Epithelia-Sensory Neuron Cross Talk Underlies Cholestatic Itch Induced by Lysophosphatidylcholine

Activation of Different Heterodimers of TLR2 Distinctly Mediates Pain and Itch

(2020) Ting-Ting Wang et al.   NEUROSCIENCE

MRGPRX4 is a G protein-coupled receptor activated by bile acids that may contribute to cholestatic pruritus

(2019) James Meixiong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MRGPRX4 is a bile acid receptor for human cholestatic itch

(2019) Huasheng Yu et al.   eLife

Cryo-EM and X-ray structures of TRPV4 reveal insight into ion permeation and gating mechanisms

(2018) Zengqin Deng et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

miRNA-711 Binds and Activates TRPA1 Extracellularly to Evoke Acute and Chronic Pruritus

(2018) Qingjian Han et al.   NEURON

Cryo-EM and X-ray structures of TRPV4 reveal insight into ion permeation and gating mechanisms

(2018) Zengqin Deng et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

High-throughput screening identified selective inhibitors of exosome biogenesis and secretion: A drug repurposing strategy for advanced cancer

(2018) Amrita Datta et al.   Scientific Reports

EASL Clinical Practice Guidelines: The diagnosis and management of patients with primary biliary cholangitis

(2017) Gideon M. Hirschfield et al.   JOURNAL OF HEPATOLOGY

Lysophosphatidic acid-induced itch is mediated by signalling of LPA5 receptor, phospholipase D and TRPA1/TRPV1

(2017) Hiroki Kittaka et al.   JOURNAL OF PHYSIOLOGY-LONDON

Regulation of Pain and Itch by TRP Channels

(2017) Carlene Moore et al.   Neuroscience Bulletin

The molecular and cellular mechanisms of itch and the involvement of TRP channels in the peripheral sensory nervous system and skin

(2017) Hiroki Kittaka et al.   ALLERGOLOGY INTERNATIONAL

Lipidomics profiling reveals the role of glycerophospholipid metabolism in psoriasis

(2017) Chunwei Zeng et al.   GigaScience

Transient Receptor Potential Vanilloid 4 Ion Channel Functions as a Pruriceptor in Epidermal Keratinocytes to Evoke Histaminergic Itch

(2016) Yong Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of TRPV1 channels by a naturally occurring omega-9 fatty acid reduces pain and itch

(2016) Sara L. Morales-Lázaro et al.   Nature Communications

Assessment of health related quality of life in polish patients with primary biliary cirrhosis

(2016) Joanna Raszeja-Wyszomirska et al.   Clinics and Research in Hepatology and Gastroenterology

Small molecule dual-inhibitors of TRPV4 and TRPA1 for attenuation of inflammation and pain

(2016) Patrick Kanju et al.   Scientific Reports

Data Normalization Strategies for MicroRNA Quantification

(2015) H. Schwarzenbach et al.   CLINICAL CHEMISTRY

Prognostic and mechanistic potential of progesterone sulfates in intrahepatic cholestasis of pregnancy and pruritus gravidarum

(2015) Shadi Abu-Hayyeh et al.   HEPATOLOGY

OPLS3: A Force Field Providing Broad Coverage of Drug-like Small Molecules and Proteins

(2015) Edward Harder et al.   Journal of Chemical Theory and Computation

Distinct functions of opioid-related peptides and gastrin-releasing peptide in regulating itch and pain in the spinal cord of primates

(2015) Heeseung Lee et al.   Scientific Reports

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

The Bile Acid Receptor TGR5 Activates the TRPA1 Channel to Induce Itch in Mice

(2014) TinaMarie Lieu et al.   GASTROENTEROLOGY

MicroRNA-146a alleviates chronic skin inflammation in atopic dermatitis through suppression of innate immune responses in keratinocytes

(2014) Ana Rebane et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Central Terminal Sensitization of TRPV1 by Descending Serotonergic Facilitation Modulates Chronic Pain

(2014) Yu Shin Kim et al.   NEURON

Extracellular MicroRNAs Activate Nociceptor Neurons to Elicit Pain via TLR7 and TRPA1

(2014) Chul-Kyu Park et al.   NEURON

TRPV4 is necessary for trigeminal irritant pain and functions as a cellular formalin receptor

(2014) Yong Chen et al.   PAIN

TRPV4 channel activity is modulated by direct interaction of the ankyrin domain to PI(4,5)P2

(2014) Nobuaki Takahashi et al.   Nature Communications

Analysis of responses to the TRPV4 agonist GSK1016790A in the pulmonary vascular bed of the intact-chest rat

(2013) Edward A. Pankey et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Phosphatidylinositol-4,5-biphosphate-dependent rearrangement of TRPV4 cytosolic tails enables channel activation by physiological stimuli

(2013) Anna Garcia-Elias et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

UVB radiation generates sunburn pain and affects skin by activating epidermal TRPV4 ion channels and triggering endothelin-1 signaling

(2013) Carlene Moore et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct stem cells contribute to mammary gland development and maintenance

(2011) Alexandra Van Keymeulen et al.   NATURE

Lysophosphatidic acid directly activates TRPV1 through a C-terminal binding site

(2011) Andrés Nieto-Posadas et al.   Nature Chemical Biology

Lysophosphatidic Acid Is a Potential Mediator of Cholestatic Pruritus

(2010) Andreas E. Kremer et al.   GASTROENTEROLOGY

Ablation of TrpV1 neurons reveals their selective role in thermal pain sensation

(2009) Santosh K. Mishra et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

BrafV600E cooperates with Pten loss to induce metastatic melanoma

(2009) David Dankort et al.   NATURE GENETICS

Structural determinants of gating in the TRPV1 channel

(2009) Héctor Salazar et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

MicroRNAs: novel regulators in skin inflammation

(2008) E. Sonkoly et al.   CLINICAL AND EXPERIMENTAL DERMATOLOGY

Lysophosphatidic acid (LPA) and its receptors

(2008) Kyoko Noguchi et al.   CURRENT OPINION IN PHARMACOLOGY

Behavioral differentiation between itch and pain in mouse

(2008) Steven G. Shimada et al.   PAIN