Targeting Intercellular Communication in the Bone Microenvironment to Prevent Disseminated Tumor Cell Escape from Dormancy and Bone Metastatic Tumor Growth
出版年份 2021 全文链接
标题
Targeting Intercellular Communication in the Bone Microenvironment to Prevent Disseminated Tumor Cell Escape from Dormancy and Bone Metastatic Tumor Growth
作者
关键词
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出版物
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 6, Pages 2911
出版商
MDPI AG
发表日期
2021-03-15
DOI
10.3390/ijms22062911
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Phase 1b/2a study of galunisertib, a small molecule inhibitor of transforming growth factor-beta receptor I, in combination with standard temozolomide-based radiochemotherapy in patients with newly diagnosed malignant glioma
- (2020) Antje Wick et al. INVESTIGATIONAL NEW DRUGS
- Epigenetic therapy inhibits metastases by disrupting premetastatic niches
- (2020) Zhihao Lu et al. NATURE
- Bone metastases in thyroid cancer
- (2020) Nicole M. Iñiguez-Ariza et al. Journal of Bone Oncology
- The force awakens: metastatic dormant cancer cells
- (2020) So-Yeon Park et al. EXPERIMENTAL AND MOLECULAR MEDICINE
- BL-8040, a CXCR4 antagonist, in combination with pembrolizumab and chemotherapy for pancreatic cancer: the COMBAT trial
- (2020) Bruno Bockorny et al. NATURE MEDICINE
- Entry and exit of chemotherapeutically-promoted cellular dormancy in glioblastoma cells is differentially affected by the chemokines CXCL12, CXCL16, and CX3CL1
- (2020) Vivian Adamski et al. ONCOGENE
- Tumor-infiltrating regulatory T cells, CD8/Treg ratio, and cancer stem cells are correlated with lymph node metastasis in patients with early breast cancer
- (2020) Luis Alberto Solis-Castillo et al. Breast Cancer
- Adrenergic Blockade Promotes Maintenance of Dormancy in Prostate Cancer Through Upregulation of GAS6
- (2020) Ann M. Decker et al. Translational Oncology
- FoxP3+ T regulatory cells in cancer: Prognostic biomarkers and therapeutic targets
- (2020) Reem Saleh et al. CANCER LETTERS
- Osteoblast-Osteoclast Communication and Bone Homeostasis
- (2020) Jung-Min Kim et al. Cells
- Bone Metastasis Pain, from the Bench to the Bedside
- (2019) Federica Aielli et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Phase I Study of BI 853520, an Inhibitor of Focal Adhesion Kinase, in Patients with Advanced or Metastatic Nonhematologic Malignancies
- (2019) Maja J. A. de Jonge et al. Targeted Oncology
- Umbilical cord blood‑derived Helios‑positive regulatory T�cells promote angiogenesis in acute lymphoblastic leukemia in mice via CCL22 and the VEGFA‑VEGFR2 pathway
- (2019) Xue Li et al. Molecular Medicine Reports
- Pharmacological inhibition of the IKKε/TBK-1 axis potentiates the anti-tumour and anti-metastatic effects of Docetaxel in mouse models of breast cancer
- (2019) Ryan T. Bishop et al. CANCER LETTERS
- Phase II, Multicenter, Randomized Trial of Docetaxel plus Prednisone with or Without Cediranib in Men with Chemotherapy‐Naive Metastatic Castrate‐Resistant Prostate Cancer
- (2019) Elisabeth Heath et al. ONCOLOGIST
- Osteopontin as a multifaceted driver of bone metastasis and drug resistance
- (2019) Xiaocong Pang et al. PHARMACOLOGICAL RESEARCH
- CXCR4 antagonism in combination with IDO1 inhibition weakens immune suppression and inhibits tumor growth in mouse breast cancer bone metastases
- (2019) Jian Zhang et al. OncoTargets and Therapy
- A Phase 2 Study of Galunisertib (TGF-β1 Receptor Type I Inhibitor) and Sorafenib in Patients With Advanced Hepatocellular Carcinoma
- (2019) R.K. Kelley et al. Clinical and Translational Gastroenterology
- The bone metastasis niche in breast cancer: potential overlap with the haematopoietic stem cell niche in vivo
- (2019) Gloria Allocca et al. Journal of Bone Oncology
- Phase I/II trial of the CXCR4 inhibitor plerixafor in combination with bortezomib as a chemosensitization strategy in relapsed/refractory multiple myeloma
- (2019) Irene M. Ghobrial et al. AMERICAN JOURNAL OF HEMATOLOGY
- Detection of disseminated tumor cells in bone marrow predict late recurrences in operable breast cancer patients
- (2019) Kjersti Tjensvoll et al. BMC CANCER
- A Phase Ib/II Trial of the First-in-Class Anti-CXCR4 Antibody Ulocuplumab in Combination with Lenalidomide or Bortezomib Plus Dexamethasone in Relapsed Multiple Myeloma
- (2019) Irene M. Ghobrial et al. CLINICAL CANCER RESEARCH
- Phase 2 study of the focal adhesion kinase inhibitor defactinib (VS-6063) in previously treated advanced KRAS mutant non-small cell lung cancer
- (2019) David E. Gerber et al. LUNG CANCER
- Osteoblast-Secreted Factors Mediate Dormancy of Metastatic Prostate Cancer in the Bone via Activation of the TGFβRIII–p38MAPK–pS249/T252RB Pathway
- (2018) Li-Yuan Yu-Lee et al. CANCER RESEARCH
- Focal Irradiation and Systemic TGFβ Blockade in Metastatic Breast Cancer
- (2018) Silvia C. Formenti et al. CLINICAL CANCER RESEARCH
- Myeloid-Derived Suppressor Cells: Immune-Suppressive Cells That Impair Antitumor Immunity and Are Sculpted by Their Environment
- (2018) Suzanne Ostrand-Rosenberg et al. JOURNAL OF IMMUNOLOGY
- Interleukin-6 receptor inhibitor suppresses bone metastases in a breast cancer cell line
- (2018) Hiroki Wakabayashi et al. Breast Cancer
- Pigment Epithelium-Derived Factor (PEDF) as a Regulator of Wound Angiogenesis
- (2018) Elizabeth R. Michalczyk et al. Scientific Reports
- Efficacy of the highly selective focal adhesion kinase inhibitor BI 853520 in adenocarcinoma xenograft models is linked to a mesenchymal tumor phenotype
- (2018) Ulrich A. Hirt et al. Oncogenesis
- Parathyroid Hormone-Related Protein Negatively Regulates Tumor Cell Dormancy Genes in a PTHR1/Cyclic AMP-Independent Manner
- (2018) Rachelle W. Johnson et al. Frontiers in Endocrinology
- Multimodal Treatment of Bone Metastasis—A Surgical Perspective
- (2018) Henry Soeharno et al. Frontiers in Endocrinology
- Recent developments in topoisomerase targeted cancer chemotherapy
- (2018) KirkE. Hevener et al. Acta Pharmaceutica Sinica B
- Denosumab versus zoledronic acid for preventing symptomatic skeletal events in Asian postmenopausal women with oestrogen-receptor-positive advanced breast cancer: an outcome analyses with a mean follow-up of 3 years
- (2018) Chi Zhang et al. BMC MUSCULOSKELETAL DISORDERS
- Dormant tumour cells, their niches and the influence of immunity
- (2018) Erica T. Goddard et al. NATURE CELL BIOLOGY
- Metastatic bone disease: Pathogenesis and therapeutic options
- (2018) Stella D'Oronzo et al. Journal of Bone Oncology
- Development of Bone Targeting Drugs
- (2017) Molly Stapleton et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Skeletal Colonization by Breast Cancer Cells Is Stimulated by an Osteoblast and β2AR-Dependent Neo-Angiogenic Switch
- (2017) Patrick L Mulcrone et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Cell-penetrating peptides selectively targeting SMAD3 inhibit profibrotic TGF-β signaling
- (2017) Jeong-Han Kang et al. JOURNAL OF CLINICAL INVESTIGATION
- Growth Arrest-Specific 6 Enhances the Suppressive Function of CD4+CD25+Regulatory T Cells Mainly through Axl Receptor
- (2017) Guang-ju Zhao et al. MEDIATORS OF INFLAMMATION
- Sympathetic Signaling Reactivates Quiescent Disseminated Prostate Cancer Cells in the Bone Marrow
- (2017) Ann M. Decker et al. MOLECULAR CANCER RESEARCH
- BDNF regulates the expression and secretion of VEGF from osteoblasts via the TrkB/ERK1/2 signaling pathway during fracture healing
- (2017) Zitao Zhang et al. Molecular Medicine Reports
- IL-33 and ST2 mediate FAK-dependent antitumor immune evasion through transcriptional networks
- (2017) Bryan Serrels et al. Science Signaling
- Role of bone marrow macrophages in controlling homeostasis and repair in bone and bone marrow niches
- (2017) Simranpreet Kaur et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- The role of radiation therapy in bone metastases management
- (2017) Francesca De Felice et al. Oncotarget
- Clinical Characteristics and Prognostic Factors in Bone Metastases from Lung Cancer
- (2017) Li Zhang et al. MEDICAL SCIENCE MONITOR
- IL-33 and ST2 mediate FAK-dependent antitumor immune evasion through transcriptional networks
- (2017) Bryan Serrels et al. Science Signaling
- Osteomacs and Bone Regeneration
- (2017) Lena Batoon et al. Current Osteoporosis Reports
- A phase I, pharmacokinetic and pharmacodynamic study of GSK2256098, a focal adhesion kinase inhibitor, in patients with advanced solid tumors
- (2016) J. C. Soria et al. ANNALS OF ONCOLOGY
- Bone marrow micrometastases in early breast cancer–30-year outcome
- (2016) J Mansi et al. BRITISH JOURNAL OF CANCER
- Myeloid-Derived Suppressor Cells Endow Stem-like Qualities to Breast Cancer Cells through IL6/STAT3 and NO/NOTCH Cross-talk Signaling
- (2016) D. Peng et al. CANCER RESEARCH
- Bone-targeted therapy use in patients with bone metastases from lung cancer: A systematic review of randomized controlled trials
- (2016) Nathalie LeVasseur et al. CANCER TREATMENT REVIEWS
- Differential Effect on Bone Lesions of Targeting Integrins: Randomized Phase II Trial of Abituzumab in Patients with Metastatic Castration-Resistant Prostate Cancer
- (2016) M. Hussain et al. CLINICAL CANCER RESEARCH
- Disseminated tumor cells and dormancy in prostate cancer metastasis
- (2016) Emma E van der Toom et al. CURRENT OPINION IN BIOTECHNOLOGY
- Resting and injury-induced inflamed periosteum contain multiple macrophage subsets that are located at sites of bone growth and regeneration
- (2016) Kylie Anne Alexander et al. IMMUNOLOGY AND CELL BIOLOGY
- Recombinant Gas6 augments Axl and facilitates immune restoration in an intracerebral hemorrhage mouse model
- (2016) Lu-sha Tong et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- CD169+ macrophages mediate pathological formation of woven bone in skeletal lesions of prostate cancer
- (2016) Andy C Wu et al. JOURNAL OF PATHOLOGY
- Emerging roles of T helper 17 and regulatory T cells in lung cancer progression and metastasis
- (2016) Erin A. Marshall et al. Molecular Cancer
- Pharmacological targeting of CXCL12/CXCR4 signaling in prostate cancer bone metastasis
- (2016) M. Katie Conley-LaComb et al. Molecular Cancer
- Induction of LIFR confers a dormancy phenotype in breast cancer cells disseminated to the bone marrow
- (2016) Rachelle W. Johnson et al. NATURE CELL BIOLOGY
- Circulating and disseminated tumour cells — mechanisms of immune surveillance and escape
- (2016) Malte Mohme et al. Nature Reviews Clinical Oncology
- A Phase II randomized study of galunisertib monotherapy or galunisertib plus lomustine compared with lomustine monotherapy in patients with recurrent glioblastoma
- (2016) Alba A. Brandes et al. NEURO-ONCOLOGY
- Axl signaling induces development of natural killer cells in vitro and in vivo
- (2016) Eun-Mi Kim et al. PROTOPLASMA
- The Nature of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment
- (2016) Vinit Kumar et al. TRENDS IN IMMUNOLOGY
- Comparison of Clinicopathological Features and Prognosis in Triple-Negative and Non-Triple Negative Breast Cancer
- (2016) Jingdan Qiu et al. Journal of Cancer
- Management of skeletal-related events in patients with advanced prostate cancer and bone metastases: Incorporating new agents into clinical practice
- (2016) Alan So et al. CUAJ-Canadian Urological Association Journal
- Axl is required for TGF-β2-induced dormancy of prostate cancer cells in the bone marrow
- (2016) Kenji Yumoto et al. Scientific Reports
- Disseminated tumor cells from the bone marrow of patients with nonmetastatic primary breast cancer are predictive of locoregional relapse
- (2015) A. D. Hartkopf et al. ANNALS OF ONCOLOGY
- A phase I trial combining carboplatin/doxorubicin with tocilizumab, an anti-IL-6R monoclonal antibody, and interferon-α2b in patients with recurrent epithelial ovarian cancer
- (2015) E. M. Dijkgraaf et al. ANNALS OF ONCOLOGY
- Regulation of Tumor Metastasis by Myeloid-Derived Suppressor Cells
- (2015) Thomas Condamine et al. Annual Review of Medicine
- Biodistribution of Fracture-Targeted GSK3β Inhibitor-Loaded Micelles for Improved Fracture Healing
- (2015) Stewart A. Low et al. BIOMACROMOLECULES
- Making sense of hematopoietic stem cell niches
- (2015) P. E. Boulais et al. BLOOD
- The TGF-β Signaling Regulator PMEPA1 Suppresses Prostate Cancer Metastases to Bone
- (2015) Pierrick G.J. Fournier et al. CANCER CELL
- The Contribution of Angiogenesis to the Process of Metastasis
- (2015) Diane R. Bielenberg et al. CANCER JOURNAL
- Identification of Bone-Derived Factors Conferring De Novo Therapeutic Resistance in Metastatic Prostate Cancer
- (2015) Y.-C. Lee et al. CANCER RESEARCH
- Nuclear FAK Controls Chemokine Transcription, Tregs, and Evasion of Anti-tumor Immunity
- (2015) Alan Serrels et al. CELL
- Molecular Pathways: Targeting the CXCR4-CXCL12 Axis--Untapped Potential in the Tumor Microenvironment
- (2015) S. Scala CLINICAL CANCER RESEARCH
- Effects of cilengitide in osteoclast maturation and behavior
- (2015) Anastasia Chillà et al. EXPERIMENTAL CELL RESEARCH
- Combination chemotherapy with cyclophosphamide, epirubicin and 5-fluorouracil causes trabecular bone loss, bone marrow cell depletion and marrow adiposity in female rats
- (2015) Chiaming Fan et al. JOURNAL OF BONE AND MINERAL METABOLISM
- Macrophages Promote Osteoblastic Differentiation In Vivo: Implications in Fracture Repair and Bone Homeostasis
- (2015) Linda Vi et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Macrophages: Their Emerging Roles in Bone
- (2015) Benjamin P Sinder et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Immature myeloid cells directly contribute to skin tumor development by recruiting IL-17–producing CD4+T cells
- (2015) Myrna L. Ortiz et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Bone metastasis and the metastatic niche
- (2015) Guangwen Ren et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Sorting nexin 9 differentiates ligand-activated Smad3 from Smad2 for nuclear import and transforming growth factor β signaling
- (2015) Mark C. Wilkes et al. MOLECULAR BIOLOGY OF THE CELL
- AZD9150, a next-generation antisense oligonucleotide inhibitor of STAT3 with early evidence of clinical activity in lymphoma and lung cancer
- (2015) David Hong et al. Science Translational Medicine
- Secretome of human bone marrow mesenchymal stem cells: an emerging player in lung cancer progression and mechanisms of translation initiation
- (2015) Oshrat Attar-Schneider et al. TUMOR BIOLOGY
- NR2F1 controls tumour cell dormancy via SOX9- and RARβ-driven quiescence programmes
- (2015) Maria Soledad Sosa et al. Nature Communications
- Bone marrow macrophages support prostate cancer growth in bone
- (2015) Fabiana N. Soki et al. Oncotarget
- Downregulation of CXCR4 in Metastasized Breast Cancer Cells and Implication in Their Dormancy
- (2015) Kentaro Nobutani et al. PLoS One
- TBK1 Regulates Prostate Cancer Dormancy through mTOR Inhibition
- (2015) Jin Koo Kim et al. NEOPLASIA
- Cardiac Safety of TGF-β Receptor I Kinase Inhibitor LY2157299 Monohydrate in Cancer Patients in a First-in-Human Dose Study
- (2014) Richard J. Kovacs et al. Cardiovascular Toxicology
- Osteal Tissue Macrophages Are Intercalated throughout Human and Mouse Bone Lining Tissues and Regulate Osteoblast Function In Vitro and In Vivo
- (2014) M. K. Chang et al. JOURNAL OF IMMUNOLOGY
- Effect of radium-223 dichloride on symptomatic skeletal events in patients with castration-resistant prostate cancer and bone metastases: results from a phase 3, double-blind, randomised trial
- (2014) Oliver Sartor et al. LANCET ONCOLOGY
- Pharmacologic Suppression of JAK1/2 by JAK1/2 Inhibitor AZD1480 Potently Inhibits IL-6-Induced Experimental Prostate Cancer Metastases Formation
- (2014) L. Gu et al. MOLECULAR CANCER THERAPEUTICS
- Phase I Study of GC1008 (Fresolimumab): A Human Anti-Transforming Growth Factor-Beta (TGFβ) Monoclonal Antibody in Patients with Advanced Malignant Melanoma or Renal Cell Carcinoma
- (2014) John C. Morris et al. PLoS One
- Model of Tumor Dormancy/Recurrence after Short-Term Chemotherapy
- (2014) Shenduo Li et al. PLoS One
- Dormancy of Cancer Cells with Suppression of AKT Activity Contributes to Survival in Chronic Hypoxia
- (2014) Hiroko Endo et al. PLoS One
- Osteal macrophages support physiologic skeletal remodeling and anabolic actions of parathyroid hormone in bone
- (2014) S. W. Cho et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Exosomes from bone marrow mesenchymal stem cells contain a microRNA that promotes dormancy in metastatic breast cancer cells
- (2014) M. Ono et al. Science Signaling
- Phase II clinical trial of cediranib in patients with metastatic castration-resistant prostate cancer
- (2013) William L. Dahut et al. BJU INTERNATIONAL
- Clinical significance of disseminated tumour cells in non-small cell lung cancer
- (2013) A K Rud et al. BRITISH JOURNAL OF CANCER
- Angiogenic factors in bone local environment
- (2013) Shek Man Chim et al. CYTOKINE & GROWTH FACTOR REVIEWS
- Myeloid-Derived Suppressor Cells Enhance Stemness of Cancer Cells by Inducing MicroRNA101 and Suppressing the Corepressor CtBP2
- (2013) Tracy X. Cui et al. IMMUNITY
- Strontium-89 (Sr-89) chloride in the treatment of various cancer patients with multiple bone metastases
- (2013) Sadamoto Zenda et al. International Journal of Clinical Oncology
- Tumour cell survival mechanisms in lethal metastatic prostate cancer differ between bone and soft tissue metastases
- (2013) Canan Akfirat et al. JOURNAL OF PATHOLOGY
- The perivascular niche regulates breast tumour dormancy
- (2013) Cyrus M. Ghajar et al. NATURE CELL BIOLOGY
- Alpha Emitter Radium-223 and Survival in Metastatic Prostate Cancer
- (2013) C. Parker et al. NEW ENGLAND JOURNAL OF MEDICINE
- AZD1480: A Phase I Study of a Novel JAK2 Inhibitor in Solid Tumors
- (2013) E. R. Plimack et al. ONCOLOGIST
- T Cells Induce Pre-Metastatic Osteolytic Disease and Help Bone Metastases Establishment in a Mouse Model of Metastatic Breast Cancer
- (2013) Ana Carolina Monteiro et al. PLoS One
- Placental Growth Factor Expression Is Required for Bone Marrow Endothelial Cell Support of Primitive Murine Hematopoietic Cells
- (2013) Xiaoying Zhou et al. PLoS One
- Cord Blood-Derived Macrophage-Lineage Cells Rapidly Stimulate Osteoblastic Maturation in Mesenchymal Stem Cells in a Glycoprotein-130 Dependent Manner
- (2013) Tania J. Fernandes et al. PLoS One
- Doxorubicin-Mediated Bone Loss in Breast Cancer Bone Metastases Is Driven by an Interplay between Oxidative Stress and Induction of TGFβ
- (2013) Tapasi Rana et al. PLoS One
- Targeting CXCL12/CXCR4 signaling with oncolytic virotherapy disrupts tumor vasculature and inhibits breast cancer metastases
- (2013) M. Gil et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- PlGF: A Multitasking Cytokine with Disease-Restricted Activity
- (2013) M. Dewerchin et al. Cold Spring Harbor Perspectives in Medicine
- Immunological effects of the TGFβ-blocking antibody GC1008 in malignant pleural mesothelioma patients
- (2013) James P Stevenson et al. OncoImmunology
- Phase Ib safety and pharmacokinetic study of volociximab, an anti-α5β1 integrin antibody, in combination with carboplatin and paclitaxel in advanced non-small-cell lung cancer
- (2012) B. Besse et al. ANNALS OF ONCOLOGY
- Agents Targeting Prostate Cancer Bone Metastasis
- (2012) Khalid Mohammad et al. Anti-Cancer Agents in Medicinal Chemistry
- Presence of Tumour-infiltrating FOXP3+Lymphocytes Correlates with Immature Tumour Angiogenesis in Renal Cell Carcinomas
- (2012) Hai-Lun Zhan et al. Asian Pacific Journal of Cancer Prevention
- Osteoblast-specific transcription factor Osterix (Osx) and HIF-1α cooperatively regulate gene expression of vascular endothelial growth factor (VEGF)
- (2012) Dafu Chen et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Myeloid-Derived Suppressor Cells Function as Novel Osteoclast Progenitors Enhancing Bone Loss in Breast Cancer
- (2012) A. Sawant et al. CANCER RESEARCH
- MED12 Controls the Response to Multiple Cancer Drugs through Regulation of TGF-β Receptor Signaling
- (2012) Sidong Huang et al. CELL
- A randomized, dose–response, multicenter phase II study of radium-223 chloride for the palliation of painful bone metastases in patients with castration-resistant prostate cancer
- (2012) S. Nilsson et al. EUROPEAN JOURNAL OF CANCER
- Twenty-five years of PTHrP progress: From cancer hormone to multifunctional cytokine
- (2012) Laurie K McCauley et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Cilengitide affects tumor compartment, vascularization and microenvironment in experimental bone metastases as shown by longitudinal 18F-FDG PET and gene expression analysis
- (2012) Maren Bretschi et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- TNF signaling drives myeloid-derived suppressor cell accumulation
- (2012) Xueqiang Zhao et al. JOURNAL OF CLINICAL INVESTIGATION
- Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation
- (2012) Yanqiu Liu et al. JOURNAL OF CLINICAL INVESTIGATION
- Tumor-Infiltrating Monocytic Myeloid-Derived Suppressor Cells Mediate CCR5-Dependent Recruitment of Regulatory T Cells Favoring Tumor Growth
- (2012) E. Schlecker et al. JOURNAL OF IMMUNOLOGY
- Regulation of osteoclast structure and function by FAK family kinases
- (2012) Brianne J. Ray et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Multiple roles of COUP-TFII in cancer initiation and progression
- (2012) Lacey M Litchfield et al. JOURNAL OF MOLECULAR ENDOCRINOLOGY
- Effect of monocytes/macrophages on the early osteogenic differentiation of hBMSCs
- (2012) R. P. Pirraco et al. Journal of Tissue Engineering and Regenerative Medicine
- Study on the distribution features of bone metastases in prostate cancer
- (2012) Changyin Wang et al. NUCLEAR MEDICINE COMMUNICATIONS
- Monocytes Induce STAT3 Activation in Human Mesenchymal Stem Cells to Promote Osteoblast Formation
- (2012) Vicky Nicolaidou et al. PLoS One
- Both osteopontin-c and osteopontin-b splicing isoforms exert pro-tumorigenic roles in prostate cancer cells
- (2012) Tatiana M. Tilli et al. PROSTATE
- Induction of Osteogenesis in Mesenchymal Stem Cells by Activated Monocytes/Macrophages Depends on Oncostatin M Signaling
- (2012) Pierre Guihard et al. STEM CELLS
- Comparison of distribution characteristics of metastatic bone lesions between breast and prostate carcinomas
- (2012) CHANG-YIN WANG et al. Oncology Letters
- Regulatory T cells in the bone marrow microenvironment in patients with prostate cancer
- (2012) Ende Zhao et al. OncoImmunology
- Cilengitide: The First Anti-Angiogenic Small Molecule Drug Candidate. Design, Synthesis and Clinical Evaluation
- (2011) Carlos Mas-Moruno et al. Anti-Cancer Agents in Medicinal Chemistry
- Positive feedback between PGE2 and COX2 redirects the differentiation of human dendritic cells toward stable myeloid-derived suppressor cells
- (2011) N. Obermajer et al. BLOOD
- Effect of transforming growth factor beta (TGF-β) receptor I kinase inhibitor on prostate cancer bone growth
- (2011) Xinhai Wan et al. BONE
- VCAM-1 Promotes Osteolytic Expansion of Indolent Bone Micrometastasis of Breast Cancer by Engaging α4β1-Positive Osteoclast Progenitors
- (2011) Xin Lu et al. CANCER CELL
- Tumor-Derived Jagged1 Promotes Osteolytic Bone Metastasis of Breast Cancer by Engaging Notch Signaling in Bone Cells
- (2011) Nilay Sethi et al. CANCER CELL
- Antiangiogenic and Antimetastatic Activity of JAK Inhibitor AZD1480
- (2011) H. Xin et al. CANCER RESEARCH
- Gap Junction-Mediated Import of MicroRNA from Bone Marrow Stromal Cells Can Elicit Cell Cycle Quiescence in Breast Cancer Cells
- (2011) P. K. Lim et al. CANCER RESEARCH
- Bone marrow and the control of immunity
- (2011) Ende Zhao et al. Cellular & Molecular Immunology
- Cancer Dormancy: A Model of Early Dissemination and Late Cancer Recurrence
- (2011) D. Paez et al. CLINICAL CANCER RESEARCH
- Persistence of Disseminated Tumor Cells in the Bone Marrow of Breast Cancer Patients Predicts Increased Risk for Relapse--A European Pooled Analysis
- (2011) W. Janni et al. CLINICAL CANCER RESEARCH
- The ratio of VEGF/PEDF expression in bone marrow mesenchymal stem cells regulates neovascularization
- (2011) Wei Fan et al. DIFFERENTIATION
- Randomised phase II study of siltuximab (CNTO 328), an anti-IL-6 monoclonal antibody, in combination with mitoxantrone/prednisone versus mitoxantrone/prednisone alone in metastatic castration-resistant prostate cancer
- (2011) K. Fizazi et al. EUROPEAN JOURNAL OF CANCER
- Anti-tumor effect in human breast cancer by TAE226, a dual inhibitor for FAK and IGF-IR in vitro and in vivo
- (2011) Naito Kurio et al. EXPERIMENTAL CELL RESEARCH
- Mechanisms of cancer cell metastasis to the bone: a multistep process
- (2011) Lalit R Patel et al. Future Oncology
- Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrow
- (2011) Yusuke Shiozawa et al. JOURNAL OF CLINICAL INVESTIGATION
- Denosumab versus zoledronic acid for treatment of bone metastases in men with castration-resistant prostate cancer: a randomised, double-blind study
- (2011) Karim Fizazi et al. LANCET
- Denosumab and bone-metastasis-free survival in men with castration-resistant prostate cancer: results of a phase 3, randomised, placebo-controlled trial
- (2011) Matthew R Smith et al. LANCET
- Focal adhesion kinase inhibitors are potent anti-angiogenic agents
- (2011) Miguel A. Cabrita et al. Molecular Oncology
- Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL–RANK signalling
- (2011) Wei Tan et al. NATURE
- Treatment Outcome and Prognostic Factors for Patients with Bone-Only Metastases of Breast Cancer: A Single-Institution Retrospective Analysis
- (2011) N. Niikura et al. ONCOLOGIST
- Cilengitide inhibits metastatic bone colonization in a nude rat model
- (2011) Tobias B�uerle ONCOLOGY REPORTS
- Slow-Cycling Therapy-Resistant Cancer Cells
- (2011) Nathan Moore et al. STEM CELLS AND DEVELOPMENT
- Induction of Heart Valve Lesions by Small-Molecule ALK5 Inhibitors
- (2011) Mark J. Anderton et al. TOXICOLOGIC PATHOLOGY
- Notch3 in Human Breast Cancer Cell Lines Regulates Osteoblast-Cancer Cell Interactions and Osteolytic Bone Metastasis
- (2010) Zhiyuan Zhang et al. AMERICAN JOURNAL OF PATHOLOGY
- Biochemical and molecular mechanisms of action of bisphosphonates
- (2010) Michael J. Rogers et al. BONE
- Myeloid-derived suppressor cells: more mechanisms for inhibiting antitumor immunity
- (2010) Suzanne Ostrand-Rosenberg CANCER IMMUNOLOGY IMMUNOTHERAPY
- Breast Cancer Dormancy Can Be Maintained by Small Numbers of Micrometastases
- (2010) Lisa Willis et al. CANCER RESEARCH
- Anti-Placental Growth Factor Reduces Bone Metastasis by Blocking Tumor Cell Engraftment and Osteoclast Differentiation
- (2010) L. Coenegrachts et al. CANCER RESEARCH
- Novel STAT3 Phosphorylation Inhibitors Exhibit Potent Growth-Suppressive Activity in Pancreatic and Breast Cancer Cells
- (2010) L. Lin et al. CANCER RESEARCH
- Cediranib/AZD2171 Inhibits Bone and Brain Metastasis in a Preclinical Model of Advanced Prostate Cancer
- (2010) J. J. Yin et al. CANCER RESEARCH
- Clinical and Correlative Results of SWOG S0354: A Phase II Trial of CNTO328 (Siltuximab), a Monoclonal Antibody against Interleukin-6, in Chemotherapy-Pretreated Patients with Castration-Resistant Prostate Cancer
- (2010) T. B. Dorff et al. CLINICAL CANCER RESEARCH
- Interleukin-6 in bone metastasis and cancer progression
- (2010) Tasnim Ara et al. EUROPEAN JOURNAL OF CANCER
- Cilengitide inhibits progression of experimental breast cancer bone metastases as imaged noninvasively using VCT, MRI and DCE-MRI in a longitudinal in vivo study
- (2010) Tobias Bäuerle et al. INTERNATIONAL JOURNAL OF CANCER
- Hedgehog Signaling Induced by Breast Cancer Cells Promotes Osteoclastogenesis and Osteolysis
- (2010) Shamik Das et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2010) Diana P. Trebec-Reynolds et al. JOURNAL OF CELLULAR BIOCHEMISTRY
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- (2010) Alison T. Stopeck et al. JOURNAL OF CLINICAL ONCOLOGY
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- (2010) Hagen Kennecke et al. JOURNAL OF CLINICAL ONCOLOGY
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- (2010) Vidya Ganapathy et al. Molecular Cancer
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- (2010) A. Bruni-Cardoso et al. MOLECULAR CANCER RESEARCH
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- (2010) Thomas Schmidt et al. NATURE
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- (2010) Subhra K Biswas et al. NATURE IMMUNOLOGY
- Bisphosphonates in oncology: evidence for the prevention of skeletal events in patients with bone metastases
- (2010) Thomas Polascik Drug Design Development and Therapy
- PEDF regulates osteoclasts via osteoprotegerin and RANKL
- (2009) Toru Akiyama et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
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- (2009) Julia Bollrath et al. CANCER CELL
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- (2009) M. K. Srivastava et al. CANCER RESEARCH
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- (2009) T. M. Morgan et al. CLINICAL CANCER RESEARCH
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- (2009) John Kosteva et al. CURRENT OPINION IN ONCOLOGY
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- (2009) Kristin Harris et al. EUROPEAN JOURNAL OF CANCER
- The influence of chemotherapy on bone mineral density, quantitative ultrasonometry and bone turnover in pre-menopausal women with breast cancer
- (2009) Peyman Hadji et al. EUROPEAN JOURNAL OF CANCER
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- (2009) Alberto Ruffato et al. EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
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- (2009) Hernan Roca et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Anticancer mechanisms of doxorubicin and zoledronic acid in breast cancer tumor growth in bone
- (2009) P. D. Ottewell et al. MOLECULAR CANCER THERAPEUTICS
- Differential epidermal growth factor receptor signaling regulates anchorage-independent growth by modulation of the PI3K/AKT pathway
- (2009) J O Humtsoe et al. ONCOGENE
- Smad2 and Smad3 have opposing roles in breast cancer bone metastasis by differentially affecting tumor angiogenesis
- (2009) M Petersen et al. ONCOGENE
- Hypoxia and TGF-β Drive Breast Cancer Bone Metastases through Parallel Signaling Pathways in Tumor Cells and the Bone Microenvironment
- (2009) Lauren K. Dunn et al. PLoS One
- Osteal macrophages: A new twist on coupling during bone dynamics
- (2008) Allison R. Pettit et al. BONE
- Dual focal adhesion kinase/Pyk2 inhibitor has positive effects on bone tumors
- (2008) Cedo M. Bagi et al. CANCER
- Overexpression of Interleukin-1β Induces Gastric Inflammation and Cancer and Mobilizes Myeloid-Derived Suppressor Cells in Mice
- (2008) Shuiping Tu et al. CANCER CELL
- Dkk-1 secreted by mesenchymal stem cells inhibits growth of breast cancer cells via depression of Wnt signalling
- (2008) Ling Qiao et al. CANCER LETTERS
- Disseminated Tumor Cells of Breast Cancer Patients: A Strong Prognostic Factor for Distant and Local Relapse
- (2008) F.-C. Bidard et al. CLINICAL CANCER RESEARCH
- The dual role of IL-6-type cytokines on bone remodeling and bone tumors
- (2008) Frédéric Blanchard et al. CYTOKINE & GROWTH FACTOR REVIEWS
- The presence of tumor-infiltrating FOXP3+ lymphocytes correlates with intratumoral angiogenesis in endometrial cancer
- (2008) Alexandra Giatromanolaki et al. GYNECOLOGIC ONCOLOGY
- Stat3 mediates myeloid cell–dependent tumor angiogenesis in mice
- (2008) Maciej Kujawski et al. JOURNAL OF CLINICAL INVESTIGATION
- Prognostic Significance of Disseminated Tumor Cells in the Bone Marrow of Prostate Cancer Patients Treated With Neoadjuvant Hormone Treatment
- (2008) Jens Köllermann et al. JOURNAL OF CLINICAL ONCOLOGY
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- (2008) Martine P. Roudier et al. JOURNAL OF UROLOGY
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