MicroRNA-128a represses chondrocyte autophagy and exacerbates knee osteoarthritis by disrupting Atg12

Osteoarthritis year in review 2017: clinical

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MicroRNAs and Autophagy: Fine Players in the Control of Chondrocyte Homeostatic Activities in Osteoarthritis

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Mechanisms Regulating PRC2 Recruitment and Enzymatic Activity

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Regulation of Chondrocyte Survival in Mouse Articular Cartilage by p63

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Osteoarthritis: toward a comprehensive understanding of pathological mechanism

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Fis1 depletion in osteoarthritis impairs chondrocyte survival and peroxisomal and lysosomal function

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Identification of synovial fluid microRNA signature in knee osteoarthritis: differentiating early- and late-stage knee osteoarthritis

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The Inhibition of microRNA-128 on IGF-1-Activating mTOR Signaling Involves in Temozolomide-Induced Glioma Cell Apoptotic Death

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Targeted deletion of Atg5 in chondrocytes promotes age-related osteoarthritis

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MicroRNA-124 inhibits the progression of adjuvant-induced arthritis in rats

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FGFR3/fibroblast growth factor receptor 3 inhibits autophagy through decreasing the ATG12–ATG5 conjugate, leading to the delay of cartilage development in achondroplasia

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Snail2/Slug cooperates with Polycomb repressive complex 2 (PRC2) to regulate neural crest development

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Targeted Deletion of Autophagy Genes Atg5 or Atg7 in the Chondrocytes Promotes Caspase-Dependent Cell Death and Leads to Mild Growth Retardation

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Osteoarthritis

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Silencing of miR-101 Prevents Cartilage Degradation by Regulating Extracellular Matrix–related Genes in a Rat Model of Osteoarthritis

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FGF signalling regulates bone growth through autophagy

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ATG12–ATG3 interacts with Alix to promote basal autophagic flux and late endosome function

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Autophagy protects chondrocytes from glucocorticoids-induced apoptosis via ROS/Akt/FOXO3 signaling

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miR-124, -128, and -137 Orchestrate Neural Differentiation by Acting on Overlapping Gene Sets Containing a Highly Connected Transcription Factor Network

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MicroRNA-128 inhibits EMT of human osteosarcoma cells by directly targeting integrin α2

(2015) Xinsheng Liu et al.   TUMOR BIOLOGY

MicroRNA-9 Promotion of Interleukin-6 Expression by Inhibiting Monocyte Chemoattractant Protein-Induced Protein 1 Expression in Interleukin-1β-Stimulated Human Chondrocytes

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The Relationship of Autophagy Defects to Cartilage Damage During Joint Aging in a Mouse Model

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Ubiquitination and proteasomal degradation of ATG12 regulates its proapoptotic activity

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Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis

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Signature of circulating microRNAs in osteoarthritis

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Regulation of the Catabolic Cascade in Osteoarthritis by the Zinc-ZIP8-MTF1 Axis

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Emerging regulators of the inflammatory process in osteoarthritis

(2014) Ru Liu-Bryan et al.   Nature Reviews Rheumatology

Intra-articular injection of synthetic microRNA-210 accelerates avascular meniscal healing in rat medial meniscal injured model

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Genome-Wide DNA Methylation Study Identifies Significant Epigenomic Changes in Osteoarthritic Cartilage

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Early Response of Mouse Joint Tissue to Noninvasive Knee Injury Suggests Treatment Targets

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FoxO Transcription Factors Support Oxidative Stress Resistance in Human Chondrocytes

(2014) Yukio Akasaki et al.   Arthritis & Rheumatology

In Vivo Cyclic Compression Causes Cartilage Degeneration and Subchondral Bone Changes in Mouse Tibiae

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Boning up on autophagy

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Lin28 Enhances Tissue Repair by Reprogramming Cellular Metabolism

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Inhibition of TGF-β signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis

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Biologic agents in osteoarthritis: hopes and disappointments

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Autophagy in Human Health and Disease

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Overexpression of hsa-miR-148a promotes cartilage production and inhibits cartilage degradation by osteoarthritic chondrocytes

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TFEB-mediated autophagy rescues midbrain dopamine neurons from  -synuclein toxicity

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Brief Report: Carboxypeptidase B Serves as a Protective Mediator in Osteoarthritis

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Gene Expression Pattern of Cells From Inflamed and Normal Areas of Osteoarthritis Synovial Membrane

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Dkk-1 promotes angiogenic responses and cartilage matrix proteinase secretion in synovial fibroblasts from osteoarthritic joints

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Inhibition of cathepsin K reduces cartilage degeneration in the anterior cruciate ligament transection rabbit and murine models of osteoarthritis

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Changes in the epigenetic status of theSOX-9promoter in human osteoarthritic cartilage

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Macro view of microRNA function in osteoarthritis

(2012) Shigeru Miyaki et al.   Nature Reviews Rheumatology

The expression and function of microRNAs in chondrogenesis and osteoarthritis

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MicroRNA-128 downregulates Bax and induces apoptosis in human embryonic kidney cells

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Primary culture and phenotyping of murine chondrocytes

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