosolic Nuclease TREX1 Regulates Oligosaccharyltransferase Activity Independent of Nuclease Activity to Suppress Immune Activation

(2015) Maroof Hasan et al.   IMMUNITY

DNA Damage Primes the Type I Interferon System via the Cytosolic DNA Sensor STING to Promote Anti-Microbial Innate Immunity

(2015) Anetta Härtlova et al.   IMMUNITY

Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9

(2015) Umeharu Ohto et al.   NATURE

Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases

(2015) Daxing Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

cGAS-mediated stabilization of IFI16 promotes innate signaling during herpes simplex virus infection

(2015) Megan H. Orzalli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA-Damage-Induced Type I Interferon Promotes Senescence and Inhibits Stem Cell Function

(2015) Qiujing Yu et al.   Cell Reports

BRCA1 Regulates IFI16 Mediated Nuclear Innate Sensing of Herpes Viral DNA and Subsequent Induction of the Innate Inflammasome and Interferon-β Responses

(2015) Dipanjan Dutta et al.   PLoS Pathogens

Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production

(2014) Michael J. White et al.   CELL

Apoptotic Caspases Prevent the Induction of Type I Interferons by Mitochondrial DNA

(2014) Anthony Rongvaux et al.   CELL

Intrinsic Self-DNA Triggers Inflammatory Disease Dependent on STING

(2014) Jeonghyun Ahn et al.   JOURNAL OF IMMUNOLOGY

Cytosolic-DNA-Mediated, STING-Dependent Proinflammatory Gene Induction Necessitates Canonical NF- B Activation through TBK1

(2014) T. Abe et al.   JOURNAL OF VIROLOGY

Viral Carcinogenesis: Factors Inducing DNA Damage and Virus Integration

(2014) Yan Chen et al.   Cancers

Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization

(2013) Xin Li et al.   IMMUNITY

Oxidative Damage of DNA Confers Resistance to Cytosolic Nuclease TREX1 Degradation and Potentiates STING-Dependent Immune Sensing

(2013) Nadine Gehrke et al.   IMMUNITY

Immune Sensing of DNA

(2013) Søren R. Paludan et al.   IMMUNITY

Structural mechanism of cytosolic DNA sensing by cGAS

(2013) Filiz Civril et al.   NATURE

DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking

(2013) T. Kondo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA-PK is a DNA sensor for IRF-3-dependent innate immunity

(2012) Brian J Ferguson et al.   eLife

Cutting Edge: Ku70 Is a Novel Cytosolic DNA Sensor That Induces Type III Rather Than Type I IFN

(2011) X. Zhang et al.   JOURNAL OF IMMUNOLOGY

The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells

(2011) Zhiqiang Zhang et al.   NATURE IMMUNOLOGY

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

IFI16 is an innate immune sensor for intracellular DNA

(2010) Leonie Unterholzner et al.   NATURE IMMUNOLOGY

RNA Polymerase III Detects Cytosolic DNA and Induces Type I Interferons through the RIG-I Pathway

(2009) Yu-Hsin Chiu et al.   CELL

Structural and Functional Relationships of the XPF/MUS81 Family of Proteins

(2008) Alberto Ciccia et al.   Annual Review of Biochemistry

RPA nucleic acid-binding properties of IFI16-HIN200

(2008) Hongyue Yan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Trex1 Prevents Cell-Intrinsic Initiation of Autoimmunity

(2008) Daniel B. Stetson et al.   CELL

TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines

(2008) Ken J. Ishii et al.   NATURE