Drug metabolism in the lungs: opportunities for optimising inhaled medicines

Visualizing the spatial localization of ciclesonide and its metabolites in rat lungs after inhalation of 1-μm aerosol of ciclesonide by desorption electrospray ionization-time of flight mass spectrometry imaging

(2021) Eiichi Yamamoto et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Innovative preclinical models for pulmonary drug delivery research

(2020) Stephan Ehrmann et al.   Expert Opinion on Drug Delivery

Pulmonary Metabolism of Substrates for Key Drug-Metabolizing Enzymes by Human Alveolar Type II Cells, Human and Rat Lung Microsomes, and the Isolated Perfused Rat Lung Model

(2020) Katarina Rubin et al.   Pharmaceutics

Remdesivir for Treatment of COVID-19: Combination of Pulmonary and IV Administration May Offer Aditional Benefit

(2020) Duxin Sun   AAPS Journal

Advantages of the Parent Nucleoside GS-441524 over Remdesivir for Covid-19 Treatment

(2020) Victoria C. Yan et al.   ACS Medicinal Chemistry Letters

Functional and metabolic impairment in cigarette smoke-exposed macrophages is tied to oxidative stress

(2019) Daniel S. Aridgides et al.   Scientific Reports

Efficacy and safety of inhaled alpha-1-antitrypsin in patients with severe alpha-1-antitrypsin deficiency and frequent exacerbations of Chronic Obstructive Pulmonary Disease

(2019) Jan Stolk et al.   EUROPEAN RESPIRATORY JOURNAL

Effects of Macromolecular Crowding on Biochemical Systems

(2019) Todd P. Silverstein et al.   JOURNAL OF CHEMICAL EDUCATION

Imaging drugs, metabolites and biomarkers in rodent lung: a DESI MS strategy for the evaluation of drug-induced lipidosis

(2019) Alex Dexter et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Xenobiotica-metabolizing enzymes in the lung of experimental animals, man and in human lung models

(2019) F. Oesch et al.   ARCHIVES OF TOXICOLOGY

Treatment with inhaled α1-antitrypsin: a square peg in a round hole?

(2019) Miriam Barrecheguren et al.   EUROPEAN RESPIRATORY JOURNAL

Development of new in vitro models of lung protease activity for investigating stability of inhaled biological therapies and drug delivery systems

(2019) Arcadia Woods et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Ontogeny and Biology of Human Small Airway Epithelial Club Cells

(2018) Wu-Lin Zuo et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Genotoxicity of fine and coarse fraction ambient particulate matter in immortalised normal (TT1) and cancer-derived (A549) alveolar epithelial cells

(2018) Ian W.H. Jarvis et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Spray-drying of konjac glucomannan to produce microparticles for an application as antitubercular drug carriers

(2018) Filipa Guerreiro et al.   POWDER TECHNOLOGY

Role of the Basement Membrane as an Intestinal Barrier to Absorption of Macromolecules and Nanoparticles

(2018) Julia Mantaj et al.   MOLECULAR PHARMACEUTICS

Human CYP2A13 and CYP2F1 Mediate Naphthalene Toxicity in the Lung and Nasal Mucosa of CYP2A13/2F1-Humanized Mice

(2017) Lei Li et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Co-inhalation of roflumilast, rather than formoterol, with fluticasone more effectively improves asthma in asthmatic mice

(2017) Hussam A Murad et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Engineered sodium hyaluronate respirable dry powders for pulmonary drug delivery

(2017) Francesco Martinelli et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Selective Nonsteroidal Glucocorticoid Receptor Modulators for the Inhaled Treatment of Pulmonary Diseases

(2017) Martin Hemmerling et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Biocompatible Synthetic Lung Fluid Based on Human Respiratory Tract Lining Fluid Composition

(2017) Abhinav Kumar et al.   PHARMACEUTICAL RESEARCH

Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses

(2017) Timothy P. Sheahan et al.   Science Translational Medicine

Deoxyribonuclease 1 reduces pathogenic effects of cigarette smoke exposure in the lung

(2017) Paul T. King et al.   Scientific Reports

Drug-metabolizing Enzymes and Efflux Transporters in Nasal Epithelium: Influence on the Bioavailability of Intranasally Administered Drugs

(2016) Paula Oliveira et al.   CURRENT DRUG METABOLISM

Ciclesonide: A Pro-Soft Drug Approach for Mitigation of Side Effects of Inhaled Corticosteroids

(2016) Jatinder Kaur Mukker et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys

(2016) Travis K. Warren et al.   NATURE

Identification of amino acid determinants in CYP4B1 for optimal catalytic processing of 4-ipomeanol

(2015) Constanze Wiek et al.   BIOCHEMICAL JOURNAL

Macromolecular crowding: Macromolecules friend or foe

(2015) Shruti Mittal et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Effect of CYP3A5*3 on asthma control among children treated with inhaled beclomethasone

(2015) Chris Stockmann et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Extrahepatic metabolism at the body's internal–external interfaces

(2014) Ursula Gundert-Remy et al.   DRUG METABOLISM REVIEWS

Induction of CYP1A1, CYP1A2, CYP1B1, increased oxidative stress and inflammation in the lung and liver tissues of rats exposed to incense smoke

(2014) Tajamul Hussain et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Bronchial airway gene expression in smokers with lung or head and neck cancer

(2014) Eric Van Dyck et al.   Cancer Medicine

Fluticasone Propionate Pharmacogenetics: CYP3A4*22 Polymorphism and Pediatric Asthma Control

(2013) Chris Stockmann et al.   JOURNAL OF PEDIATRICS

Regulatory toxicology considerations for the development of inhaled pharmaceuticals

(2012) Keith Owen   DRUG AND CHEMICAL TOXICOLOGY

Pharmacokinetic evaluation of roflumilast

(2011) Gezim Lahu et al.   Expert Opinion on Drug Metabolism & Toxicology

DNA methylation of the CYP1A1 enhancer is associated with smoking-induced genetic alterations in human lung

(2011) Xavier Tekpli et al.   INTERNATIONAL JOURNAL OF CANCER

Reverse Transcription Polymerase Chain Reaction (RT-PCR) Analysis of Proteolytic Enzymes in Cultures of Human Respiratory Epithelial Cells

(2011) Leonie Baginski et al.   Journal of Aerosol Medicine and Pulmonary Drug Delivery

The Inhaled Glucocorticoid Fluticasone Propionate Efficiently Inactivates Cytochrome P450 3A5, a Predominant Lung P450 Enzyme

(2010) Takahiro Murai et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Effect of Macromolecular Crowding on Reaction Rates: A Computational and Theoretical Study

(2009) Jun Soo Kim et al.   BIOPHYSICAL JOURNAL

Effects of rifampicin on the pharmacokinetics of roflumilast and roflumilast N-oxide in healthy subjects

(2009) Nassr Nassr et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Quantification of Tryptophan Transport and Metabolism in Lung Tumors Using PET

(2009) C. Juhasz et al.   JOURNAL OF NUCLEAR MEDICINE