Treatment with inhaled α1-antitrypsin: a square peg in a round hole?

Decline in FEV1 and hospitalized exacerbations in individuals with severe alpha-1 antitrypsin deficiency

(2019) Adriana-Maria Hiller et al.   International Journal of Chronic Obstructive Pulmonary Disease

Efficacy and safety of inhaled alpha-1-antitrypsin in patients with severe alpha-1-antitrypsin deficiency and frequent exacerbations of Chronic Obstructive Pulmonary Disease

(2019) Jan Stolk et al.   EUROPEAN RESPIRATORY JOURNAL

Tratamiento aumentativo para el enfisema por déficit de alfa-1 antitripsina: Pro

(2018) Miriam Barrecheguren et al.   ARCHIVOS DE BRONCONEUMOLOGIA

Tratamiento aumentativo para el enfisema por déficit de alfa-1 antitripsina: Pro

(2018) Miriam Barrecheguren et al.   ARCHIVOS DE BRONCONEUMOLOGIA

Exacerbation heterogeneity in COPD: subgroup analyses from the FLAME study

(2018) Claus Vogelmeier et al.   International Journal of Chronic Obstructive Pulmonary Disease

Long-term evolution of lung function in individuals with alpha-1 antitrypsin deficiency from the Spanish registry (REDAAT)

(2018) Cristina Esquinas et al.   International Journal of Chronic Obstructive Pulmonary Disease

European Respiratory Society statement: diagnosis and treatment of pulmonary disease in α1-antitrypsin deficiency

(2017) Marc Miravitlles et al.   EUROPEAN RESPIRATORY JOURNAL

ICS Use May Modify FEV1 Decline in α1-Antitrypsin Deficiency Patients with Relatively High Blood Eosinophils

(2017) Emma V. Low et al.   RESPIRATION

Treatment of lung disease in alpha-1 antitrypsin deficiency: a systematic review

(2017) Ross Edgar et al.   International Journal of Chronic Obstructive Pulmonary Disease

Deterioration of quality of life is associated with the exacerbation frequency in individuals with alpha-1-antitrypsin deficiency – analysis from the German Registry

(2017) Nikolas Bernhard et al.   International Journal of Chronic Obstructive Pulmonary Disease

Potential treatment benefits and safety of roflumilast in COPD: a systematic review and meta-analysis

(2016) Lianfang Yuan et al.   International Journal of Chronic Obstructive Pulmonary Disease

Efficacy of augmentation therapy for emphysema associated with α1-antitrypsin deficiency: enough is enough

(2015) Bruno Balbi et al.   EUROPEAN RESPIRATORY JOURNAL

Intravenous augmentation treatment and lung density in severe α1 antitrypsin deficiency (RAPID): a randomised, double-blind, placebo-controlled trial

(2015) Kenneth R Chapman et al.   LANCET

Reduction of severe exacerbations and hospitalization-derived costs in alpha-1-antitrypsin-deficient patients treated with alpha-1-antitrypsin augmentation therapy

(2012) Juan Carlos Barros-Tizón et al.   Therapeutic Advances in Respiratory Disease

Acute Exacerbations of Chronic Obstructive Pulmonary Disease

(2011) Mona Bafadhel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE