Article
Oncology
Sukanya Basu, Yang Dong, Rahul Kumar, Collene Jeter, Dean G. Tang
Summary: Cancer cell heterogeneity and plasticity pose significant challenges to effective clinical treatments. Research has shown that cancer cells can exhibit stem-like characteristics and undergo dynamic changes during tumor progression. In addition, tumors also contain a population of non-proliferative cells that are resistant to anti-mitotic drugs. Understanding these unique cell populations in tumors can lead to the development of new therapeutic strategies to prevent relapse and metastasis.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Oncology
Changlin Yang, Guimei Tian, Mariana Dajac, Andria Doty, Shu Wang, Ji-Hyun Lee, Maryam Rahman, Jianping Huang, Brent A. Reynolds, Matthew R. Sarkisian, Duane Mitchell, Loic P. Deleyrolle
Summary: This study reveals the diversity of cell types and dynamic behaviors in glioblastoma, particularly the heterogeneity between slow-cycling cells and cells defined by the expression of stem cell markers. The findings shed light on the potential mechanisms underlying tumor resilience and treatment resistance, and provide insights for the development of precision and effective therapies for brain cancer.
Article
Multidisciplinary Sciences
Francesco Antonica, Lucia Santomaso, Davide Pernici, Linda Petrucci, Giuseppe Aiello, Alessandro Cutarelli, Luciano Conti, Alessandro Romanel, Evelina Miele, Toma Tebaldi, Luca Tiberi
Summary: Quiescent cells in high-grade glioma patients play a significant role in tumor invasiveness, recurrence, and treatment resistance. Targeting and visualizing these cells has been a challenge, but it was found that a population of malignant cells expressing Prominin-1 in a non-proliferating state contribute to tumor infiltration. The use of a DYRK1A/B inhibitor, Harmine, has shown promise in reducing the number of quiescent and infiltrating cancer cells.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Shunsuke Yahiro, Teruya Kawamoto, Shuichi Fujiwara, Hitomi Hara, Naomasa Fukase, Ryoko Sawada, Toshiyuki Takemori, Tomohiro Miyamoto, Yutaka Mifune, Kenichiro Kakutani, Yuichi Hoshino, Shinya Hayashi, Tomoyuki Matsumoto, Takehiko Matsushita, Michiyo Koyanagi-Aoi, Takashi Aoi, Ryosuke Kuroda, Toshihiro Akisue
Summary: Ewing sarcoma is an aggressive malignant bone tumor. The presence of slow-cycling cells (SCCs) is associated with tumor progression, recurrence, and metastasis. This study successfully identified and characterized SCCs in Ewing sarcoma cell lines using a label-retaining system. The findings may contribute to understanding the molecular mechanisms and developing targeted therapies for Ewing sarcoma.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Elle Koren, Alona Feldman, Marianna Yusupova, Avihay Kadosh, Egor Sedov, Roi Ankawa, Yahav Yosefzon, Waseem Nasser, Stefanie Gerstberger, Liam B. Kimel, Noa Priselac, Samara Brown, Sam Sharma, Travis Gorenc, Ruby Shalom-Feuerstein, Hermann Steller, Tom Shemesh, Yaron Fuchs
Summary: Koren and Feldman et al. discovered a distinct population of Thy1-expressing stem cells in the basal layer of the mouse epidermis that contribute to epidermal replenishment and wound repair. These stem cells display unique transcriptional signatures and exhibit slower cell cycle kinetics compared to basal epidermal progenitors. The ablation of Thy1(+) cells impairs epidermal homeostasis and repair, highlighting the critical role of these stem cells in maintaining the integrity of the epidermis.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Gulsen Turkoglu, Gozde Kayadibi Koygun, Mediha Nur Zafer Yurt, Seyda Nur Pirencioglu, Sundus Erbas-Cakmak
Summary: A molecular keypad lock with photodynamic activity when exposed to GSH, esterase, and light in sequence is fabricated and effectively kills drug resistant MCF7 cancer cells. This work demonstrates the first biological application of small molecular keypad locks.
Article
Oncology
Molly Dore, Sara Filoche, Kirsty Danielson, Claire Henry
Summary: LNG-resistant cells may have more oncogenic potential than their LNG-sensitive counterparts, with significant changes in mRNA expression of KLF4 and SATB2 indicating promising initial results for biomarker discovery to guide LNG-IUS treatment of early stage endometrial cancer.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Federica Foglietta, Manuela Macri, Patrizia Panzanelli, Andrea Francovich, Gianni Durando, Francesca Garello, Enzo Terreno, Loredana Serpe, Roberto Canaparo
Summary: Ovarian cancer is a deadly disease with high mortality, frequent relapses, and drug resistance. Sonodynamic therapy, which combines a sonosensitizer and low-intensity ultrasound, is a promising approach for cancer treatment. This research investigates the use of the chemotherapeutic drug Doxorubicin as a sonosensitizer to induce cell death in ovarian cancer cells and prevent recurrence. The results show that this sonodynamic therapy with Doxorubicin is effective and operates through a ROS-dependent mechanism and immune sensitization based on the activation of the ICD pathway.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Nanoscience & Nanotechnology
Mariana Morais, Vera Machado, Francisca Dias, Patricia Figueiredo, Carlos Palmeira, Gabriela Martins, Rui Fernandes, Ana Rita Malheiro, Kirsi S. Mikkonen, Ana Luisa Teixeira, Rui Medeiros
Summary: The glucose-functionalized silver nanoparticles showed promising cytotoxic effects on CRPC cells, indicating their potential as a future therapeutic approach for patients with PCa resistant to hormone therapy or metastatic disease.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Immunology
Selene E. Di Carlo, Jerome Raffenne, Hugo Varet, Anais Ode, David Cabrerizo Granados, Merle Stein, Rachel Legendre, Jan Tuckermann, Corinne Bousquet, Lucie Peduto
Summary: This study identified a specific type of cells called ADAM12 that induce pathological angiogenesis and immunosuppression in mouse models of melanoma, pancreatic cancer, and prostate cancer. Depletion of these cells restores functional tumor vasculature, reduces hypoxia and acidosis, and inhibits tumor growth.
Article
Multidisciplinary Sciences
Yaara Oren, Michael Tsabar, Michael S. Cuoco, Liat Amir-Zilberstein, Heidie F. Cabanos, Jan-Christian Hutter, Bomiao Hu, Pratiksha I. Thakore, Marcin Tabaka, Charles P. Fulco, William Colgan, Brandon M. Cuevas, Sara A. Hurvitz, Dennis J. Slamon, Amy Deik, Kerry A. Pierce, Clary Clish, Aaron N. Hata, Elma Zaganjor, Galit Lahav, Katerina Politi, Joan S. Brugge, Aviv Regev
Summary: Recent studies have revealed that cancer cells can enter different lineages in response to treatment, with distinct biological characteristics and metabolic programs. Proliferative capacity of drug-tolerant persister cells is associated with upregulation of antioxidant gene programs and a metabolic shift to fatty acid oxidation.
Article
Dentistry, Oral Surgery & Medicine
T. Nakano, K. A. Warner, A. E. Oklejas, Z. Zhang, C. Rodriguez-Ramirez, A. G. Shuman, J. E. Nor
Summary: This study demonstrated the therapeutic potential of mTOR inhibitors in targeting cisplatin-resistant cancer stem cells in salivary gland mucoepidermoid carcinoma. Combining mTOR inhibitors with platinum-based chemotherapy may offer a promising treatment strategy for patients with advanced MEC.
JOURNAL OF DENTAL RESEARCH
(2021)
Article
Oncology
Yida Zhang, Lile He, Ananthan Sadagopan, Tao Ma, Gianpietro Dotti, Yufeng Wang, Hui Zheng, Xin Gao, Dian Wang, Albert B. DeLeo, Song Fan, Ruochuan Sun, Ling Yu, Liyuan Zhang, Gongxian Wang, Soldano Ferrone, Xinhui Wang
Summary: FIR significantly upregulates B7-H3 expression on RT-resistant PCSCs and bulk cells, leading to potent cytotoxicity of B7-H3 CAR T cells to FIR-treated PCSCs, and significantly improved antitumor efficacy in mice.
MOLECULAR CANCER THERAPEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Eric Chekwube Aniogo, Blassan P. George, Heidi Abrahamse
Summary: Cancer resistance is a major concern in cancer treatment. Photodynamic therapy (PDT) and photobiomodulation (PBM) can improve therapeutic outcomes, and PBM may enhance the anti-tumor efficacy of ZnPcS4-PDT on resistant MCF-7 breast cancer cells by inducing autophagy.
Article
Biochemical Research Methods
Giada Forlani, Enoch B. Antwi, Daniel Weis, Mehmet A. Oeztuerk, Bastian A. W. Queck, Dominik Brecht, Barbara Di Ventura
Summary: The LEXY optogenetic tool with mutated LOV variants showed improved depletion of certain POIs from the nucleus in Drosophila embryos. However, when tested in mammalian cells, these variants led to increased cytoplasmic localization of proteins both after illumination and during dark phases, indicating higher system leakiness.
ACS SYNTHETIC BIOLOGY
(2022)