Viral infections in humans and mice with genetic deficiencies of the type I IFN response pathway

Mendelian susceptibility to mycobacterial disease: recent discoveries

(2020) Jacinta Bustamante   HUMAN GENETICS

Homozygous STAT2 gain-of-function mutation by loss of USP18 activity in a patient with type I interferonopathy

(2020) Conor Gruber et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Insights into the Role of Innate Immunity in Cervicovaginal Papillomavirus Infection from Studies Using Gene-Deficient Mice

(2020) Carolina Scagnolari et al.   JOURNAL OF VIROLOGY

Contribution of STAT1 to innate and adaptive immunity during type I interferon-mediated lethal virus infection

(2020) So Ri Jung et al.   PLoS Pathogens

A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing Antibodies

(2020) Ahmed O. Hassan et al.   CELL

STAT2 Limits Host Species Specificity of Human Metapneumovirus

(2020) Meredith C. Rogers et al.   Viruses-Basel

A Novel Complete Autosomal-Recessive STAT1 LOF Variant Causes Immunodeficiency with Hemophagocytic Lymphohistiocytosis–Like Hyperinflammation

(2020) Daniel F.R. Boehmer et al.   Journal of Allergy and Clinical Immunology-In Practice

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

(2020) Qian Zhang et al.   SCIENCE

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

(2020) Paul Bastard et al.   SCIENCE

Genetic Lesions of Type I Interferon Signalling in Human Antiviral Immunity

(2020) Christopher J.A. Duncan et al.   TRENDS IN GENETICS

Differential pathogenesis of Usutu virus isolates in mice

(2020) Sarah C. Kuchinsky et al.   PLoS Neglected Tropical Diseases

Herpes simplex encephalitis in a patient with a distinctive form of inherited IFNAR1 deficiency

(2020) Paul Bastard et al.   JOURNAL OF CLINICAL INVESTIGATION

Species-specific pathogenicity of severe fever with thrombocytopenia syndrome virus is determined by anti-STAT2 activity of NSs

(2019) Rokusuke Yoshikawa et al.   JOURNAL OF VIROLOGY

Impaired control of multiple viral infections in a family with complete IRF9 deficiency

(2019) María Bravo García-Morato et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A novel variant in STAT2 presenting with hemophagocytic lymphohistiocytosis

(2019) Mohammed F. Alosaimi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Inherited IFNAR1 deficiency in otherwise healthy patients with adverse reaction to measles and yellow fever live vaccines

(2019) Nicholas Hernandez et al.   JOURNAL OF EXPERIMENTAL MEDICINE

STING induces early IFN-β in the liver and constrains myeloid cell-mediated dissemination of murine cytomegalovirus

(2019) Pia-Katharina Tegtmeyer et al.   Nature Communications

Human inborn errors of immunity to infection affecting cells other than leukocytes: from the immune system to the whole organism

(2019) Shen-Ying Zhang et al.   CURRENT OPINION IN IMMUNOLOGY

A New Patient with Inherited TYK2 Deficiency

(2019) Shokouh Azam Sarrafzadeh et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Human SNORA31 variations impair cortical neuron-intrinsic immunity to HSV-1 and underlie herpes simplex encephalitis

(2019) Fabien G. Lafaille et al.   NATURE MEDICINE

Severe type I interferonopathy and unrestrained interferon signaling due to a homozygous germline mutation in STAT2

(2019) Christopher J. A. Duncan et al.   Science Immunology

Obstructive Lymphangitis Precedes Colitis in Murine Norovirus–Infected Stat1-Deficient Mice

(2018) Audrey Seamons et al.   AMERICAN JOURNAL OF PATHOLOGY

Inborn Errors of RNA Lariat Metabolism in Humans with Brainstem Viral Infection

(2018) Shen-Ying Zhang et al.   CELL

The Discovery of the Antiviral Resistance Gene Mx: A Story of Great Ideas, Great Failures, and Some Success

(2018) Otto Haller et al.   Annual Review of Virology

A Brief Historical Perspective on the Pathological Consequences of Excessive Type I Interferon Exposure In vivo

(2018) Yanick J. Crow et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Life-threatening influenza pneumonitis in a child with inherited IRF9 deficiency

(2018) Nicholas Hernandez et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The human CIB1–EVER1–EVER2 complex governs keratinocyte-intrinsic immunity to β-papillomaviruses

(2018) Sarah Jill de Jong et al.   JOURNAL OF EXPERIMENTAL MEDICINE

STAT2 Signaling Regulates Macrophage Phenotype During Influenza and Bacterial Super-Infection

(2018) Radha Gopal et al.   Frontiers in Immunology

IFNAR2 Is Required for Anti-influenza Immunity and Alters Susceptibility to Post-influenza Bacterial Superinfections

(2018) Kelly M. Shepardson et al.   Frontiers in Immunology

A novel kindred with inherited STAT2 deficiency and severe viral illness

(2017) Leen Moens et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Long-Term Survival After Hematopoietic Stem Cell Transplantation for Complete STAT1 Deficiency

(2017) Samuele Naviglio et al.   JOURNAL OF CLINICAL IMMUNOLOGY

IRF9 Prevents CD8 + T Cell Exhaustion in an Extrinsic Manner during Acute Lymphocytic Choriomeningitis Virus Infection

(2017) Magdalena Huber et al.   JOURNAL OF VIROLOGY

Type-I interferon signalling through IFNAR1 plays a deleterious role in the outcome after stroke

(2017) Moses Zhang et al.   NEUROCHEMISTRY INTERNATIONAL

The Interferon (IFN) Class of Cytokines and the IFN Regulatory Factor (IRF) Transcription Factor Family

(2017) Hideo Negishi et al.   Cold Spring Harbor Perspectives in Biology

A novel Zika virus mouse model reveals strain specific differences in virus pathogenesis and host inflammatory immune responses

(2017) Shashank Tripathi et al.   PLoS Pathogens

Animal Models of Emerging Tick-Borne Phleboviruses: Determining Target Cells in a Lethal Model of SFTSV Infection

(2017) Keita Matsuno et al.   Frontiers in Microbiology

A Mouse Model of Zika Virus Pathogenesis

(2016) Helen M. Lazear et al.   Cell Host & Microbe

Modeling Zika Virus Infection in Mice

(2016) Shannan L. Rossi et al.   Cell Stem Cell

Host genetics of severe influenza: from mouse Mx1 to human IRF7

(2016) Michael J Ciancanelli et al.   CURRENT OPINION IN IMMUNOLOGY

The emerging role of interferon regulatory factor 9 in the antiviral host response and beyond

(2016) Tamara Suprunenko et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Tyrosine kinase 2 is not limiting human antiviral type III interferon responses

(2016) Sebastian Fuchs et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Interferon lambda 4 expression is suppressed by the host during viral infection

(2016) MeeAe Hong et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Recent advances in understanding norovirus pathogenesis

(2016) Stephanie M. Karst et al.   JOURNAL OF MEDICAL VIROLOGY

A recombinant DNA vaccine protects mice deficient in the alpha/beta interferon receptor against lethal challenge with Usutu virus

(2016) Miguel A. Martín-Acebes et al.   VACCINE

Biallelic JAK1 mutations in immunodeficient patient with mycobacterial infection

(2016) Davide Eletto et al.   Nature Communications

A Susceptible Mouse Model for Zika Virus Infection

(2016) Stuart D. Dowall et al.   PLoS Neglected Tropical Diseases

A novel presentation of homozygous loss-of-function STAT-1 mutation in an infant with hyperinflammation—A case report and review of the literature

(2016) Charlotte Burns et al.   Journal of Allergy and Clinical Immunology-In Practice

Signal transducer and activator of transcription 2 deficiency is a novel disorder of mitochondrial fission

(2015) Rojeen Shahni et al.   BRAIN

On intuition and the discovery of interferon

(2015) Ion Gresser   CYTOKINE & GROWTH FACTOR REVIEWS

Human TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndrome

(2015) Alexandra Y. Kreins et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Spectrum of disease outcomes in mice infected with YFV-17D

(2015) Andrea K. Erickson et al.   JOURNAL OF GENERAL VIROLOGY

Human IFNAR2 deficiency: Lessons for antiviral immunity

(2015) Christopher J. A. Duncan et al.   Science Translational Medicine

Selective Blockade of Interferon-α and -β Reveals Their Non-Redundant Functions in a Mouse Model of West Nile Virus Infection

(2015) Kathleen C. F. Sheehan et al.   PLoS One

STAT1 Signaling Is Essential for Protection againstCryptococcus neoformansInfection in Mice

(2014) Chrissy M. Leopold Wager et al.   JOURNAL OF IMMUNOLOGY

IRF7-Dependent Type I Interferon Production Induces Lethal Immune-Mediated Disease in STAT1 Knockout Mice Infected with Lymphocytic Choriomeningitis Virus

(2014) W. Li et al.   JOURNAL OF VIROLOGY

Human but Not Mouse Hepatocytes Respond to Interferon-Lambda In Vivo

(2014) Pascale Hermant et al.   PLoS One

Mendelian susceptibility to mycobacterial disease: Genetic, immunological, and clinical features of inborn errors of IFN-γ immunity

(2014) Jacinta Bustamante et al.   SEMINARS IN IMMUNOLOGY

Type-I interferon response affects an inoculation dose-independent mortality in mice following Japanese encephalitis virus infection

(2014) Kotaro Aoki et al.   Virology Journal

The Role of Innate versus Adaptive Immune Responses in a Mouse Model of O'Nyong-Nyong Virus Infection

(2013) Robert L. Seymour et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Lethal Crimean-Congo Hemorrhagic Fever Virus Infection in Interferon α/β Receptor Knockout Mice Is Associated With High Viral Loads, Proinflammatory Responses, and Coagulopathy

(2013) Marko Zivcec et al.   JOURNAL OF INFECTIOUS DISEASES

The Pathogenesis of Severe Fever with Thrombocytopenia Syndrome Virus Infection in Alpha/Beta Interferon Knockout Mice: Insights into the Pathologic Mechanisms of a New Viral Hemorrhagic Fever

(2013) Y. Liu et al.   JOURNAL OF VIROLOGY

Structural basis of a unique interferon-β signaling axis mediated via the receptor IFNAR1

(2013) Nicole A de Weerd et al.   NATURE IMMUNOLOGY

Infection of Type I Interferon Receptor-Deficient Mice with Various Old World Arenaviruses: A Model for Studying Virulence and Host Species Barriers

(2013) Toni Rieger et al.   PLoS One

STAT2 deficiency and susceptibility to viral illness in humans

(2013) S. Hambleton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development of a Highly Protective Combination Monoclonal Antibody Therapy against Chikungunya Virus

(2013) Pankaj Pal et al.   PLoS Pathogens

Inborn errors of human STAT1: allelic heterogeneity governs the diversity of immunological and infectious phenotypes

(2012) Stephanie Boisson-Dupuis et al.   CURRENT OPINION IN IMMUNOLOGY

Immunity to infection in IL-17-deficient mice and humans

(2012) Sophie Cypowyj et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The JAK-STAT Pathway at Twenty

(2012) George R. Stark et al.   IMMUNITY

Structural and dynamic determinants of type I interferon receptor assembly and their functional interpretation

(2012) Jacob Piehler et al.   IMMUNOLOGICAL REVIEWS

Type I Interferon Signaling Protects Mice From Lethal Henipavirus Infection

(2012) Kévin P. Dhondt et al.   JOURNAL OF INFECTIOUS DISEASES

Mice Deficient in STAT1 but Not STAT2 or IRF9 Develop a Lethal CD4+ T-Cell-Mediated Disease following Infection with Lymphocytic Choriomeningitis Virus

(2012) M. J. Hofer et al.   JOURNAL OF VIROLOGY

TYK2 Kinase Activity Is Required for Functional Type I Interferon Responses In Vivo

(2012) Michaela Prchal-Murphy et al.   PLoS One

Severe impairment of IFN-  and IFN-  responses in cells of a patient with a novel STAT1 splicing mutation

(2011) D. Vairo et al.   BLOOD

Lethality and pathogenesis of airborne infection with filoviruses in A129  /  -/- interferon receptor-deficient mice

(2011) M. S. Lever et al.   JOURNAL OF MEDICAL MICROBIOLOGY

The Naturally Attenuated Kunjin Strain of West Nile Virus Shows Enhanced Sensitivity to the Host Type I Interferon Response

(2011) S. Daffis et al.   JOURNAL OF VIROLOGY

Inborn errors of anti-viral interferon immunity in humans

(2011) Vanessa Sancho-Shimizu et al.   Current Opinion in Virology

Induction and function of type I and III interferon in response to viral infection

(2011) David E Levy et al.   Current Opinion in Virology

STAT2 Mediates Innate Immunity to Dengue Virus in the Absence of STAT1 via the Type I Interferon Receptor

(2011) Stuart T. Perry et al.   PLoS Pathogens

Life-threatening infectious diseases of childhood: single-gene inborn errors of immunity?

(2010) Alexandre Alcaïs et al.   Annals of the New York Academy of Sciences

A novel form of human STAT1 deficiency impairing early but not late responses to interferons

(2010) X.-F. Kong et al.   BLOOD

Mouse STAT2 Restricts Early Dengue Virus Replication

(2010) Joseph Ashour et al.   Cell Host & Microbe

Novel STAT1 Alleles in a Patient with Impaired Resistance to Mycobacteria

(2010) Ines Ackerl Kristensen et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Crimean-Congo hemorrhagic fever virus infection is lethal for adult type I interferon receptor-knockout mice

(2010) S. Bereczky et al.   JOURNAL OF GENERAL VIROLOGY

A Novel Role for IFN-Stimulated Gene Factor 3II in IFN-  Signaling and Induction of Antiviral Activity in Human Cells

(2010) A. N. Morrow et al.   JOURNAL OF IMMUNOLOGY

Lambda Interferon Renders Epithelial Cells of the Respiratory and Gastrointestinal Tracts Resistant to Viral Infections

(2010) M. Mordstein et al.   JOURNAL OF VIROLOGY

Lambda Interferon Is the Predominant Interferon Induced by Influenza A Virus Infection In Vivo

(2010) N. A. Jewell et al.   JOURNAL OF VIROLOGY

Anti-retroviral effects of type I IFN subtypes in vivo

(2009) Nicole Gerlach et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A partial form of recessive STAT1 deficiency in humans

(2009) Ariane Chapgier et al.   JOURNAL OF CLINICAL INVESTIGATION

A Mouse Model for Studying Viscerotropic Disease Caused by Yellow Fever Virus Infection

(2009) Kathryn C. Meier et al.   PLoS Pathogens

Host Responses to Wild-Type and Attenuated Herpes Simplex Virus Infection in the Absence of Stat1

(2008) T. J. Pasieka et al.   JOURNAL OF VIROLOGY

A Mouse Model for Chikungunya: Young Age and Inefficient Type-I Interferon Signaling Are Risk Factors for Severe Disease

(2008) Thérèse Couderc et al.   PLoS Pathogens

Pyogenic Bacterial Infections in Humans with MyD88 Deficiency

(2008) H. von Bernuth et al.   SCIENCE

Interferon-λ Contributes to Innate Immunity of Mice against Influenza A Virus but Not against Hepatotropic Viruses

(2008) Markus Mordstein et al.   PLoS Pathogens

IFN-Lambda (IFN-λ) Is Expressed in a Tissue-Dependent Fashion and Primarily Acts on Epithelial Cells In Vivo

(2008) Caroline Sommereyns et al.   PLoS Pathogens