SIRT3 ameliorates osteoarthritis via regulating chondrocyte autophagy and apoptosis through the PI3K/Akt/mTOR pathway

Chondro-protective effects of celastrol on osteoarthritis through autophagy activation and NF-κB signaling pathway inhibition

(2020) Kai Feng et al.   INFLAMMATION RESEARCH

Pleiotropic effect of fibrates on senescence and autophagy in osteoarthritis

(2019) Marta Anna Szychlinska et al.   EBioMedicine

MiR-27a promotes the autophagy and apoptosis of IL-1β treated-articular chondrocytes in osteoarthritis through PI3K/AKT/mTOR signaling

(2019) Chen Cai et al.   Aging-US

miR-940 regulates the inflammatory response of chondrocytes by targeting MyD88 in osteoarthritis

(2019) Jian Cao et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Intra-articular injection of hUC-MSCs expressing miR-140-5p induces cartilage self-repairing in the rat osteoarthritis

(2019) Yiyun Geng et al.   JOURNAL OF BONE AND MINERAL METABOLISM

Sirtuin 3 deficiency does not impede digit regeneration in mice

(2019) Emily Busse et al.   Scientific Reports

Inhibition of miR-20 promotes proliferation and autophagy in articular chondrocytes by PI3K/AKT/mTOR signaling pathway

(2018) Weidong He et al.   BIOMEDICINE & PHARMACOTHERAPY

miR-140-5p/miR-149 Affects Chondrocyte Proliferation, Apoptosis, and Autophagy by Targeting FUT1 in Osteoarthritis

(2018) Zi Wang et al.   INFLAMMATION

Cytokine-induced interleukin-1 receptor antagonist protein expression in genetically engineered equine mesenchymal stem cells for osteoarthritis treatment

(2018) Simone Gabner et al.   JOURNAL OF GENE MEDICINE

Mitochondrial DNA variation and the pathogenesis of osteoarthritis phenotypes

(2018) Francisco J. Blanco et al.   Nature Reviews Rheumatology

FoxO transcription factors modulate autophagy and proteoglycan 4 in cartilage homeostasis and osteoarthritis

(2018) Tokio Matsuzaki et al.   Science Translational Medicine

Preventing muscle wasting by osteoporosis drug alendronate in vitro and in myopathy models via sirtuin-3 down-regulation

(2018) Hsien-Chun Chiu et al.   Journal of Cachexia Sarcopenia and Muscle

Role of the Inflammation-Autophagy-Senescence Integrative Network in Osteoarthritis

(2018) Claire Vinatier et al.   Frontiers in Physiology

TFEB, a potential therapeutic target for osteoarthritis via autophagy regulation

(2018) Gang Zheng et al.   Cell Death & Disease

MicroRNA-128a represses chondrocyte autophagy and exacerbates knee osteoarthritis by disrupting Atg12

(2018) Wei-Shiung Lian et al.   Cell Death & Disease

Mechanical loading mitigates osteoarthritis symptoms by regulating endoplasmic reticulum stress and autophagy

(2018) Weiwei Zheng et al.   FASEB JOURNAL

Sirtuin 3 suppresses the formation of renal calcium oxalate crystals through promoting M2 polarization of macrophages

(2018) Junhua Xi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Sirtuin-3 Promotes Adipogenesis, Osteoclastogenesis, and Bone Loss in Aging Male Mice

(2017) Linh Ho et al.   ENDOCRINOLOGY

Sirt3 confers protection against neuronal ischemia by inducing autophagy: Involvement of the AMPK-mTOR pathway

(2017) Shu-Hui Dai et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sirtuin 3 is required for osteogenic differentiation through maintenance of PGC-1ɑ-SOD2-mediated regulation of mitochondrial function

(2017) Yong Ding et al.   International Journal of Biological Sciences

Lentiviral vector-mediated shRNAs targeting a functional isoform of the leptin receptor (Ob-Rb) inhibit cartilage degeneration in a rat model of osteoarthritis

(2017) S.L. Deng et al.   OSTEOARTHRITIS AND CARTILAGE

The protective role of autophagy in experimental osteoarthritis, and the therapeutic effects of Torin 1 on osteoarthritis by activating autophagy

(2016) Ni-Tao Cheng et al.   BMC MUSCULOSKELETAL DISORDERS

Autophagy in osteoarthritis

(2016) Hyelin Jeon et al.   CONNECTIVE TISSUE RESEARCH

Leptin promotes apoptosis and inhibits autophagy of chondrocytes through upregulating lysyl oxidase-like 3 during osteoarthritis pathogenesis

(2016) Z.M. Huang et al.   OSTEOARTHRITIS AND CARTILAGE

Sirtuin 3 (SIRT3) maintains bone homeostasis by regulating AMPK-PGC-1β axis in mice

(2016) Jeong-Eun Huh et al.   Scientific Reports

Aging Promotes Sirtuin 3-Dependent Cartilage Superoxide Dismutase 2 Acetylation and Osteoarthritis

(2016) Yao Fu et al.   Arthritis & Rheumatology

Sirt3 Protects Cortical Neurons against Oxidative Stress via Regulating Mitochondrial Ca2+ and Mitochondrial Biogenesis

(2014) Shu-Hui Dai et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Impact of Obesity and Knee Osteoarthritis on Morbidity and Mortality in Older Americans

(2013) Elena Losina et al.   ANNALS OF INTERNAL MEDICINE

The role of mitochondria in osteoarthritis

(2011) Francisco J. Blanco et al.   Nature Reviews Rheumatology